Volume 4 ~ Issue 9 September 2014

 

 

Paper Type

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Research Paper

Title

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A GOOD TEACHER – MEDICAL STUDENTS VIEWS

Country

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India

Authors

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DR. MAMATHA P SAMAGA|| DR. HEMALATHA NR

Page No.

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01-05

Paper Index

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DOI :10.9790/3013-04090105

ANED :: DDL :05.3013/04900105  

Lectures have been the most common form of teaching and learning since ancient times. Success of lecturing sessions is inextricably linked with the excellent teaching process. The objective of our study was to find out medical students views about good teacher.The study instrument was a self-administered questionnaire. The study design was cross sectional. 86 pre-clinical M.B.B.S students volunteered to take part in the study. The questionnaire required the respondents to rate 15 parameters and responses were based on a 5 point Likert-scale. Descriptive statistics was used for analysis of data and results were expressed as percentage. Among females, majority 30 (63.9%) agreed for use of technology by teachers followed by 29(61.8%) strongly agreeing for teacher summarizing topic at the end of the class, 28(59.7%) for teacher to use simple language and 27(57.4%) for teacher to have good sense of humour. Among males, majority 36 (92.16%) strongly agreed for teacher to have good sense of humour followed by 29(74.3%) for teacher summarising topic at the end of the lecture, 27(69.1%) for teacher to have command on subject. Students views should be considered and follow up studies should be carried out so that appropriate changes in teaching style can be made to justify the place of lecture as a mode of instruction in undergraduate medical education

 

Key Words: Good teacher ,Lectures, medical students, medical education.

[1]. Seth V, Upadhyaya P, Ahmad M, Moghe V. Powerpoint or chalk and talk: Perceptions of medical students versus dental students in a medical college in India. Adv Med Educ Pract 2010;1:11-6.

[2]. Bligh DA (2000). What's the use of lectures? (San Francisco: Jossey-Bass; pp. 4)

[3]. Sachdeva AK. Use of effective feedback to facilitate adult learning. J. Cancer, Educ., 1996;11:106-18.

[4]. Biehn JT: Characteristics of an effective medical teacher.Can Fam Physician 1976, 22:1325-1326.
[5] Boyer EL: Medical education.Web site. [http://medicaleducation.wetpaint.com/ ] [6]. Nnodim JO, Ohanaka EC, Osuji CU. A follow up comparative study of two modes of learning human anatomy. Clin. Anat., 1996:9:252-62.


Paper Type

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Research Paper

Title

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Extraction of Squid (Photololigo Duvaucelii) Myofibrillar and Sarcoplasmic Proteins to Create A Skin Prick Test Reagent In The Diagnosis of Food Allergy

Country

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Indonesia

Authors

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Hendra Wijaya|| Fransiska Rungkat Zakaria|| Dahrul Syah|| Endang Prangdimurti

Page No.

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06-14

Paper Index

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DOI : 10.9790/3013-040906014

ANED :: DDL :05.3013/049006014 

The major and minor allergens in fish and shellfish that have been identified are broadly spread in the myofibrillar and sarcoplasmic proteins. This study aimed to create the SPT reagents of squid myofibrillar and sarcoplasmic proteins to improve sensitivity and specificity diagnosis. Myofibrillar protein fraction was composed of 11 protein bands with the molecular weights of 18.2-108.4 kDa and sarcoplasmic protein fraction was composed of 13 protein bands with the molecular weights of 9.5-119.3 kDa. The allergenic myofibrillar protein has the molecular weights of 8.9-122.7 kDa while the allergenic sarcoplasmic protein has the molecular weights of 11.8-143.9 kDa. Each allergen extract was formulated into a SPT reagent met the requirements of the European Pharmacopoeia Monograph on Allergen Products 7 (2010:1063) for the parameters of moisture content, protein content, sterility and microbiology. A SPT to the respondents indicated that the sensitivity value of squid myofibrillar reagent was 86% and squid sarcoplasmic reagent was 64% with a negative error rate for each myofibrillar and sarcoplasmic reagents was 14% and 36%, respectively. The result diagnosis of squid myofibrillar and sarcoplasmic would generate sensitivity value at 100%. The separation of squid proteins into myofibrils and sarcoplasm for SPT could improve its sensitivity value and lowered the negative misdiagnosis. The specificity of each myofibrillar and sarcoplasmic proteins was 100% with an error rate of positive diagnosis occurrence at 0%.

 

Key-words:allergy diagnosis, myofibrillar, sarcoplasmic, squid, skin prick test.

[1] Direktorat Jenderal Perikanan Tangkap, Capture fisheries statistics of indonesia 2007-2012 (Jakarta: Direktorat Jenderal Perikanan Tangkap, 2013).
[2] R. Pawankar, G.W. Canonica, S.T. Holgate, R.F. Lockey, White Book on Allergy (United Kingdom: World Allergy Organization (WAO), 2011).
[3] L. Heinzerling, A. Mari, K.C. Bergmann, M. Bresciani, G. Burbach, U. Darsow, S. Durham, W. Fokkens, M. Gjomarkaj, T. Haahtela, A.T. Bom, S. Wöhrl, H. Maibach, R. Lockey. The skin prick test-European standards, Clin Trans Allergy, 3(3), 2013, 1-10.

[4] H. Ebruster. The prick test, a recent cutaneous test for the diagnosis of allergic disorders, Wiener klinische Wochenschrift, 71, 1959, 551-554.
[5] K.Y. Jeong, C.S. Hong, J.S. Lee, J.W. Park. Optimization of allergen standardization, Yonsei Med J, 52(3), 2011, 393–400.
[6] R. Esch, T. Grier. Allergen compatibilities in extract mixtures, Immunol Allergy Clin North Am, 31, 2011, 227–239.


Paper Type

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Research Paper

Title

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Dynamics of Combined Oral Contraceptive: A Study of Some Haematological Parameters in Female Wistar Rats

Country

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Zaria

Authors

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Toryila J.E ||Amadi K||Odeh S.O|| Adelaiye A.B||Egesie U.G.||Achie L N

Page No.

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15-19

Paper Index

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DOI : 10.9790/3013-0409015019

ANED :: DDL :05.3013/049015019 

Contraception is the intentional prevention of fertilization from taking place through the use of various devices, sexual practices, barrier methods and hormonal contraception. Contraception is as old as human existence.. Oral contraceptives are a simple form of contraception used by women worldwide. The oral contraceptive is one of the greatest and most influential developments of the twentieth century.Haematopoiesis is the process by which all lineages of blood cells are generated in a hierarchical and stepwise manner from immature cells present in the bone marrow (BM)' and subsequently released into circulating blood and peripheral organs for further maturation steps and/or effector function.Several haemorheological and haemostatic parameters has been associated closely with hormone replacement therapy. Such parameters include blood viscosity, plasma viscosity, haematocrit value, fibrinogen level and fibrinolytic activity. This research priority included efforts to discover the effect of COC (DUOFEM) on haematological parameters.

 

Key-words:Combined Oral Contraceptives, Haematological parameters, Wistar rats.

[1] Abdalla T.M., Kordofani A.A.Y., Nimir A.A.H. (2008). Haemostatic studies in Sudanese women on oral contraceptive pills. Khartoum Medical Journal, 1(3): 116-118.
[2] Ahmed J. Al-Husaynee and Muna A. Kashmona (2007). Effect of combined oral contraceptive pills on some haemostatic parameters. Annals of the College of Medicine Mosul, 33(1 & 2): 66-69.
[3] Akhigbe R.E., Azeez M.O., Ige S.F., Oyeyipo L.P., Ajao F.O. and Alade A.O. (2008). Haematological effects of long-term administration of combined oral contraceptive in rats. International Journal of Pharmacology, 4(5): 403-406.


Paper Type

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Research Paper

Title

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Catheter –Associated Urinary Tract Infection, Management, And Preventions

Country

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Malaysia

Authors

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MurtazaMustafa ||JaistinTamin ||Rajesh K Muniandy

Page No.

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20-26

Paper Index

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DOI : 10.9790/3013-0409020026

ANED :: DDL :05.3013/049020026 

Catheter-associated urinary tract infections(CA-UTIs) or health care associated UTIs are most common inhospitals, and in long term-care facilities(LTCFs)Up to 25% of patients in the hospitals have a catheter inserted at some time during their stay. Long term catheterization and catheter insertion outside operating room, lack of systemic antimicrobial therapy, female sex, old age, diabetes, elevated serum creatinine,and,instrumentation of urinary tract are the risk factors of CA-bacteriuria. Urinary catheterization provides easier access of uropathogens to bladder. Bacteria attached to catheter form micro colonies that mature into biofilims, these biofilms protect uropathogens from antibiotics. Diagnosis of UTI is based on significant bacteriuria. Frequently isolated uropathogens include Escherichia coli, enterococcus , enterobacteriacae, and Candida albicans. Empiric treatment should be based on Gram stain, culture and antibiotic susceptibility results. Lo E, et al. guidelines for prevention and surveillance of CA-UTIs are useful

 

Key-words:Catheter-associated urinary Tract Infection(CA-UTI),Management, Prevention.

[1] Direktorat Jenderal Perikanan Tangkap, Capture fisheries statistics of indonesia 2007-2012 (Jakarta: Direktorat Jenderal Perikanan Tangkap, 2013).
[2] R. Pawankar, G.W. Canonica, S.T. Holgate, R.F. Lockey, White Book on Allergy (United Kingdom: World Allergy Organization (WAO), 2011).
[3] L. Heinzerling, A. Mari, K.C. Bergmann, M. Bresciani, G. Burbach, U. Darsow, S. Durham, W. Fokkens, M. Gjomarkaj, T. Haahtela, A.T. Bom, S. Wöhrl, H. Maibach, R. Lockey. The skin prick test-European standards, Clin Trans Allergy, 3(3), 2013, 1-10.

[4] H. Ebruster. The prick test, a recent cutaneous test for the diagnosis of allergic disorders, Wiener klinische Wochenschrift, 71, 1959, 551-554.
[5] K.Y. Jeong, C.S. Hong, J.S. Lee, J.W. Park. Optimization of allergen standardization, Yonsei Med J, 52(3), 2011, 393–400.
[6] R. Esch, T. Grier. Allergen compatibilities in extract mixtures, Immunol Allergy Clin North Am, 31, 2011, 227–239.


Paper Type

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Research Paper

Title

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Synthesis, characterization and antimicrobial evaluation of novel diethyl (2-phenylquinazolin-4-ylamino) (phenyl) methyl phosphate

Country

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India

Authors

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Venkateswarulu A. Maddina ||Mohan B. Kalyankar || P.A. Kulkarni

Page No.

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27-30

Paper Index

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DOI : 10.9790/3013-0409027030

ANED :: DDL :05.3013/049027030 

A convenient and efficient one-pot reaction has been employed for the synthesis of new a- aminophosphonates 4a-4l via Kabachnik-Fields reaction in 89-95 % yields. In the procedure developed, equimolar quantities of 2- phenylquinazoline-4-amine 1, various aromatic aldehydes 2a-2l and triethyl phosphite 3 was carried out under solvent-free conditions using Alum (KAl (SO4)2.12H2O). The products were characterized by IR, 1H and 13C spectra and elemental analysis. All the synthesized compounds were screened for in vitro antibacterial activity (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, and Salmonella typhimurium) and antifungal activity (Candida albicans, Aspergillus niger).

 

Key-words:α-Aminophosphonate, Kabachnik-fields reaction, Antibacterial and antifungal activities

[1] Barlett, P.A.; Hanson, J.E.; Giannousis, P.P. J. Org. Chem. 1990, 55, 6268.
[2] Wang, H.L.; Zhou, J.; Qiu, Y.G.; Feng, K.S.; Chen, R.Y. Phosphorus, Sulfur, Silicon 1995, 104, 135.
[3] (a) Zhou, J.; Chen, R.Y.; Yang, X.F. Heteroatom Chem. 1998, 9, 369. (b) Zhou, J.; Chen, R.Y. J. Chem. Res. (S) 1998, 5, 254. (c) Zhou, J.; Chen, R.Y. Synth. Commun. 1998, 28, 2653.
[4] (a) Kafarski, P.; Lejczak, B. Curr. Med. Chem. Anticancer Agents 2001, 1, 301. (b) Kiran, Y.B.; Reddy, C.D.; Gunasekar, D.; Suresh Reddy, C.; Barbosa, L.C.A.; Annette L. Eur. J. Medicinal Chem. 2008, 43, 885.
[5] De Lombaert, S.; Blanchard, L.; Tan, J.; Sankane, Y.; Berry, C.; Ghai, R.D. Bioorg. Med. Chem. Lett. 1995, 5, 145.
[6] Kafarski, P.; Lejczak, B. Phosphorus, Sulfur, Silicon, Relat. Elem. 1991, 63, 193.
[7] Atherton, F.R.; Hassall, C.H.; Lambert, R.W. J. Med. Chem. 1986, 29, 29.
[8] (a) Kukhar, V.P.; Solodenko, V.A. Rus. Chem. Rev (Engl. Trans.) 1987, 56, 859. (b) Yokomatsu, T.; Yoshida, Y.; Shibuya, S. J. Org. Chem. 1994, 59, 7930.


Paper Type

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Research Paper

Title

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Study of some Pulmonary Function Tests in Children with Sickle Cell Anemia: Correlation with Iron Overload

Country

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Egypt

Authors

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Adel A Hagag, Mohamed S ElFarargy, Yousef M Mansour

Page No.

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31-37

Paper Index

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DOI : 10.9790/3013-0409031037

ANED :: DDL :05.3013/049031037 

Background: Sickle cell disease is hereditary hemoglobinopathy characterized by abnormal hemoglobin production, hemolytic anemia, and intermittent occlusion of small vessels, leading to acute and chronic tissue ischemia, and organ damage. Pulmonary function tests can differentiate between obstructive or restrictive lung diseases, assess the severity of the disease and evaluate the degree of efficacy of therapy in patients with sickle cell anemia.

 

Key-words:Sickle cell anemia. Iron overload. Pulmonary functions

[1]. Smiley D, Dagogo-Jack S, Umpierrez G. Therapy insight: Metabolic and endocrine disorders in sickle cell disease. Nat Clin Pract Endocrinol Metab 2008; 4 (2): 102-109.
[2]. Michael R, DeBaun , Vichinsky E. The diseases of blood. In: kliegman R, Behrman R, (eds), Nelson textbook of Pediatrics, 18th ed. Philadelphia: WB Saunders, USA 2008; 2026-2031.
[3]. Frei AC, Guo Y, Jones DW, Pritchard KA Jr, Fagan KA, Hogg N, Wandersee NJ. Vascular dysfunction in a murine model of severe hemolysis. Blood 2008; 112(2): 398- 405.
[4]. Machado RF, Gladwin MT. Chronic sickle cell lung disease: New insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension. Br J Haematol 2005; 129 (4):449-464.
[5]. Vij R and Machado RF. Pulmonary complications of hemoglobinopathies. Chest 2010; 138 (4) 973-983.
[6]. Peters T, Giovanniello TJ, Apt L, Ross JF. A simple improved method for the determination of serum iron. J Lab Clin Med 1956; 48(2):280-8.


Paper Type

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Research Paper

Title

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Nitrobenzene Poisoning (A Case Report) Methhemoglobinemia Due to Nitrobenzene Ingestion (Paint Solvent, Oil of Mirbane)

Country

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RAJASTHAN

Authors

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Dr. Virendra Goyal || Dr. Narendra Rungta ||Dr. Manish Munjal||Dr Virendra Goyal

Page No.

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38-39

Paper Index

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DOI : 10.9790/3013-0409038039

ANED :: DDL :05.3013/049038039 

A case of acute poisoning with nitrobenzene is presented where clinical evaluation and timely management, with repeated intravenous methylene blue & Blood transfusions helped to save a life. It is impor-tant to take care of the secondary cycling of nitrobenzene from body stores in patients presenting late, after heavy exposure.

 

Key-words:Acute methaemoglobinaemia, methylene blue, nitrobenzene poisoning

[1]. Gupta G, Poddar B, Salaria M, Parmar V. Acute nitrobenzene poisoning. Indian Pediatr.2000;37:1147–8.
[2]. Dutta R, Dube SK, Mishra LD, Singh AP. Acute methemglobinemia. Internet J Emerg Intensive Care Med. 2008;11:1092–4051.
[3]. Michelle, Kumar M. methemoglobinemia over view e Medicine from Web med. Available from:http://www.emedicine.medscape.com/article/956528-overview [cited in 2010]
[4]. Chongtham DS, Phurailatpam, Singh MM, Singh TR. Methemglobinemia in nitrobenzene poisoning. J Postgrad Med. 1997;43:73–4.


Paper Type

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Research Paper

Title

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Synthesis of 2-[{4-(t-amino-1-yl)but-2-yn-1-yl }oxy]-1,3-benzothiazole derivatives as H3-antagonists

Country

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UAE

Authors

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Ragheed Al- Rahmani|| Elham Al-kaissi|| Tawfeeq Arafat|| Mohammad Ghattas|| Zuhair Muhi-eldeen

Page No.

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40-49

Paper Index

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DOI : 10.9790/3013-0409040049

ANED :: DDL :05.3013/049040049 

Background: Aminoacetylenicoxybenzothiazole derivatives were synthesized from the reaction of 2-hydroxybenzothiazole with 3-bromoprop-1-yne to generate 2-(prop-2-ynl-1-yloxy)-1,3-benzothiazole (RM-1). A mixture of 2-(prop-2-yn-1-yloxy)-1,3-benzothiazole, paraformaldehyde, cyclic amine and cuprous chloride catalytic amount, in peroxide-free dioxane through Mannich reaction yielded the desired aminoacetylenicoxybenzothiazoles (RM- 2-7). The mp, IR, 1H-NMR, 13C-NMR and elemental analysis were consistent with the assigned structures. The design of these compounds as H3 antagonists was based on the rationalization for the important criteria needed to overlap effectively with H3 receptor to induce antagonistic activity. These criteria are: 1) The basic amino group for ionic binding. 2) The acetylenic group for electrostatic interaction. 3) The 2-butyne provide the appropriate distance between the basic nitrogen and benzthiazole. 4) Oxy ether to provide hydrogen bonding with H3 receptor and 5) benzothiazole group found in H3 antagonists and many other biologically active compounds. The docking results showed that all the designed compounds have a good H3 receptor antagonism especially RM-7 which have -6 (kcal/mol). These results provide a good lead to design more effective H3 antagonists in managing Alzheimer's and other diseases like depression, epilepsy, schizophrenia and many other CNS disorders.

 

Key-words:Alzheimer, aminoacetylenic derivatives, 2-hydroxythiadiazole derivatives, H3 antagonists

[1] F Campagna, M Catto , R Purgatorio, CD Altomare, A Carotti, AD Stradis, and G Palazzo, Synthesis and biophysical evaluation of arylhudrazono-1H-2- indolinones as β-amyloid aggregation inhibitors, Bioorg Medi Chem Lett, 46, 2011, 275-284.

[2] WL Wu, M Domalski, DA Burnett, H Josien, T Bara, M Rajagopalan, R Xu, J Clader, WJ Greenlee, A Brunskill, LA Hyde, RA Del Vecchio, ME Cohen-Williams, L Song, J Lee, G Terracina, O Zhang, A Nomeir, EM Parker, and L Zhang, Discovery of SCH 900229, a Potent Presenilin 1 selective γ-secretase Inhibitor for the Treatment of Alzheimer`s disease, ACS Med Chem Lett, 3(11), 2012, 892-896. .

[3] F Zeng, Synthesis and In vitro Evaluation of Imidazo[1,2-b]- pyridines as ligands for β-Amyloid Plaques, ACS Med Chem Lett, 1(2), 2010, 80-84.

[4] J Ceras, N Cirauqui, S Pérez-Silanes, I Aldana, A Monge, and S Galiano, Novel sulfonylurea derivatives as H3 reveptor antagonists. Preliminary SAR studies, Eur J Med Chem, 52, 2012, 1-13.

[5] S Rizzo, M Bartolini, L Ceccarini, L Piazzi, S Gobbi, A Cavalli, M Recanatini, V Andrisano, A Rampa, Targeting Alzheimer`s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238, Bioorg Med Chem 18, 2010, 1749-1760.

[6] CN Johnson, A Roland, and N Upton N, New symptomatic strategies in Alzheimer`s disease. Drug Discovery Today: Therapeutic Strategies, 1, 2004, 13- 19.