The higher danger of the disease spreading throughout the rest of Asia and Europe should be taken into account. Lumpy skin disease is a developing bovine viral disease that is endemic in most African countries and some Middle Eastern ones. It is critical to comprehend the constraints and channels of dispersion, as evidenced by the recent rapid spread of disease in once disease-free nations. Goatpox and sheeppox can both be brought on by the same agent, Capripoxvirus. Given that they pose a risk to global trade and could be exploited as tools of economic bioterrorism, the economic impact of these diseases is a major issue. Because of the scarcity of reliable vaccines and the widespread poverty in farming communities.......

Keywords:- capripox, epidemiology, lumpy skin disease, transboundary disease.

[1]. Calistri P, De Clercq K, Gubbins S, Klement E, Stegeman A, Cortiñas Abrahantes J, et al. Lumpy skin disease epidemiological report IV: data collection and analysis. EFSA Journal. 2020;18(2):6010.
[2]. Tuppurainen ESM, Babiuk S, Klement E. Lumpy skin disease. Springer international Publishing, USA, 2018, pp 47-51.
[3]. Swiswa S, Masocha M, Pfukenyi DM, Dhliwayo S, Chikerema SM. Long-term changes in the spatial distribution of lumpy skin disease hotspots in Zimbabwe. Tropical Animal Health and Production. 2017;49:195–199.
[4]. Negesso G, Hadush T, Tilahun A, Teshale A. Trans-Boundary Animal Disease and Their Impacts on International Trade: A Review. Academic Journal of Animal Diseases. 2016;5:53–60.
[5]. Kardjadj M. Capripoxviruses : Transboundary Animal Diseases of Domestic Ruminants. Annals of Virology and Research. 2016;2(3):1024.

Background: The main challenge of the pharmaceutical industry in the last years is to implement eco-friendly methods in quality control of medicines based on the principles of green analytical chemistry. In this study, green analytical method for potentiometric titration of sildenafil citrate (SC) in film-coated tablets was optimized and validated. Materials and Methods: The quantitative determination of sildenafil citrate in film-coated tablets, dissolved in 50 mL 1% (v/v) Polysorbate 80 solution, was performed using potentiometric titration with 0.1 M sodium hydroxide. Validation of the method included linear regression analysis based on eleven different quantities of the sildenafil citrate, active substance and determination of specificity, precision and accuracy in accordance with ICH guideline........

Keywords:- Sildenafil citrate; film-coated tablets; potentiometric titration; surfactants

[1]. Namiesnik J. Green analytical chemistry - Some remarks. Journal of Separation Science. 2001; 24(2): 151 – 153 [2]. Gałuszka A, Migaszewski Z, Namiesnik J. The 12 principles of green analytical chemistry and the significance mnemonic of green analytical practices. Trends in Analytical Chemistry. 2013; 50:78-84 [3]. ICH Harmonised Tripartite Guideline. Specifications: test procedure and acceptance criteria for drug substances and new drug product: Chemical substances Q6A. ICH Expert Working Group. Geneva, Switzerland: International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use; 2005 [4]. Ouranidis A, Tsiaxerli A, Vardaka E, Markopoulou CK, Zacharis CK, Nicolaou I et al. Sildenafil 4.0—Integrated Synthetic Chemistry, Formulation and Analytical Strategies Effecting Immense Therapeutic and Societal Impact in the Fourth Industrial Era. Pharmaceuticals. 2021; 14(4): 365.
[5]. Daraghmeh N, Al-Omari M, Badwan AA, Jaber AM. Determinaton of sildenafil citrate and related substances in the commercial products and tablet dosage form using HPLC. Journal of pharmaceutical and biomedical analysis. 2001; 25(3-4):483-92.

Idiopathic Intracranial Hypertension is a disorder of unknown etiology characterized by chronically elevated intracranial pressure (ICP) and the most important neurological manifestation is papilledema. If left untreated, chronic papilledema may lead to secondary progressive optic atrophy, visual field loss and ultimately blindness. In the current scenario of increasing number of IIH cases and its strong correlation with obesity a reevaluation of trends in IIH are needed to improvise the quality of health care provided to the patients. Here, a female patient was admitted with complaints of headache for 2 weeks and upon her neurological and ophthalmic examinations, it was concluded with the diagnosis of Idiopathic Intracranial Hypertension. She was treated in a private hospital withdiuretics and analgesics. Upon being symptomatically relieved and clinically stable, the patient was discharged.

[1]. Biousse V, Newman NJ. The expanding spectrum of idiopathic intracranial hypertension. Eye. 2022.
[2]. Corbett JJ, Mehta MP. Cerebrospinal fluid pressure in normal obese subjects and patients with pseudotumor cerebri. Neurology.2021
[3]. Smith JL. Whence pseudotumor cerebri J Clin Neuro-ophthalmol.2020.
[4]. Durcan FJ, Corbett JJ, Wall M. The incidence of pseudotumor cerebri. Population studies in Iowa and Louisiana. Arch Neurol.2020.
[5]. Radhakrishnan K. Idiopathic intracranial hypertension (pseudotumor cerebri). Archives of Neurology. 1993;50(1):78.

This comprehensive review thoroughly evaluates the state-of-the-art techniques employed in the extraction, fractionation, and analytical profiling of therapeutic bioactives sourced from a diverse array of natural origins. Addressing specialists and researchers in the field, this article offers a systematic examination of advanced methodologies that are integral to the current landscape of bioactive compound research. The review commences by providing an extensive examination of extraction methodologies, highlighting critical parameters such as solvent selection, temperature, and duration to optimize the yield and purity of bioactive compounds. It proceeds to search through advanced fractionation techniques, presenting a detailed comparison of column chromatography, solid-phase extraction, and preparative HPLC, with a focus on their efficacy in the isolation and purification of target compounds.........

Keywords: bioactives, plant, phytochemicals, flavonoids, terpenes, extraction, fractionation, purification, modern methods, green techniques, Supercritical, SFE, HPLC

[1] Xiang Q, Li M, Wen J, Ren F, Yang Z, Jiang X and Chen Y 2022 The bioactivity and applications of pomegranate peel extract: A review J Food Biochem 46 e14105
[2] Tedeschi P, Nigro M, Travagli A, Catani M, Cavazzini A, Merighi S and Gessi S 2022 Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease Int J Mol Sci 23
[3] Maayah Z H, Takahara S, Ferdaoussi M and Dyck J R B 2020 The anti-inflammatory and analgesic effects of formulated full- spectrum cannabis extract in the treatment of neuropathic pain associated with multiple sclerosis Inflamm Res 69 549-58
[4] Banerjee S, Anand U, Ghosh S, Ray D, Ray P, Nandy S, Deshmukh G D, Tripathi V and Dey A 2021 Bacosides from Bacopa monnieri extract: An overview of the effects on neurological disorders Phytother Res 35 5668-79

Burn injuries are accidental health issues from which most people are suffering nowadays. A simple burn with a chemical might be theextent of danger that could take the life of any human being or other animal. Chemical burn injuries like acid burns are quite common in various countries. This study is aimed at evaluating the impact of multiple plant extracts with chitosan on wound healing activity. Asian countries including Bangladesh, and India are rich in natural resources and medicinal plants useful in the treatment of burn wounds. To compare the healing activity of multiple plant preparations (Azadirecta indica, Curcuma Longa, Aloe barbadensis) with a combination of Chitosan nanoparticles on body weight, burn wound size, bacterial colony count, WBC count, and body temperature in Sulphuric.......

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