Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to a defect in insulin secretion and/or action. In Cameroon, the prevalence of diabetes is estimated at 6 %. Its treatment is mainly based on expensive drugs with many side effects. Therefore, it is important to search for new well-tolerated and inexpensive drugs for the population. The present study aimed to formulate antidiabetic capsules based on the rhizome of Zingiber officinale. The rhizomes were cleaned, cut, and dried in an oven at 50°C, then finely crushed to obtain a crude powder. A part of this powder was subjected to maceration in water in order to prepare an aqueous powder extract. Another part was used as is for encapsulation..........

Keywords : Zingiber officinale, antidiabetic, formulation, capsules,ITM.

[1]. Rapport OMS sur le diabète. 2016 [cité 25 nov 2023] ;
[2]. Al-Amin M, Martha T, Khaled K., Riitta P, Muslim A. Anti-diabetic and hypolipidaemic properties... - Google Scholar [Internet]. 2006 [cité 2 déc 2023].
[3]. Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. International Journal of Food Sciences and Nutrition. sept 2013;64(6):682‑6.
[4]. Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. Journal of Complementary and Integrative Medicine. 1 juin 2015 ;12(2) :165‑70.

Potatoes play a crucial role as a fundamental and cost-effective staple food in Nigeria, with their nutritional content being influenced by various factors such as the potato variety, and processing methods. This research study assesses the anti-nutrients in different potato varieties and their peels. The findings reveal that potato peels exhibit elevated levels of flavonoids and anthocyanins, followed by polyphenols. Additionally, they contain minor quantities of tannins, oxalates, saponins, and alkaloids. White flesh sweet potatoes such as EBSA1, EBSA2, and EBSA3 had higher concentrations of all the antinutrients in both flesh and peels compared to the o Orange-Fleshed Sweet Potatoes (OFSP) such as NRCR5, NRCR7, NRCR9, NRCR13, NRCR17, and NRCR18. The anti-nutrients in the peels were significantly higher than in the flesh in all the samples. The levels of antinutrients in potatoes especially the peels showed that eating potato peels has health-benefiting compounds more than the flesh.

[1]. Akpe, M. A., Ashishie, P. B., & Akonjor, O. A. (2021). Evaluation of some phytochemicals in raw and cooked Ipomea batatas (Lam.), (Sweet Potato), Solanum tuberosum (Irish Potato) and Dioscorea cayenensis (Yellow Yam). Journal of Applied Sciences and Environmental Management, 25, 1563- 1567. https://doi.org/10.4314/jasem.v25i9.3
[2]. Albishi, T., John, J. A., Al-Khalifa, A. S., and Shahidi, F. (2013). Phenolic content and antioxidant activities of selected potato varieties and their processing by-products. J. Funct. Foods, 5, 590-600
[3]. Brown, C. (2005). Antioxidants in potato. Am. J. Potato Res., 82, 163-172
[4]. Baba, S. A., & Malik, S. A. (2015). Determination of total phenolic and flavonoid content, antimicrobial and antioxidant activity of a root extract of Arisaema jacquemontii Blume. Journal of Taibah University for Science, 9, 449–454. https:// doi.org/10.1016/j.jtusci.2014.11.001
[5]. Ejikeme, C. M., Ezeonu, C. S., & Eboatu, A. N. (2014). Determination of physical and phytochemical constituents of some tropical timbers indigenous to Niger Delta area of Nigeria. European Scientific Journal, 10(18), 247–270. https://doi.org/10.19044/esj.2014.v10n18p%pDvořák, P., and Čepl, J. (2009). Cultivar differences of total anthocyanins and anthocyanidins in red and purple-fleshed potatoes and their relation to antioxidant activity. Food Chem., 114, 836-843.

Vitamin B12, an essential micronutrient with multifaceted roles in human physiology, encounters significant challenges concerning its stability when exposed to light. The photolabile nature of Vitamin B12 poses a substantial concern in various industries, necessitating innovative strategies to safeguard its stability and efficacy. Cyclodextrins, notably beta-cyclodextrin and its derivative, hydroxypropyl beta-cyclodextrin, present promising capabilities as host molecules, forming inclusion complexes with guest compounds. This study investigates the potential of beta-cyclodextrin and hydroxypropyl beta-cyclodextrin to enhance the light stability of Vitamin B12 through inclusion complexation. The research aims to elucidate and compare the interactions between Vitamin B12 and these cyclodextrins, specifically focusing on their efficacy in shielding Vitamin B12 from.......

KEYWORDS: Vitamin B12, Cyclodextrins, Inclusion Complexation, Light Stability, Photodegradation, Hydroxypropyl Beta-Cyclodextrin.

[1]. Wdowik T, Gryko D. C–C Bond Forming Reactions Enabled by Vitamin B12─ Opportunities and Challenges. ACS Catalysis. 2022 May 17;12(11):6517-31. https://doi.org/10.1021/acscatal.2c01596.
[2]. Qadeer K, Arsalan A, Ahmad I, Fatima K, Anwar Z, Ahmed S, Mahmud S. Photochemical interaction of cyanocobalamin and hydroxocobalamin with cysteine. Journal of Molecular Structure. 2021 Mar 15; 1228:129441. https://doi.org/10.1016/j.molstruc.2020.129441
[3]. Juzeniene A, Nizauskaite Z. Photodegradation of cobalamins in aqueous solutions and in human blood. Journal of Photochemistry and Photobiology B: Biology. 2013 May 5; 122:7-14. https://doi.org/10.1016/j.jphotobiol.2013.03.001
[4]. Carneiro SB, Costa Duarte FÍ, Heimfarth L, Siqueira Quintans JD, Quintans-Júnior LJ, Veiga Júnior VF, Neves de Lima ÁA. Cyclodextrin–drug inclusion complexes: In vivo and in vitro approaches. International journal of molecular sciences. 2019 Feb 2;20(3):642. https://doi.org/10.3390/ijms20030642
[5]. Iacovino R, Rapuano F, Caso JV, Russo A, Lavorgna M, Russo C, Isidori M, Russo L, Malgieri G, Isernia C. β-Cyclodextrin inclusion complex to improve physicochemical properties of pipemidic acid: Characterization and bioactivity evaluation. International journal of molecular sciences. 2013 Jun 25;14(7):13022-41. https://doi.org/10.3390/ijms140713022.

It is increasingly difficult to define what an anxiolytic is, since anxiety is multiple although many symptoms are common. The other hand the most used drugs in different forms of anxiety were first used as antidepressants. This article tries to put together the different effective anxiolytics used and describe their pharmacology. Anxiolytics, also known as anti-anxiety drugs, are primarily used to manage anxiety disorders and related conditions. These medications work by reducing excessive nervousness, fear, and apprehension. The most commonly prescribed anxiolytics are benzodiazepines (e.g., diazepam, lorazepam), which enhance the effect of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits neuronal activity, resulting in sedation and relaxation....

KEYWORDS: Clinical Pharmacology, Benzodiazepine, Dopamine Receptors, Pregabalin, Buspirone, Psychosomatic, Hydroxyzine.

[1]. Lang PJ, McTeague LM, Bradley MM (2014) Pathological anxiety and function/dysfunction in the brain's fear/defense circuitry. Restor Neurol Neurosci 32: 63-77. Link: https://goo.gl/jAo3dC
[2]. Chua HC, Chebib M (2017) GABAA Receptors and the Diversity in their Structure and Pharmacology. Adv Pharmacol 79: 1-34. Link: https://goo.gl/UhPGZw
[3]. Van Rooyen JM, Offermeier J (1985) Pharmacokinetics of the benzodiazepines. S Afr Med J 10-13. Link: https://goo.gl/BGk3H9
[4]. Chin RF (2014) What are the best ways to deliver benzodiazepines in children/patients with prolonged convulsive seizures? Epileptic Disord 16 1: 50-58. Link: https://goo.gl/PrfxU9
[5]. Dailly E, Bourin M (2008) Use of benzodiazepines in the aged patient: clinical and pharmacological considerations. Pak J Pharm Sci 21: 144-505. Link https://goo.gl/o5UjBf

Background: Diabetes as a global problem increases in prevalence worldwide. Treatment of diabetes mellitus currently uses synthetic drugs.As we know, synthetic drugs have many side effects. Therefore, some people use herbal medicine asan alternative to treat diseases. One of them is Catharanthus roseus. This plant is a herbal medicine that has the potential as antidiabetic. Material and Methods: This article reviews the phytochemical compounds and in vivo and in vitro antidiabetic activity testing of Catharanthus roseus in the last decade. Three bibliographic databases were used as sources of information (PubMed, ScienceDirect, and Google Scholar). The keywords used in this literature search were "Antidiabetic,""Pharmacology,""Phytochemical,"and "Catharanthus roseus."......

KEYWORDS: antidiabetic;Catharanthus roseus; pharmacology;phytochemical

[1]. American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Vol 37.; 2014. doi:10.2337/dc14-S081
[2]. PERKENI. Pedoman Pengelolaan Dan Pencegahan Diabetes Melitus Tipe 2 Di Indonesia 2021. PB PERKENI; 2021.
[3]. International Diabetes Federation. 10th ed.; 2021. www.diabetesatlas.org
[4]. Putra RJS, Anisyah A, P HR. Kejadian Efek Samping Potensial Terapi Obat Anti Diabetes Pada Pasien Diabetes Melitus Berdasarkan Algoritme Naranjo. Pharm J Indones. 2017;2(2):45-50.
[5]. Pandanwangi S, Zuniarto AA, Mubarok H. Analisa Drug Related Problems (Drps) Pasien Gagal Ginjal Dengan Komplikasi Diabetes Mellitus di RSUD X. Pharma Xplore J Ilmu Farm. 2018;3(1):170-183.

Les soins pharmaceutiques est l'ensemble des actes et services que le pharmacien doit procurer à un patient, afin d'améliorer sa qualité de vie. [1] Cette étude a pour objectif de dresser le bilan de six mois d'une présence pharmaceutique dans une unité d'Onco-hématologie.........

KEYWORDS: Intervention pharmaceutique, Onco –Hématologie, Soins Pharmaceutiques.

[1]. Garnier S. La pharmacie clinique en pratique. Création d'un outil de formation destiné aux internes et étudiants en pharmacie [Thèse d'exercice]. Nancy, France : Université Henri Poincare ; 2007.
[2]. F.Ayadi, D.Ghedira ; A.Hassairi Étude des interventions pharmaceutiques dans deux services cliniques à l'hôpital tunisien universitaire Sahloul.Le Pharmacien Hospitalier et Clinicien51(2), June 2016 :p .116-122
[3]. M.Hubault ; H.M.Späth ,L.MaletaS.BauleraS.Jacquin-CourtoisadJ.LuautéadG.RodeA.Janoly-DumenilImpact économique des interventions pharmaceutiques en services de rééducation neurologique. Le Pharmacien Hospitalier et Clinicien 52(3), September 2017, Pages 250-259
[4]. AbderrezzaqZiane, Corinne Ngami, RafikYoub, Mohamed HazemAtri, Raoul Aikpa, FaribaKabirian, Francis Fauvelle . Évaluation de la qualité des interventions pharmaceutiques chez le sujet âgé de plus de 75 ans. Journal de pharmacie clinique. 32 (4) Décembre 2013. p.243
[5]. Société Française de Pharmacie Clinique. Référentiel de Pharmacie Hospitalière. [En ligne]. 2010 [cité le 01 avril 2017]. http://sfpc.eu/fr/item1/finish/34-documents-sfpc-public/20-referentiel-de-pharmacie-hospitaliere-sfpc-v2010/0.html

Background: A simple, specific, linear, precise and accurate reverse phase liquid chromatographic (RP-HPLC) method was developed to analysis speed by minimizing run time and retention timeof Cetirizine Hydrochloride in tablet dosage forms. The chromatographic separation was performed using Phenomenex Luna 5μ C18 100A (250 x 4.6 mm). Mobile phase composed of Acetonitrile and water (60:40 v/v) was selected and a flow rate of 1.000 ml/minute is monitored with injection volume of 20μl. Detection was carried out at 229 nm. The method was validated as per ICH guidelines. The retention time for CetirizineHydrochloride is observed as 2.3 minutes. Linearity range was observed in concentration of 50 - 150 μg/ml for Cetirizine Hydrochloride. The percentage recovery of Cetirizine Hydrochlorideis 100%. The correlation coefficients for both the components are close to 1. The proposed method was validated and successfully applied to the estimation of CetirizineHydrochloride in tablet dosage forms.

KEYWORDS: Cetirizine Hydrochloride, method development, Validation.

[1]. Rudaz. S., Souverain. S., Schelling. C.,andDeleersM.Anal. Chim. Acta,Development and validation of a heart-cutting liquid chromatography–mass spectrometry method for the determination of process-related substances in cetirizine tablets.2003, 492:271–282.
[2]. Nightingale, C.H. 1996. Treating allergic rhinitis with second-generation antihistamines. Pharmacotherapy, 1996, 16: 904-914.
[3]. P Beringer, A der Marderosian, L. Felton, et al, "Remington: The Science and Practice of Pharmacy" Lippincott Williams & Wilkins, Philadelphia, 21st ed., 2006.
[4]. European Medicines Agency, "Guideline on Excipients in the Dossier for Application for Marketing Authorisation of a Medicinal Product" Doc. Ref. EMEA/CHMP/QWP/396951 /2006, London, 6 November 2006.
[5]. Kuchekar BS, Shinde GS, Naikwadi IT, Todkar KJ, Kharade SV, "Specrtophotometric estimation of ambroxol hydrochloride in tablets" Indian J Pharm Sci, 2003; 65(2): 193-195.