This research paper basically based on the natural light cream now a days there increasing demand for the herbal cosmetics in our country as well as other country.The herbal skin lightening are used to beautify it is also remove the dead cells the herbal fairness or skin lightening cream by using the glycyrrhiza glabra root extract solanum tuberosum the various type of formulation oil in water {o/w] base & water in oil [w/o] base type herbal skin whitening cream with minimum side effects and combine glycyrrhiza glabra root extract skin brightening cream,and ointment.Cream-toiletry consists of many diverse substances inside the form of a thick liquid that possesses soothing as well as moisturizing outcomes prepared by maceration method and it is evaluated by various phytochemical and pharmacognostic studies.........

KEYWORDS: Light cream, UV spectroscopic,IR spectroscopy, Stability, sterilization, Evaluation, Methods, Moisture O/W, W/O, Spreadibilty, Skin, Membrane, Viscosity, Extract, Parameters, Apparatus, Product, Natural, Curve, etc.

[1]. Adhirajan, N., Dixit, V. K. and Chandrakasan, G. Development and evaluation of herbal formulations for hair growth. Indian Drugs, 2001; 38(11): 559 – 563.
[2]. Aswal A, Karla H, Rout A. Preparation and evaluation of polyherbal cosmetic cream. Scholars Research Library, 2013, 5, 83-88.
[3]. Ashwini, S. D., Somishwar, S. K. and Shweta, S. S. Formulation and evaluation of vanishing herbal cream of crude drugs. American J. Ethnomedicine, 2014; 1(5): 313-318.
[4]. Alalor CA, Igwilo CI, Jeroh E. Evaluation of the antibacterial properties of aqueous and methanol extracts of Cassia alata. J Pharm Allied Health Sci. 2012;2:40–6.
[5]. Arun Rasheed et al., Standardisation of herbal formulation International Journal of. Phytotherapy, 2012; 2(2): 74-88.

Background: Glinus oppositifolius (GO) is an endemic herbaceous plant found in tropical Asian countries and is native in Vietnam. In this study, the effects of two GO standardized extracts (Biovip and Tox-off) and their major isolates were evaluated on the anti-inflammatory activity by determining the expression of PGE2 production and COX-2 mRNA in RAW 264.7 cells. We observed the COX-2 mRNA expression, as well as PGE2 production was significantly inhibited by Biovip and Tox-off. Moreover, five isolated compounds: TRA-GO1 to TRA-GO5 showed the inhibition effects on both COX-2 mRNA expression and PGE2 production. Among them, three compounds (TRA-GO1, TRA-GO2, and TRA-GO5) showed the most potent effect. Mechanistically, Biovip and Tox-off, as well as the major isolated compounds, suppressed NF-κB activation and TNF-α production in a dose-dependent manner in RAW 264.7 cells.........

Keywords:- Glinus oppositifolius; Tox-off and Biovip; Traphanoside GO1 (TRA-GO1), Anti-inflammation, COX-2, PGE2, NF-κB, TNF-α.

[1]. Burkill HM, The useful plants of West Africa. Royal Botanical Gardens, Kew. 1985; 1: 319.
[2]. Traore F, Faure R, Ollivier E, Gasquet M, Azas N, Debrauwer L, Keita A, Timon-David P, Balansard G, Structure and antiprotozoal activity of triterpenoid saponins from Glinus oppositifolius. Planta Med. 2000; 66(04): 368-371.
[3]. Ragasa CY, Espineli DL, Mandia EH, Don MJ, Shen CC, A new triterpene from Glinus oppositifolius. Chin J Nat Med. 2012; 10(4): 284-286.
[4]. Natarajan P, Thirupathi AT, Sekharan TR, Sundar AS, Arivukkarasu R, Ganesan M, Hepatoprotective effect of Glinus oppositifolius Linn. Res J Pahrmacol Pharmacodyn. 2010; 2(4): 289-292.
[5]. Chopin J, Dellamonica G, Markham KR, Nair AGR, Gunasegaran R, 2″-p-Coumaroylvitexin 7-glucoside from Mollugo oppositifolia. Phytochemistry. 1984; 23(9): 2106-2108.

Topiramate is frequently used for the treatment of epilepsy and migraines. It has been liked to the emergence of metabolic disorders like acidosis and hypokalaemia. 10% of people in Europe have kidney stones and this tendency has never been examined analytically. 1-2% of all kidney stones are caused by drug-induced renal calculi. 1-2% of all renal calculi are caused by drugs. There are two categories of medicines that are reportedly capable of causing calculi. The first one contains medications that are poorly soluble excrete a lot of urine, and encourage crystallisation in the urine among that Atazanavir and protease inhibitors used to treat patients with human immunodeficiency virus (HIV) as well as sulphadiazine used to treat cerebral toxoplasmosis are the most common causes among them.

[1]. Dell'Orto VG, Belotti EA, Goeggel-Simonetti B, Simonetti GD, Ramelli GP, Bianchetti MG, Lava SA. Metabolic disturbances and renal stone promotion on treatment with topiramate: a systematic review. Br J Clin Pharmacol. 2014 Jun;77(6):958 -64. doi: 10.1111/bcp.12283. PMID: 24219102; PMCID: PMC4093921.
[2]. Salek T, Andel I, Kurfurstova I. Topiramate induced metabolic acidosis and kidney stones - a case study. Biochem Med (Zagreb). 2017 Jun 15;27(2):404-410. doi: 10.11613/BM.2017.042. PMID: 28694730; PMCID: PMC5493179.
[3]. Daudon M, Frochot V, Bazin D, Jungers P. Drug-Induced Kidney Stones and Crystalline Nephropathy: Pathophysiology, Prevention and Treatment. Drugs. 2018 Feb;78(2):163-201. doi: 10.1007/s40265-017-0853-7. PMID: 29264783.
[4]. Ramsay L. Kuo, Michael E. Moran, Dennis H. Kim, Harrison M. Abrahams, Mark D. White, and James E. Lingeman. Topiramate - Induced Nephrolithiasis. Journal of Endourology 2002 16:4, 229-231.
[5]. Salek T, Andel I, Kurfurstova I. Topiramate induced metabolic acidosis and kidney stones - a case study. Biochem Med (Zagreb). 2017 Jun 15;27(2):404-410. doi: 10.11613/BM.2017.042. PMID: 28694730; PMCID: PMC5493179.

Background: Patients with heart failure with reduced ejection fraction (HFrEF) can now be managed with a variety of medications, such as angiotensin-converting enzyme inhibitors (ACEi), beta-blockers (BB), angiotensin receptor blockers (ARBs), and the recently developed angiotensin receptor-neprilysin inhibitor (ARNI). The target dose of HFrEF guideline-directed medicinal therapy yields the best results. However, as a greater number of medicinal therapies for HFrEF become accessible, physicians must increasingly manage frequently overlapping drug adverse effects, achieve target dosages, and use multiple medications concurrently. The purpose of our research was to investigate the impact of dose titration on the improvement of Ejection fraction (EF) in HFrEF patients............

Key Word: Dose titration; Heart failure; reduced ejection fraction; angiotensin-converting enzyme inhibitor; beta-blockers.

[1]. Murphy, Sean P.; Ibrahim, Nasrien E.; Januzzi, James L. (2020). Heart Failure With Reduced Ejection Fraction. JAMA, 324(5), 488–504.
[2]. McDonagh T.A., Metra M., Adamo M., Gardner R.S., Baumbach A., Böhm M., Burri H., Butler J., Čelutkienė J., Chioncel O., et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur. Heart. J. 2021;42:3599–3726.
[3]. Tsao C.W., Aday A.W., Almarzooq Z.I., Alonso A., Beaton. A.Z., Bittencourt M.S., Boehme A.K., Buxton A.E., Carson A.P., Commodore-Mensah Y., et al. Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association. Circulation. 2022;145:e153–e639.
[4]. Groenewegen A., Rutten F.H., Mosterd A., Hoes A.W. Epidemiology of heart failure. Eur. J. Heart. Fail. 2020;22:1342–1356.
[5]. Yancy CW, Jessup M, Bozkurt B, et al. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation. 2017;136(6):e137-e161.