Cefotaxime sodium is a β-lactam antibiotic belonging to the third-generation cephalosporin class that can undergo hydrolysis when dissolved. Cefotaxime must be dissolved in an appropriate solvent. Once dissolved, cefotaxime must be used immediately. The purpose of this study was to determine the effect of storage temperature on the concentration of cefotaxime sodium injection with 0.9% NaCl solvent. Cefotaxime sodium injection was dissolved in 0.9% NaCl solvent and then stored at refrigeration (2-8°C) and room temperature (25-30°C) for storage periods of 0, 1, 3, 5, 7, and 10 days. Quality tests were then conducted, including organoleptic and pH measurements, and the determination of concentration using HPLC........

Keywords : Cefotaxime Sodium; temperature; concentration; HPLC.

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