November - 2021 (Volume-11 ~ Issue-11 ~ Series-1)

Paper Type

::

Research Paper

Title

::

Sunscreen Activity of Carotenoid Fraction, Norbixin, and Bixinfrom Bixaorellana Linn. Seeds

Country

::

Indonesia

Authors

::

Yuvianti Dwi Franyoto || Erna Rizkyana || Lia Kusmita || Mutmainah || Ika Puspitaningrum

Page No.

::

01-07

The use of synthetic sunscreens can cause contact dermatitis, so natural sunscreens are preferred. Kesumbakeling (annatto) contains carotenoids such as norbixin, which has conjugated double bonds that cause photoprotection. This study aims to determine the potential of the carotenoid fraction and norbixin as an active ingredient in sunscreen by measuring the SPF, %TE and %TP values using UV-Visible Spectrophotometry. The results showed that the yield of the carotenoid fraction was 3,73 0.33% with 16,66  0.49% of norbixin content and 84,57  0,54% of bixin content. The identification of norbixin produced a bluish-green color and a single spot on TLC with an Rf of 0,82 with a spectral pattern at  457,30; 486,30 and 567,70 nm. The identification of bixin produced a cornflower-blue color and a single spot on TLC with an Rf of 0,37 with a spectral pattern at  352,00; 458,00 dan 486,70 nm.........

 

KEYWORDS: Bixaorellana, Bixin, Carotenoid fraction, Norbixin, Sunscreen

[1]. Hassan I, Dorjay K, Sami A dan Anwar P., 2013. Sunscreens and Antioxidants as Photo-protective Measures: An update. Our Dermatology Online, 4(3): 369–374. https://dx.doi.org/10.7241/ourd.20133.92
[2]. Cefali LC, Ataide JA, Moriel P, Foglio MA dan Mazzola PG., 2016. Plant-based active photoprotectants for sunscreens. International Journal of Cosmetic Science, 38: 346–353. https://dx.doi.org/10.1111/ics.12316
[3]. Satyanarayana A, Prabhakara Rao P dan Rao D., 2003. Chemistry, processing and toxicology of annatto (Bixa orellana L.). J Food Sci Technol, 40(2): 131–141.
[4]. Alwis D, Chandrika U dan Jayaweera P., 2021. Photostability of apocarotenoids on surface of TiO2 semiconductor nanoparticles. Journal of Photochemistry and Photobiology A: Chemistry, 407: 113061.https://dx.doi.org/10.1016/j.jphotochem.2020.113061
[5]. Abdassah M, Aryani R, Surachman E dan Muchtaridi M., 2015. In-vitro assessment of effectiveness and photostability avobenzone in cream formulations by combination ethyl ascorbic acid and alpha tocopherol acetate. Journal of Applied Pharmaceutical Science, 5(6): 070–074.https://dx.doi.org/10.7324/JAPS.2015.50611


Paper Type

::

Research Paper

Title

::

Prospective Study on Utilization Pattern of Corticosteroids on DVL Patients at a Tertiary Care Teaching Hospital

Country

::

India

Authors

::

Aswin Leethiyal.A || Gayathri.M || Dr.Mahesh Kumar.V.P || Dr.Kannambal. K

Page No.

::

08-13

BACKGROUND: Corticosteroids are steroid hormones secreted by adrenal cortex. It is extremely useful in the treatment of skin disorders. They have an important role because of their anti-inflammatory, immune-suppressive and anti-proliferative effect on keratinocytes. AIM: To study the utilization pattern of corticosteroids for various dermatological condition at a tertiary care teaching hospital. METHODOLOGY: A hospital based prospective observational study for 6 months on Rajah Muthiah Medical College, Chidambaram by enrolling outpatient and inpatient considering study criteria. Prescription with atleast one steroid were collected and analysed for utilization pattern of corticosteroids. RESULTS: Out of 75 patients studied, females (76%) were highly prescribed with corticosteroids than males (24%). Age group of 51-60 (25.3%) were highly prescribed with corticosteroids......

 

Keywords: Corticosteroids, Utilization Pattern, Prednisolone, Adverse Drug Reaction.

[1]. NationalLibraryOfMedicine,HistoryoftheDevelopmentofCorticosteroidTherapyTGBenedek , ClinExpRheumatol . sep – oct 2011. [Accessed sep-oct 2011:29(5 suppl 68):S-5-12.Epub2011oct21]
[2]. Experimentaland Clinical Pharmacology, The Role OftheCorticosteroidsinthedermatology,MichaelLee andRobinMarks,AustPrescr1998,21:9-11,1January1998,DOI:10.18773/austprescr.1998.010.Availableat:https://www.nps.org.au/australian-prescriber.
[3]. IndianJournalOfDermatology,Use ofTopicalCorticosteroidsinDermatology: AnEvidence–based approach, Anupam Das and Saumya Panda 2017 may-jun ;62(3):237-250. doi:10.4103/ijd.IJD-169-17.Availableat:https://www.ncbi.nlm.nih.gov/pmcAdrenalGlands,JohnsHopkinsMedicine, Availableat:https://www.hopkinsmedicine.org
[4]. AdrenalGlandHormones –CanadianCancer SocietyAvailableat:https://www.cancer.ca/en/cancer
[5]. .RheumaticdiseaseclinicsofNorthAmerica, Corticosteroids–MechanismofActioninHealth and Disease , SivapriyaRamamoorthy and John A.Cidlowski ,2016 feb;42(1):132.doi:10.1016/j.rdc.2015.08.002.


Paper Type

::

Research Paper

Title

::

Bridging anticoagulation therapy in patient undergoing coronary artery bypass graft: A systematic review

Country

::

Malaysia

Authors

::

Wardati Mazlan-Kepli || Chuah Sim Mei || Haizun Athirah Ismail || Soo Pei Yean || Foo Yen See

Page No.

::

14-25

Background: Patients undergoing coronary artery bypass grafting (CABG) remain at risk of subsequent major adverse cardiovascular and bleeding events. This study reviewed the available evidence on the safety of bridging anticoagulation therapy administered periprocedure CABG and the occurrence of major adverse cardiovascular events (MACE) and bleeding events. We systematically searched Ovid/MEDLINE, PubMed/MEDLINE, and Cochrane Library (Wiley) databases from inception until 8th April 2020. All randomized controlled trials (RCT) of participants (aged >18 years) undergoing CABG surgery and receiving perioperative - bridging anticoagulation therapy were included. Two investigators conducted title and abstract screening while another two investigators screened full text articles according to pre-specified inclusion criteria. The primary endpoint was a MACE, which consists of a composite of all-cause mortality......

 

Keywords: CABG, anticoagulant, major adverse cardiovascular event.

[1]. Celermajer DS, Chow CK, Marijon E, Anstey NM, Woo KS. Cardiovascular Disease in the Developing World: Prevalences, Patterns, and the Potential of Early Disease Detection. J Am Coll Cardiol 2012; 60: 1207-16.
[2]. Doenst T, Haverich A, Serruys P, Bonow RO, Kappetein P, Falk V, Velazquez E, Diegeler A, Sigusch H. PCI and CABG for Treating Stable Coronary Artery Disease: JACC Review Topic of the Week. J Am Coll Cardiol 2019; 73: 964-76.
[3]. Sousa-Uva M, Neumann F-J, Ahlsson A, Alfonso F, Banning AP, Benedetto U, Byrne RA, Collet J-P, Falk V, Head SJ, Jüni P, Kastrati A, Koller A, Kristensen SD, Niebauer J, Richter DJ, Seferović PM, Sibbing D, Stefanini GG, Windecker S, Yadav R, Zembala MO, Group ESCSD. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur J Cardiothorac Surg 2019; 55: 4-90.
[4]. Valgimigli M, Bueno H, Byrne RA, Collet JP, Costa F, Jeppsson A, Juni P, Kastrati A, Kolh P, Mauri L, Montalescot G, Neumann FJ, Petricevic M, Roffi M, Steg PG, Windecker S, Zamorano JL, Levine GN. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 2018; 39: 213-60.


Paper Type

::

Research Paper

Title

::

Drug Interaction of Covid-19 In Intensive Care Unit Patients In South Kalimantan, Indonesia

Country

::

Indonesia

Authors

::

Juwita Ramadhani || Karina Erlianti || Hasniah || Muhammad Fauzi || Aris Fadillah || Fauzi Rahman

Page No.

::

26-28

A drug interaction is a pharmacological or clinical response to the administration of two or more drugs that differs from the response. One of the risk factors for drug interactions is patients in ICU care so that they are at greater risk for drug interactions. Often drug interactions are unknown in patients so it is important to investigate COVID-19 drug interactions especially in ICU patients because there are very few studies available thereby increasing patient safety in hospital ICU care. This study was conducted retrospectively by cross-sectional observational analytic to look at the drug interactions of COVID-19 in ICU patients in May - October 2020. This study was conducted at one of the Hospitals that has ICU facilities for COVID-19. Drugs prescribed during the patient's hospitalization were evaluated for drug interactions using the drugs.com Data were taken from 68 patients with a total of 1020 prescriptions..........

 

KEYWORDS: Drug Interaction, COVID-19, Intensive Care Unit

[1]. Magro, L., U. Moretti, and R. Leone, Epidemiology and characteristics of adverse drug reactions caused by drug-drug interactions. Expert Opin Drug Saf, 2012. 11(1): p. 83-94.
[2]. Lima, R.E. and S.H. De Bortoli Cassiani, Potential drug interactions in intensive care patients at a teaching hospital. Rev Lat Am Enfermagem, 2009. 17(2): p. 222-7.
[3]. Gupta, M., et al., A study of potential drug-drug interactions among critically ill patients at a tertiary care hospital. 2017, 2017. 5(4): p. 5.
[4]. Rismanbaf, A. and S. Zarei, Liver and Kidney Injuries in COVID-19 and Their Effects on Drug Therapy; a Letter to Editor. Archives of academic emergency medicine, 2020. 8(1): p. e17-e17.
[5]. Yang, X., et al., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine, 2020. 8(5): p. 475-481.