Liver cancer the third most commonly diagnosed cancer and fourth most common cause of mortality. The survival rate can be increased by earlier diagnosis and better treatment regimen. PET/CT has recently become a vital part to achieve this goal by providing the detailed information regarding tumor lesions than other techniques. Combination of FDG PET/CT has been used initially and proven to be of great benefit for the assessment of liver cancer. Due to some limitation of FDG, a new diagnostic tracer has to be introduced. Radiolabelled peptides are widely used now a days for imaging cancer lesions. The present study aimed to compare the three radiolabelled peptides 68Ga DOTA-NOC acetate, 68Ga PSMA-11 and 68Ga RGD efficiency on DEN and Phenobarbitone induced hepatocellular.......

KEYWORDS: PET/CT, 68Ga DOTA-NOC acetate,68Ga PSMA-11,68Ga RGD, liver cancer

[1]. Anand P, Kunnumakara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, et al. Cancer is a Preventable Disease that Requires Major Lifestyle Changes. Pharmaceutical Research. 2008;25(9):2097–116.
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The increase in the number of Indonesian people's self-medication in both chemical and traditional medicine has been described by the Central Statistics Agency in 2019, namely an increase of 0.72% from 2018 to 71.46% in 2019. The high number of self-medication requires a capable pharmaceutical worker. understand how self-medication. The purpose of this research is to evaluate the knowledge and behavior of non-narcotic analgesic drugs among 12th-grade pharmacy students of Citra Medika Vocational High School, Magelang City as prospective pharmaceutical technical personnel...........

Keywords: Self-medication, analgesic, evaluation

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[2] A. Mansjoer, Capita Selecta Medicine Volume 1, 3rd ed. Jakarta: Media Aesculapius, 2000.
[3] Sylvie Fainzang, Self-Medication and Society Mirages of Autonomy, 1st ed. Routllege Falmer, 2020.
[4] Minister of Health of the Republic of Indonesia, "Regulation of the Minister of Health of the Republic of Indonesia Number 919/MenKes/PER/X/1993 concerning Criteria for Drugs that Can be Dispensed Without a Prescription," Regul. Minist. Heal. Repub. Indones., vol. 16, no. 1, pp. 1988–1989, 1993.
[5] Central Bureau of Statistics, "Percentage of Population Self-medicating During the Last Month, 2017-2019." National Socio-Economic Survey, Jakarta, 2019, [Online]. Available: https://www.bps.go.id/indicator/30/224/1/persentase-penduduk-yang-mengobati-sendiri-selama-sebulan-terakhir.html.

A new series of pyrimidine derivatives have been synthesized by reacting substituted pyrimidine carboxylic acid with substituted aniline to get substituted pyrimidine amide (3), which was de-methylated using BBr3 to form hydroxy derivative of substituted pyrimidine amide (4). This was further alkylated with respective alkyl halide to synthesize substituted pyrimidine derivatives (5)...

Keywords:Multi-component reactions, Pyrimidine derivative, antimicrobial activity, minimum inhibitory concentration (MIC).

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Breadfruit leaves (Artocarpus altilis) contain of antibacterial substances toward Streptococcus mutans causing dental caries, with the inhibition in amount of 21,37 mm in the concentration of 20% (very strong). Besides caries, the teeth color is also known as a dental problem that has a relation with someone's aesthetic. Lime (Citrus aurantifolia) is one of the natural ingredientsthat contain of citric acid that can be used as the teeth whitener. This observation was intended to know about the formula and physical evaluation of toothpaste also to find out theeffect of variation of breadfruit leaves extract concentration to the physical evaluation of toothpaste. This observation used experimental method with 3 variation of breadfruit leaves extract concentration in amount of 20%, 15%, 10%. The result that obtained (numeric data) was analyzed by SPSS with Kruskall-Wallis test for the.........

KEYWORDS: PCOS, Toothpaste, breadfruit leaves extract, lime, physical evaluation

[1]. Depkes RI. (1995). Indonesian Pharmacope 4th edition. Jakarta: Departemen Kesehatan Republik Indonesia.
[2]. Yuliastri, Wa Ode, dkk. (2019). Breadfruit Leaves (Artocarpus altilis) Herbal Toothpaste Formulation and Its Antibacterial Activity Test Towards Streptococcus mutans. Indonesia Mandala Pharmacon Journal, Vol. 05, No. 01. https://doi.org/10.35311/jmpi.v5i01.35.
[3]. Bempa, S. L. P., Fatimawali., & Perengkuan, W. G. (2016). Breadfruit Leaves Extract (Artocarpus altilis) Inhibition Test On Bacteria Streptococcus mutansGrowth. Pharmacon, Vol.5, No. 4. 2302-2493. https://doi.org/10.35799/pha.5.2016.13967.
[4]. Makasenda, E. F. ., Wicaksono, D. A., & Khoman, J. A. (2018). The Discoloration of Composite Resin On Immersion In Vinegar (Asetic acid ) and Lime (Citrus aurantifolia). E-GIGI. https://doi.org/10.35790/eg.6.2.2018. 20149
[5]. Prastiwi, S. S., & Ferdiansyah, F. (2017). Article Review: The Subtances and Pharmacological Activity of (Citrus aurantifolia s.). Farmaka.

In traditional medicine, cannabis-based preparations have been used for a thousand of years for treatment of various diseases. The clinical use of cannabis-based preparations is limited due to legal and ethical reasons, and therefore there is a lack of data for the therapeutic potential of cannabinoids. By searching the FDA site, we identified three approved cannabis-based medicines for treatment of anorexia, nausea and vomiting caused by chemotherapy and two particularly severe forms of child epilepsy (Lennox-Gastaut and Dravet's syndrome). By searching the EMA site, we identify only one cannabis-based medicine authorized for use in the European Union – Epidyolex. But, EMA recognized possible positive therapeutic outcome of three cannabinoids (cannabidiol, cannabinol-9-carboxylic acid (resunab and lenabasum) and cannabidivarin) for which by the European Commission was granted status.........

KEYWORDS: Approved cannabis-based medicines, Tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabinol (CBN), Cannabidiverin

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