Background: Dietary supplements (DS) are products intended to enrich the diet. Worldwide DS are categorized as food and regulated as food. However, most of the consumers of these products consider DS as natural safe products which have the ability not only to enrich the diet but also to improve health. Nowadays DS are involved in the nutrition of many people. Moreover, DS are involved in the management of different health conditions although DS are not medicines and differ from the pharmaceuticals in many aspects including regulation, safety testing, quality testing, etc. In the past 10 years many studies reported that more than 20% of the DS worldwide have poor quality: contaminations, unproper labeling, undeclared pharmaceutical compounds, etc. This could be regarded as a natural consequence of the lack of obligatory analytical control for DS worldwide. The aim of the present study was to analyze the content of pesticides residues in weight loss dietary supplements.......

Keywords:- Dietary supplements; Pesticides; Weight loss; Obesity; GC-MS; LC-MS.

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Numerous publications on reviews and research on niosomes have been published in the last decade. This demonstrates the interest in niosomes among researchers due to their benefits over other vesicular carrier systems. Niosomes demonstrate great potential as drug carriers due to their ability to maintain biocompatibility, biodegrade and induce minimal immune response. The primary constituents of pharmaceutical administration systems is a suitable transporter that shield the medication from swift breakdown and amplifies drug levels in the anticipated tissues. They are produced when nonionic surfactants and cholesterol self-associate in liquid facet(water based). The current review provides information on contemporary niosomal drug delivery system, preparation methodologies, characterization approaches, research, as well as niosomes as drug carriers.

Keywords:- Niosomes, novel drug delivery system, Cholesterol, Proniosomes, thin film hydration method, anti-cancer drugs

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L'hypertension est une des principales causes de décès dans le monde. De nombreuses molécules et plantes sont utilisées avec succès dans sa prise en charge. Catharentus Roseus est une plante de la famille des apocynacées habituellement utilisée en médecine traditionnelle dans le traitement de nombreuses pathologies dont l'hypertension. L'objectif de la présente étude était de mettre au point des gélules à base de l'extrait aqueux de Catharentus Roseus et d'en évaluer l'activité anti hypertensive......

Keywords:- Catharentus roseus, Hypertension, L-NAME, rats, Formulation, MTA.

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Pharmaceutical research has been dedicated to advancing drug delivery methods to enhance therapeutic outcomes and patient adherence. Buccal drug delivery systems, a novel approach, leverage the oral mucosa's unique attributes to provide an alternative to traditional administration routes. This study focuses on the formulation, molecular insights, and therapeutic implications of gabapentin buccal tablets, exploring the potential of this innovative approach. By examining drug formulation, physicochemical attributes, and patient-specific factors, the study reveals the interplay that affects gabapentin buccal absorption. This research contributes to the growing understanding.....

Keywords:-Mouth dissolving Tablet, Orodispersible Tablets, gabapentin, Buccal drug delivery system

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Lactic acid bacteria (LAB) are beneficial bacteria for humans and animals. However, the sleep characteristics and functions of plant LAB in human remain unclear. Here, we isolated LAB from the jeju Aloe vera in Korea, and identified one Lactobacillus helveticus KJMA-0001(AlabTM) using matrix associated laser desorption/ionization time of flight and 16S rRNA/DNA full genome sequence analyses. AlabTM survived at pH 4.5 for 24 h. In addition, this strain survived well in simulated gastric juice of humans containing pepsin and exhibited high resistance to bile salts. Effect of AlabTM on sleep related behaviors and patterns in Drosophila melanogaster was examined in both baseline and caffeine treated conditions. Total......

Keywords:-Aloe vera; plant lactic acid bacteria; Lactobacillus helveticus; sleep inducing effect; gamma-ami- nobutyric acid activity; AlabTM

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