January - 2021 (Volume-11 ~ Issue-1 ~ Series-1)

Paper Type

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Research Paper

Title

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Toxicity Study of Thalaga Parpam in Rats

Country

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India

Authors

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Dr. S. Balamani || Dr. Chandra Raveendran

Page No.

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01-05

Introduction: Thalaga Parpam is a Siddha Herbo-mineral formulation useful in wide range of diseases and disorders. Efficacy of formulation depends on their genuineness of herbs and mineral used. Authentication of herbs by experts is first and fundamental step for standardization of herbo-mineral formulation. In this paper acute and sub acute toxicity study of Thalaga Parpam were studied. Methods: The standard methods recommended in toxicity study guidelines Methods for chemicals by OECD was followed. Results: no any abnormal behavioural observed in acute and sub acute toxicity studies of Thalaga Parpam. Conclusion: Findings of the study is helpful in standardization of toxicity studies showed in LD50 value 2000mg/kg body weight and NOAEL in Sub acute toxicity study of Siddha formulation Thalaga Parpam, which will promote global acceptance of the formulation and reputation of the Siddha medical system.

KEYWORDS: Acute and sub acute toxicity study, Thalaga Parpam, Siddha Medicine

[1]. Thiagarajan R., Gunapadam thathu jeeva vaguppu, indian medicine and homoeopathy department, chenai, edition, 1999. P. 251
[2]. Abel-salam, B.K.A. 2012. Immunomodulatory effects of black seeds and garlic on alloxan-induced Diabetes in albino rat. Allergology Immunopathology, 40(6): 336-340.
[3]. Afroz, R., Tanvir, E.M., Hossain, M.F., Gan, S.H., Parvez, M., Aminul Islam, M. & Khalil, M.I. 2014. Protective effect of Sundarban honey against acetaminophen-induced acute hepatonephrotoxicity in rats.
[4]. Al-Waili, N.S. 2003a. Effects of daily consumption of honey solution on hematological indices and blood levels of minerals and enzymes in normal individuals. Journal of Medicinal Food, 6(2): 135-140.
[5]. Al-Waili, N.S. 2003b. Intravenous and intrapulmonary administration of honey solution to healthy sheep: effects on blood sugar, renal and liver function tests, bone marrow function, lipid profile, and carbon tetrachloride-induced liver injury. Journal of Medicinal Food, 6(3): 231- 247.


Paper Type

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Research Paper

Title

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Printed Material Model as a Drug Information Services For Patient Refer-Back in National Insurance of Health (Indonesia)

Country

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Indonesia

Authors

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Sarmalina Simamora || Ratnaningsih || Tedi || Sonlimar Mangunsong

Page No.

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06-11

Background: Each drug has a dose, administration, frequency, even different usage times. and need to be correct usage information. The incorrect usage can reduce its effectiveness even can make it more dangerous general, when dispensing at the pharmacy, the provision of information is made by writing simple rules of use called the label and is equipped with a little verbal information. Moreover, this may not be remembered by the patient if the patient receives many items of medicine. The Aim of study :It has has been designed by providing posters and brochures of some diabetes drugs that are often used in National Insurance of Health (JKN) participants to measure the blood glucose level before and after an intervention.Methods This is intervention research with pre and post-test group designs......

KEYWORDS; drug information, brochures, diabetic , intervention.

[1]. Celio J, Ninane F, Bugnon O, Schneider MP. Pharmacist-nurse collaborations in medication adherence-enhancing interventions: A review. Patient Educ Couns. 2018 Jul;101(7):1175-1192. doi: 10.1016/j.pec.2018.01.022. Epub 2018 Feb 9. PMID: 29628282.
[2]. Athiyah U., Riskayanti E, Fenitasari D., Rakhmawati, Nugraheni G., Nita Y., 2014. Profil Informasi Obat pada Pelayanan Resep Metformin dan Glibenklamid di Apotek di Wilayah Surabaya, Jurnal Farmasi Komunitas Vol. 1, No.1(2014) 5-1.
[3]. Kemenkes, 2016. Peraturan Menteri Kesehatan Republik Indonesia Nomor 73 Tahun 2016 Tentang Standar Pelayanan Kefarmasian Di Apotek. Kementerian Kesehatan RI, Jakarta
[4]. Widya IN, Lestari K, Abdulah R, Salma K. Ghassani. 2013. Pengaruh Pelayanan Informasi Obat terhadap Keberhasilan Terapi Pasien Diabetes Melitus Tipe 2. Jurnal Jurnal Farmasi Komunitas. Volume 2, Nomor 4, Desember 2013.


Paper Type

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Research Paper

Title

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Effect of some Traditional Alcoholic Beverages on Sexual Behavior of Albino Rats

Country

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Nigeria

Authors

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Moritiwon O || Wannang NN || Ogundeko TO || Ogaji JI

Page No.

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12-18

Background: There are growing concerns regarding the production, distribution and uncontrolled use of alcoholic beverages in our society today. The effects of these traditional alcoholic beverages on the sexual behavior of male and female albino rats is the aim of the study. Materials and Methods: A total of 60 normal albino rats (spaque Dawley strain) weighing 180-200g of about 12 weeks and were in different cages of thirty males (a) and females (b) respectively. These were randomly divided into five groups of six animals per cage and were administered with various doses of four freshly brewed local alcoholic beverages - goskolo, burukutu, pito and ogogoro purchased daily from the same commercial brewer for a period of 30 days. On day 31, the animals were placed in transparent glass cage and after an adaptation period of 10 minutes, sexually receptive females were presented to the males at a time by introducing them into the cage. iordiosis display and......

Keywords: Fermentation; Mount Latency; Intromission Latency; Ejaculation Latency; Mount Frequency; two chambered model; sexual motivation test

[1]. Toxicology and Health Risk Assessment: Reproductive and Developmental Toxicity. ChemSafetyPro.com. Little Pro on 2016-04-25
[2]. Kim JH., Scialli AR. Thalidomide: The Tragedy of both defects, effective treatment of disease. Toxicology Science. 2012; 139 (1): 25-32
[3]. World Health Organization. International programme on chemical safety. Principle of for evaluating health risk to reproduction associated with exposure to chemicals environmental health criteria. Geneva: 2001; WHO Press, 225.
[4]. Crowe LC; George WH. "Alcohol and human sexuality: Review and integration". Psychological Bulletin. 1989; 105 (3): 374–86. doi:10.1037/0033-2909.105.3.374. PMID 2660179.
[5]. David J.H. Alcohol Science, Policy and Public Health, Historical Evolution of alcohol consumption in the society. 2013; Oxford, Oxford University Press, 1-40.


Paper Type

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Research Paper

Title

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Knowledge, Attitude, and Practices of Community Pharmacists on Antibiotic Resistance and Antimicrobial Stewardship in Lusaka, Zambia

Country

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Zambia

Authors

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Steward Mudenda || Mutinta Hankombo || Zikria Saleem || Mohammad Jaffar Sadiq || Michelo Banda || Derick Munkombwe || Chiluba Mwila || Maisa Kasanga || Annie Chibwe Zulu || Jimmy Mapenzi Hangoma || Webrod Mufwambi || Lungwani Tyson Muungo || Ronald Mutati Kampamba || Andrew Munkuli Bambala || Noor Mohammed Abdulrahman || Muhammad Akram || John Bwalya Muma

Page No.

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19-31

Background: Antibiotic resistance is among the major threats to global health. Due to limited information on the subject matter in Zambia, we assessed the knowledge, attitude, and practices of community pharmacists on antibiotic resistance and antimicrobial stewardship. Materials and Methods: We conducted a descriptive cross-sectional study among 144 randomly selected community pharmacists through a structured questionnaire. Data were analysed using Statistical Package for Social Sciences version 22 at 95% confidence level. The Fisher's exact test was used to determine the relationship between sociodemographic factors of community pharmacists and their knowledge, attitude, and practices on antibiotic resistance and antimicrobial stewardship.......

Keywords: Antibiotic resistance, antimicrobial stewardship, attitude, community pharmacists, knowledge, practices, Zambia

[1]. Conly J, Johnston B. Where are all the new antibiotics? The new antibiotic paradox. Can J Infect Dis Med Microbiol. 2005; 16(3):159-160.
[2]. Gottlieb T, Nimmo GR. Antibiotic resistance is an emerging threat to public health: an urgent call to action at the Antimicrobial Resistance Summit 2011. Med J Aust. 2011; 194:281-283.
[3]. Collignon PJ, McEwen SA. One Health - It's Importance in Helping to Better Control Antimicrobial Resistance. Trop Med Infect Dis. 2019; 4(1):22.
[4]. Jinks T, Lee N, Sharland M, et al. A time for action: antimicrobial resistance needs global response. Bull World Health Organ. 2016; 94(8):558-558A.
[5]. Friedman ND, Temkin E, Carmeli Y. The negative impact of antibiotic resistance. Clin Microbiol Infect. 2016; 22: 416– 422.


Paper Type

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Research Paper

Title

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Relation of Serum Creatinine with Renal Resistive Index in Nephrotic Syndrome

Country

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India

Authors

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Dr. Hage Niku || Dr. (Prof) Pranoy Dey

Page No.

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32-40

Background: Nephrotic syndrome is a very common childhood disease, commonly affecting children between ages 2-6 yrs of age. Serum creatinine level reflects the glomerular filtration rate. In clinical practice creatinine clearance is often used as a marker of glomerular filtration rate. Aims: To see whether renal resistive index increases in children with nephrotic syndrome with high serum creatinine level. Settings and Design: Hospital based analytical study Methods and Material: Serum creatinine values were evaluated in relation to the severity of nephrotic syndrome. 63 children were taken into study (>1 year and <12 years), and were divided into 2 groups (≤6years and >6 years). The serum creatinine values of each group were compared with the renal resistive index of nephrotic syndrome. RRI was determined from USG renal Doppler by applying the following formula......

Keywords: renal resistive index, nephrotic syndrome, usg renal Doppler, serum creatinine.

[1]. Kliegman R, Stanton B, St. Geme J, Schor N, Behrman R, Nelson W. Nelson textbook of pediatrics. 21st ed. pp 2789-2804canada: Elsevier;

[2]. Lane J. Pediatric Nephrotic Syndrome Clinical Presentation: History, Physical Examination [Internet]. Emedicine.medscape.com. 2020 [cited 30 August 2020]. Available from: https://emedicine.medscape.com/article/982920-clinical

[3]. Ruth EM, Kemper MJ, Leumann EP, Laube GF, Neuhaus TJ. Children with steroid-sensitive nephrotic syndrome come of age: long-term outcome. J Pediatr. 2005;147:202–207. doi: 10.1016/j.jpeds.2005.03.050

[4]. Fakhouri F, Bocquet N, Taupin P, Presne C, Gagnadoux MF, Landais P, Lesavre P, Chauveau D, Knebelmann B, Broyer M, Grunfeld JP, Niaudet P. Steroid-sensitive nephrotic syndrome: from childhood to adulthood. Am J Kidney Dis. 2003;41:550–557. doi: 10.1053/ajkd.2003.50116.

[5]. Abeyagunawardena AS, Sebire NJ, Risdon RA, Dillon MJ, Rees L, Van't Hoff W, Kumarasiri PV, Trompeter RS. Predictors of long-term outcome of children with idiopathic focal segmental glomerulosclerosis. PediatrNephrol. 2007;22:215–221. doi: 10.1007/s00467-006-0264-6.