The motivation behind this audit article fundamentally is to discuss medical care conveyance arrangement of India in contrast with other created nations like Norway USA ,china and so forth ,with their approaches followed by the significant part of Clinical drug specialist to give great medical services benefits that may diminish diabetes predominance and a couple of proposals to improve medical care association. System embraced that the writing audit search in Pub Med, Cochrane, Embase, Google researcher , science immediate and Official government sites were performed. Admittance to great medical care framework can applies beneficial outcome on monetary and social movement in any nation including India. The general well being status should be tended to through different arrangement..........

Keywords: Pharmacy Education; Health policies, Healthcare setup, impact of clinical pharmacist ,Diabetes Mellitus.

[1]. Ma S, Sood N, "A Comparison of the Health Systems in China and India.," Rand Corporation: CA, USA,, 2008. .
[2]. Peters DH, Rao KS, Fryatt R. , "Lumping and splitting: the health policy agenda in India.," Health Policy Plan , vol. 18, no. (3), p. 249–26, 2003.
[3]. "MOHFW National Health Policy.," New Delhi Ministry of Health and Family Welfare, Govt. of India, 1983. .
[4]. Bhagavathula AS,Sarkar BR, Patel I., "Clinical pharmacy practice in developing countries: Focus on India and Pakistan.," Archives of Pharmacy Practice , vol. 5, no. 91, 2014.
[5]. Shaikh BT, Hatcher J., " Health seeking behaviour and health service utilization in Pakistan: challenging the policy makers.," Journal of Public Health , vol. 27, pp. 49-54, 2005

Endophytic fungi from medicinal plants are important natural sources of bioactive secondary metabolites for pharmaceutical industries to explore new drugs. The objective of this research was to isolate endophytic fungi from flowers, roots and leaves of Heliotropium indicum using two different growth media, Potato Dextrose Agar (PDA) and Maltose Extract Agar (MEA). The antibacterial activity of isolated endophytic fungi was determined against two Gram-positive (S. aureus and B. cereus) and two Gram-negative (E. coli and P. aeruginosa) bacteria. Agar disc diffusion assay was used to check the antibacterial activity at the concentrations of 400 μg/disc, 200 μg/disc, 100 μg/disc, 50 μg/disc, 25 μg/disc and 12.5 μg/disc for the isolated endophytic fungi from flowers, roots and leaves of H. indicum. More endophytic fungi were isolated from flowers, roots and leaves of H. indicum in MEA media than PDA media..........

Keywords: Antibacterial, Heliotropium indicum, Disc diffusion, B. cereus, E.coli, P. aeruginosa, S. aureus

[1]. Abdullah, M. S., Dash, G. K. (2013). A review on Heliotropium indicum L. (boraginaceae), International Journal of Pharmaceutical Sciences and Research 4 (4) : 1253-1258.
[2]. Afzan, A., Ahmad, N. (2005). In vitro screening of five local medicinal plants for antibacterial activity using disc diffusion method, Tropical Biomedicine 22(2):165-17.
[3]. Arun, K. G., Robert, A. A., Kannan, V. R. J. (2015). Exploration of endophytic microorganisms from selected medicinal plants and their control potential to multi drug resistant pathogens, Journal of Medicinal Plants Studies 3 (2): 49-57.
[4]. Bhardwaj, A., Agrawal, P.(2014).A review fungal endophytes as a store house of bioactive compound, World Journal of Pharmacy and Pharmaceutical Sciences 3 (9):228-237.
[5]. Boye, A., Koffuor, G.A., Amoateng, P., Ameyaw, E.O., Abaitey, A. K. (2012). Analgesic Activity and Safety Assessment of Heliotropium indicum Linn. (Boraginaceae) in Rodents, International Journal of Pharmacology8 (2):91-100.

The phytochemical screening showed that of Nerium oleander contained alkaloids, flavonoids, carbohydrates, tannins, phenolics, saponins, cardenolides, cardiac glycosides, pregnanes, triterpenoids, triterpenes and steroids. The previous pharmacological studies revealed that Nerium oleander possessed antioxidant, anticancer, antimicrobial, antiparasitic, antinflammatory, analgesic dermatological, hypolipidemic, antidiabetic, cardiovascular and central nervous effects. current review highlighted the bioactive ingredients and pharmacological effects of Nerium oleander.

Keywords: Nerium oleander, ingredients, pharmacology, therapeutic

[1]. Al-Snafi AE. Oils and fats contents of medicinal plants, as natural ingredients for many therapeutic purposes- A review. IOSR Journal of Pharmacy 2020; 10(7): 1-41.
[2]. Al-Snafi AE. Phenolics and flavonoids contents of medicinal plants, as natural ingredients for many therapeutic purposes- A review. IOSR Journal of Pharmacy 2020; 10(7): 42-81.
[3]. Al-Snafi AE. Medicinal plants with central nervous effects (part 2): plant based review. IOSR Journal of Pharmacy 2016; 6(8): 52-75.
[4]. Al-Snafi AE, Talab TA and Majid WJ. Medicinal plants with central nervous activity - An overview (part 1). IOSR Journal of pharmacy 2019, 9(3): 52-102.

[5]. Al-Snafi AE. Medicinal plants for prevention and treatment of cardiovascular diseases - A review. IOSR Journal of Pharmacy 2017; 7(4): 103-163.

The chemical analysis of Nasturtium officinale showed the presence of alkaloids, flavonoids, saponins, terpenoids/steroids, protein, essential and volatile oils, glycosides, tannins, folic acid, vitamins and elements. The previous pharmacological studies revealed that Nasturtium officinale possessed hypolipidemic, anti-inflammatory, hepato and reno protective, antidiabetic, antioxidant, anticancer, antimicrobial, dermatological, antigenotoxic, anti-urolithiatic and antigenotoxic effects. The current review highlighted the chemical ingredients and pharmacological effects of Nasturtium officinale.

Keywords: Nasturtium officinale, ingredients, pharmacology, therapeutic

[1]. Al-Snai AE. Iraqi medicinal plants with antifungal effect- A review. IOSR Journal of Pharmacy 2019; 9(7): 16-56.
[2]. Al-Snai AE. Iraqi medicinal plants with antiviral effect- A review. IOSR Journal of Pharmacy 2019; 9(7): 57-75.
[3]. Al-Snai AE. Iraqi medicinal plants with antibacterial effect- A review. IOSR Journal of Pharmacy 2019; 9(8): 22-103.
[4]. Al-Snai AE, Al-Kamel ML, Esmail ME. Antifungal effect of Alhagi maurorum phenolic extract. IOSR Journal of Pharmacy 2019; 9(8): 7-14.
[5]. Al-Snafi AE. Medical benefit of Lallemantia iberica- A review. To Chemistry Journal 2019; 3: 128-133.

The chemical analysis of Narcissus tazetta showed that it contained flavonoids, alkaloids, saponins, tannins, cardiac glycosides, oil, steroids, terpenoids and anthraquinones. The pharmacological investigation showed that Narcissus tazetta antibacterial and antifungal, antiviral, antimalerial, anticancer, antioxidant, dermatological, cardiovascular, immunomodulatory and acetylcholinesterase inhibitory effects. The current review discussed the chemical constituents and pharmacological effects of Narcissus tazetta.

Keywords: Narcissus tazetta, ingredients, pharmacology, therapeutic

[1]. 1-Orhan IE . Biotechnological production of plant secondary metabolites. Bentham ebook, 2012: 107.
[2]. Al-Snafi AE. Constituents and pharmacology of Luffa cylindrica- A review. IOSR Journal of Pharmacy 2019; 9(9):68-79.

[3]. Al-Snafi AE. A review on Lawsonia inermis: A potential medicinal plant. International Journal of Current Pharmaceutical Research 2019; 11(5):1-13.

[4]. Al-Snafi AE. Medicinal value of Lagerstroemia speciosa: An updated review. International Journal of Current Pharmaceutical Research 2019; 11(5):18-26.
[5]. Al-Snafi AE. Chemical constituents and pharmacological activities of Lantana camara- A review. Asian J Pharm Clin Res 2019; 12912):10-20.

Background:Phenothiazine is one of the protypical pharmaceutical lead molecules in medicinal chemistry. Derivatives of phenothiazines are highly bioactive and have widespread applications including antipsychoyic, antiemetic,neuroleptic action, antiproleferative effect, inhibition of P-gylcoprotein transport function, urinary antiseptic, antihelmenthic and insecticide Materials and Method:A modified and improved method was followed for synthesis of 10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)-2-(trifluoromethyl)-10H-phenothiazine-5-oxide dihydrochloride and 10-(3-(4-(2-hydroxyethyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine-5,5-dioxide dihydrochloride by hydrogen peroxide oxidation of 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazine-10-yl)propyl)piperazine-1-yl)ethanol dihydrochloride and 10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)-2-(trifluoromethyl)-10H-phenothiazine5-oxide dihydrochloride, respectively, at room temperature..........

Keywords: Phenothiazine-5-oxide, Phenothiazine-5,5-dioxide, Antipsychotic, Invitro anti-inflammatory, Serial dilution antibacterial method.

[1]. Psychosis: Symptoms, Causes and Risk factors: July 2020. Cited fromhttps://www.healthline.com/health/psychosis.
[2]. Introduction to Psychosis: July 2020. Cited from https://en.wikipedia.org/wiki/Psychosis#Causes.

[3]. R. Srinivasa Murthy. National Mental Health Survey of India 2015–2016.Indian Journal of Psychiatr. Jan-Mar 2017;59(1):21–26.

[4]. Suresh Bada Math and Ravindra Srinivasaraju. Indian Psychiatric epidemiological studies: Learning from the past. Indian Journal of PyschiatryJan 2010;52(Suppl1):S95–S103.
[5]. Fluphenazine-Uses, Side effects and Warnings: Aug 2020. Cited from https://www.drugs.com/mtm/fluphenazine.html.