This study was designed to evaluate the antipyretic activity of the aqueous extract of Zingiber officinale rhizome by the use of Brewer's yeast induced pyrexia method in female rats. The animals were randomly divided into 5 groups, the first group was served as a control group, the second group was subcutaneously injected by 30% yeast suspension (10 ml/kg). The third group was served as a standard group, it treated with yeast suspension and paracetamol (150 m/kg). The fourth and fifth groups were treated with yeast suspension and with 100 and 200 mg/kg respectively. Rectal temperature was taken at the start of the test and after 19 h after yeast injection to detect the rise of rectal temperature, after then paracetamol and the plant extract were administrated. Rectal temperature was noted again after 0, 1,2 and 3 h of drug administration. The results appeared that the aqueous extract of Zingiber officinale has significant antipyretic activity at P< 0.05.

Keywords: Zingiber officinale, aqueous extract, Antipyretic.

[1]. Dimie, O. (2011). Fever, fever patterns and diseases called 'fever'-A review. Journal of Infection and Public Health.4: 108—124.
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Annona reticulata Linn is a highly versatile plant in medicine for the treatment of various diseases. The plant has many activities like anti-helmintic, analgesic, anti-inflammatory, anti-pyretic, wound healing, anti-tumor and abortifacient properties. The present review article gives an overview on anticancer and antioxidant activity of leaves of Annona reticulata on EAC induce mammary tumor. The methanolic extracts of Annona reticulata is used against Ehrlich ascites carcinoma (EAC) in mice. Tumor cells (2×106 cells/mice) are injected into the hind limb of mice subcutaneously and tumor is allowed to develop. The effect of methanolic extracts of Annona reticulata is checked on the growth of tumor.

Keywords: Annona reticulata, anti-tumor, antioxidant, EAC.

[1]. Sarkar Mahanandan ,Das Mousumi,Mitra Debmalya,Jena Aditya Kumar,De Arnab, Samanta Amalesh.Anticancer potential of methanolic and aqueous extract of Leucas indica. Againstehrlich ascites carcinoma cells on swiss albino mice.International research journal of
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[4]. Rohini Ahuja, Neeraj Agrawal, Alok Mukerjee.Evaluation of anticancer potential of Terminalia chebula Fruits against Ehrlich Ascites Carcinoma induced cancer in mice. Journal of Scientific and Innovative Research. 2013; 2(3):549-54.

The objective of the present study was to investigate, if there exists a relationship between ACE insertion/ deletion genotypes and anti-hypertensive treatment being received by type-2 diabetes mellitus (T2DM) patientswith hypertension. This is a non-interventional study where a total of 46 T2DM cases with hypertension were recruited and 45 healthy normotensive subjects served as controls. The anti-hypertensive medications being received were Angiotensin Receptor Blockers (ARBs 40mg, OD), Calcium Channel Blockers (5mg, OD), Beta-Blockers (25mg, OD) and Diuretics (12.5mg, OD) either alone or in combination. It was observed that 70% of the patients with II-genotype responded to angiotensin receptor blockers (ARBs) whereas, nearly 92% of the patients of DD-genotype responded to calcium channel blockers (50%)/ beta-blocker (42.35%) either alone or in combination............

Keywords: Hypertension, Type2 Diabetes Mellitus, ACE gene I/D-Genotypes, Anti-Hypertensive Treatment.

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Objective: The objective of the present analysis as a part of a Prevention Study, we investigated whether concomitant administration of policosanol with diuretics induces some specific adverse event or disturbance on any safety indicator in older patients. Methods: We randomised 1470 elderly patients at high coronary risk to policosanol 5 mg/day or placebo for 3 years. For this analysis, the records of all patients (368) taking diuretics were included. Analysis was by Intention-to-treat. Results: Both groups were well matched at baseline. Policosanol effects persisted during the whole study. At study completion, policosanol reduced low-density lipoprotein cholesterol (LDL-C) (29.1 %), total cholesterol (19.6 %), triglycerides (22.5 %) and raised high-density lipoprotein cholesterol (HDL-C) (13.8 %). Of 368 patients consuming diuretics............

Keywords: policosanol, diuretics, elderly, hypercholesterolemia, drug interactions.

[1]. Mozaffarian D, Benjamin EJ, Go AS. Heart Disease and Stroke Statistics-2016 Update: A Report from the American Heart Association. Circulation. 2016;133:e38-46.
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A method to assay quinine sulfate, which is utilized for the treatment of Plasmodium falciparum, is presented using isocratic high performance liquid chromatography (HPLC). Elution of the analyteis detected with ultraviolet light detector, set at 222 nm. The stock solution of quinine sulfate was prepared in solvent conditions that consisted of 64 % ethanol (v/v) and 36 % water (v/v), at a concentration of 1.3155 x 10-2 molar. The test samples of quinine sulfate that were injected into HPLC instrument were mainly in a solvent that consisted of 95% (v/v) water and 5 % ethanol (v/v). The solvent utilized for column of the HPLC instrument was 5 % ethanol, 1 % glacial acetic acid (v/v), and 94 % water (v/v)............

[1]. Merrick C. Plasmodium falciparum. Emerging Topics in Life Sciences, 2017; (6): 517-23.
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Cisplatin as chemotherapeutic agents is consideredone of important drug for treatment of many malignant disorders. Prolonged and Conventional administration methods for cisplatine reduce its effectiveness to the target organ beside side-effects, as nephrotoxicity and ototoxicity. Nanotechnology holds several promises in cancer therapeutics. It can increase the ability of the drug toward the target site of the tumor cells, reach otherwise lesser-accessible sites and reduce the frequency of administration. The present study explored the efficacy of cisplatin coated albumin nanoparticle as a sustained delivery system.To attain this goal, cisplatin was loaded onto albumin nanoparticles (NPs),characterization of the formed albumin nanoparticles was done using surface plasmon spectra using UV-spectroscopy .The morphology of nanoparticles (NPs) were determined by scanning electron microscope (SEM ), transmission electron microscope...........................

Keywords: Cisplatin, albumin nanoparticle, drug release, pancreatic cancer cells.

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The diversity in chemical structure of sponge derived metabolites is related to an equally diverse pattern of activities.Scientist in the field of natural products chemistry and research suggest that sponges have the potential to provide future drugs againsts important diseases,such as a range of viral diseases,malaria,inflammations,immunesuppressive diseases and various malignant neoplasms.Sponges,the dominant benthic organism has filter feeding mechanism, deposits heavy metals in their tissues.These heavy metals have a major role in many of the biological reactions involved in cytotoxicity.Research findings shows that,Haliclonatenuiramosa,which can be used asbioindicators for heavy metal pollution ,had significantly higher heavy metal concentration at near shore region due to anthropogenic input .

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Tacrolimus exhibits its nephrotoxic effect in relation to its inhibition of one of the antioxidant enzymes named catalase. Glutathione peroxidase catalysesa similar reaction done by catalase. The factor which increases GPx's activity is Glutathione levels.Subsequently, Glutathione levelsare increased by N-Acetyl cysteine (NAC). Thus, it seems NAC can influence the prevention of Tacrolimus mediated nephrotoxicity. In this study,Sprague-Dawley ratsreceived1 mg/kg/day dose of tacrolimus in the control group while the three treatment groupsreceived 1mg/kg/day of tacrolimuswith NAC in 100,200 and 300 mg/kg/day doses respectivelyfor 28 days. Upon study completion, the biochemical markers of tacrolimus nephrotoxicity (urinary microalbumin,serum creatinine and BUN) showed......

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