Introduction : Pancreatic cancer occurs as pancreatic adenocarcinoma, with a poor prognosis, which represents, in addition to pathophysiological changes, great psychosocial impacts on the patient's life, due to the fact that the disease presents itself, in most cases, late, making it difficult to early detection of tumor or pre-malignant tumors. Objective: To demonstrate updated data about the clinical aspects, diagnosis and treatments of the disease. Method: To obtain the data, 38 articles on the subject were used, researched in the main books and articles related to pancreatic cancer, from 2010 to 2021. Statistical were performed observing the equality between the understandings cited by each author, so that the thesis about each point of this article was confirmed Results : Mortality and incidence of pancreatic cancer are increasing rapidly.......

KEYWORDS: pancreas ; cancer ; surgery

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[5]. Lulu Zhang, Santosh Sanagapalli , and Alina Stoita . Challenges in diagnosis of pancreatic cancer . World Journal of Gastroenterology. DOI: https:// 10.3748/ https://dx.doi.org/10.3748%2Fwjg.v24.i19.2047wjg.v24.i https://dx.doi.org/10.3748%2Fwjg.v24.i19.204719.2047 . 2018

Corticosteroids are a group of medications that are structurally and pharmacologically similar to the endogenous hormone cortisol. The mechanisms of action for the therapeutic effects and clinical improvement associated with corticosteroids are also responsible for most of the adverse effects associated with its chronic use or its use in high doses. Prescription of corticosteroids is on the increaseamong patients seen in our clinical practice. The increase in steroid prescription is associated with increasing frequency of complications associated with its chronic use. The main objective of this study is to review the prescription pattern of steroids in our practice and to also assess how patients are counselled before they are started on these agents.......

KEYWORDS: Corticosteroids, counselling, prescription, adverse effects, Lagos.

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Background: A simple, specific, linear, precise and accurate reverse phase liquid chromatographic (RP-HPLC) method was developed to analysis speed by minimizing run time and retention timeof Cetirizine Hydrochloride in tablet dosage forms. The chromatographic separation was performed using Phenomenex Luna 5μ C18 100A (250 x 4.6 mm). Mobile phase composed of Acetonitrile and water (60:40 v/v) was selected and a flow rate of 1.000 ml/minute is monitored with injection volume of 20μl. Detection was carried out at 229 nm. The method was validated as per ICH guidelines. The retention time for CetirizineHydrochloride is observed as 2.3 minutes. Linearity range was observed in concentration of 50 - 150 μg/ml for Cetirizine Hydrochloride. The percentage recovery of Cetirizine Hydrochlorideis 100%. The correlation coefficients for both the components are close to 1. The proposed method was validated and successfully applied to the estimation of CetirizineHydrochloride in tablet dosage forms.

KEYWORDS: Cetirizine Hydrochloride, method development, Validation.

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Malaria is an acute febrile disease that is caused due to the parasite infection, transmitted in humans by female anopheles mosquito bite. Malaria is one of the leading reasons of mortality worldwide, but the early detection and quick acting treatment can fend off these unpleasant results. In Africa and some Asian countries, malaria is the most common disease,while in other developed countries it occurs due to import from endemic countries. As early as the 2nd century BC Chinese people used sweet sagewort plant to cure malarial fever. Quinine began to be used as an anti-malarial drug much later..........

KEYWORDS: Malaria, Hydroxychloroquine, Nano-technological strategies and Nanoject.

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Background: ParkiaspeciosaHassk is widely known as stink bean and one of the edible plants that have not been cultivated as medicinal plants yet Materials and Methods:Samples were collected randomly from the local market in Kemaman, Terengganu. The pods were separated from the seed and cleaned thoroughly using tap water. Extraction process by maceration using three solvents, n-hexane, ethyl acetate, and ethanol 95%. Qualitative phytochemical analysis of the extract was determined. Antimicrobial activity using Kirby-Bauer (KB) method. Results: Maceration of ethanol 95% had the highest percent yield of 17.57% among all extracts.The phytochemical analysis resulted in the three extracts containing flavonoids. The three extracts with different solvents produced antimicrobial activity......

KEYWORDS: Antimicrobial, Parkia speciose Hassk, Kirby-Bauer Disc Susceptibility Test.

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