Volume 8 ~ Issue 9,~Version 1, ~ September - 2018


Paper Type

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Research Paper

Title

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Evaluation of the antipyretic activity of the aqueous extract of Zinger (Zingiber officinale) rhizome in female rats

Country

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Iraq

Authors

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Awatif M. Al-Saaedi || Zainab Mohsin Ibrahim

Page No.

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01-03

Paper Index
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XXXX

This study was designed to evaluate the antipyretic activity of the aqueous extract of Zingiber officinale rhizome by the use of Brewer's yeast induced pyrexia method in female rats. The animals were randomly divided into 5 groups, the first group was served as a control group, the second group was subcutaneously injected by 30% yeast suspension (10 ml/kg). The third group was served as a standard group, it treated with yeast suspension and paracetamol (150 m/kg). The fourth and fifth groups were treated with yeast suspension and with 100 and 200 mg/kg respectively. Rectal temperature was taken at the start of the test and after 19 h after yeast injection to detect the rise of rectal temperature, after then paracetamol and the plant extract were administrated. Rectal temperature was noted again after 0, 1,2 and 3 h of drug administration. The results appeared that the aqueous extract of Zingiber officinale has significant antipyretic activity at P< 0.05.

 

Keywords: Zingiber officinale, aqueous extract, Antipyretic.

[1]. Dimie, O. (2011). Fever, fever patterns and diseases called 'fever'-A review. Journal of Infection and Public Health.4: 108—124.
[2]. Edward, J. W., Sameer, H-J., Mike, C. and Lui, F. (2016). The pathophysiological basis and consequences of fever. Critical Care. 20(200). DOI 10.1186/s13054-016-1375-5
[3]. Eugene, C. C. (1982). Behavioral and autonomic thermoregulation in terrestrial ectotherms. In A companion to animal physiology. (Richard C. Taylor, Kjell, J. and Liana, B., Ed).1st edition. PP 198-216. Cambridge University Press. New York. USA.
[4]. Goda, Y., Kiuchi, F., Shibuya, M. and Sankawa, U. (1992). Inhibitors of prostaglandin biosynthesis from Dalbergia odorifera, Chemical and Pharmaceutical Bulletin. 40 (9): 2452–2457.
[5]. Govindarajan, V. S.( 1982a) Ginger: Chemistry, technology, and quality evaluation: Part 1. Crit Rev Food Science & Nutrition. 17:1-96.

 

Paper Type

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Research Paper

Title

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Review Article on Anticancer and Anti-Oxidant Activity of Leaves of Annona Reticulata on EAC Induced Mammary Tumor

Country

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India

Authors

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Kashikant Yadav || Nagarathna P.K.M || Diana Moria Martin Lou || Gyamcho Bhutia

Page No.

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04-11

Paper Index
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XXXX

Annona reticulata Linn is a highly versatile plant in medicine for the treatment of various diseases. The plant has many activities like anti-helmintic, analgesic, anti-inflammatory, anti-pyretic, wound healing, anti-tumor and abortifacient properties. The present review article gives an overview on anticancer and antioxidant activity of leaves of Annona reticulata on EAC induce mammary tumor. The methanolic extracts of Annona reticulata is used against Ehrlich ascites carcinoma (EAC) in mice. Tumor cells (2×106 cells/mice) are injected into the hind limb of mice subcutaneously and tumor is allowed to develop. The effect of methanolic extracts of Annona reticulata is checked on the growth of tumor.

 

Keywords: Annona reticulata, anti-tumor, antioxidant, EAC.

[1]. Sarkar Mahanandan ,Das Mousumi,Mitra Debmalya,Jena Aditya Kumar,De Arnab, Samanta Amalesh.Anticancer potential of methanolic and aqueous extract of Leucas indica. Againstehrlich ascites carcinoma cells on swiss albino mice.International research journal of
pharmacy. 2013; 4 (6):183-88.
[2]. N. Sri Sainadh, Nagarathna PKM, Vasantha Kumar C, SC Kulkarni.Evaluation of Anti-Cancer Activity of Kigelia africana on EAC Induced Breast Tumors.Journal of Pharmacy and
Sciences. 2013; 2(3):78-84.
[3]. A. Jenecius ,V.R. Mohan.Evaluation of Anticancer Potential of Bacolepsis nervosa decne.Ex. Moq. Against Ehrlich Ascites Carcinoma Induced Cancer in Swiss Albino Mice.International research journal of pharmacy. 2014; 27(1):292-97.
[4]. Rohini Ahuja, Neeraj Agrawal, Alok Mukerjee.Evaluation of anticancer potential of Terminalia chebula Fruits against Ehrlich Ascites Carcinoma induced cancer in mice. Journal of Scientific and Innovative Research. 2013; 2(3):549-54.

 

Paper Type

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Research Paper

Title

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Relationship Between Ace Insertion/Deletion Genotypes And Response To Anti-Hypertensive Medications In T2dm Patients With Hypertension

Country

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India

Authors

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Dr. Mohd Ishaq || Nusrath Fathima || Faiz Unnisa Begum || Farheen Fatima || Ruqia Nasreen || Sara Nikhat || Uzma Afreen Sultana

Page No.

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12-18

Paper Index
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XXXX

The objective of the present study was to investigate, if there exists a relationship between ACE insertion/ deletion genotypes and anti-hypertensive treatment being received by type-2 diabetes mellitus (T2DM) patientswith hypertension. This is a non-interventional study where a total of 46 T2DM cases with hypertension were recruited and 45 healthy normotensive subjects served as controls. The anti-hypertensive medications being received were Angiotensin Receptor Blockers (ARBs 40mg, OD), Calcium Channel Blockers (5mg, OD), Beta-Blockers (25mg, OD) and Diuretics (12.5mg, OD) either alone or in combination. It was observed that 70% of the patients with II-genotype responded to angiotensin receptor blockers (ARBs) whereas, nearly 92% of the patients of DD-genotype responded to calcium channel blockers (50%)/ beta-blocker (42.35%) either alone or in combination............

 

Keywords: Hypertension, Type2 Diabetes Mellitus, ACE gene I/D-Genotypes, Anti-Hypertensive Treatment.

[1]. Jitendra k. Epidemiology of hypertension: clinical queriesin nephrology.2(2); 56-61, 2013.
[2]. Rahimni K,C.A Emin, Mahon S. Epidemiology of blood pressure and its worldwide management, circulation research, 116: 925-936: 2015.

[3]. Carretero OA, Oparil S; Oparil (January 2000). "Essential hypertension. Part I: definition andetiology". Circulation. 101 (3):32935. doi:10.1161/01.CIR.101.3.329.

[4]. Mohamed Berraho, Youness El Achhab, Abdelilah Benslimane, Karima EL Rhazi, Mohamed Chikri, and Chakib Nejjari. Hypertension and type 2 diabetes: a cross-sectional study in Morocco (EPIDIAM Study).Pan Afr Med J. 11: 52. 2012.
[5]. Bild D, Teutsch SM. The control of hypertension in persons with diabetes: A public health approach. Public Health Rep;102: 522-529: 1987.

 

Paper Type

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Research Paper

Title

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Concomitant Use Of Policosanol And Diuretics In Older Patients With Type Ii Hypercholesterolemia

Country

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Cuba

Authors

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José Illnait-Ferrer || Julio César Fernández-Travieso || Lilia Fernández-Dorta || Sarahí Mendoza-Castaño || Rosa Más-Ferreiro || Rafael Gámez-Menéndez || Ernesto López-González || Meilis Mesa-Angarica

Page No.

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19-28

Paper Index
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XXXX

Objective: The objective of the present analysis as a part of a Prevention Study, we investigated whether concomitant administration of policosanol with diuretics induces some specific adverse event or disturbance on any safety indicator in older patients. Methods: We randomised 1470 elderly patients at high coronary risk to policosanol 5 mg/day or placebo for 3 years. For this analysis, the records of all patients (368) taking diuretics were included. Analysis was by Intention-to-treat. Results: Both groups were well matched at baseline. Policosanol effects persisted during the whole study. At study completion, policosanol reduced low-density lipoprotein cholesterol (LDL-C) (29.1 %), total cholesterol (19.6 %), triglycerides (22.5 %) and raised high-density lipoprotein cholesterol (HDL-C) (13.8 %). Of 368 patients consuming diuretics............

 

Keywords: policosanol, diuretics, elderly, hypercholesterolemia, drug interactions.

[1]. Mozaffarian D, Benjamin EJ, Go AS. Heart Disease and Stroke Statistics-2016 Update: A Report from the American Heart Association. Circulation. 2016;133:e38-46.
[2]. Boekholdt SM, Hovingh GK, Mora S. Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials. J Am Coll Cardiol. 2014; 64:485-94.
[3]. Cholesterol Treatment Trialists' (CTT) Collaboration, Fulcher J, O'Connell R. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials. Lancet. 2015;385:1397-1405.
[4]. Felix FJ, Grau M, Fernandez D. Cholesterol and cardiovascular disease in the elderly. Facts and Gaps. Aging Dis. 2013;4(3):154-69.
[5]. Mas R: Policosanol Drugs of the Future. 2000;25:569-86.

 

Paper Type

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Research Paper

Title

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High Performance Liquid Chromatography Assay of Anti-Malarial Quinine Sulfate Utilizing Isocratic Solvent Conditions

Country

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USA

Authors

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Ronald Bartzatt || Mai Han Cassandra Nguyen || Gunner Brantley || Aysha Hussain || Keerthi Shaik || Purnima Gajmer || Zohal Alizai || Mara Bullock

Page No.

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29-38

Paper Index
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XXXX

A method to assay quinine sulfate, which is utilized for the treatment of Plasmodium falciparum, is presented using isocratic high performance liquid chromatography (HPLC). Elution of the analyteis detected with ultraviolet light detector, set at 222 nm. The stock solution of quinine sulfate was prepared in solvent conditions that consisted of 64 % ethanol (v/v) and 36 % water (v/v), at a concentration of 1.3155 x 10-2 molar. The test samples of quinine sulfate that were injected into HPLC instrument were mainly in a solvent that consisted of 95% (v/v) water and 5 % ethanol (v/v). The solvent utilized for column of the HPLC instrument was 5 % ethanol, 1 % glacial acetic acid (v/v), and 94 % water (v/v)............

[1]. Merrick C. Plasmodium falciparum. Emerging Topics in Life Sciences, 2017; (6): 517-23.
[2]. Rich S , Leendertz F, Xu G, Lebreton M, Djoko C, Aminake M, Takang K, Diffo J, Pike G, Rosenthal B, Formenty P, Boesch C, Ayala F, Wolfe N. The origin of malignant malaria. Proceedings of the National Academy of Sciences, 2009; 106(35): 14902-7.
[3]. Perkins D, Were T, Davenport G, Kempaiah P, Hittner J, Ong'Echa J. Severe malarial anemia: innate immunity and pathogenesis. International Journal of Biological Sciences, 2011; 7(9): 1427-42.
[4]. Perlmann P, Troye-Blomberg M. Malaria blood stage infection and its control by the immune system. Folia Biologica, 2000; 46(6): 210-8.
[5]. Vaughan A, Aly SI, Kappe S. Malaria parasite pre-erythrocytic stage infection: gliding and hiding. Cell Host & Microbe, 2008; 4(3): 209-18.[6]. Rogerson SJ. Management of malaria in pregnancy. Indian J Med Res, 2017; 146(3): 328-333.

 

Paper Type

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Research Paper

Title

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Synthesis and Characterization of Cisplatin-Loaded BSA (Bovine Serum Albumin) Nanoparticles as Drug Delivery System against Pancreatic Cancer Cells

Country

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Egypt

Authors

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Sohier M.Syame || Zaki Monawar Eisa || Ragaa Eltayeb || Ashraf S. Hakim || MagdyKhalil M

Page No.

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39-48

Paper Index
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XXXX

Cisplatin as chemotherapeutic agents is consideredone of important drug for treatment of many malignant disorders. Prolonged and Conventional administration methods for cisplatine reduce its effectiveness to the target organ beside side-effects, as nephrotoxicity and ototoxicity. Nanotechnology holds several promises in cancer therapeutics. It can increase the ability of the drug toward the target site of the tumor cells, reach otherwise lesser-accessible sites and reduce the frequency of administration. The present study explored the efficacy of cisplatin coated albumin nanoparticle as a sustained delivery system.To attain this goal, cisplatin was loaded onto albumin nanoparticles (NPs),characterization of the formed albumin nanoparticles was done using surface plasmon spectra using UV-spectroscopy .The morphology of nanoparticles (NPs) were determined by scanning electron microscope (SEM ), transmission electron microscope...........................

 

Keywords: Cisplatin, albumin nanoparticle, drug release, pancreatic cancer cells.

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[2]. D Wang, andS.J.Lippard,Cellular processing of platinum anticancer,DrugsNat Rev Drug Discov, 4, 2005, 307–320.
[3]. L Kelland ,The resurgence of platinum-based cancer chemotherapy,Nat Rev Cancer, 2007, 7, 573–584.
[4]. J. Reedijk,New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA,Proceeding of the National Academy of Sciences of the United States of America,2003,100, 3611–3616.
[5]. . S Ishida, J. Lee, D.Thiele, andI. Herskowitz, Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals, PNAS, 2002, 99, 14298-302.

 

Paper Type

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Research Paper

Title

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Sponges As Heavy Metal Accumalators And As Cytotoxic Agents

Country

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India

Authors

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Rani.S,V.Padmaja

Page No.

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49-56

Paper Index
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XXXX

The diversity in chemical structure of sponge derived metabolites is related to an equally diverse pattern of activities.Scientist in the field of natural products chemistry and research suggest that sponges have the potential to provide future drugs againsts important diseases,such as a range of viral diseases,malaria,inflammations,immunesuppressive diseases and various malignant neoplasms.Sponges,the dominant benthic organism has filter feeding mechanism, deposits heavy metals in their tissues.These heavy metals have a major role in many of the biological reactions involved in cytotoxicity.Research findings shows that,Haliclonatenuiramosa,which can be used asbioindicators for heavy metal pollution ,had significantly higher heavy metal concentration at near shore region due to anthropogenic input .

[1]. ""Bioactive Natural substances from marine sponges",New developments and Prospects For Pharmaceuticals,OMICS International
[2]. Mohammed FerdousMehbub,Jie lei et al,Marine sponge derived natural products between 2001 and 2010,Trends and Oppurtunities for discovery of Bioactives,Marine Drugs,2014,12(8),4539-4577

[3]. J.L Carballo,S.A.Naranjo,J.C Garcia Gomez,Use of marine sponges as stress indicators in marine ecosystems at Algericas Bay (Southern Iberian Peninsula).Marine Ecology progress series,Vol 135:109122,1996
[4]. J.VenkateswaraRao,K.Srikanth,RamjeePallela,T.GnaneshwarRao The use of marine sponge,Haliclonatenuiramosa as bioindicator to monitor heavy metal pollution in the coasts of Gulf of Mannar,India,Enviorn .Monit.Assess (2009) 156,451-459
[5]. Paul.B.tchounwon,Clement.G.Yedjou and Dwanye.J.Sutton,Heavy metal toxicity and the environment.EXS.2012:101;133-164