This study aimed to present a simplified and safe diagnostic evaluation protocol applicable to facial aesthetic procedures, with an emphasis on the integrated use of adipometry and imaging ultrasound as complementary exams. The protocol aims to support the personalized selection of micro- and macro-focused ultrasound tips, considering the anatomical depth of the tissues and the thickness of the subcutaneous fat. The proposal includes demonstrating the effectiveness of the method through the analysis of anatomical sections and its clinical applicability in cases of non-surgical facelifts.......

Keywords : Microfocused ultrasound, adipometry, SMAS, facial aesthetics, clinical planning, Dermatology, aesthetic technologies, cadaver facial dissection.

[1]. Alam M, White LE, Martin N, Witherspoon J, Yoo S, West DP. Ultrasound skin tightening. Dermatol Surg. 2010;36(6):915-922.
[2]. Laubach HJ, Makin IR, Barthe PG, Slayton MH, Manstein D. Intense focused ultrasound: evaluation of a new treatment modality for precise microcoagulation within the skin. Dermatol Surg. 2008;34(5):727-734.
[3]. Wanitphakdeedecha R, Sathaworawong A, Manuskiatti W. Efficacy and safety of a focused ultrasound system for the treatment of facial laxity in Asians. Dermatol Surg. 2011;37(9):1441-1448.
[4]. Fabi SG, Goldman MP. Retrospective evaluation of microfocused ultrasound for facial skin tightening. Dermatol Surg. 2014;40(5):569-575.
[5]. Beer K. Volume loss: causes and consequences. J Drugs Dermatol. 2013;12(9):s160–s163.

Monopolar radiofrequency (RF) is a technology used to treat tissue sagging, skin rejuvenation, andredefine facial contours. It generates controlled heat that activates fibroplasty, neocollagenesis, and neoelastogenesis, promoting rejuvenation. Rejera® technology, based on 6.78 MHz monopolar radiofrequency emission, operates through capacitive coupling with deep dermal heating, respecting the integrity of the epidermis. The development of a clinical protocol based on the Glogau classification allows the individualization of therapy according to the degree of photoaging and skin sagging.......

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Keywords : Rejuvenation, radiofrequency, Regera®, Glogau classification, skin sagging, aesthetics, aesthetic medicine, facial aesthetics, Dermatology, aesthetic technologies.

[1]. Elsaie ML. Cutaneous remodeling and photorejuvenation using radiofrequency devices. Indian J Dermatol. 2009;54(3):201–205.
[2]. Gold MH. Tissue tightening: a hot topic utilizing deep dermal heating. J DrugsDermatol. 2007;6(12):1238–1242.
[3]. Laubach HJ, Makin IR, Barthe PG, Slayton MH, Anderson RR. Intense focused ultrasound: evaluation of a new treatment modality for precise microcoagulation within the skin. Dermatol Surg. 2010;36(5):632–641.
[4]. Sadick NS, Makino Y. Selective electro-thermolysis in aesthetic medicine: a review. Lasers Surg Med. 2004;34(2):91–97.
[5]. Fitzpatrick R, Geronemus R, Goldberg D, Kaminer M, Kilmer S, Ruiz-Esparza J. Multicenter study of noninvasive radiofrequency for skin tightening. Lasers Surg Med. 2003;33(3):145–151.

Ensuring the safety, efficacy, and regulatory compliance of pharmaceutical products remains a critical public health priority, particularly in developing markets where resource constraints, infrastructural gaps, and prevalence of substandard medicines present significant challenges. This study explores the application of Lean Six Sigma (LSS) principles and Failure Modes and Effects Analysis (FMEA) within Nigeria's National Agency for Food and Drug Administration and Control (NAFDAC) to strengthen pharmaceutical quality assurance (PQA) and regulatory oversight........

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Keywords : Lean Six Sigma, Failure Modes and Effects Analysis, NAFDAC, pharmaceutical quality assurance, regulatory oversight, developing markets, risk management.

[1]. AAPS Open. (2019). Drug manufacturing and access to medicines: The West African story. AAPS Open. https://aapsopen.springeropen.com/articles/10.1186/s41120-019-0032-x
[2]. Anders, S., Mastej, P., & Qu, T. (2025). Design for Green Lean Six Sigma to improve sustainability of bulk pharmaceutical product packaging. International Journal of Lean Six Sigma. https://doi.org/10.1080/21693277.2025.2461010
[3]. Antony, J., Sunder, M. V., & Karakostas, B. (2021). Lean Six Sigma in pharmaceutical and healthcare industries: Driving operational excellence. Springer.
[4]. Bhat, S., Chavan, R., Avhad, S., & Gore, R. (2022). Lean Six Sigma in healthcare: A systematic literature review. Processes, 10(12), 2696. https://doi.org/10.3390/pr10122696
[5]. Bhat, S., Sharma, A., & Ramesh, S. (2020). Application of Six Sigma tools in pharmaceutical manufacturing: A systematic review. Journal of Pharmaceutical Innovation, 15(4), 395–410. https://doi.org/10.1007/s12247-020-09432-1