April - 2020 (Volume-10 ~ Issue-4 ~ Series-1)

Paper Type

::

Research Paper

Title

::

A Study on Hearing Screening Among Patients with Neonatal Asphyxia in a Rural Tertiary Care Hospital

Country

::

India

Authors

::

Swati Mondal || Ganesh Chandra Gayen || Ritam Ray

Page No.

::

01-04

Objectives: To screen neonates with neonatal asphyxia for assessment of early hearing loss Materials and Methods: Prospective study over a period of 1 year (January, 2017 to December, 2017). 100 term birth asphyxiated hypoxic ishchemic encephalopathy stage I, II, III infants attending well baby clinic of Otorhinolaryngology department & Paediatrics department of Burdwan Medical College &Hospital, Burdwan for hearing assessment were assessed audiologically. Results: 100 patients attended our ENT OPD for audiological assessment of hearing from January, 2017 to December, 2017. 56 infants passed at 1st OAE test and declared normal. At 2nd OAE, 37 out of those 44 infants were declared normal. BERA confirmed hearing loss due to hypoxic brain damage in only 1 infant. Conclusion: Early detection of this hearing loss in extremely important for early institution of appropriate management to minimize morbidity in those affected and reduce the burden of this disability in our community. Screening tests like Otoacoustic emmision test is important tools to identify this hearing loss at the earliest subjected to confirmation by BERA.

 

Keywords: Hearing loss; Neonata asphyxia; Otoacoustic Emission; Brainstem Evoked Response Audiometry

[1]. de Haan M, Wyatt JS, Roth S, Vargha-Khadem F, Gadian D, Mishkin M. Brain and cognitive-behavioural development after asphyxia at term birth. Dev Sci. 2006;9:350-8..
[2]. Lawn JE, Cousens S, Zupan J and for the Lancet Survival Steering team. 4 million neonatal deaths: when? where? why? Lancet. 2005;365:891-900.
[3]. Amini E, Farahani Z K, Samani M R, Hamedi H, Zamani A, Yazdi A K et al. Assessment of Hearing Loss by OAE in Asphyxiated Newborns. Iran Red Crescent Med J. 2014 Jan; 16(1): e6812.
[4]. Ohl C, Dornier L, Czajka C, Chobaut JC, Tavernier L. Newborn hearing screening on infants at risk. Int J Pediatr Otorhinolaryngol. 2009;73(12):1691–5. doi: 10.1016/j.ijporl.2009.08.027
[5]. Pourarian S, Khademi B, Pishva N, Jamali A. Prevalence of hearing loss in newborns admitted to neonatal intensive care unit. Iran J Otorhinolaryngol. 2012;24(68):129–34.

 

Paper Type

::

Research Paper

Title

::

A Study on clinicopathology and surgical outcome of Parotid Gland Neoplasm

Country

::

India

Authors

::

Ganesh Chandra Gayen || Ashim Sarkar || Ritam Ray

Page No.

::

05-10

Objectives :To analyze the demographic, clinicopathological and treatment aspects of parotid gland tumours. Materials and Methods : Prospective institutional based observational study over a period of 2 years from January 2015 and December 2017 in the Department of ENT, Burdwan Medical College & Hospital, Burdwan.This study includes 100 cases who presented with parotid swelling during the study period. All the patients were examined carefully to roughly assess the extent of tumour after meticulous history taking. Fine needle aspiration cytology (FNAC), ultrasonography of neck and CT Scan of neck was done routinely, MRI of neck was done in selective cases. Results : The age range of the patient affected was between 20 and 70 years with mean age of 41.5 years. Benign tumuors(82%) were 4.55 times more common (82%) than malignant tumours. The most common benign tumuor was pleomorphic adenoma(60.90%), and...........

 

Keywords: Parotid gland tumour; Facial nerve palsy; Parotidectomy

[1]. Ellis Gray L, Auclair Paul L, Gnepp Douglas R. Surgical Pathology of the Salivary Glands. 2nd ed., Vol. 25. Philadelphia: W. B. Saunders; 1991. p. 61-91.
[2]. Witt RL. The significance of the margin in parotid surgery for pleomorphic adenoma. Laryngoscope 2002;112:2141-54.
[3]. Xiao C,Zhan K,White-Gibertson S,et al. Predictors of nodal metastasis in parotid malignancies. Otolaryngol Head Neck Surg 2015;154(1):121-130.
[4]. Ashim Kumar et al. Complications of Parotid Surgery A Study of 30 Cases.Bangladesh Journal of Otorhinolaryngology, [S.l.], v. 21, n. 1, p. 23-27, jul. 2015.
[5]. Lin CC, Tsai MH, Huang CC, Hua CH, Tseng HC, Huang ST. Parotid tumors: A 10-year experience. Am J Otolaryngol Head Neck Med Surg 2008;29:94-100.

 

Paper Type

::

Research Paper

Title

::

COVID-19: A Short Review on Possible Treatments

Country

::

India

Authors

::

Sheelu Monga

Page No.

::

11-13

The disease causes respiratory illness (like the flu) with symptoms such as a cough, fever, and in more severe cases, difficulty in breathing. As coronavirus (COVID-19) can be spread from person to person, isolation restricts the movement of someone who is ill to prevent the spread elsewhere. Coronavirus disease spreads primarily through contact with an infected person when they cough or sneeze. It also spreads when a person touches a surface or object that has the virus on it, then touches their eyes, nose, or mouth. It takes 2-14 days for the symptoms to appear in which the first symptom is fever. The possible treatments of COVID-19 include anti-inflammatory treatments and passive antibodies..

 

Keywords: COVID-19, cytokines, immunity, antibody

[1]. Bennardo, F., Buffone, C., & Giudice, A. (2020). New therapeutic opportunities for COVID-19 patients with Tocilizumab: Possible correlation of interleukin-6 receptor inhibitors with osteonecrosis of the jaws. Oral Oncology, 104659. https://doi.org/10.1016/j.oraloncology.2020.104659
[2]. Chan, J. F.-W., Zhang, A. J., Yuan, S., Poon, V. K.-M., Chan, C. C.-S., Lee, A. C.-Y., Chan, W.-M., Fan, Z., Tsoi, H.-W., Wen, L., Liang, R., Cao, J., Chen, Y., Tang, K., Luo, C., Cai, J.-P., Kok, K.-H., Chu, H., Chan, K.-H., … Yuen, K.-Y. (2020). Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. https://doi.org/10.1093/cid/ciaa325
[3]. Day, M. (2020). Covid-19: European drugs agency to review safety of ibuprofen. BMJ (Clinical Research Ed.), 368, m1168. https://doi.org/10.1136/bmj.m1168
[4]. Gautret, P., Lagier, J.-C., Parola, P., Hoang, V. T., Meddeb, L., Mailhe, M., Doudier, B., Courjon, J., Giordanengo, V., Vieira, V. E., Dupont, T., Honoré, S., Colson, P., Chabrière, E., Scola, B. La, Rolain, J.-M., Brouqui, P., & Raoult, D. (2020). Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents, 105949. https://doi.org/10.1016/j.ijantimicag.2020.105949

 

Paper Type

::

Research Paper

Title

::

Industrial Applications of Liquid Peracetic Acid Disinfectant: A Review

Country

::

India

Authors

::

Dr. Vivek Vishwe || Kalpana Bhatwadekar

Page No.

::

14-16

Peracetic acid (PAA) serves as an excellent antimicrobial agent and hence it is widely used in the formulations of disinfectants for effective actions. It has already been known to have outstanding activity against bacteria, fungi, viruses and bacterial or fungal endospores. This unique feature of Peracetic acid makes it an important kind of disinfectant that can be used in various industries including medical, food & beverage, veterinary, agriculture and paper & pulp industries. This article primarily aims at the industrial applications of liquid Peracetic acid disinfectant in these various fields.

 

Keywords: Peracetic acid, Disinfectant, Applications.

[1]. Rutala W, Weber D, and the Healthcare Infection Control Practices Advisory Committee (HICPAC) Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008, https://www.cdc.gov/infectioncontrol/guidelines/disinfection/
[2]. Yoo J. Review of Disinfection and Sterilization – Back to the Basics. Infect Chemother 2018; 50(2): 101-109.
[3]. Malchesky P. Peracetic Acid and Its Application to Medical Instrument Sterilization. Artificial Organs 1993; 17: 147-152.
[4]. Boyce J. Modern technologies for improving cleaning and disinfection of environmental surfaces in hospitals. Antimicrobial Resistance and Infection Control 2016; 5: 1-10.
[5]. Baldry M . The bactericidal, fungicidal and sporicidal properties of hydrogen peroxide and peracetic acid. Journal of Applied Bacteriology 1983; 54: 417-423.

 

Paper Type

::

Research Paper

Title

::

Applying 3 Level Polynomial Design for Optimisation, Method Development and Validation for Ibuprofen and Caffeine By RP-UPLC Method

Country

::

India

Authors

::

A Vikram || Dr R Shanmugam || Dr K Madhuri || Dr C.K Ashok Kumar

Page No.

::

17-45

Background: their exist several methods that uses combination of paracetamol and caffeine with the help of UPLC frame work. But with different combination of simple reverse phase Ultra performance liquid chromatography (RP-UPLC) method has been developed by statistical design of experiment for determination of Ibuprofen and Caffeine. These drugs are used as Non-steroidal anti-inflammatory drug (NSAID) and Central nervous system stimulant (CNS stimulant). Materials and Methods: The separation was carried out using mobile phase consisting of Methanol and water (Adjusting with ortho phosphoric acid of PH 4.5) ratio of 70:30 v/v. The column used is UHP ASB C18, (1.9μm, 2.1 X 50 mm) with flow rate of 0.1 ml/min using PDA detection at 254nm.The calibration curves were linear over a concentration range of 2001.2-6003.6 μg/mL and 325.2-975.6 μg/mL for Ibuprofen and Caffeine. The retention times of Ibuprofen and Caffeine were found to.......

 

Keywords: Caffeine, Ibuprofen, RP-UPLC, Methanol, Ortho phosphoric acid, Design of experiment

[1]. Beckett A.H and Stenlake J.B; Text book of pharmaceutical chemistry 4th Edn,-part 2 CBS publishers and Distriburots, New Delhi,1998:278,307
[2]. Douglas Skoog A., James Hollar F. and Timothy Nieman, a Principle of Instrumental Analysis. 5thed., Thomson Learning Inc. Singapore, 1998;110 ,300
[3]. Sharma,B.K., Instrumental method of Chemical Analysis, 24th ed., GOEL Publishing House, Meerut,2005; 46, 68.
[4]. www.Inova.fo/upload/myndasavan/uflc%20 prominence.pdf.
[5]. Kofman J., Zhao Y., Maloney T., Baumgartner T., Bujalski R.: Am. Pharm. Rev. 2006; 9: 88.