July - 2022 (Volume-12 ~ Issue-7 ~ Series-1)

Paper Type

::

Research Paper

Title

::

Pancreas Cancer: A Literary Review

Country

::

 

Authors

::

Ana Paula Schneider Bruck || Bruna Fernandes da Silva || Camila da Silva Senna Barroso || Isadora Cristina Teixeira Bono || Leticia Margon Manzini de Souza || Michelle Lima Garcez || Orlando Chiarelli Neto

Page No.

::

01-11

Introduction : Pancreatic cancer occurs as pancreatic adenocarcinoma, with a poor prognosis, which represents, in addition to pathophysiological changes, great psychosocial impacts on the patient's life, due to the fact that the disease presents itself, in most cases, late, making it difficult to early detection of tumor or pre-malignant tumors. Objective: To demonstrate updated data about the clinical aspects, diagnosis and treatments of the disease. Method: To obtain the data, 38 articles on the subject were used, researched in the main books and articles related to pancreatic cancer, from 2010 to 2021. Statistical were performed observing the equality between the understandings cited by each author, so that the thesis about each point of this article was confirmed Results : Mortality and incidence of pancreatic cancer are increasing rapidly.......

 

KEYWORDS: pancreas ; cancer ; surgery

[1]. McCain et al. Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes . World Journal of Gastroenterology.DOI: 10.3748 / wjg.v24.i 43.4846 . 2018
[2]. Klein. APEpidemiology of pancreatic cancer: understanding the role of lifestyle and hereditary risk factors . Nature Reviews Gastroenterology & Hepatology. DOI https://doi.org/10.1038/s41575-021-00457-x. 2021 _
[3]. Cai et al . Advances in theepidemiologyofpancreaticcancer : Trends, riskfactors , screening, andprognosis https://doi.org/10.1016/j.canlet.2021.06.027 . 021 Elsevier BV Allrightsreserved . 2021.
[4]. Beg,Muhammad et al. Impact of Diabetes Mellitus on the Outcome of Pancreatic Cancer . Plosone.DOIhttps://doi.org/10.1371/journal.pone.0098511 https://doi.org/10.1371/journal.pone.0098511. _ 2014.
[5]. Lulu Zhang, Santosh Sanagapalli , and Alina Stoita . Challenges in diagnosis of pancreatic cancer . World Journal of Gastroenterology. DOI: https:// 10.3748/ https://dx.doi.org/10.3748%2Fwjg.v24.i19.2047wjg.v24.i https://dx.doi.org/10.3748%2Fwjg.v24.i19.204719.2047 . 2018


Paper Type

::

Research Paper

Title

::

Use of corticosteroids in medical practice: Pattern of prescription, adverse effects and pre-prescription counselling practices

Country

::

Nigeria

Authors

::

Ogundele SO || Dada AO || Olaosebikan BH || Amisu M || Cole-Adeife OM || Dr. Sunday O. Ogundele

Page No.

::

12-16

Corticosteroids are a group of medications that are structurally and pharmacologically similar to the endogenous hormone cortisol. The mechanisms of action for the therapeutic effects and clinical improvement associated with corticosteroids are also responsible for most of the adverse effects associated with its chronic use or its use in high doses. Prescription of corticosteroids is on the increaseamong patients seen in our clinical practice. The increase in steroid prescription is associated with increasing frequency of complications associated with its chronic use. The main objective of this study is to review the prescription pattern of steroids in our practice and to also assess how patients are counselled before they are started on these agents.......

 

KEYWORDS: Corticosteroids, counselling, prescription, adverse effects, Lagos.

[1]. Yasir M, Goyal A, Bansal P, Sonthalia S. Corticosteroid Adverse Effects. (Updated 2021 Mar 3). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK531462/
[2]. Liu, D., Ahmet, A., Ward, L, Krishnamoorthy P, Mandelcorm ED, Leigh R, Brown JP, Cohen A, Kim H. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. All AsthClinImmun 2013; 9: 30. https://doi.org/10.1186/1710-1492-9-30.
[3]. Hengge UR, Ruzicka T, Schwartz RA, Cork MJ. Adverse effects of topical glucocorticosteroids. J Am AcadDermatol. 2006;54(1):1-15; quiz 16-8. DOI: 10.1016/j.jaad.2005.01.010. PMID: 16384751.
[4]. van Staa TP, Leufkens HG, Abenhaim L, Begaud B, Zhang B, Cooper C. Use of oral corticosteroids in the United Kingdom. QJMed. 2000;93(2):105-11. DOI: 10.1093/qjmed/93.2.105. PMID: 10700481.
[5]. Royal College of Physicians Guidelines Writing Group. Glucocorticoid-induced osteoporosis: Guidelines for prevention and treatment. London: Royal College of Physicians, 2002.


Paper Type

::

Research Paper

Title

::

Development and Validation of RP-HPLC Method For quantitative Estimation of Cetirizine HCL in Pharmaceutical Formulation as Per ICH Guideline

Country

::

India

Authors

::

Dr. Gayatri Barabde || Aarti Babu Kokate || Dr. Sushama Ambadekar

Page No.

::

17-25

Background: A simple, specific, linear, precise and accurate reverse phase liquid chromatographic (RP-HPLC) method was developed to analysis speed by minimizing run time and retention timeof Cetirizine Hydrochloride in tablet dosage forms. The chromatographic separation was performed using Phenomenex Luna 5μ C18 100A (250 x 4.6 mm). Mobile phase composed of Acetonitrile and water (60:40 v/v) was selected and a flow rate of 1.000 ml/minute is monitored with injection volume of 20μl. Detection was carried out at 229 nm. The method was validated as per ICH guidelines. The retention time for CetirizineHydrochloride is observed as 2.3 minutes. Linearity range was observed in concentration of 50 - 150 μg/ml for Cetirizine Hydrochloride. The percentage recovery of Cetirizine Hydrochlorideis 100%. The correlation coefficients for both the components are close to 1. The proposed method was validated and successfully applied to the estimation of CetirizineHydrochloride in tablet dosage forms.

 

KEYWORDS: Cetirizine Hydrochloride, method development, Validation.

[1]. Rudaz. S., Souverain. S., Schelling. C.,andDeleersM.Anal. Chim. Acta,Development and validation of a heart-cutting liquid chromatography–mass spectrometry method for the determination of process-related substances in cetirizine tablets.2003, 492:271–282.
[2]. Nightingale, C.H. 1996. Treating allergic rhinitis with second-generation antihistamines. Pharmacotherapy, 1996, 16: 904-914.
[3]. P Beringer, A der Marderosian, L. Felton, et al, "Remington: The Science and Practice of Pharmacy" Lippincott Williams & Wilkins, Philadelphia, 21st ed., 2006.
[4]. European Medicines Agency, "Guideline on Excipients in the Dossier for Application for Marketing Authorisation of a Medicinal Product" Doc. Ref. EMEA/CHMP/QWP/396951 /2006, London, 6 November 2006.
[5]. Kuchekar BS, Shinde GS, Naikwadi IT, Todkar KJ, Kharade SV, "Specrtophotometric estimation of ambroxol hydrochloride in tablets" Indian J Pharm Sci, 2003; 65(2): 193-195.