Background and Objectives: Angina pectoris refers to the pain from the heart felt in the pectoral regionsof the upper chest. It is a predominant symptom of ischemicheart disease caused by transient episodes ofmyocardial ischemia. The traditional medications for the treatment were discovered about 60years ago. The current presentations and complications associated with angina are hardly well catered for by such medicines and present daymanagement keeps evolving. The need for bringing health practitioners and researchers up to speed with recent advances in drug management of angina pectoris becomes essential. Methods: This review examines published literature of the last 20years on the pharmacotherapeutic approaches to angina pectoris management.Online search of published literature from reputable sources of pubmed, researchgate and google scholar were used as well as offline......

Keywords: Pharmacotherapy, angiogenesis, angina, lipoprotein apheresis

[1]. Abrams, J. (1985). Hemodynamic effects of nitroglycerin and long-acting nitrates. American Heart Journal, 110(1 Pt 2):216– 224.
[2]. Abrams, J. (1992). Mechanisms of action of the organic nitrates in the treatment of myocardial ischemia. American Journal of Cardiology, 70(8):30b–42b.
[3]. Alderman, E. L., Davies, R. O., Crowley, J. J. et al. (1975). Dose response effectiveness of propranolol for the treatment of angina pectoris. Circulation, 51(6):964– 975.
[4]. Anonymous (No date). The influence of febuxostat on coronary artery endothelial dysfunction in participants with chronic stable angina. Https://clinicaltrials.gov/ct2/show/NCT01763996 (Retrieved on 30th January 2020).
[5]. Arora, R. R., Chou, T. M., Jain, D. et al. (1999). The multicenter study of enhanced external counterpulsation (MUST-EECP): effect of EECP on exercise-induced myocardial ischemia and anginal episodes. Journal of American College Cardiology, 33(7):1833–40.

Objectives: To assess the hearing status in elderly patients in a rural tertiary care hospital Materials and Methods: 55 patients over the age of 59 years with hearing loss as the chief complaint attending out patient department of ENT department of Burdwan Medical College & Hospital, Burdwan over a period of 1 year (January, 2018 to December, 2018) were selected for this study for hearing assessment. Results: Out of 55 patients. (i.e. 110 ears), 33 (60%) were males and 22 (40%) were females with male-to-female ratio 1.5:1. Mean age of patients were 72.81 +10.21. Pure tone audiometry showed moderate hearing loss is more common. The most prevalent audiometric configurations were gradual sloping (59.09%). The patients had symptoms associated with hearing loss were tinnitus (16 patients, 29.09%), blockage (7 patients, 12.72%), vertigo (6 patients, 10.08%) and vague sensation (1 patient, 1.81%). Conclusion: Majority of elderly persons suffer from age related hearing loss which imposes a negative impact on the quality of life of those persons. It is a major public health problem.

Keywords: Hearing loss; Elderly patients; Pure Tone Audiometry

[1]. Greco M C, Russo I CP. Audiological findings of elderly individuals of a private clinic in são paulo city.
Acta ORL. 2006;24(4):245–54
[2]. Valete R, Cláudia M, Rozenfeld S. Auditory screening in the elderly: comparison between self-report and
audiometry. Braz J Otorhinolaryngol. 2005;71(2):193–200.
[3]. Hinchcliffe R. The threshold of hearing as a function of age. Acustica. 1959, 9:303-308.
[4]. Corso J. Age and sex differences in pure tone thresholds.Arch.Otolaringol. 1963, 77:385-405.
[5]. Guest JF, Greener MJ, Robinson AI, Smith AF. Impacted cerumen: composition, production, epidemiology and management. QJM. 2004, 97:477-88.

Background: During general anesthesia airway control is usually provided by laryngoscopy and endotracheal intubation. These are noxious stimuli leading to extreme haemodynamic stress and is associated with intense sympathoadrenal response marked by tachycardia, hypertension and arrhythmia which can be deleterious to pateients. The Aim of our study was to compare effects of IV dexmedetomidine with esmolol in attenuating the pressor response du ring laryngoscopy and intubation. Methods-90 patients of ASA I and ASA II grade between 18-65 yr scheduled for elective non cardiac surgery under general anaesthesia.The patients were randomly divided into three groups(n=30).Group C received placebo,Group E received 1.0 mg/kg of esmolol and group D received 1μg per kg of dexmedetomidine intravenously over 15 min and just before induction...........

Keywords: Dexmedetomidine, esmolol, , intubation, laryngoscopy, hemodynamic response

[1]. Reid & amp; Brace: Irritation of respiratory tract and its reflex effect on heart-Surgery Gynaecology Obstetrics. 1940;70:157.
[2]. Derbyshire D, Chmielewski A, Fell D. Plasma catecholamine responses to tracheal intubation. Anaesth. 1983;55(9):855-60
[3]. Fox EJ, Sklar GS, Hill CH, Villanueva R, King BD. Complications Related to the Pressor Response to Endotracheal Intubation. Anesthesiology. 1977;47(6):524–5.
[4]. Martin DE, Rosenberg H, Aukburg SJ, Bartkowski RR, Edwards MW, Greenhow DE, et al. Low-dose fentanyl blunts circulatory responses to tracheal intubation. Anesth Analg. 1982;61(8):680–4.
[5]. Ebert JP, Pearson JD, Gelman S, Harris C, Bradley EL. Circulatory responses to laryngoscopy: the comparative effects of placebo, fentanyl and esmolol. Can J Anaesth. 1989;36(3 Pt 1):301–6.

COVID-19 (coronavirus disease 2019) was declared by WHO as public health emergency of international concern. The coronavirus outbreak came to light on December 31, 2019 when China informed the World Health Organisation of large number of cases of pneumonia of an unknown cause in Wuhan City in Hubei Province. Subsequently the disease spread from China to the rest of the world. The WHO has now declared it a pandemic. The virus has been named SARS-CoV-2 and the disease is now called COVID-19.As of now no specified treatment or medications is available for COVID-19. In this article I have discussed some keypoints regarding the outbreak of disease and impact from Wuhan to other parts of the world, pathogenesis, transmission, diagnostic procedures, prevention and management of COVID-19.

Keywords: COVID-19, SARS-CoV-2,pandemic, transmission, prevention and management

[1]. Hui DS, I Azhar E, Madani TA, Ntoumi F, Kock R, Dar O, et al. (February 2020). "The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China". International Journal of Infectious Diseases. 91: 264–266. doi:10.1016/j.ijid.2020.01.009. PMC 7128332. PMID 31953166 [2]. "WHO Director-General's opening remarks at the media briefing on COVID-19". World Health Organization (WHO) (Press release). 11 March 2020. Archived from the original on 11 March 2020. Retrieved 12 March 2020. [3]. "COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU)". ArcGIS. Johns Hopkins University. Retrieved 23 May2020. [4]. "WHO Director-General's opening remarks at the media briefing on COVID-19 - 11 March 2020". World Health Organization (WHO) (Press release). 11 March 2020. Archived from the original on 11 March 2020. Retrieved 12 March 2020. [5]. Wee SL, McNeil Jr. DG, Hernández JC (30 January 2020). "W.H.O. Declares Global Emergency as Wuhan Coronavirus Spreads". The New York Times. Archived from the original on 30 January 2020. Retrieved 30 January 2020.

The carrot (Daucus carota subsp. sativus) is a root vegetable, usually orange in colour, though purple, black, red, white, and yellow cultivars exist. Carrot is a root vegetable with carotenoids, flavonoids, polyacetylenes, vitamins, and minerals, all of which possess numerous nutritional and health benefits. Besides lending truth to the old adage that carrots are good for eyes, carotenoids, polyphenols and vitamins present in carrot act as antioxidants, anticarcinogens, and immunoenhancers. Anti-diabetic, cholesterol and cardiovascular disease lowering, anti-hypertensive, hepatoprotective, renoprotective, and wound healing benefits of carrot have also been reported. The cardio- and hepatoprotective, anti-bacterial, anti-fungal, anti-inflammatory, and analgesic effects of carrot seed extracts are also noteworthy. All are discussed in this review article. Carrot is one of the important root vegetables rich in bioactive compounds like carotenoids and dietary fibers with appreciable levels of several other functional components..........

KEYWORDS: Daucus carota, Chemical Composition, Antioxidants, Phytochemicals, Disease Prevention

[1]. Simon, P.W. (2000) Domestication, Historical Development and Modern Breeding of Carrot. Plant Breeding Reviews,19, 157-190.
[2]. Dias, J.S. (2012) Major Classes of Phytonutriceuticals in Vegetables and Health Benefits: A Review. Journal of Nutritional Therapeutics, 1, 31-62.
[3]. Dias, J.S. (2012) Nutritional Quality and Health Benefits of Vegetables: A Review. Food and Nutrition Sciences, 3,1354-1374.
[4]. Sun, T., Simon, P.W. and Tamumuhardjo, S.A. (2009) Antioxidant Phytochemicals and Antioxidant Capacity of Biofortified Carrots (Daucus carota L.) of Various Colors. Journal of Agricultural and Food Chemistry, 57, 4142-4147.
[5]. Simon, P.W. and Goldman, I.L. (2007) Carrot. In: Sing, R.J., Ed., Genetic Resources, Chromosome Engineering, and Crop Improvement, CRC Press, Boca Raton, 497-516.

Labetalol Hydrochloride has been widely used as an anti-hypertensive drug. The present study concerns with the development and evaluation of Hydrodynamically balanced system of Labetalol Hydrochloride by using the different natural polymer such as chitosan(animal derived) and its different grades low medium and high molecular chitosan along with a plant derived polymer which is psyllium husk. We encorporated the natural polymer to eliminate the risk of toxicity. This formulation is designed to prolong the gastric residence time, increase the bioavailability and sustain the drug release pattern. The hydrodynamic ally balanced capsule was prepared by the help of ordered mixing technique and the evaluation is performed by the different study pattern such as in vitro dug release..........

Keywords: Hydrodynamically balanced system, labetalol hydrochloride, chitosan, plantago ovate, anti-hypertensive drug, toxicity, bioavailability

[1]. Ali J, Arora S, Ahuja A, Babbar AK, Sharma RK, Khar RK, Baboota S. Formulation and development of hydrodynamically balanced system for metformin: in vitro and in vivo evaluation. European journal of pharmaceutics and biopharmaceutics.2007 Aug 31;67(1):196-201
[2]. Ankur raj Sharma, Afroz khan et al (2014) a gastroretentive drug delivery: an approach to enhance gastric retention for prolong drug release. Internationaljournal of pharmaceutical science's and research, Vol 5 issue 4, page no. 1095
[3]. Arora S, Ali J, Ahuja A, Khar RK, Baboota S. Floating drug delivery systems: a review. AapsPharmSciTech.2005 Sep 1;6(3):E372-90.