Background: Hyperlipidemia characterized by the abnormal elevation of plasma lipoprotein is the most prevalent indicator for cardiovascular diseases. This study screened, analyzed and accessed the anti-hyperlipidemic potentials of the phytochemicals and anti-nutrient compositions of ethanolic extracts of Hunteriaumbellata seeds with a view to utilizing the plants in the management of obesity and hyperlipidemia, and early stage renal dysfunction using high fat diet model in rats. Materials and Methods: Thirty healthy albino rats were randomly divided into five equal groups: Group I received normal saline (2 ml/kg bwt); Group II received a high fat diet; Group III received Orlistat (50 mg/kg bwt);Group IV Orlistat (50 mg/kg bwt) + H. umbellata.......

KEYWORDS: Hunteriaumbellata; Hepatocellular injury; Kidney injury; Hyperlipidemic; Phytochemicals

[1]. Joshi PK., Chawla R A, Mistry D H,Pithawala M A. Obesity- An excuse or a blame. Eastern Journal of Medicine. 2016; 21(2): 56-63.
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[3]. Tang J. Yan H,Zhuang S. Inflammation and oxidative stress in obesity-related glomerulopathy.Int. J.Nephrol. 2012: doi:10.1155/2012/608397.
[4]. Hall JE, Henegar JR, Dwyer TM, Liu J, Da Silva AA, Kuo JJ, Tallam L. Is obesity a major cause of chronic renal disease? Adv.Ren. Replace Ther. 2004; 11: 41-54.
[5]. Choudhury D, Tuncel M, Levi M. Disorders of lipid metabolism and chronic kidney disease in the elderly. SeminNephrol. 2009; 29(6):610-620

Water is necessary for manufacturing, medicinal and clinic reasons, in the formulation and processing of medications and additional well-being merchandises and for clean-up and sanitation reasons. Water is most important and widely used in the pharmaceutical industry as a natural resource ingredient, and solvent in the dispensation, active pharmaceutical ingredient preparation, and production of medicinal products and intermediates. Regulator of the excellence of water all through the manufacture, storages and delivery processes, as well as bacteriological and organic quality, is a most important concern. Therefore, Present study employed to determine the microbiological prevalence within the waters used for pharmaceutical product preparation. An experimental and prevalence study was employed.........

KEYWORDS: Water, Microbiological profile, Pharmaceutical water, Product preparation, Pseudomonas spp.

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Objectives : Background: Population explosion is the major cause of poverty and environmental degradation in developing countries. The geometric growth in human population has negatively affected the social, economic and technological development ofhuman race. There is need to solve this problem by looking in the direction of controlling the population size through effective, safe, and reversible contraceptives. The burden of contraceptives still lie on women, however there is a growing awareness that men are willing to share this burden. There is still yet no effective chemical contraceptives in use for males, hence the need to search the morass of medicinal plants for possible sources of male contraceptives.......

KEYWORDS: Justicia carnea, antispermatogenic, antioxidant enzymes, sperm count, sperm motility, live - dead ratio, testosterone, overpopulation, malondialdehyde, phytoconstituents, proximate

[1]. Correa GM. Chemical constituents and biological activities of species of Justicia: A review. Braz J Pharmacogn 2012; 22: 220-238.
[2]. Wasshausen DC, Wood JR. Acanthaceae of Bolivia. Contributions from the US National Herbarium 2004; 49: 151-152.
[3]. Parker JL, Pearson B. New plant records from the big island for 2010-2011. Records of the Hawaii biological survey for 2011. Part II: Plants. Bishop Museum Occasional Papers 2012; 113: 65-74.
[4]. Benneth,RN.,Mellon,FA.,Foildl,N.,Pratt,JH.,Dupont,MS.,Perkins,L.,Kroon,PA. Profillingglucosinolatesand phenolicsinvegetative andreproductive tissuesof the multipurpose trees of Moringa oleifera and Moringa stenopetala L. Journal of Agricultural and Food Chemistry2004;51(12):546-3553.
[5]. Oramah IT. The effects of population growth in Nigeria. Journal of Applied Sciences 2006; 6(6) : 1332 - 1337.

Background: Background: Management of the diabetes is a greatest challenge before the generation, as it is engulfing 10% of the total healthcare budget alone. Treatment with the synthetic hypoglycemic approach presents severe side effects with piles up the diabetic complications. Treatment of diabetes with the aid of herbal is gaining much attention. Present study evaluates the Ethanolic extract of the Annona squamosa for reducing hyperglycemia along with other biochemical alteration. Materials and method: Study included thirty male rats divided into five groups, Group I Normal control, Group II-Diabetic control, Group III- A. squamosa extract (150 mg/kg) (DT150), Group IV- A. squamosa extract (250 mg/kg) (DT250), and Group V- Rosiglitazone.......

KEYWORDS: Annona squamosa, Hyperglycemia, ALT, AST, Lipid profile, Rosiglitazone

[1]. Unnikrishnan R, Anjana RM, Mohan V. Diabetes mellitus and its complications in India. Nat Rev Endocrinol. 2016; 12(6):357-370.

[2]. International Diabetic Fedreation. IDF diabetes atlas 9th Edition. Available at: https//www.diabetesatlas.org. 2019

[3]. Tang Q, Li X, Song P, Xu L. Optimal cut-off values for the homeostasis model assessment of insulin resistance (HOMA-IR) and pre-diabetes screening: Developments in research and prospects for the future. Drug Discov Ther. 2015; 9(6):380-385.

[4]. Deshpande AD, Harris-Hayes M, Schootman M. Epidemiology of diabetes and diabetes-related complications. Phys Ther. 2008 Nov; 88(11):1254-64.

[5]. Tuttolomondo A, Maida C, Pinto A. Diabetic foot syndrome as a possible cardiovascular marker in diabetic patients. J Diabetes Res. 2015; 2015():268390.

Background: There are reports that chewing arecanut or betel quid is carcinogenic or harmful to humans. On close examination of such reports it was seen that there are so many lacunae, including improper identification of the actual chewing product, method of approach, etc. in most of such research. In some others the data were collected on certain readily available chewing products, containing arecanut as one of the ingredients, such as pan masala or gutkha where either the total ingredients used are fully disclosed or their quality ascertained, and correlated the results to arecanut or betel quid chewing without taking cognizance of the effects of other ingredients used in such chewing products.......

KEYWORDS: arecanut; betel nut; Areca catechu; betel quid; human health; tooth problem; cancer.

[1]. IARC, Monograph on the evaluation of carcinogenic risks to humans. In: Betel quid and arecanut chewing. Lyon, France. 2004; 85: 37-293.

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[3]. Chowdappa P, Cheriyan H. Arecanut: Production, consumption and marketing. Indian J Arecanut, Spices & Med Plants. 2016; 18(4): 6-15.
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Protein secondary structure plays an important role to understanding metabolisms studies. Several studies describe that regular/partial consumption of camel milk for significantly improved the condition of diabetic patients and experimental animals. Moreover, various studies also found that camel milk more similar in comparison to other ruminants with human insulin. Primary protein structure similarity along with its physicochemicall evidence and various favorable hypothesis suggest that camel milk similar/ analog or contains unidentified small molecules of 'insulin-mimic' regulatory value or other properties to put off or slow trying to understand the secondary structure analysis of insulin and camel milk by using bioinformatics tools and techniques. The study revealed that the camel insulin itself is most likely not responsible for anti-diabetic properties of camel milk and due to low pH, good buffering agent and presence of metals therefore, camel milk contains 'insulin-like' small molecular substances that mimic insulin interaction with its receptor.

KEYWORDS: Anti- diabetic agent, Camel milk, Insulin, Secondary structure, Transmembrane proteins

[1]. Agrawal RP, Dogra R, Mohta N, Tiwari R, Singhal S and Sultania S (2009) Beneficial effect of camel milk in diabetic nephropathy. Acta Biomed 80: 131-134.
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