February - 2025 (Volume-15 ~ Issue-2)

Paper Type

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Research Paper

Title

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Evaluation of the Analgesic Potential of Moringa oleifera Leaf Extract in Mice

Country

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Nigeria

Authors

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Megha S. Gajale, Varsha Kadam, Vaishnavi Khandre

Page No.

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01-09

A highly prized plant found in many tropical and subtropical nations is Moringa oleifera. The leaves of Moringa oleifera may include phytochemical components with analgesic effects, such as antioxidant and anti-inflammatory qualities. Pain is a disagreeable, unpleasant, and annoying sensation that is frequently the sole symptom used to diagnose a number of illnesses and conditions. Using the acetic acid-induced writhing test, Eddy's hot plate test, and the tail flick method, the current study aims to assess the analgesic potential of Moringa oleifera. The three tests used in this investigation of analgesic action detection are:1) Eddy's Hot Plate Test; 2) Acetic Acid Induced Test; and 3) Tail Flick Method. In both models, the ethanolic leaf extract of Moringa oleifera demonstrated both cerebral and peripheral analgesic effects. Research is required to identify the active ingredients causing the effect that has been seen and to uncover the potential mechanism of action that underlies its anti-nociceptive properties.

Keywords : Acetic Acid Induced Writhing Test, Analgesic, Eddy's Hot Plate Method, Ethanolic Extract of Moringa Oleifera.

[1]. Zulfiker AH, Mahbubur R, Kamal H, Hamid K, Mazumder ME, Rana MS. In vivo analgesic activity of ethanolic extracts of two medicinal plants — Scoparia dulcis L. and Ficus racemosa linn. Biol Med 2010;2:42-8.
[2]. Nur Zahirah Abd Rani, Khairana Husain and Endang Kumolosasi, Moringa genus: A Review of Phytochemistry and Pharmacology. Frontiers in pharmacology. Drug and Herbal Research 4. Fahey JW. A review of the medical evidence for its nutritional.
[3]. Fahey JW. A review of the medical evidence for its nutritional, therapeutic, and prophylactic properties: Part 1. Trees Life J 2005;1:5–15.
[4]. B.Vinoth, R. Manivasagaperumal and S. Balamurugan. Phytochemical Analysis and antibacterial activity of Moringa olifiera. International Journal of Research in Biological Sciences2012; 2(3): 98-102.
[5]. Vinı´cius M. Gadotti, Leonardo O. Schmeling, Cla´ udia Machado, Fernanda H. Liz, Valdir Cechinel Filho, Christiane Meyre-Silva and Adair R. S. Santos. Antinociceptive action of the extract and the flavonoid quercitrin isolated from Bauhinia microstachya leaves. JPP 2005, 57: 1345–1351.


Paper Type

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Research Paper

Title

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Ocular Drug Delivery System

Country

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India

Authors

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Abhishek Kumar Gautam

Page No.

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10-18

Ocular drug delivery remains a significant challenge for pharmacologists and drug delivery scientists due to the complex anatomy and physiology of the eye. Various barriers, including static barriers (corneal, scleral, and retinal layers, along with the blood-aqueous and blood-retinal barriers) and dynamic barriers (tear dilution, lymphatic clearance, and conjunctival and choroidal blood flow), hinder effective drug penetration, particularly into the posterior segment. Additionally, the presence of efflux pumps further complicates drug delivery. In recent years, researchers have focused on targeting influx transporters in different ocular tissues to enhance drug uptake. At the same time, advanced colloidal drug delivery systems, including nanoparticles............

Keywords : Ocular, Barriers, Anatomy, Physiology, Dynamic, Corneal, Scleral, Retinal, Blood-Aqueous, Tear, Lymphatic, Penetration, Nanoparticles, Nanomicelles, Liposomes, Microemulsion.

[1]. Ananthula HK, Vaishya RD, Barot M, Mitra AK. Duane's Ophthalmology. In: Tasman W, Jaeger EA, editors. Bioavailability. Philadelphia: Lippincott Williams & Wilkins; 2009. [Google Scholar]
[2]. Gipson IK, Argueso P. Role of mucins in the function of the corneal and conjunctival epithelia. Int Rev Cytol. 2003;231:1–49. doi: 10.1016/S0074-7696(03)31001-0. [DOI] [PubMed] [Google Scholar]
[3]. Ahmed I. The noncorneal route in ocular drug delivery. In: Mitra AK, editor. Ophthalmic drug delivery systems. New York: Marcel Dekker; 2003. pp. 335–63. [Google Scholar]
[4]. Klyce SD, Crosson CE. Transport processes across the rabbit corneal epithelium: a review. Curr Eye Res. 1985;4(4):323–31. doi: 10.3109/02713688509025145. [DOI] [PubMed] [Google Scholar]
[5]. McLaughlin BJ, Caldwell RB, Sasaki Y, Wood TO. Freeze-fracture quantitative comparison of rabbit corneal epithelial and endothelial membranes. Curr Eye Res. 1985;4(9):951–61. doi: 10.3109/02713689509000002. [DOI] [PubMed] [Google Scholar]


Paper Type

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Research Paper

Title

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Entomotherapy in surgical practice in Ancient Egypt

Country

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India

Authors

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Hedvig Győry, Andrea.Frencz, Petrovics, Alica, Blázovics Anna

Page No.

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19-27

Background: Insects are the most diverse and numerous class of animals on earth. Their many species have been used for food and medicine worldwide for thousands of years. The best known is the honeybee and its products, honey, royal jelly and propolis, but many insects and their eggs, larvae, or pupae are also useful for medical purposes. Materials and Methods: In the ancient Egyptian rational medical records, such as the papyri of Ebers, Hearst, and the Berlin or London medicinal papyri, we find medical recipes that include insects and insect products. We used philological, linguistic, ethnopharmacological and biochemical investigations to reseach their identities, and achieved a case study focusing on the bAybAy insect............

Keywords : wound treatment; entomotherapy; ancient Egypt; material medica.

[1]. Ayieko MA, Kinyuru N, Ndong'a MF, Kenji GM. Nutritional value and consumption of black ants (Carebara vidua Smith) from the Lake Victoria Region in Kenya. Adv J Food Sci Technol. 2012;4:39–45.
[2]. Azad AK, Sermsintham N, Chandrkrachang S, Stevens WF. Chitosan membrane as a wound-healing dressing: characterization and clinical application. J Biomed Mater Res B Appl Biomater. 2004;69:216–22. doi: 10.1002/jbm.b.30000
[3]. Becker C. Bloodless coup. Funded by the Army, Oregon researchers turn to the sea to develop a revolutionary bandage that stanches heavy bleeding. Mod Healthcare. 2003;33:30–31.
[4]. Bardinet Th. Quelques aspects du « monde du minuscule » dans la pensée médicale de l'Égypte ancienne. in: Aufrere SH, Spieser C eds. Le microcosme animal en Égypte ancienne de l'effroi a la vénération. Études d'archéo- et d'ethnoarthropodologie culturelle. Leuven-Paris-Bristol 2021, 159-174.
[5]. Bíró A. Tudnivalók a különböző mézfajtákról. [What to know about different types of honey] 2014.12.01. Accessed at http://preventissimo.hu/tudastar/cikk/322; on 20.02.2025.


Paper Type

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Research Paper

Title

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Statins Overview: Balancing Benefits, Risks, and Safety in Special Populations

Country

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India

Authors

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Rajeswari M, Sechana K, Sushmitha A, Sai Nath R, Sarika Goud B, Aravind B

Page No.

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28-34

Introduction: Satins have cholesterol lowering, anti-inflammatory, anti-oxidant, Plaque stabilizing capacities and are indicated for treatment of MI, Stroke, Hyperlipidemia by FDA. Satins are used for various conditions in different populations. This article revies the usage of statins in patients with comorbid conditions according to the respective Standard Guidelines, adverse effects specific to the patient population and strategies recommended to mitigate the risk of adverse event.............

Keywords : , Hyperlipidemia, Atherosclerotic Cardiovascular Disease, Diabetes Mellitus, Myocardial Infraction.

[1]. Schiattarella GG, Perrino C, Magliulo F, Ilardi F, Serino F, Trimarco V, Izzo R, Amato B, Terranova C, Cardin F, Militello C. Statins and the elderly: recent evidence and current indications. Aging Clin Exp Res. 2012 Jun 1;24(3 Suppl):47-55.
[2]. Stewart J, McCallin T, Martinez J, Chacko S, Yusuf S. Hyperlipidemia. Pediatrics in review. 2020 Aug 1;41(8):393- 402.
[3]. Joshi SR, Anjana RM, Deepa M, Pradeepa R, Bhansali A, Dhandania VK, Joshi PP, Unnikrishnan R, Nirmal E, Subashini R, Madhu SV. Prevalence of dyslipidemia in urban and rural India: the ICMR–INDIAB study. PloS one. 2014 May 9;9(5):e96808.
[4]. Gupta R, Rao RS, Misra A, Sharma SK. Recent trends in epidemiology of dyslipidemias in India. Indian heart journal. 2017 May 1;69(3):382-92.
[5]. Jain KS, Kathiravan MK, Somani RS, Shishoo CJ. The biology and chemistry of hyperlipidemia. Bioorganic& medicinal chemistry. 2007 Jul 15;15(14):4674-99.


Paper Type

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Research Paper

Title

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Assessing the Quality of Life of Children with Type 1 Diabetes and the Impact of the Disease on the Functioning of Families, A Field Study in Kafr El-Sheikh, Egypt

Country

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Egypt

Authors

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Sheren Sobhy Sehsah, Doaa Mohamed Al ghonimy, Khadra Shabaan Hassan, Noura Abd Elwahab

Page No.

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35-39

The aim of the study was to evaluate quality of life in children with type 1 diabetes mellitus (T1DM) in Kafer El Shiekh area. A lifelong disease that requires constant management. Diabetes mellitus (DM) is a common chronic disorder in children and is caused by absolute or relative Insulin deficiency, with or without insulin resistance. Field research was conducted on 58 children with type 1 diabetes from the spring of 2023 to the spring of 2024. A questionnaire was conducted for the parents with informed consent, and some variables were examined about the patients, including age, history of infection, and response to diet, eating healthy food, growth naturally, learning difficulties, and exercise. All of these and other variables were measured; it's impact on the child, the extent of his response to it and the extent of its impact on his health condition.

Keywords : Type1diabetes mellitus, quality of life, Children, Age, six and other variables.

[1]. Al-Abdulrazzaq, D.; D. Khalifa; T. Alqaisi; F. Al-Juailla; F. Othman; S. Qabazard and H. Al- Kandari (2022). Health-related quality of life of children and adolescents with type 1 diabetes during the COVID-19 pandemic in Kuwait. Frontiers in Public Health. frontiersin.org. 10.3389/fpubh.2022.1056967. [Google Scholar]
[2]. Bekele, T. 1, T. G. Demie 2, F.Worku2,(2022) Health-Related Quality-of-Life and Associated Factors Among Children and Adolescents with Type 1 Diabetes Mellitus: A Cross-Sectional Study. Pediatric Health, Medicine and Therapeutics 2022:13. Visit http://www.dovepress.com/ testimonials.php to read real quotes from published authors. http://www.dovepress.com/pediatric-health-medicine-and-therapeutics-journal. [Google Scholar]
[3]. Federation ID. IDF Diabetes Atlas, 7th Edn. Brussels: International Diabetes Federation; (2015). [Google Scholar]
[4]. Federation ID. IDF Diabetes Atlas: 8th Edn. Brussels: International Diabetes Federation; (2017). [Google Scholar]
[5]. Girma ,D. MSc1 , R. Murugan, PhD2,K. Wondossen, MSc2, S. Yeshiwas, MD2, A. Wale, MSc1, and S. Tilahun, MS (2021). Health-Related Quality of Life and Its Associated Factors in Children and Adolescents with Type1 Diabetes, Addis Ababa, Ethiopia. Global Pediatric Health. Desalegn Girma https://orcid.org/0000-0003-0001-8553. [Google Scholar]