3-propanoyl-2H-1-benzopyran-2-one was taken with semicarbazide which gives 2-(2-oxo-2H-1-benzopyran-3-carbonyl)hydrazine-1-carboxamide. The prepared Coumarin moiety containing 2-(2-oxo-2H-1-benzopyran-3-carbonyl)hydrazine-1-carboxamide derivatives is further condensed with some aromatic aldehyde derivatives which gives other class of Schiff base. Synthesized Schiff base are analyzed for their antioxidant and antimicrobial activity. The antioxidant test was done by DPPH and Nitric oxide and antimicrobial activities employed were S. aureus, Pseudomonas, E. coli, Candida albicans, A. flavus, A. fumigates.

Key Words: Azomethine moiety ,antioxidant, antimicrobial activity, Coumarin.

[1]. Amina Mumtaz A, Mahmud T, Elsegood M R and Weaver G W, Synthesis and Characterization of New Schiff Base Transition Metal Complexes Derived from Drug Together with Biological Potential Study' Journal of Nuclear Medicine & Radiation Therapy, 7, 2016, 6-9.
[2]. Ashraf M A, Mahmood A, Wajid A: Synthesis, Characterization and Biological Activity of Schiff Bases, IPCBEE, 102011,1-7.
[3]. Chaturvedi D, Kamboj M: Role of Schiff Base in Drug Discovery Research, Chemical Sciences Journal, 7 2016,2-5.
[4]. Kajal A, Bala S, Kamboj S, Sharma N, Saini V: Schiff Bases: A Versatile Pharmacophore, Journal of Catalysts 14,2013,01-04.
[5]. Ammar A, Hanan L, Samia M, Mamdouth M,Rashedy A: Synthesis, anticancer activity and molecular docking study of Schiff base complexes containing thiazole moiety,Beni-Suef university Journal of Basic and Applied Science, 5, 2016,85-96.

Lemna minor was used traditionally as antipruritic, antiscorbutic, astringent, depurative, diuretic, febrifuge and soporific. It was also used in the treatment of colds, measles, oedema and difficulty in urination. It contained carbohydrates, proteins, lipids, flavonoid, trace elements and many other contents. The pharmacological studies revealed that it possessed antimicrobial, antioxidant, cytotoxic and immunomodulatory effects. The current review discussed the traditional uses, chemical constituents and pharmacological effects of Lemna minor.

Key words: traditional uses, constituents, pharmacological effects, Lemna minor.

[1]. Al-Snafi AE, Talab TA and Majid WJ. Medicinal plants with central nervous activity - An overview (Part 1). IOSR Journal of pharmacy 2019, 9(3): 52-102. [2]. Al-Snafi AE. Medicinal plants for prevention and treatment of cardiovascular diseases - A review. IOSR Journal of Pharmacy 2017; 7(4): 103-163.
[3]. Al-Snafi AE. Medicinal plants possessed antioxidant and free radical scavenging effects (part 3)- A review. IOSR Journal of Pharmacy 2017; 7(4): 48-62.
[4]. Al-Snafi AE. Arabian medicinal plants affected female fertility- plant based review (part 1). IOSR Journal of Pharmacy 2018; 8(7): 46-62.
[5]. Al-Snafi AE. Arabian medicinal plants affected male fertility- plant based review (part 1). IOSR Journal of Pharmacy 2018; 8(7): 63-76.

Lithospermum officinale was used traditionally as a remedy in diseases of the urogenital tract and as a spasmolytic, antidiarrhoeal, diuretic and lithotriptic, anti-gout, antitoxic, antiovulatory, febrifuge, for the stimulation of the digestion, for the elimination of foreign objects from the eyes and for the treatment of smallpox, measles and as antipruritic. Lithospermum officinale contained fatty acids, proteins, carbohydrates, pigments, minerals, shikonin, shikalkin, pyrrolizidine alkaloids, lavonoids and many other biologically active ingredients. The pharmacological studies revealed that it possessed endocrine, anticancer, burns healing, antimicrobial and antiparasitic, antioxidant, anti-inflammatory and protective effects. The current review discussed the traditional uses, chemical constituents and pharmacological and therapeutic effects of Lithospermum officinale.

Key words: Lithospermum officinale, traditional uses, constituents, pharmacological effects, therapeutic effects

[1]. Al-Snafi AE. Pharmacological importance of Herniaria glabra and Herniaria hirsuta - A review. Indo Am J P Sc 2018; 5 (4): 2167-2175.

[2]. Al-Snafi AE. Pharmacological effects and therapeutic properties of Hibiscus cannabinus- A review. Indo Am J P Sc 2018; 5 (4): 2176-2182.

[3]. Al-Snafi AE. Chemical constituents and pharmacological effect of Inula graveolens (Syn: Dittrichia graveolens)- A review. Indo Am J P Sc 2018; 5 (4): 2183-2190.

[4]. Al-Snafi AE. Pharmacology and medicinal properties of Jasminum officinale- A review. Indo Am J P Sc 2018; 5 (4): 2191-2197.

[5]. Al-Snafi AE. Pharmacological and therapeutic effects of Juniperus oxycedrus- A review. Indo Am J P Sc 2018; 5 (4): 2198-2205.

Medicinal plants possessed antibacterial activities via many mechanisms, such as disruption of cytoplasmic membrane, inhibition of cell wall synthesis, inhibition of cell membrane synthesis, inhibition of nucleic acid synthesis, inhibition of energy metabolism, as well as inhibition of bacterial virulence factors, including quorum-sensing signal receptors, enzymes and toxins. Evidence of these molecular effects at the cellular level include inhibition of biofilm formation, inhibition of bacterial attachment to host ligands, and neutralisation of bacterial toxins. The current review highlighted the medicinal plants showed antibacterial activity with their spectrum and mechanisms of action.

Key words: medicinal plant, pharmacology, antibacterial

[1]. Zangana MM, Al-Dujaily AA and Al- Snafi AE. Evaluation of short course regimen treatment of patients with active pulmonary tuberculosis in saladdin province. Med J Tikrit Univ 1998; 4: 13-17.
[2]. Al- Snafi AE, Al saadi AA and Al- Samarrai AM. Bacterial etiology of acute and chronic suppurative otitis media. Med J Tikrit Univ 1999; 5: 229-234.
[3]. Barakat SS, Al-Dujaily AA and Al-Snafi AE. Misuse of antimicrobial agents in urinary tract infection in Al- Samawa city. Med J Tikrit Univ 2000; 6: 91-95.
[4]. Al- Dujaily AA, Al-Snafi AE and Al-Shahwani SM. Antibiogram profile of neonatal septicemia in the-Qar province Med J Tikrit Univ 2000; 352-356.
[5]. Al-Dujaily AA, Al-Snafi AE and Al-Shahwani SM. Antibiogram profile of pharyngotonsillitis pathogens in Hilla City. Med J Tikrit Univ 2000; 6: 22-25