Paper Type	::	Research Paper
Title	::	Evaluation of Hepato-Renal and Haematological Protection of Ethanolic Extract of Eclipta alba in Experimental Rats
Country	::	India
Authors	::	Saravanakumar M ||, Revathi P ||, Prabhusaran N ||, Radhakrishna L
Page No.	::	01-06
Paper Index	::	XXXX
ANED	::	05.3013/XXXX

Eclipta alba has been widely used in the traditional medicine for the treatment of various liver and digestive ailments. In the present study, the effect of ethanolic crude extract of E. alba was investigated against body weight, organ weight, feed intake, nephritic markers, hepatic serum markers and haematological modification. The crude ethanolic extract of E. alba was obtained and the crude extract was administered to experimental rats. At the end of the treatment period, the level of feed intake, body and organ weight (liver and kidney) were determined. Further, serum enzyme markers, renal function tests and basic haematological screening were performed to analyse the effect of the plant extract. A marked rise was observed in the body weight and organ weight of the animals after intaking the feed. The hepatic serum markers were also observed in rising manner compared to the control group. The renal function markers were reduced significantly and the haematological levels were also increased. Our study showed significant medicinal effect of E. alba in experimental animals. The results also suggested that this ethanolic extract would be potential alternative for the management of hepatic and renal dysfunctions.

 

Keywords: Hepatic markers, renal markers, hematological markers, ethanolic extract, Eclipta alba

[1]. R.B. Sack, and J.L. Froehlich, Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins. Infection and Immunity, 35, 1982, 471-475.
[2]. C. Neha, S. Dolly, and R.M. Painuli, Screening of bioprotective properties and phytochemical analysis of various extracts of Eclipta alba whole plant. International Journal of Pharmacy and Pharmaceutical Sciences, 4, 2012, 554-560.
[3]. E.N. Quiroga, A.R. Sampietro, and M.A. Vattuone, Screening antifungal activities of selected medicinal plants. Journal of Ethnopharmacology, 74, 2011, 89-96.
[4]. K. Kathiresan, N.S. Boopathy, and S. Kavitha, Coastal vegetation–an underexplored source of anticancer drugs. Natural Products, 5, 2006, 115-119.
[5]. G.S. Kumar, K.N. Jayaveera, C.K.A. Kumar, P.U. Sanjay, B.M.V. Swamy, and D.V.K. Kumar, Antimicrobial effects of Indian medicinal plants against acne-inducing bacteria, Tropical Journal of Pharmaceutical Research, 6, 2007, 717-723.

Paper Type	::	Research Paper
Title	::	Cortinarius (Agaricales) revised taxonomy: validation of new species names or combinations
Country	::	Italy
Authors	::	B. Gasparini
Page No.	::	07-08
Paper Index	::	XXXX
ANED	::	05.3013/XXXX

Five species are transferred to Cortinarius, either as new combinations: C. atratus (= Hysterangium atratum), C. canarius (≡ Dermocybe canaria), C. kula (Dermocybe kula), or as replacement names when the basionym epithet was proccupied: C. .olens (= Hymenogaster aromaticus Velen.). The illegitimate Cortinarius mastoideus Gasparini is renamed as C. acutipapillatus. C. olens and C. atratus are renamed.

 

Key words: Cortinomyces, Dermocybe, Hymenogaster, Hysterangium.

[1]. Gasparini B, Soop K. 2008. Contribution to the knowledge of Cortinarius [Agaricales, Cortinariaceae] of Tasmania (Australia) and New Zealand. Australasian Mycologist 27(3): 173–203.
[2]. Gasparini B. 2014 Cortinarius (Agaricales) revised taxonomy: new species names or combinations. Mycosphere 4 (3): 363–454 (2013)
[3]. Grgurinovic C. 1997. Larger fungi of South Australia. The Botanic Gardens of Adelaide and State Herbarium.
[4]. Horak E. 1988. New species of Dermocybe (Agaricales) from New Zealand. Sydowia. 40:81–112
[5]. Høiland K, Holst-Jensen A. 2000. Cortinarius phylogeny and possible taxonomic implications of ITS rDNAsequences. Mycologia 92: 694–710.

Paper Type	::	Research Paper
Title	::	Ayurveda- A boon to rheumatoid arthritis sufferers
Country	::	India
Authors	::	Dr.Meera H. Kotak ||, Dr. D.V. Patel
Page No.	::	09-12
Paper Index	::	XXXX
ANED	::	05.3013/XXXX

Rheumatoid Arthritis is a chronic immune-inflammatory systemic disorder mainly affects synovial joints.Main complaint for which a patient seeks medical attention is pain, swelling in and around the joints, stiffness and limited range of motion. Other tissues and organs are also involved in patients with more extensive disease in the form of heart diseases, respiratory complications etc. Modern medical science has made so many advancements but exact aetiopathogenesisof the disease is yet to be conclusive. Modern system of medicine has drugs like corticosteroids, DMARD's and NSAID's which ameliorates the symptoms and overcome agony and crippling caused by the diseasebut the underlying pathology remains unchecked. This possesses a challenge to the physician owing to its apparent chronicity, incurability, complications and morbidity. Its signs and symptoms can be correlated with Amvatain Ayurveda. Preventive measures are described along with modalities like Langhana, Deepana-Pachana, Shodhana and Shaman have been described for the management of Amvata which directly targets the root cause of the disease. Ayurveda can do a lot for mankind in preventing as well as treatment of this dreadful disease.

 

Keywords:Amvata, Rheumatoid Arthritis, Treatment, Prevention, Ayurveda

[1]. Madhavnidana, Madhukoshavyakhya, YadunandanUpadhyay, with Vidhyodini Hindi Commentary,Chaukhambha Sanskrit sansthan, Varanasi,Vol-1, Ch.25/1-12, Reprint-2008, page no.508-12.
[2]. Chakradutta of ShriChakrapanidutta, RamnathDwivedi, with Vaidhyaprabha Hindi commentary, Chaukhambha Sanskrit Sansthan, Varanasi, Ch.25/ 1-83, Reprint-2011, page no.166-172.
[3]. BhaisajyaRatnavali , Prof. Siddhinandan Mishra, Siddhiprada Hindi vyakhya, ChaukhambaSurbhartiPrakashan, Varanasi, Ch.29/1-239, Reprint-2015, page no. 597-614.
[4]. http://www.news-medical.net/healthRheumatoid Arthritis.
[5]. AshtangSangraha, KavirajAtridevaGupt, ChaukhambhaKrishnadas academy, Varanasi, Sutrasthana 9/36, Reprint-2011, page no. 98.

Paper Type	::	Research Paper
Title	::	"Comparative clinical study between Ropivacaine and Ropivacaine with Dexmedetomidine in Epidural Anesthesia for Abdominal Hysterectomy"
Country	::	India
Authors	::	Dr. Mahendra Singh ||, Dr. Devendra Singh Negi ||, Dr. Manoj Tripathi ||, Dr. Akhilendra Singh Chandel ||, Dr. Apeksha Sharma ||, Dr. Mohd Chand Bagwan
Page No.	::	13-19
Paper Index	::	XXXX
ANED	::	05.3013/XXXX

Background: Many techniques and drug have been tried from time to time to calm the patients and eliminate the anxiety component during regional anesthesia. Ropivacaine is a good agent for use in epidural anesthesia but having side effects like neurotoxicity and cardiac toxicity. Aims: This present study is designed to evaluate effects of epidural ropivacaine 0.75% and ropivacaine 0.75% with dexmedetomidine on the patients undergoing elective abdominal hysterectomy. Settings and Design: Randomized, prospective and comparative study Methods and Material : In this study, patients were randomly allocated into two groups of 30 each. Group I(R) received epidural Ropivacaine 0.75 % (17 ml) (127.5 mg) and Group II(RD) received epidural Ropivacaine 0.75 % (17 ml) (127.5 mg) with dexmedetomidine 1.5 ug/kg. Sensory, motor and hemodynamic profile between two groups was compared. Statistical Analysis: Mean and standard deviation was calculated. Test of analysis between 2 groups was done by"t‟ test and chi square test then P value was calculated. Results and Conclusion: No significant difference was found between the groups in sensory and motor profile.( P<0.05). Hemodynamic stability was found better with dexmedetomidine. Rescue analgesic requirement was reduced in dexmedetomidine group.

[1]. Walwyn WM, Miotto KA, Evans CJ. Opioid pharmaceuticals and addiction: The issues, and research directions seeking solutions. Drug Alcohol Depend. 2010 May 1; 108(3): 156–65.
[2]. Kuthiala G, Chaudhary G. Indian J Anesth. Ropivacaine: A review of its pharmacology and clinical use. 2011 Mar; 55(2):104-10.
[3]. Asano T, Dohi S, Ohta, Shimonaka H, Iida H. Antinociception by epidural and systemic α2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth Analg. 2000; 90:400-7.
[4]. Fukushima K, Nishimi Y, Mori K, Kaneko I, Fukushima Y. Postoperative analgesic action and plasma concentration of epidural administered dexmedetomidine. Anesthesiology. 1997; 87(Suppl):744.
[5]. Walker SM, Howard RF, Keay KA, Fitzgerald M. Developmental age influences the effect of epidural dexmedetomidine on inflammatory hyperalgesia in rat pups. Anesthesiology. 2005; 102: 1226-34

Paper Type	::	Research Paper
Title	::	Assessment of insulin treatment – related knowledge among nurses in Pediatric Hospitals
Country	::	Greece
Authors	::	Dafogianni Chrysoula ||, Alikari Victoria ||, Poli Anna ||, Mpilero Eirini ||, Gerali Maria ||, Margari Nikoletta ||, Zyga Sofia2
Page No.	::	20-25
Paper Index	::	XXXX
ANED	::	05.3013/XXXX

Introduction: Nurses have a major role in insulintreatment. The aim of thisstudywas to assess nurses' knowledge focusing on insulin treatment of children. For this purpose, a self-administered questionnaire was given to 67 nurses. Sociodemographic data were recorded. Results: Eighty percent of the sample answered that they have never been trained on the special care of people with diabetes,86.6% chose the method of coursesas the first method of training,67.5% answered correctly that the most serious complication of insulin therapy is hypoglycemia while 61% of the sample answered correctly that the complication of theinsulin injection is lipohypertrophy or lipodystrophy. Conclusions: There is a need for covering the gap of nurses' knowledge and practices related to insulin treatment.For achieving that aim, continuing nursing education focusing on insulin treatment is recommended. Keywords–Assessment, insulin treatment, knowledge, nurses

[1] E.S. Moghissi, M.T. Korytkowski, M. DiNard, D. Einhorn, R.Hellman, I.B. Hirsch, and G.E. Umpierrez, American Association of Clinical Endocrinologists and American Diabetes Association Consensus Statement on Inpatient Glycemic Control, Diabetes Care, 32(6), 2009, 1119–1131. http://doi.org/10.2337/dc09-9029.
[2] Institute of Medicine, A summary of the October 2009 forum on the future of nursing: Acute care. Washington, DC: The National Academies Press, 2010, Washington.Retrieved from http://www.nap.edu/catalog.php?record_id=12855.
[3] S. Down, and F. Kirkland, Injection technique in insulin therapy, Nursing Times, 108(10), 2012, 20-21.
[4] P.L. Wakefield, and M.A. Wilson, Enhancing nurses' knowledge regarding the complex care of hospitalized patients on insulin, Journal for Nurses in Professional Development, 30(4),2014, 174-80
[5] A.H.A. Al-Ganmi, S.A. Ahmed, and K.B. Abed, Assessment of nurses knowledge concerning type 2 diabetes mellitus management with insulin therapy in intensive care units at Baghdad hospitals,Kufa Journal for Nursing Sciences, 4(3), 2014

Paper Type	::	Research Paper
Title	::	One year study of thrombocytopenia in a peripheral hospital of Mumbai
Country	::	India
Authors	::	Dr Richa Patel
Page No.	::	26-30
Paper Index	::	XXXX
ANED	::	05.3013/XXXX

Background: Thrombocytopenia (TCP) is often discovered incidently during the evaluation of a complete blood count. Presence of TCP should prompt further investigation of the patient for the correct identification of its underlying cause. Objectives: The objective of this study was to find out the incidence of thrombocytopenia in patients who were routinely advised a complete blood count (CBC) in a peripheral hospital of Mumbai.Cases of TCP were further analysed and evaluated to find its underlying cause. Materials and methods :A one year prospective hospital based study was undertaken .There were 15,000 patients(indoor and outdoor) who had a routine CBC done during this period. All hemograms were scrutinized and 375 patients with TCP were selected for the study.Furthur evaluation of these cases was carried out by clinical history, examination and investigations. Peripheral smear examination, tests for malaria,dengue, leptospirosis,HIV,HbSAg, and liver function tests were done in all cases. Blood culture,coagulation profile and bone marrow examination was done based on individual case.

[1]. Platelet and Blood vessel disorders. In: Richard E Behrman, Robert M Kliegman, Hal B Jensen, eds. Nelson Textbook of Pediatrics, 17th Edition. Saunders, 2004: 1770 – 77.
[2]. Sekhon SS,Roy Vivek.Thrombocytopenia in adults:A practical approach to evaluation and management.Southern medical journal.2006;vol99(5) 491-498.
[3]. Nair PS, Jain P,Khanduri U,Kumar.V, A study of fever associated thrombocytopenia,J of Asso of physicians of India.2006;5(1)1173.
[4]. Ali N, Anwar M, Ayyub M, Nadeem A, Jamal. Thrombocytopenia: analysis of 415 patients. Pakistan J Pathol, 2004 Dec; 15(4): 143 – 6.
[5]. Hanes SD,Quarles DA,Boucher BA. Incidence and risk factors of thrombocytopenia in critically ill trauma patients.Ann Pharmacother 1997;31:285-289.

Paper Type	::	Case Report
Title	::	MIXTURE OF LOCAL ANESTHETICS FOR BRACHIAL PLEXUS BLOCKADE - FRIEND OR FOE
Country	::	India
Authors	::	Gadkari Charuta|| Dr. Shweta Aswale || Marodkar Ketaki || Nikhade Ravikiran|| Bhure Anjali
Page No.	::	31-33
Paper Index	::	XXXX
ANED	::	05.3013/XXXX

Abstract: Traditionally surgeries on upper limb used to be performed under general anaesthesia but due to associated sequelae, increasing cost of anaesthetic agents and the problems of operation theatre pollution, focus has been shifted towards regional anaesthesia. Moreover postoperative pain relief is an added advantage of regional techniques. Here, we report a case where supraclavicular block was performed taking usual precautions however, the patient suffered local anesthetic systemic toxicity.

Keywords: brachial plexus blockade, lipid emulsion, local anesthetic systemic toxicity, seizures, supraclavicular block

[1]. Brendan T. Finucane and Ban C.H. Tsui, Complications of Brachial Plexus Anesthesia, in Brendan T. Finucane (Ed.), Complications of Regional Anesthesia, Chapter 8, second edition, (New York: Springer, 2007)121-148.pdf, last cited on 28/09/2015
[2]. Dr. Dilip Kothari, Supraclavicular brachial plexus block a new approach, Indian journal of anesthesia, august 2003; 47 (4): 287-288
[3]. Neal JM1, Gerancher JC, Hebl JR, Reg Anesth Pain Med. Upper extremity regional anesthesia, essentials of our current understanding, 2008. 2009 Mar-Apr;34(2):134-70.
[4]. Charles B. Berde and Gary R. Strichartz, chapter 30, Local Anesthetics, Miller 7th edition, volume 1, pg no. 913-939
[5]. Carlo D. Franco, Local Anesthetics, in Carlo D. Franco (Ed.), Manual of Regional Anaesthesia, Chapter 2, second edition, (Chicago IL: 2007) www.cookcountyregional.com/Chapter2.pdf, last cited on 28/09/2015
[6]. Michael F. Mulroy, MD and Michael R. Hejtmanek, MD, Prevention of Local Anesthetic Systemic Toxicity, Reg Anesth Pain Med 2010;35: 177-180

Paper Type	::	Research Paper
Title	::	Combination Of Biotin With Atorvastatin Achieves Favourable Total Cholesterol : Hdl Ratio In Secondary Dyslipidemia : A Single Centre, Prospective, Open Label, Parallel Group, Comparative Study.
Country	::	India
Authors	::	Dr.N.Asvini || Dr.G.Hemavathy || Dr.K.Vasanthira
Page No.	::	34-40
Paper Index	::	XXXX
ANED	::	05.3013/XXXX

The aim of our study is to determine the efficacy and side effect profile of the combination therapy of Biotin with Atorvastatin with the monotherapy group which received only Atorvastatin. Methodology: A total of 60 patients were randomly allocated to two groups, group A received tablet Atorvastatin 20 mg daily at bedtime and group B received tablet Biotin 5 mg along with atorvastatin 20 mg daily at bed time for 6 weeks. Fasting lipid profile was done at the end of 1, 2, 4 and 6 weeks. The primary efficacy measure was the reduction in the Total Cholesterol :HDLratio after the 6 weeks of treatment. Results: The combination therapy group had a 16.90% reduction at 1st week followed by a 39.89% reduction in LDL levels at the end of 2nd week, 42.62% reduction at the end of the 4th week and 43.28% reduction at the end of the 6th week which was greater than the 34.35%, 35.89% and 36.95% reduction seen in the control group at 2nd, 4th and 6th week respectively. The group which received combination therapy was able to achieve desirable levels of total cholesterol : HDL ratio of ≤ 3.5 at 4th and 6th weeks. Conclusion: It can be concluded that combination therapy of Biotin 5 mg with Atorvastatin 20 mg is more efficacious than Atorvastatin 20 mg alone in terms of reduction in Total cholesterol :HDLratio with less side effects.

[1]. K.Park. Park's text book of preventive and social medicine ; 20th ed ; India ; M/s Banarsidas Bhatot publishers; 2009; p 318.
[2]. Larrieta E, Velasco F, Vital P, Rojas A et al. Pharmacological concentrations of biotin reduces Serum Triglycerides and the expression of lipogenic genes, European journal of pharmacology, vol 644(1-3): p 263-268.
[3]. KD Tripathi. Essentials of medical pharmacology ; 7th ed ; New Delhi; Jaypee brothersMedical publishers (P) ltd; 2013; pg 643.
[4]. Donald M Mock, Susan B Johnson, Ralph T Hlman. Effect of biotin deficiency on serum fatty acid composition: Evidence for abnormalities in humans. The Journal of nutrition. November 1988; p 342-348
[5]. Tim cramer, Mary Briske- Anderson, Susan B.Johnson, Ralph T H olman. Effects of biotin deficiency on poly unsaturated fatty acid metabolism in rats. Journal of nutrition. November 1988: p 2047-2052

Paper Type	::	Research Paper
Title	::	Evaluation of Anti-Ulcer Activity of 70% Hydro-Ethanolic leaf extract of Argemone mexicana Linn. In Experimental Rats
Country	::	India
Authors	::	Sumia Fatima || Sana Tabassum Heena || Abdul Saheel Qureshi || Md. Azharuddin
Page No.	::	41-50
Paper Index	::	XXXX
ANED	::	05.3013/XXXX

Anti-ulcer activity of 70% Hydro-Ethanolic leaf extract of Argemone mexicana L. at a dose of (100, 200 &400mg/kg b.w p.o) was investigated in Pylorus ligation, Aspirin induced mucosal damage and water immersion stress induced gastric ulcer models in Albino wistar rats (150-200gms). In all the three models, the common parameter determined was ulcer index. In acute toxicity study (423 Guideline), there was no mortality up to a dose of 2000mg/kg b.w p.o, thus considered as maximum tolerated dose. Preliminary phytochemical studies showed the presence of Alkaloids, Carbohydrates, Flavonoids, Glycosides, Tannins etc. 70% Hydro-Ethanolic leaf extract of Argemone mexicana L. at a dose of 100, 200 and 400 mg/kg b.w p.o. produced significant inhibition of the gastric lesions in Pyloric ligation, Aspirin induced mucosal damage and water immersion stress induced gastric ulcer models. The extract (100, 200 and 400 mg/kg b.w p.o.) showed significant reduction in pH, Free acidity, Total acidity of gastric acid and ulcer index as compared to control in pylorus ligation model. Results showed that the 70% Hydro-Ethanolic leaf extract of Argemone mexicana L. exhibited significant and dose-dependent Anti-ulcer activity in all the ulcer models. Percentage ulcer protection of 70% Hydro-Ethanolic leaf extract of Argemone mexicana L. was calculated at 100, 200 and 400mg/kg b.w.p.o. for Pylorus ligation, Aspirin induced mucosal damage and water immersion stress induced gastric ulcer models and maximum protection was found at a dose of 400mg/kg b.w.p.o with 39.9%, 43.6%, 54.7%, respectively. The ulcer protective effects of the extract were comparable with those of standard drugs. Results of our study suggest that 70% Hydro-Ethanolic leaf extract of Argemone mexicana L. posses Anti-ulcer which may be due to the presence of flavonoids in the extract as it has astringent, anti-secretary, cytoprotective and antioxidant properties.

 

Keywords: Argemone mexicana, Anti-ulcer activity, Flavonoids, Percentage Ulcer Protection, Ulcer index.

[1]. Hasan Al-Baizyd A. Phytochemical Screening & in vitro Antioxidant and Thrombolytic Activities of Argemone mexicana Extracts [Internet]. Dspace.ewubd.edu. 2015. Available from: http://dspace.ewubd.edu/bitstream/handle/123456789/70/Ahamed%20_Hasan%20_Al-Baizyd.pdf?sequence=1.
[2]. Priya CL and Rao KVB. Ethnobotanical and Current Ethnopharmacological Aspects of Argemone mexicana Linn: An Overview. Int J Pharm Sci Res. 2012; 3(7):2143- 2148.
[3]. Rajvaidhya R, Nagori BP, Singh GGK, Dubey BK, Desai P and Jain S. A Review on Argemone mexicana Linn. - An Indian Medicinal Plant. Int J Pharm Sci Res. 2012; 3(8):2494-2501.
[4]. Brahmachari G, Gorai D, Roy R. Argemone mexicana: Chemical and Pharmacological aspects. Rev. bras. farmacogn. 2013 May/June; 23(3):1-14.
[5]. Wikipedia. Peptic ulcer [Internet]. 2015. Available from: https://en.wikipedia.org/wiki/Peptic_ulcer.

Paper Type	::	Research Paper
Title	::	Quality of life and adverse reactions caused by chemotherapy in breast cancer: an integrative review
Country	::	Brazil
Authors	::	Simone Yuriko Kameo || Namie Okino Sawada
Page No.	::	51-61
Paper Index	::	XXXX
ANED	::	05.3013/XXXX

The aim was to identify the current state of knowledge relevant to the adverse effects of chemotherapy in patients with breast cancer that affect quality of life (QOL). It is an integrative review in databases: CINAHL, SCOPUS, Web of science, PUBMED and SCIELO. 50 articles that met the inclusion criteria were analyzed, with most evidence level IV, which featured three groups: group 1, adverse reactions caused by chemotherapy, most commonly reported: nausea, vomiting, constipation, fatigue, insomnia, alopecia, waves heat, asthenia, cognitive dysfunction and amenorrhea; Group 2 interventions to improve QOL, reported according to specific adverse reactions; and group 3, factors that influence QOL with most related to the combination of administered chemotherapy. Adverse reactions should be evaluated in a multidisciplinary way and should be considered in decision-making, beyond individual vulnerability tests and information obtained from the evaluation QOL.

 

Keywords – Chemotherapy, Quality of Life, Integrative review, Toxicities.

[1] Brasil. Ministério da Saúde. Instituto Nacional de Câncer José Alencar Gomes da Silva. Coordenação Geral de Ações Estratégicas. Coordenação de Prevenção e Vigilância. Estimativa 2014 : incidência decâncer no Brasil. Coordenação Geral de Ações Estratégicas, Coordenação de Prevenção e Vigilância. – Rio de Janeiro, INCA, 2014. 124 p.
[2] J.C. de Matos, S.M. Pelloso, M.D. de B. Carvalho. Fatores associados à realização da prevenção secundária do câncer de mama no Município de Maringá, Paraná, Brasil. Cad. Saúde Pública, Rio de Janeiro, 27(5), 2011,S0102-311.
[3] A. Montazeri. Health-related quality of life in breast cancer patients: a bibliographic review of the literature from 1974 to 2007. J Exp Clin Cancer Res.,27(1), 2008,1-31.
[4] L. Gordon, D. Battistutta, P. Scuffham, M. Tweeddale, B. Newman. The impact of rehabilitation support services on health related quality of life for women with breast cancer. Breast Cancer Res Treat., 93(3), 2005,217–26.
[5] M. Montazeri, A. Vahdaninia, I. Harirchi, M. Ebrahimi, F. Khaleghi, S. Jarvandi. Quality of life in patients with breast cancer before and after diagnosis: an 18 months follow up study. BMC Cancer,8, 2008,330–6.