June - 2021 (Volume-11 ~ Issue-6 ~ Series-1)

Paper Type

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Research Paper

Title

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Protective Effects of Propranolol and Carvedilol on Experimentally Induced Ulcerative Colitis in Male Albino Rat

Country

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Egypt

Authors

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Nermeen Ramadan Ali Shaaban || Sohair Hanem Samir El-Menshawy || Amal Elsayed Salem || Shireen Sami Mahmoud Othman

Page No.

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01-12

Background: Ulcerative colitis (UC) is a chronic inflammatory disease of large intestine. Overproduction of free radicals, lowered antioxidant capacity, inflammation and abnormal apoptosis are involved in its pathogenesis. Propranolol and carvedilol, β-blockers with antioxidant and anti-inflammatory effects which may have a protective role in UC. The study aimed to evaluate and compare the effects of propranolol and carvedilol on UC development and to distinguish which of them have greater beneficial effect on experimentally-induced UC in male albino rats. Methods: Fifty male albino rats were randomly allocated to five groups with each group comprising eleven rats except control group composed of six rats.......

 

KEYWORDS: Ulcerative colitis, Mesalazine, Carvedilol, Propranolol

[1]. Moura, F. A., de Andrade, K. Q., dos Santos, J. C. F., et al., (2015): Antioxidant therapy for treatment of inflammatory bowel disease: does it work?. Redox Biology, 6, 617-639.
[2]. Stidham, R. W., and Higgins, P. D. (2018): Translational Research in Colorectal Cancer: Colorectal Cancer in Inflammatory Bowel Disease. Clinics in colon and rectal surgery, 31(3), 168.
[3]. Stepaniuk, P., Bernstein, C. N., Targownik, L. E., et al., (2015): Characterization of inflammatory bowel disease in elderly patients: a review of epidemiology, current practices and outcomes of current management strategies. Canadian Journal of Gastroenterology and Hepatology, 29(6), 327-333.
[4]. Mostafa, E. F., Metwally, A., and Hussein, S. A. (2018): Inflammatory Bowel Diseases Prevalence in Patients Underwent Colonoscopy in Zagazig University Hospitals. Afro-Egyptian Journal of Infectious and Endemic Diseases, 8(2), 81-87.
[5]. Gupta, R. A., Motiwala, M. N., Mahajan, U. N., et al., (2018): Protective effect of Sesbania grandiflora on acetic acid induced ulcerative colitis in mice by inhibition of TNF-α and IL-6. Journal of ethnopharmacology, 219, 222-232.


Paper Type

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Research Paper

Title

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Buddleja scordioides HBK (Salvilla) a medicinal plant in Bolsón de Mapimi, Durango, Mexico

Country

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México

Authors

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José L. Ortega-Sánchez || Aurora Martínez-Romero || José de Jesús Alba Romero

Page No.

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13-16

Traditional medicine is an alternative resource for the treatment of multiple symptoms associated with gastrointestinal diseases such as inflammation. Traditional medicine or complementary medicine is recognized today as a fundamental resource to preserve the health of millions of beings, the use of natural resources such as medicinal plants is an empirical therapeutic resource with valuable results in its healing practices, in addition to helping to protect and strengthen the cultural identity of a population, in addition to being a healing resource of wide social recognition. The objective of this review was to know the medicinal uses of the Buddleja scordioides HBK (Salvilla) plant from Bolson de Mapimí, Durango. This systematic literature review was carried out from January 2018 to march 2021. Herbal infusions, unlike pharmacological medicines, contain multiple chemical compounds of diverse nature........

 

KEYWORDS: wild plant, infusión herbal, medicina folklorica, salud intestinal, actividad antioxidante

[1]. Díaz-Rivas JO, González-Laredo R., Chávez-Simental JA, Montoya-Ayón JB, Moreno-Jiménez MR, Gallegos-Infante JA, Rocha-Guzmán NE. Comprehensive characterization of extractable phenolic compounds by UPLC-PDA-ESI-QqQ of Buddleja scordiodes plants elicited with salicylic acid. Journal of Chemistry 2018b; 1-10.
[2]. Díaz-Rivas JO, Herrera-Carrera E, Gallegos-Infante JA, Rocha-Guzmán NE, González-Laredo RF. Gastroprotective Activities of Buddleja scordioides-Role of Polyphenols against Inflammation. J Chem Biol Ther 2016; 1(2): 1-8.
[3]. Cortés AR, Delgadillo AJ, Hurtado M, Domínguez-Ramírez AM, Medina JR, Aoki K. The Antispasmodic Activity of Buddleja scordioides and Buddleja perfoliata on Isolated Intestinal Preparations. Biol Pharm Bull 2006; 29(6):1186-1190.
[4]. Deneb-Camacho M, Hernández-Peruaquia SI, Lilian-Morfin L. Tepozán (Buddleia cordata). FESC-UNAM. Proyecto PAPIME PE205907, 2009.
[5]. Rzedowsky J. Diversidad y orígenes de la flora fanerogámica de México. Acta Botánica Mexicana 1991; 14:3-21.


Paper Type

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Research Paper

Title

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A Study on Psychotropic Changes in Epilepsy. Evaluation and Regulation of Mood, Quality Of Life In Epileptic Patients

Country

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India

Authors

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Dr.Syed Mohammed Kazim || Fatima Asfia Shah || Salma Sultana || Tasneem Fatima || Umaimah Naaz || Zubair Ahmed

Page No.

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17-26

Background: The connection among psychiatry and epilepsy stays one of the points that have been persistently standing out in clinical writing since the time of Hippocrates. As of late, a few reports were distributed with respect to conceivable antagonistic mental impacts of antiepileptic medications. This paper planned to audit mental introductions in people with epilepsy and the antagonistic mental impacts of antiepileptic prescriptions. The paper additionally momentarily talks about accessible treatment choices with regards of better psychotropic treatment choices.........

 

KEYWORDS: Antiepileptic drugs, psychotropic changes, mood regulation, quality of life.

[1]. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S ILAE official report: a practical clinical definition of epilepsy". Epilepsia; 2014 June 9.
[2]. World Health Organization. Epilepsy Fact Sheet. 2016 March 4.
[3]. Chang BS, Lowenstein DH. Epilepsy. The New England Journal of Medicine- 2003, September; 349 (13): 1257–66.
[4]. Hammer GD, McGhee SJ, eds. Pathophysiology of disease : an introduction to clinical medicine (6th ed.). New York: McGraw- Hill Medical; 2010.
[5]. Harvard health publishing .Generalized Seizures (Grand Mal Seizures)[Internet].Harvard medical school: April,2009.


Paper Type

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Research Paper

Title

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The Activity of Bromelain Enzyme from Pineapple (Ananas Comosus (L) Merr): A Review

Country

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Indonesia

Authors

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Soni Muhsinin || Pratiwi Anggraeni Putri || Dadang Juanda || Rahma ziska

Page No.

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27-32

Background: Bromelain is a protein-digesting enzyme that can accelerate a hydrolysis reaction of protein. This enzyme has a form like a yellowish-white powder. To determine how to isolate this enzyme, it is first necessary to know the location of the enzyme in the source. Furthermore, similar types of enzymes from different sources will have different activity values. The purpose of this literature review is to conduct a literature search on the activity of the bromelain enzyme contained in pineapple (Ananas Comosus (L) Merr) in the pharmaceutical sector..........

 

KEYWORDS: Anti-aggregationt, antibacterial, anti-inflammatory, antifungal, anticancer, bromelain, extract pineapple

[1]. Rachmawati D, Sulistyowati E, Gultom T. Characterization The Activity Of Bromelain Enzyme From Pineapple Skin (Ananas Comosus (L.) Merr) Immobilized With Silica Gel and Cmc.Yogyakarta. 2013;(L) :1–8.
[2]. Nur S, Surati S, Rehalat R. An Enzyme Bromelin Activity On Increased Protein Dregs Coconut Flour. BIOSEL (Biology Science and Education): Jurnal Penelitian Science dan Pendidikan. 2017 Jun 7;6(1):84-93.
[3]. Bahtiyar AY, Efriyadi O, Fitriah E. The Effectiveness of the Anti-Bacterial Content of Pineapple (Ananas comosus L. Merr) in Inhibiting the Growth of Streptococcus mutans Bacteria. In Seminar Nasional Sains and Entrepreneurship IV 2017 2017 Oct 25.
[4]. Putri RM, Yuanita T, Roelianto M. Antibacterial potency of pineapple peel extract (Ananas comosus) on Enterococcus faecalis growth. Conservative Dentistry Journal. 2016 Jul 3;6(2):1-6.
[5]. Yusuf M, Alyidrus R, Irianti W, Farid N. Antifungal Activity Test of Ethanol Extract of Pineapple Skin (Ananas comosus (L.) Merr) on the Growth of Pityrosporum ovale and Candida albicans Causes Dandruff. Health Media Makassar Health Polytechnic. 2020 Dec 26;15(2):311-8. DOI: https://doi.org/10.32382/medkes.v15i2.1762


Paper Type

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Research Paper

Title

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A Systematic Review on The Commonly Available Plants With Anti-Obesity Potential

Country

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India

Authors

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N GOKUL KANNAA || P L SUJATHA || V APPA RAO || S SOWMYA || K VIJAYARANI || MANIKKAVASAGAN I

Page No.

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33-36

The development of obesity involves hormones and neurotransmitters. The Body Mass Index (BMI) help us to determine the levels of obesity. The prevalence of obesity, measured by BMI has raised to unacceptable levels both men and women worldwide with resultant hazardous health implications. Genetic, environmental, and behavioural factors influence the development of obesity. Obesity is associated with and contributes to a shortened life span, type 2 diabetes mellitus, cardiovascular disease. some cancers, kidney disease, obstructive sleep apnea, gout, osteoarthritis, and hepatobiliary disease, among others. Since an intriguing relationship between thyroid and obesity had seen. Thyroid hormones are involved in multiple physiological processes and regulating basal metabolic rate, promote the adrenergic nervous system to generate heat in response to cold exposure, stimulate gluconeogenesis and both lipolysis and lipogenesis..........

 

KEYWORDS: Obesity ,Basal Metabolic Rate(BMR), Thyroid Hormones(TH), Selinium and Zinc rich foods.

[1]. de Ruyck, J., G. Brysbaert, R. Blossey, and M.F. Lensink, 2016. Molecular docking as a popular tool in drug design, an in silico travel. Adv Appl Bioinforma and chem, 9(4): 1-6

[2]. Garrow JS. Obesity and related diseases. London: Churchill Livingstone; 1988. pp. 1–16.

[3]. Julius E Oben.04 February 2007The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress

[4]. Kazemipoor, M., C.W.J. Wan Mohamed Radzi, G.A. Cordell, and I. Yaze, 2012. Safety, efficacy and metabolism of traditional medicinal plants in the management of obesity: a review. Int J of Chem Eng and Appl, 3(4): 288-292.

[5]. Kim, S., P.A. Thiessen, E.E. Bolton, J. Chen, G. Fu, A. Gindulyte, L. Han, J. He, S. He, B.A. Shoemaker, and J. Wang, 2015. PubChem substance and compound databases. Nucleic Acids res, 44(D1): D1202-D1213.