Diabetes mellitus is a highly prevalent disease requiring continuous treatment. Long-term use of antidiabetic drugs can cause side effects. Therefore, this article was designed to provide updated information on the phytochemical and antidiabetic activity of Morindacitrifolia. This review presents the literature evidence from January 2011 to December 2021. Three bibliographic databases were used as the primary sources of information (Pubmed, Google Scholar, ScienceDirect). A total of 16 studies were used in this paper based on feasibility, including eight articles on phytochemicals and eight on antidiabetics. Phytochemical compounds in Morindacitrifolia are alkaloids, flavonoids, steroids, tannins, saponins, terpenoids, phenolics, cardiac glycosides, anthocyanins, anthraquinones, leucoantosians, coumarins, reducer compounds, and asperulosidic acid. Pharmacological studies reported that Morindacitrifolia was proven to have an antidiabetic activity observed from several parameters, including blood glucose levels, plasma insulin, histopathological examination, and others.

Keywords : Antidiabetic, antihyperglycemic, hypoglycemic, Morindacitrifolia, phytochemical.

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Because nuclear factor-kB (NF-kB) has been implicated in the pathogenesis of gastric carcinoma, this transcription factor is a potential target for the treatment of this devastating disease. AlabTM peptide is one of the antitumor peptides derived Lactobacillus helveticus KTCT 15075BP, and it has shown NF-kB inhibitory activity. It is pharmacologically safe, but its bioavailability is poor after oral administration. Alab peptide was nanoencapsulated in a exosomal delivery system to allow intravenous administration of smart probiotic Nutrient Delivery System(NDS). We studied the in vitro and in vivo effects of this exosomal nanoencapsulated alab peptide on proliferation, apoptosis, signaling, and angiogenesis...........

Keywords : Gastric carcinoma, apoptosis, angiogenesis, exosomal nanoencapsulation, probiotic Nutrient Delivery System(NDS), anticancer effects, AlabTM peptide

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Chronic wounds tend to be suffered by people with diabetes mellitus and paralysis, which causes decubitus ulcers. The older the age, low the immunity and the risk of getting infected with the wound become higher. Staphylococcus aureus, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus have been reported as the common causes in this case. This has led to reduced quality of life and depression in some patients; even post-amputation surgery sites of the part still have the potential complication of infection. Rhoeo discolor, occurs in many tropical countries that are found to have antibacterial properties because of their phenolic contents...........

Keywords : Molecular docking; Methicillin-resistant Staphylococcus aureus; Rhoeo discolor;Pseudomonas aeruginosa; Staphylococcus aureus.

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This study was designed to assess the general public's perception, knowledge, attitude and behaviour on antibiotic resistance in a Bangalore, a metropolitan city in the south of India. It also tries to decipher whether the level of education and the professional status of an individual has a positive association with the level of knowledge on antibiotic resistance.Of all the participants who participated in the study, around 95.5% of the surveyed population received a university education. About 81.6% of the participants had knowledge about antibiotic resistance and 82.2% of them believed that many bacterial infections are becoming increasingly resistant to treatment with antibiotics. 65.4% of the respondents believed that antibiotic resistance...........

Keywords : Antibiotic resistance, Drugs, Internal Medicine.

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This study was carried out to determine the antibacterial effects of saponins from Prosopis africana and Ziziphus abyssinica. Saponins were isolated using ethanol, diethyl ether and isopropanol as solvents, and evaluated for antimicrobial activity against medically important bacteria (S. aureus, and E. coli), using nutrient agar. Antimicrobial activity was performed using paper disc method. The saponin isolated from P. africana leaves was active and showed the highest zone of inhibition at concentration 30mg/ml against S. aureus and E. coli. The saponin isolated from Z. abyssinica leaves showed the highest zone of inhibition at concentration 10 and 30mg/ml respectively............

Keywords : Extract; Prosopis Africana; Zizipus abyssinica; Saponins; Inhibition.

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