Simple, precise, economic, less time consuming visible spectroscopic method for Deflazacort was developed by using 2, 2- Bipyridyl and Ferric Chloride. The absorption maximum of the chromogen was found to be 540 nm. The developed method was obeying Beer Lambert's law in the range of 50-250 μg/ml concentration. The method has also been statistically evaluated and the results were within the regulated limits. Molar absorptivity, Sand ell's sensitivity and correlation–co-efficient were found to be 1.406 x 103, 0.143 and 0.999 respectively and the method is free from the interferences of other additives present in the tablet formulation.

Keywords: ...........

[1]. Patel, S.A; Development and Validation of Spectrophotometric methods for Estimation of Deflazacort in Pharmaceutical dosage form; International Journal of Pharmacy and Pharmaceutical Science; 3 (5), 2011, 269-272
[2]. Bagchi A, Mukherjee P, Kaur I, Singh R, Semwal A; Development and validation of UV spectrophotometric method for estimation of Deflazacort in bulk drug and Pharmaceutical formulation; International Journal of Drug Development & Research, 4 (3), 2012, 369-373.
[3]. Patel Satish A, Patel Natvarlal J; Development and validation of spectrofluorimetric method for estimation of deflazacort in tablets; Journal of Applied Pharmaceutical Science, 01 (7), 2011, 127-131.
[4]. Cardoso S ; Development and validation of reversed phase HPLC method for the determination of Deflazacort in pharmaceutical dosage forms; Chromatographia 65(9-10), 2007, 591-594.
[5]. Ozkan Y, Savaser A, Tas C, Uslu B, Ozkan S ; Drug dissolution studies and determination of deflazacort in pharmaceutical formulations and human serum samples by RP-HPLC.; Liq Chromatogr & Related Techno; 26(13), 2003, 2141-2156.

The present work was carried out to examine the binding efficiency of pyrethroids-Cypermethrin, Flumethrin, and Deltamethrin on CYP41, encoding cytochrome P450 of Rhipicephalusannulatus by computational docking studies. The protein structure of CYP41 was predicted using Phyre2 web portal, and the structure validation was performed using SAVES4 server. The predicted structure was docked with different commonly used pyrethroids using GLIDE. Among the acaricidesdocked, Flumethrin showed the best binding energy. There are no considerable variations among the binding energy levels and scores of the acaricides with the target molecule. From the study, we inferred that CYP41 is an effective target for the selected pyrethroids.

Keywords: Cytochrome P450, docking, Homology modelling, Pyrethroids, Rhipicephalusannulatus

[1]. D R Nelson, L Koymans, T Kamataki, J JStegeman, R Feyereisen, D J Waxman, and L C Gunsalus,P450 Superfamily: Update on new sequences, gene mapping nomenclature. Pharmacogenetics andGenomics, 6(1),1996, 1-42.

[2]. G D Wheelock, and J G Scott, The role of cytochrome P450 lpr in deltamethrin metabolism by pyrethroid-resistant and susceptible strains of house flies. Pesticide Biochemistry and Physiology, 43(1),1992, 67-77.

[3]. N Liu, and J G Scott, Genetic analysis of factors controlling high-level expression of cytochrome P450, CYP6D1, cytochrome b5, P450 reductase, and monooxygenase activities in LPR house flies, Musca domestica.Biochemical genetics, 34(3-4),1996, 133-148.

[4]. W Xiao-Ping, andAA Hobbs,Isolation and sequence analysis of a cDNA clone for a pyrethroid inducible cytochrome P450 from Helicoverpaarmigera. Insect Biochemistry and Molecular Biology, 25(9),1995, 1001-1009.

[5]. M E Scharf, J Hemingway, G J Small and G W Bennett, Examination of esterases from insecticide resistant and susceptible strains of the German cockroach, Blattellagermanica (L.). Insect Biochemistry and Molecular Biology, 27(6),1997, 489-497.

Eating Disorders are psychological disturbances associated with irregular eating habits and severe distress about body weight or shape [1]. They result in inadequate or excessive food intake which can ultimately damage an individual's well-being [1]. Eating Disorders are complex disorders, influenced by a facet of factors. It is generally believed that these disorders are combinations of biological, psychological, and environmental disturbances [1]. Eating disorders can develop during any stage in life but typically appear during the young adulthood. These conditions are treatable, however; the symptoms and consequences can be fatal if not addressed properly [2]. The most common eating disorders include anorexia nervosa, bulimia nervosa and binge eating disorder [2]. In this study we sought to review these common eating disorders.

Keywords: ...........

[1] Eating Disorders: Symptoms, Signs, Causes & Articles For Treatment Help. Eating Disorder Hope. 2018. Available at: https://www.eatingdisorderhope.com/information/eating-disorder.

[2] American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), American Psychiatric Association, Arlington, VA 2013.

[3] Hudson JI, Hiripi E, Pope HG Jr, Kessler RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol Psychiatry 2007; 61:348.

[4] Pedersen CB, Mors O, Bertelsen A, et al. A comprehensive nationwide study of the incidence rate and lifetime risk for treated mental disorders. JAMA Psychiatry 2014; 71:573.

[5] Steinhausen HC, Jakobsen H, Helenius D, et al. A nation-wide study of the family aggregation and risk factors in anorexia nervosa over three generations. Int J Eat Disord 2015; 48:1.

Tuberculosis (TB), which is one of the oldest diseases known to affect humans and is likely to have existed in prehominids, is a major cause of death worldwide. This disease is caused by bacteria of the Mycobacterium tuberculosis complex and usually affects the lungs, although other organs are involved in up to one third of cases. If properly treated, TB caused by drug susceptible strains is curable in virtually all cases. If untreated, the disease may be fatal within 5 years in 50 -65% of cases. Transmission usually takes place through the airborne spread of droplet nuclei produced by patients with infectious pulmonary TB. With a population of about 1252 million, India is the largest country in the Region..............

Keywords: Tuberculosis, calcium, vitamin D, Protein, albumin.

[1]. India TB burden [Internet]. [cited 2015 Nov 24]. Available from: http://www.searo.who.int/tb/annual-tb-report-2015.pdf

[2]. World Health Organization, ―Global tuberculosis control: surveillance, planning and financing,‖ WHO/HTM/TB/2009.411, WHO, Geneva, Switzerland, 2009. View at Google Scholar

[3]. C. D. Wells, J. P. Cegielski, L. J. Nelson et al., ―HIV infection and multidrug-resistant tuberculosis—the perfect storm,‖ Journal of Infectious Diseases, vol. 196, no. 1, pp. S86–S107, 2007. View at Publisher · View at Google Scholar · View at Scopus

[4]. WHO TB Global report 2015 [Internet]. [cited 2015 Nov 24]. Available from:http://apps.who.int/iris/bitstream/10665/191102/1/9789241565059_eng.pdf?ua=1

[5]. T. R. Frieden, T. R. Sterling, S. S. Munsiff, C. J. Watt, and C. Dye, ―Tuberculosis,‖ The Lancet, vol. 362, no. 9387, pp. 887–899, 2003. View at Publisher · View at Google Scholar · View at Scopus

Objectives: The main objectives of the study was to identify and classify the drug-drug interactions based on their severity, Mechanism , Clinical Outcome and to identify the most frequently interacting drug combination for the departments of General Medicine, General Surgery, Gastroenterology, Orthopedics, Gynecology and Dermatology. Methodology: A prospective observational study was conducted for six months. The data of patients was collected and analyzed from inpatient departments of General Medicine, General Surgery, Gastroenterology, Orthopedics, Gynecology and Dermatology respectively. Results: A total of 250cases were observed and 150 cases containing Drug-Drug Interactions are considered for the study during the period of August-2016 to January-2017............

Keywords: Actual Drug-Drug Interactions, Potential Drug-Drug Ineractions, Major, Minor, Pharmacokinetic, Pharmacodynamic.

[1]. Sandson N. Drug-drug interaction: the silent epidemic. Psychiatric Services 2005;56(1):22-4.
[2]. Merlo J et al. Prescriptions with potential drug interactions dispensed at Swedish pharmacies in January 1999: cross sectional study. BMJ 2001;323:427-8.
[3]. Kappa PA, Klop AC, Jenkins LS. Drug interactions in primary health care in the George subdistrict, South Africa: a cross-sectional study. South AfrFamPract 2013;55(1):78-84.
[4]. Grattagliano I, Portineasa P, D'Ambrosio G, Palmieri VO, Palaseiano G. Avoiding drug interactions: here's Help. J FamPract 2010;59(6):322-9.
[5]. Peng CC, Glassman PA, Marks IR, Powler C, Castigliene B, Good CB. Retrospective drug utilization review: incidence of clinically relevant potential drug-drug interactions in a large ambulatory population. J Manag Care Pharm 2003;9(6):513-22.

The lymphatic system is an important part of the immune system. It helps in removal of interstitial fluid and its dissolved substances from the tissues, initiates and coordinates immune responses for removal of cellular debris and helps to absorb fats and other substances from the GI tract. Consequently, improving the lymph movement is of a great benefit. Unlike the circulatory system, the lymphatic system does not have any pumping mechanism to move the lymph and therefore its upward movement depends upon the movement of the muscles surrounding the lymph vessels.[1],[2] Other factors like sedentary lifestyle, stress, tissue injury, etc, restrict the flow of lymph. Enhancement of the lymph movement helps in improving the detoxification process, regenerating the burned or damaged tissues and many other benefits, all of which prove to improve human health status. Hence, it is important to explore and understand the various ways by which the lymph movement can be enhanced. This review focuses on the various techniques which help enhance the lymph movement and various benefits of enhanced lymph movement.

Keywords: Lymph movement, detoxification, toxins, restricted lymph flow, techniques, enhancement of lymph movement, benefits.

[1] Ross and Wilson- Anatomy and Physiology in Health and Illness (Anne Waugh, Allison Grant, 12th Edition)

[2] Human Physiology: From cells to systems (Lauralee Sherwood)
[3] Principles of Anatomy and Physiology (J.Tortora, Bryan Derrickson13th EditionGerard)

[4] Chikly BJ. Manual thechniques addressing the lymphatic system: Origins and development. J Am Osteopath Assoc. 2005;105:457–474.
[5] Eisenhart AW, Gaeta TJ, Yens DP. Osteopathic manipulative treatment in the emergency department for patients with acute ankle sprains. J Am Osteopath Assoc. 2003;103:417–421.

Pituitary hormones GH and PRL have been used as external stimulating agents in farm animals to increase the yield of milk and meat. Here, a simple, protocol for purification of Growth Hormone (GH) and Prolactin (PRL) from the pituitary glands of Indian domestic goats (Capra hircus) has been described. Extraction of pituitaries with ammonium sulphate coupled with QAE-Sephadex anion exchange chromatography provided purified GH. The GH preparation was found to be pure in SDS-PAGE analysis and immuno-reactive to anti-buffalo GH antibody in ELISA. QAE-Sephadex was also useful in fractionating goat GH into different charge isoforms. PRL was purified from an alcoholic extract by gel-filtration chromatography on S-200.The PRL preparation was found to be pure in SDS-PAGE analysis................

Keywords: Caprine, Goat, Prolactin, Growth Hormone, Anterior pituitary, Purification, Lactogenic, Protocol

[1] Norman AW, Litwack G: Hormones. Second Edition, Publisher Academic Press, 2014, ISBN; 0080919065, 9780080919065.

[2] Hartog M. Physiological and Pathological Roles of Growth Hormone. Postgrad Med J 1964; 40 (466): 470–478.

[3] Knight CH. Overview of Prolactin‟s role in farm animal lactation. Livest Prod Sci 2001; 70 (1–2): 87–93.

[4] Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin: structure, function, and regulation of secretion. Physiol Rev 2000; 80 (4): 1523-631.

[5] Chêne N Martal J, de la Llosa P, Charrier J. Growth Hormones. II. Structure function relationships. Reprod Nutr Develop 1989; 29: 1-25

Nateglinide is a novel, exceedingly physiologic, glucose regulator lately ratified for the handling of type-2 diabetes mellitus. Nateglinide has a rapid commencement and diminutive duration of insulinotropic action those outcomes in decline of glucose level. The persistence of this study is to develop a floating tablet of Nateglinide to boost its bioavailability and sustained action. Tablets were prepared by direct compression method, using Ethyl cellulose, Carbopol 930 and pvpk-30. Tablets were evaluated for in vitro drug release features like hardness, thickness, friability, weight variation and floating properties. Additional tablets were evaluated for In vitro drug release studies for 24 hours. The tablets unveiled controlled and prolonged release while moving over the dissolution medium, polymer rearrangement played a critical role.

Keywords: Nateglinide, floating tablets, ethyl cellulose, sodium bicarbonate, sustained drug release.

[1]. Laila H. Emara, Aya R. Abdou1, Ahmed A. El-ashmawy, Nadia M. Mursi. Preparation and evaluation of Metronidazole sustained release floating tablets. International Journal of Pharmacy and Pharmaceutical Sciences, 2014; 6 (9): ISSN- 0975-1491.
[2]. Bardonnet PL, Faivre V, Pugh WJ, Piffaretti JC, Falson F. Gastroretentive Dosage Forms: Overview and Special Case of Helicobacter Pylori. J Cont Rel 2006; 111 (1-2):1-18.
[3]. Adibkia K, Hamedeyazdan S, Javadzadeh Y. Drug Release Kinetics and Physicochemical Characteristics of Floating Drug Delivery Systems. Expert Opin Drug Deliv 2011; 8(7): 891-903.
[4]. Chawla G, Gupta P, Koradia V, Bansal AK. Gastroretention a Means to Address Regional Variability in Intestinal Drug Absorption. Pharm Technol 2003; (7):52-68.

The present research work focuses on the development and evaluation of theophylline press coated tablet, showing controlled release pattern consigned with chronotherapeutics aspects. Provided HPMC K100LV and HPMC K4M were used in the different formulation as coating polymer for development of press coated tablet for controlled release. The formulation powder mixtures were evaluated for pre-compression parameters such as angle of the repose, bulk density, tapped bulk density, Carr's index and Hausner's ratio. Batches containing combination of HPMC K100LV and K4M controlled the drug release better at low concentration of high viscosity grade and it was used to optimize the formulation for pulsatile release...........

Keywords: Theophylline; pulsatile press coated tablet; chronotherapeutics; HPMC (K100LV and K4M); FT-IR.

[1] Remington JP, Beringer P. Remington: The science and practice of pharmacy, 2005.

[2] Davis SS, Illum L. Drug delivery systems for challenging molecules. Int J Pharm. 1998 ;176(1):1-8.
[3] Burnside B.A., Go X., Fiske K., Couch R.A., Treacy D.J., Chang R.K., Mc Guinness C.M., Rudnic E.M., US20036605300 2003.
[4] Yie W. Chien, Novel Drug Delivery Systems, (2) 139,164.

[5] Nagar M, Singhai S, Chopra VS, Gautam N, Trivedi P. Chronotropic systems; an emerging trend in drug delivery for pulsed release in Chrono pharmacotherapy. International Journal of Pharmaceutical and Clinical Research. 2010;2(1):10-19.

OBJECTIVE. The purpose of this study was to obtain normative data for Motor-Free Visual Perception Test (MVPT) in Chennai children.To find out the performance difference between genders. METHOD. Three Hundred and Thirty One typically developing children comprising of 167 girls and 164 boys were taken from normal school situated in various parts of Chennai. RESULTS. No significant difference (F=0.150, p=0.698) between gender on MVPT performance. Pearson correlation exhibits positive correlation (r= 0.746, p<0.001) between age and raw. CONCLUSION. Cultural influence has been scrutinized in visual perception. It also suggested that there was no gender difference and raw score increases as age matures. This study concluded that there is a strong need to ensure that norms for visual perceptual test are appropriate for specific cultural group being assessed. The norms produced in this study form the baseline for MVPT and can be used for screening and therapeutic purpose.

Keywords: ...........

[1] Dr.U.Ganapathy Sankar & S.Priyadaharshini, Standardisation of Short Sensory Profile (SSP) among Indian children. International Journal of Pharma and biosciences,2014, 5(4): (B) 260-266
[2] Ganapathy Sankar U & R,Priya. Normative data of Evaluation tool for children Handwriting – Manuscript (ETCH-M) for Chennai children,Indian Journal of Physiotherapy & Occupational Therapy July-September 2011, Vol. 5, No.3; pp 179-182.
[3] Mahalakshmi, R & Ganapathy Sankar U. Normative data of Evaluation tool for children Handwriting – Cursive (ETCH-C) for Chennai children, Indian Journal of Physiotherapy & Occupational Therapy Oct-Dec 2010, Vol. 4, No.4; pp 48-51
[4] Dr.U.Ganapathy Sankar. A study to identify effects of Sensory Integration (SI) therapy activities to reduce self-stimulating and self-injurious behaviours in children with autism: a pilot study,International Journal of Pharma and biosciences,2015,6(4),1163-1167.
[5] Berry, K.E.. Developmental test of Visual motor Integration (4th ed.,). Los Angeles: Western Psychol Corp,1977.

Background: Burns are a common problem in the Democratic Republic of Congo and other many countries in the world. It management poses a difficult challenge. The purpose of this study was to investigate medicinal plants used in the Eastern part of the Democratic Republic of Congo, especially in Rutshuru territory, used in management of burns. Material and methods: Ninety-three healers belonging were interviewed about the plant species used in traditional medicine for the management of burns in Rutshuru area. The name of the plants, the plant parts, the modes of preparation and the modes of administration of recipes were recorded. Cited plants were collected and identified at herbarium of the Laboratory of Ecology and Plants Resource Management, Faculty of Sciences, Official University of Bukavu...........

Keywords: Medicinal plant, Burn, Rutshuru

[1]. Bahramsoltani R, Farzaei MH, Rahimi R. Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review. Arch Dermatol Res 2014; 306: 601-617.
[2]. Rudall N, Green A. Burns: Clinical and prognosis. Clin Pharm 2010; 2: 245-248.
[3]. De Campos EP, Trombini LN, Rodrigues R, Portella DL, Werner AC, Ferraz MC, De Oliveira RVM, Cogo JC, Oshima‑Franco Y, Aranha N, Gerenutti M. Healing activity of Casearia sylvestris Sw. in second‑degree scald burns in rodents. BMC Res Notes. 2015; 8:269. DOI 10.1186/s13104-015-1251-4.
[4]. Chen S, Ming-Zhong S, Wang B, Hao L, Zhang C, Xin Y. Wound healing effects of cactus extracts on second degree superficial burned mice. J Med Plants Res 2011; 5(6): 973-978.
[5]. Hasselt EJV. Burns manual. 2nd edition 2008. Dutch Burns Foundation. Malawi, p150.

The antimicrobial activities have been searched previously on plant infection control and for food preservation. Current research have studied the mode of action of ITCs attracted attention of several researchers. The objective of this review is to discuss the current knowledge and hypothesis for the antibacterial effect of the leaves of the Brassica oleracea plant. (ITCs) of organic extract of leaves of the Brassica oleracea plant on some vegetative microorganism like Candida albicans, Staphylococcus spp., Salmonella spp., Klebsiellaspp., Bacillus spp. and yeast.

Keywords: Brassica oleracea plant, antibacterial properties

[1]. Jaiswal, A.K., Gupta, S., Abu-Ghannam, N. & Cox, S. (2011). Application of Baranyi function to model the antimicrobial properties of solvent extract from Irish York cabbage against food spoilage and pathogenic bacteria. Food Science and Technology International, 17(5), 495-502).
[2]. Kusznierewicz B, Bartoszek A, Wolska L, Drzewiecki J, Gorinstein S and Namies´nik J. (2008). Partial characterization of white cabbages (Brassica oleracea var. capitata f. alba) from different regions by glucosinolates, bioactive compounds, total antioxidant activities and proteins.LWT - Food Science and Technology 41(1): 1–9.
[3]. Taveira M, Pereira DM, Sousa C, Ferreres F, Andrade PB, Martins A, et al. (2009). In vitro cultures of Brassica oleracea l. var. costata dc: potential plant bioreactor for antioxidant phenolic compounds. Journal of Agricultural andFood Chemistry 57(4): 1247–1252.
[4]. Saeed, S. and P. Tariq, 2006. Effects of some seasonal vegetables and fruits on the growth of bacteria. Pakistan Journal of Biological Sciences, 9(8): 1547-1551.

The narrow tunable emission spectra and high photo-luminescence efficiency make QDs potentially the most practical candidates for making quantum-dot light emitting devices. In the last decade or more, a considerable amount of research has been focused on developing highly efficient QD-LEDs.[1-4] Quantum dot led have great potential for being used for energy efficient high colour quality thin-film display and solid-state lighting. The wide absorption spectrum, band gap tunability and cheap solution processibility make quantum-dot a promising candidate for solar cells as well. Additionally, solution-processed quantum dot allows processing onto light-weight exible substrates through spin coating, spray-coating, reel-to-reel printing and inkjet printing which can potentially reduce the fabrication and packaging cost[5].

Keywords: ...........

[1] L.E.Brus (2007) "Chemistry and Physics of Semiconductor Nanocrystals" (PDF).Retrieved 7 July 2009.
[2] D.J. Norris (1995). "Measurement and Assignment of the Size-Dependent Optical Spectrum in Cadmium Selenide (CdSe) Quantum Dots, PhD thesis, MIT".hdl:1721.1/11129.
[3] C. B.,Murray, Kagan, C. R.; Bawendi, M. G. (2000). "Synthesis and Characterization of MonodisperseNanocrystals and Close-Packed NanocrystalAssemblies".Annual Review of MaterialsResearch30(1):545–610.Bibcode:2000AnRMS..30..545M. doi:10.1146/annurev.matsci.30.1.545.
[4] "Nanotechnology Information Center: Properties, Applications, Research, and Safety Guidelines". American Elements.