Current-Issue

Volume 7 ~ Issue 9,~Version 1,~September - 2017


Paper Type

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Research Paper

Title

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Nephro Protective, Diuretic and Anti inflammatory Evaluation of
Monocot Grass Kyllinga triceps rottb

Country

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India

Authors

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Amit Upadhyay || Dr. Suman Jain

Page No.

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01-04

Paper Index
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XXXX

Kyllinga triceps rottb in commonly grown monocot grass of Gwalior Chambal region. In ayurvedic literatures it is known as musta. In various ethno botanical studies grass is reported to be diuretic, anti inflammatory hepatoprotective and antidiabetic. In present study we have been evaluated kullinga triceps rhizomes for its diuretic, nephroprotective and anti inflammatory potential.

 

Keywords: ..............

[1]. K.K. Saxena, Saini Manish, Bhatt Shaily, virani Shalini, Asian Journal of pharmaceutical and clinical research, 09, 1, 2016, 113-117.
[2]. Kota kumar pavan, P. Prasad Dharani, A. Rao Narayana P. Reddy Dayakar, Abhinay G., International journal of pharma and bio Sciences, vol-1, 4, 2010, 435-438. Ref
[3]. Amrita Bhaiji, Rakesh Sagar, Subhan Gankar Nandy, Ranjah Sudhanshu Swain, Bhusan Himanshu, Sahoo, International Research Journal of Pharmacy, 2012, 3, 5, 246-250.
[4]. Rajesh Kumar S., Manohar S., Ramesh K, International journal of pharm fech research, 2014, 6, 1, 403-408.
[5]. Patil S Praveen, Medabala tambi, chrstina, Suyana Bahu Suresh, Asian Journal of Pharmaceutical and clinical Research, 7, 4, 2014, 157-159.
[6]. Harish M.S., Samiula D.S., Indian journal of Pharmacology, 2000, 32, 112-113.
[7]. Chitra M., Jagachitra J., Int. J. Pharmacol. Biol, Sci., Vol-1 (2), 2007, 53-55.

 

Paper Type

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Research Paper

Title

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Identification and Structure Elucidation of Principle Active Flavonoids from Aqueous-Methanolic Extract Of Olea Cuspidata

Country

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India

Authors

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Preeti Majgaine || D. L. Verma

Page No.

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05-09

Paper Index
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XXXX

Olea cuspidata, a subspecies of Olea europaea and native to Indian Himalaya, is a oil producing evergreen traditional medicinal plant. Olea cuspidata is an excellent fodder producing plant and its leaves have been used as a good supplement to lactating animals of Kumaun hills. The leaves of the plant have medicine to cure cardiovascular and various forms of inflammatory diseases by the local inhabitants of kumaun hills. Therefore, various extracts derived from the leaves of the plant were screened for the isolation and characterization of prominent active catechol grouping flavonoids.

 

Keywords: Olea cuspidata, flavonoids, antioxidant activity.

[1]. Altona, C. and Hasnoot, C.A.G. (1980). Org. Mag_. Resonance. 13. p. 417.
[2]. Bors, W., Hellers, W., Michel, C., Saran, M. Radical chemistry of flavonoid antioxidants. In, Antioxidants in therapy and preventive medicine. Vol.1,165–170. New York: Plenum Press.1990.
[3]. Chandler B.V. and Harper, K.A. (1961). Aust. J. Chem., 14, 586.
[4]. Feigl, E. (1960). In spot test in organic chemistry. Elsevier publishing company, London, p. 337.
[5]. Geiger, H and Homberg.. H. (1983). Z. T~la1urt`orsch. 3316). p. 253-257.

 

Paper Type

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Research Paper

Title

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Anti ulcer Activity of Ethanolic Extract of Kyllinga Triceps Rottb. Rhizomes

Country

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India

Authors

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Amit Upadhyay || Dr. Suman Jain

Page No.

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10-12

Paper Index
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XXXX

Kyllinga Triceps family cyperaceae more over known as musta is a herbacious, perennial monocot grass scattered throughout India. In the present study plant extract is evaluated for anti ulacer activity with the help of ulcer index. Ranitidine is used as standard drug. Preliminary phytochemical studies and acute oral toxicity studies were also carried out. The extract showed significant reduction in Ph, gastric volume, total acidity and ulcer index in dose dependant manner as compared to control. The extract did not produced any toxic effect even at high doses. Anti ulcer effects are probably due to the presence of terpenes and terpenoids.

 

Keywords: Kyllinga triceps, ranitidine, ulcer index, terpenes and terpeniods, cyperaceae

[1]. G Kumar Bharath, Kumari Divya, G Sravanthi, G Rajeshwar, V Umadevi, Kotla Goud Niranjan, Int. J. Pharm. Sci. Drug Res. 2014, 6, 1, 38-40.
[2]. Rao Mahadeva U.S., Ahmad Ado Bashir, Mohd suryati Khamsah, Zin Thant Malaysian J. of Analytical sciences 20, 5, 2016, 1203-1216.
[3]. Deore Bhalchandra, Sapakal Dnyandev Vinayak, Dashpure laxman Neelam Naikwade S. Nilofer, J. of Applied pharmaceutical science, 01, 05, 2011, 151-154.
[4]. Amin Jalilzadeh Ghader, Najarnezhad vahid, Anassori Ehsan, Mosta Favi Mosta Fa, Keshipour hadi, Iranian Journal of Pharmaceutical Research 2015, 14, 4, 1163-1170.
[5]. Okonta Mathew Jegbefume, Adibe Maxwell, Ubaka Chukwuemeka, Asian Pacific journal of tropical medicine, 2010, 412-420.

 

Paper Type

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Research Paper

Title

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Corrosion Inhibitive Effects of Tylophora Indica (A Medicinanl Plant) on Tin in Acidic Media

Country

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India

Authors

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Archna Kumari || Dr. Alok Chaturvedi || Dr.Seema Kothari

Page No.

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13-19

Paper Index
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XXXX

Corrosion can be considered either chemical or electro chemical in nature . Corrosion decays the metallic properties.Corrosion of metals may be prevented by either barrier protection , sacrificial protection , by alloying or by antirust solutions of ligands containing N , S, O, Se and P as hetero atoms. The naturally occurring plant product are eco-friendly, non-polluting , less toxic, easily available , biodegradable and economic to be used as corrosion inhibitor . Tylophora Indica is known as anantmul. This plant is distributed throughout southern and eastern part of India in plain and forest places. The plant has been reported to contain 0.2 - 0.46 % alkaloid viz, tylophorine flavonoids............

 

Keywords: Tylophora Indica, Corrosion inhibition efficiency, Corrosion rate, Weight loss method, thermometric method, Tin metal etc.

[1]. A.A El. Warraky and El.Meleigt ,"Electrochemical and Spectroscopic Investigation of Synergestic Effects in Corrosion Inhibitor of Al Bronze Part 1- in pure HCl," Journal of British Corrosion, vol.37 No. 4 ,2000.305-310.
[2]. H.Ashassi-.Sorkhabi ,B.Shabani ,B.Alighalipour and D.Seifzadeh, "The Effect of Some Schiff Bases on the Corrosion of Aluminiumn in HCl Solution", Applied Surface Science, vol.252 No.12, 2006,.4039-4047.
[3]. G.Berkt,A.Pinharbasi and C.Orgretir, "Benzimi- dazole-2-tione and Benzgoxazale-2 tione Dervative as Corrosion Iinhibitors for Al in HCl Acid," Anticorrosion, Method and Material vol. 51,No.4,2004,282-293.
[4]. A.H.Ali Ahmed ,A.H. Ahmed ,T.A. Mohammad and B.H. Mohammad ",Chelates and Corrosion Inhibition of Newly Synthesized Schiff Bases Derived from o- tolidine," Transition Metal Chemistry , vol.32, No.4,2004,461-467.
[5]. R.K. Upadhayay,S.Anthony and S.P .Mathur , Polish J. of Chem.43,(2007),238.

 

Paper Type

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Research Paper

Title

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Auto-activated Thrombin Expression from Pichia pastorisSMD1168 Optimized by Plackett-Burman Design and Response Surface Methodology

Country

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Indonesia

Authors

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Muhammad Fadhlillah || Wulan Pertiwi || Ersanda Hafiz || Sheila Chairunnisa || Eria S. Widyaningsih || Inten Ihsannunisa || Toto Subroto

Page No.

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20-27

Paper Index
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XXXX

Recombinant thrombin (rThrombin) has been used topically as one component of fibrin sealant as the tissue adhesive. Recombinant prethrombin-2 is used as the precursor to generate rThrombin which is then activated by ecarin. Autoactivated thrombin (autoTrm) can be produced by altering four amino acids (EDGE) in prethrombin-2 thus obviate the use of ecarin and simplify the purification process. In this study, Pichia pastorisSMD1168 was used to producing autoTrm in flask culture. Influencing factors on P. pastorisSMD1168 culture in producing autoTRM were screened by Plackett-Burman (PB) design and the optimization of was carried out by Response Surface Methodology............

 

Keywords: Autoactivated thrombin, P. pastoris SMD1168, PTM1 supplemented medium, Placket-Burman design, Response SurfaceMethodology

[1]. Bas D, Boyaci IH, Bas D, Boyaci IH. 2007. Modeling and optimization I: Usability of response surface methodology. J Food Eng. 78:836–45.
[2]. Cereghino GP, Cereghino JL, Ilgen C, Cregg JM. 2002. Production of recombinant proteins in fermenter cultures of the yeast Pichia pastoris. CurrOpinBiotechnol. 13(4):329-32.
[3]. Cregg JM, Cereghino JL, Shi JY, Higgins DR. 2000. Recombinant protein expression in Pichia pastoris. Mol Biotechnol. 16:23–52. [4]. Enus S., Natadisastra G., Shahib MN, Sulaeman R. 2011. Peran lem fibrin otologus pada penempelan tandur konjungtiva bulbi mata kelinci terhadap ekspresi gen fibronektin dan integrin. MKB. 43:183-188
[5]. Plackett RL, Burman JP. 1946. The design of optimum multifactorial experiments. Biometrika. 33:305–25.

 

Paper Type

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Research Paper

Title

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A New Species of Rare Monogenoidean Genus Thaparogyrus Gusev, 1976 from gills of Labeo bata (Hamilton, 1822)

Country

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India

Authors

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Dr. Karuna Vaishya

Page No.

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28-29

Paper Index
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XXXX

A new species of rare monogenoidean genus Thaparogyrus Gusev, 1976 has been described. The worms were collected on the gills of L. bata at Manjhura, District Kheri. It is characterized by the dissimilar size of hooks and copulatory tube broad at base pointed at ends; accessory piece with two short flaps support to hold the tube medially and solid tip of tube by terminal flap and broad base of copulatory tube also attached to accessory piece of copulatory complex.

 

Keywords: ...............

[1] Gusev, A. V. 1976a. Freshwater Indian Monogenoidea. Principles of systematics, analysis of world faunas and their evolution. Indian J. Helminth, 25 & 26, 1-241.
[2] Gusev, A. V. 1976b. The systematic composition of the Indian fauna, Zoogeography and Evolution of freshwater monogeneans. Novaya Seriva., 35, 5-32.
[3] Jain, S. L. 1957b. Monogenea of Indian freshwater fishes. VI. Three new Trematodes belonging to the genus Neodactylogyrus Price, 1938 (Family: Dactylogyridae) from some freshwater fishes of Lucknow, India. Proc. Nat. Acad. Sci., 27, 53-63.
[4] Jain, S. L. 1960. Monogenea of Indian freshwater fishes. XII. New Dactylogyrid trematodes from the gill filaments of Cyprinidae and Gobidae hosts. Sobr. Libro Hom. E. Caballeroy C., 161-171.
[5] Lim, L.H.S. 1996. Thaparocleidus Jain, 1952, the senior synonym of Siluridiscoides Gussev, 1976 (Monogenea: Odiscoidinae), Syst. Parasitol., 35, 207-215.

 

Paper Type

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Research Paper

Title

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Synthesis, Optimization and Characterization of Folate-Chitosan polymer conjugate for Possible Oral delivery of Macromolecular drugs

Country

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Egypt

Authors

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Eman Sadder El-Leithy || Hend Mohamed Abdel-Bar || Raghda Abd el-Moneum

Page No.

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30-38

Paper Index
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XXXX

Folate-chitosan (FA-CS) conjugate was assorted as a pharmaceutical approach to increase the cellular uptake of macromolecular drugs. It was synthesized by coupling the carboxylic group of the folic acid (FA) with the amino group of chitosan (CS) using carbodiimide. The designed conjugate was suggested to combine the mutual features of both FA and CS. Factors affecting the conjugation process was optimized using Box-Behnken design to maximize the amount of FA that could be coupled with CS. The influence of FA: CS ratio, reaction temperature and time on coupling ratio were studied. The prepared FA-CS conjugate was subjected to in-depth study including FT-IR, 1H NMR, mass spectroscopy, DSC, and XRD studies............

 

Keywords: Box-Behnken, Chitosan, Conjugate, Folic acid, Optimization.

[1] Griffin BT, Guo J, Presas E, Donovan MD, Alonso MJ, O'Driscoll CM, 2016. Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs. Adv Drug Deliv Rev, 15, 2016, 367-380.
[2] Rekha MR, Sharma CP, Oral delivery of therapeutic protein/peptide for diabetes--future perspectives, Int J Pharm,440(1), 2013, 48-62.
[3] Wang XQ, Zhang Q, pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs, Eur J Pharm Biopharm,82(2), 2012, 219-248.
[4] Chaturvedi K, Ganguly K, Kulkarni AR, Rudzinski WE, Krauss L, Nadagouda MN, Aminabhavi TM, Oral insulin delivery using deoxycholic acid conjugated PEGylated polyhydroxybutyrate co-polymeric nanoparticles, Nanomedicine (Lond),10(10), 2015,1569-1652.
[5] Yin N, Brimble MA, Harris PW, Wen J, Enhancing the Oral Bioavailability of Peptide Drugs by using Chemical Modification and Other Approaches, Med chem 4, 2014,763-769

 

Paper Type

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Research Paper

Title

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Pattern of Acute Poisoning Presenting at a Tertiary Care Hospital

Country

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India

Authors

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Surya Diana Sande || Padmaja Uday kumar

Page No.

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39-42

Paper Index
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XXXX

Acute poisoningis a medical emergency. It is important to know the nature, severity and outcome of acute poisoning cases in order to take up appropriate planning, prevention and management techniques. This studyaimed to assess the pattern and outcome of acute poisoning cases in a tertiary care hospital in Karnataka. This is a retrospectivehospital record-basedwhichstudyincluded 120 cases. Data on Sociodemographicdetails, type of poisoning, outcome, circumstances of poisoning (suicidal/accidental) and treatmentgivenwerecollected in the prestructuredproforma. Poisoningwas more commonamong males (61.67%) compared to females (38.33). Most cases of acute poisoningpresentedamong............

 

Keywords: Acute poisoning, pattern and outcome, tertiary care hospital

[1] KSN. Reddy, The essentials of forensic medicine and Toxicology (Hyderabad:Sugunadevi, 2013)
[2] WHO: Environmental Health Criteria 2010.
[3] L Vijaykumar, Indian research on suicide, Indian Journal of Psychiatry,52, 2010, 25-8.
[4] A Basu, Study of Organophosphorus poisoning over 3 years, Journal of association of Physicians of India, 36, 1988, 21.

 

Paper Type

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Research Paper

Title

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Virtual Docking Analysis of Zeorin With Fungal Glucan Transglycosylase

Country

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India

Authors

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Ashutosh Pathak

Page No.

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43-45

Paper Index
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XXXX

Lichen thallus, a consortium of mycobiont and photobiont, produces numerous secondary metabolites and zeorin is one of them. The antifungal activity of zeorin producing lichen extracts have provided the evidence for the current study. The present study was focused on the binding affinity and virtual docking of glucan transglycosylase (Gas2p). The structure of protein was downloaded from RSCB whereas the ligand file was downloaded from PubChem compound database. The docking was performed using AutoDock Vina and visualized by Chimera 1.11.2 whereas the active binding sites were evaluated by MetaPocket 2.0. The successful docked results of Gas2p with zeorin exhibited the potential of zeorin in the inhibition of glucan chain elongation of fungal cell wall via disturbing the hydrolysis and transglycosylation activity of glucan transglycosylase and proves its potential as candidate for future antifungal drug.

 

Keywords: Docking, fungal cell wall, Glucan transglycosylase, Lichen, zeorin

[1] A. Pathak, R.K. Mishra, S.K. Shukla, R. Kumar, A. Pandey, M. Pandey, and A. Dikshit, Flavoaparmelia caperata, a host for Beauveria sp. in subalpine forest of Chakrata district, Uttarakhand, India, and Natural selection in B. bassiana, Asian Journal of Microbiology, Biotechnology and Environmental Sciences, 18(4), 2016, 983-990.
[2] K. Molnar, and E. Farkas, Current results on biological activities of lichen secondary metabolites: A Review, Zeitschrift fur Naturforschung C, 65, 2010, 157-173.
[3] A. Pathak, R.K. Mishra, S.K. Shukla, R. Kumar, M. Pandey, M. Pandey, A. Qidwai, and A. Dikshit, In vitro evaluation of antidermatophytic activity of five lichens, Cogent Biology, 2, 2016, 1197472.
[4] K. Marijana, R. Branislav, and S. Slobodadn, Antimicrobial activity of the lichen Lecanora frustulosa and Parmeliopsis hyperopta and their divaricatic acid and zeorin constituents, African Journal of Microbiology Research, 4(9), 2010, 885-890.