Paper Type	::	Research Paper
Title	::	Biodiversity of Earthworms and their Distribution in Different Regions of Uttar Pradesh state of India
Country	::	India
Authors	::	Om Prakash
Page No.	::	01-09

Biodiversity of earthworm species in different states of India has been carried out by several workers in vairous ecosystems. After Stephenson (1923), nobody mentioned total species of earthworms of Uttar Pradesh. Present research article described 50 species with 28 genera and 06 families of earthworms from Uttar Pradesh state of India.In addition, their distribution in this state along with other parts of India and other countries was discussed.

 

Keywords: Earthworm fauna, Checklist, Distribution ,Uttar Pradesh state, India.

[1]. Agrawal, D. & O.P. Agrawal (2009).A study of the biodiversity of earthworms in and around Gwalior, Madhya Pradesh. In: Earthworm Ecology and Environment (ed.S.M.Singh), International Book Distributing Company Publication,Lucknow ,India.p.15-24.
[2]. Blanchart, E. & J.M. Julka (1997). Influence of forest disturbance on earthworm (Oligochaeta) communities in the Western Ghats (south India).Soil Biology and Biochemistry,29:303-306.
[3]. Chaudhuri, P.S. & G. Bhattacharjee (1999).Earthworm resources of Tripura. Proceedings of the National Academy of Sciences,India, 69 (B), II, 159-170.
[4]. Chaudhuri, P. S., S. Nath, & R. Paliwal (2008). Earthworm population of rubber plantation (Hevea brasiliensis) in Tripura, India. In : Tropical Ecology , 49 (2) : 225-234.
[5]. Chaudhuri,P.S. & G. Bhattacharjee (2005). Earthworms of Tripura (India).Ecology, Environment and Conservation,11(2): 295-301.

Paper Type	::	Research Paper
Title	::	Effect of Melatonin Premedication on Postoperative Analgesic Requirement in Laparoscopic Cholecystectomy Surgery
Country	::	India
Authors	::	Rajeev Kumar Dubey || Shivika Srivastava || P K Gupta
Page No.	::	10-15

The pineal hormone, melatonin (N-acetyl-5-methoxytryptamine), has several recognized functions that can make it an attractive option for premedication, including the regulation of circadian rhythms, and sedative, analgesic, anti-inflammatory, antioxidative, and chronobiotic effects. The present study was designed to determine the effect of oral melatonin premedication on sedation, analgesia, and postoperative analgesic requirement in patients undergoing laparoscopic cholecystectomy. This randomized, double-blind, placebo-controlled study included 100 patients of either sex, ASA physical status I–II, scheduled for laparoscopic cholecystectomy..................

 

Keywords: Melatonin, Premedication, Postoperative pain, Sedation.

[1]. Moyers JR. Preoperative medication. In: Barash PG, Cullen BF, Stoelting RK, eds. Clinical Anesthesia.3rd ed. Philadelphia: Lippincott-Raven, 1997:519-33.
[2]. Kain ZN, Mayes LC, Bell C, Weismann S, Hofstadter MB, Rimar S. Premedication in the United States: a status report. Anesth Analg 1997;84:427-32.
[3]. Ebadi M, Govitrapong P, Phansuwan-Pujito P, Nelson F, Reiter RJ. Pineal opioid receptors and analgesic action of melatonin. J Pineal Res 1998;24(4):193-200.
[4]. Claustrat B, Brun J, Chazot G. The basic physiology and pathophysiology of melatonin. Sleep Med Rev 2005;9(1):11-24.
[5]. Reiter RJ, Robinson J. Melatonin: Your Body's Natural Wonder Drug. New York, NY, USA: Bantam Books; 1995.

Paper Type	::	Research Paper
Title	::	Spectral and Biological investigations of Nd(III) Juglonates
Country	::	India
Authors	::	Abhaysinh S. Kadam || Mrudula P. WADEKAR
Page No.	::	16-23

Metal chelates of Nd(III) with Lawsone , juglone, Phthiocol and Plumbagin are synthesized and are characterized with the help of elemental analysis, Infrared spectroscopy, UV visible spectrosco and TGA. Morphological changes as a result of chelation are studied from their SEM photographs. The ligands and metal chelates are screened against four bacterial strains; B. subtilis, S. aureus, E. coli and P. aeruginosa. All the properties of chelates investigated are compared to explore effect of chelation and ring isomerism.

 

Keywords: Nd(III) chelates, Juglones, spectroscopic properties, antimicrobial activity

[1]. S. Padhye, P. Dandawate, M Yusuf, A Ahmad, FH Sarkar. Perspectives on medicinal properties of plumbagin and its analogs. , 2012, 32(6), 1131-58.
[2]. R. Jeyachandran, A. Mahesh, L. Cindrella, S. Sudhaka, K. Pazhanichamy. Antibacterial activity of plumbagin and root extracts of plumbago zeylanica L., acta biologica cracoviensia series botanica , 2009, 51/1, 17–22.
[3]. V. Ambrogi, D. Artini, DE. Carneri, S. Castellino, E. Dradi, W. Longemann, G. Meinardi, DI Somma M, G. Tosolini, Studies on the antibacterial and antifungal properties of 1,4 naphthoquinones, Br.J.Pharmacol. 1970,40, 871-880.
[4]. A. Brandelli, B. Delmar, M. Martinelli, V. Stefani, E. G. Gerbas, Antimicrobial activity of 1,4 naphthoquinones by metal complexation, Braz. J. Pharm. Sci. 2004, 40(2) , 248-253.
[5]. Y.B. Ji, G.S. Xin, Z.Y. Qu, X. Zou and M. Yu , Mechanism of juglone-induced apoptosis of MCF-7 cells by the mitochondrial pathway, Genetics and Molecular Research 2016, 15 (3): gmr.15038785, 1-16.

Paper Type	::	Research Paper
Title	::	Phytochemical Screening of Main Classes of Secandary Metaboloties From Boerhaavia diffusa Growing In Three Major District Of Kumaun Himalaya
Country	::	India
Authors	::	Shweta Majgaine || D. L. Verma
Page No.	::	24-29

Boerhaavia diffusa belonging to the family Nyctaginace is is mainly a diffused perennial herbaceous creeping weed of India and well known for its traditional medicinal properties in Kumaun Himalaya. Keeping in the view the tremendous traditional use of B. diffusa as a medicine in Kumoun Himalaya. The study deals with the investigation of phytochamical screening of main classes of secondary metabolites from different parts (above ground components and below ground components) of B. diffusa collected from different study sites from foot hill to hot temperate valley of Kumoun Himalaya.

 

Keywords: Boerhaavia diffusa, Phytochemical Screening, Punarnava, Altitudinal gradient.

[1]. Costa, A. F. Farmacogonosia, Lisboa: Eds. Fundacao Calouste Gulbenkian, 1994.
[2]. Evans W.C., Trease and Evans Pharmacognosy. 14th Edt. Harcourt Brace and Company. Asia Pvt. Ltd. Singapore, 1997.
[3]. Horborne, J.B., Phytochemical methods: A guide to modern techniques of plant analysis. 3rd Edn. Chapman and Hall Publishers, London, U.K., 1998.

Paper Type	::	Research Paper
Title	::	Corrosion Inhibition Effect of Flower of Euphorbia Caducifolia for Iron in Acid Media
Country	::	India
Authors	::	Reena Sharma || Alok Chaturvedi || R.K. Upadhyay
Page No.	::	30-37

Corrosion is a natural process. It is gradual destruction of metal by chemical or electrochemical reaction with their environment. It may be prevented by either alloying or by anti rust solutions. The naturally occurring plant products are eco-friendly, compatible, nonpolluting, less toxic, easily available, biodegradable and economic to be used as corrosion inhibitor. Euphorbia caducifolia has been selected to study its corrosion inhibition efficiency. It is easily available in any season...............

 

Keywords: Alloying, anti rust solution, corrosion inhibitor, Euphorbia caducifolia, weight loss, thermometric.

[1]. D. Kesavan, M. K. Gopirama and N. Sulochana, Che. Sci., Rev. lett. 1(1), (2012), 1-8.
[2]. H. Keypour, S. Salezadeh, R.D. Pritichand and R.V. Parish, Inorg. Chem., 11, (2000), 5787.
[3]. W. T. Tseng, C. H. Lo and S. C. Lee, J. of Electrochem. Society, 148(5), (2001), C327.
[4]. S. K. Pal, A. Krishnan, P.K. Das and A.G. Samuelsen, J. Organomettalic Chem., 575, (2000), 5587.
[5]. R. Tripathi, A. Chaturvedi and R. K. Upadhyay, Res. J. Chem. Sci., 2(2), (2012), 18.

Paper Type	::	Research Paper
Title	::	Synergistic action of L-Ascorbic acid and α-Tocopherol on arsenic trioxide mediated oxidative stress in HL-60 cells
Country	::	India
Authors	::	Vineetha R C || Binu P || Arathi P || Harikumaran Nair R
Page No.	::	38-45

Acute promyelocytic leukemia (APL) is a distinctive subtype of acute myeloid leukemia (AML), which accounts for approximately 10% of all acute myeloid leukemia cases. It has been reported that arsenic trioxide (As2O3) is a very effective therapeutic agent against APL. Recent studies showed that oxidative stress plays a key role in As2O3-induced cytotoxicity. The present study aims to evaluate the synergistic potential of L-Ascorbic acid and α-Tocopherol in arsenic trioxide chemotherapy. The APL cell line HL-60 was used for the study. Cells were subjected to morphological analysis, cell viability assay...............

 

Keywords: Acute promyelocytic leukemia, Arsenic trioxide, α-Tocopherol, L-Ascorbic acid, oxidative stress

[1]. M.M. Rahman, M.K. Sengupta, S. Ahamed, U.K. Chowdhury, D. Lodh, A. Hossain , B. Das, N. Roy, K.C. Saha, S.K. Palit and D. Chakraborti. Arsenic contamination of groundwater and its health impact on residents in a village in West Bengal, India, Bulletin of the World Health Organization, 83(1), 2005, 49-57.

[2]. T. Halttunen, S. Salminen, and R. Tahvonen, Rapid removal of lead and cadmium from water by specific lactic acid bacteria, International journal of food microbiology, 114(1), 2007, 30-35.

[3]. M.S. Tallman, What is the role of arsenic in newly diagnosed APL?, Best Practice & Research Clinical Haematology, 21(4), 2008, 659-666.

[4]. B.L. Powell, Arsenic trioxide in acute promyelocytic leukemia: potion not poison, Expert review of anticancer therapy, 11(9), 2011, 1317-1319.

[5]. R.A. Ducas, M.D. Seftel, J. Ducas and C. Seifer, Monomorphic ventricular tachycardia caused by arsenic trioxide therapy for acute promyelocytic leukaemia, The journal of the Royal College of Physicians of Edinburgh, 41(2), 2011, 117-118.

Paper Type	::	Research Paper
Title	::	Evaluation Of Anti Bacterial Activity and Anti-Inflammatory Activity of Diastase Conjugated Naringin
Country	::	India
Authors	::	Ch.Supriya || Dr.Ch.Sivareddy || Dr.M.Basaveswarao || Ch.Kalyani || V.Deviswetha
Page No.	::	46-52

The flavonoids comprise a large class of low-molecular-weight plant metabolites ubiquitously distributed in food plants. These dietary antioxidants exert significant antitumor, antiallergic, and anti-inflammatory effects. Narngin is a naturally occurring chemical found in fruits and vegetables. Flavonoids such as naringin, are antioxidants, antibacterial and anti inflammatory agents. The molecular mechanisms of their biological effects remain to be clearly understood. Flavonoids have more therapeutic activity and less solubility................

 

Keywords: Flavonoids, HPLC, enzymatic conjugation, bioavailability, diastase , naringin.

[1]. "Anti - inflammatory & Anti - allergy agents in medicinal chemistry " 2 (1): 57-65 T. Tanaka. S. Hiya, T. Hirano, M. Kotani, M. Matsumoto, A. Fujita and I Kawase. Volume : 2 Issue Number:1.
[2]. "Anti - cancer potential of flavonoids: recent trends and future perspectives ". Priya Batra and Anil K. Sharma, 3 Biotech. 2013 Dec; 3(6): 439-459. Published online 2013 Feb 12. doi: 10.1007/s13205-013-0117-5.
[3]. "Flavonoids as Antioxidants" Peri - Giorgio Pietta Institute of Advanced Biomedical Technologies, National Council of Research Via F.lli Cervi 93, 20090 Segrate (MI), Italy J. Nat. Prod., 2000 , 63 (7), pp 1035 -1042. DOI: 10.1021/no9904509 Publication Date (web): May 27, 2000.
[4]. "Anti - inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat" Teresita Guardia, Alejandar Ester Rotelli, Americo Osvaldo Juarez, Lilian Eugenia Pelzer, Volume 56, Issue 9, 1 August 2001.
[5]. "Antiviral activity of four types of bioflavonoid against dengue virus type -2" Keivan Zandi, Boon - Teong Teoh, sing -sin Sam, Pooi -Fong Wong, Mohd Rais Mustafa and Sazaly AbuBakarEmail author Virology Journal20118:560 DOI: 10.1186/1743-422X-8-560.

Paper Type	::	Research Paper
Title	::	Eco-friendly synthesis of gold nanoparticles by gold mine bacteria Brevibacillus formosus and their antibacterial and biocompatible studies
Country	::	India
Authors	::	B. S. Srinath || K. Namratha || K. Byrappa
Page No.	::	53-60

Nanotechnology is recently emerging in various fields especially in biomedical applications as many pathogenic organisms are gaining resistant against available antibiotics. In the present tudy, we have synthesized biocompatible therapeutic gold nanoparticles using Brevibacillus formosus isolated from the Hutti gold mine, India. Gold nanoparticles (AuNPs) synthesised by the reduction of gold chloride (HAuCl4) using bacterial metabolites as reducing and stabilizing agents. The synthesized AuNPs are characterized by using UV-vis spectroscopy, Fourier transfer infrared spectroscopy (FTIR), Dynamic light scattering (DLS) and Transmission electron microscopy (TEM)...............

 

Keywords: Antibacterial activity, Eco-friendly synthesis, Gold nanoparticles, DLS, TEM.

[1]. J. Li, Q. Li, X. Ma, B. Tian, T. Li, J. Yu, S. Dai, Y. Weng, Y. Hua, Biosynthesis of gold anoparticles by the extreme bacterium Deinococcus radiodurans and an evaluation of their antibacterial properties, Int. J. Nanomedicine. 11 (2016) 5931–5944.
[2]. T.S. Dhas, V.G. Kumar, V. Karthick, K. Govindaraju, T. Shankara Narayana, Biosynthesis of gold
nanoparticles using Sargassum swartzii and its cytotoxicity effect on HeLa cells, Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 133C (2014) 102–106.
[3]. K.N. Thakkar, S.S. Mhatre, R.Y. Parikh, Biological synthesis of metallic nanoparticles, Nanomedicine Nanotechnol. Biol. Med. 6 (2010) 257–262.
[4]. N. Pugazhenthiran, S. Anandan, G. Kathiravan, N.K.U. Prakash, S. Crawford, M. Ashokkumar,
Microbial synthesis of silver nanoparticles by Bacillus sp., J. Nanoparticle Res. 11 (2009) 1811.
[5]. K. Quester, M. Avalos-Borja, E. Castro-Longoria, Biosynthesis and microscopic study of metallic nanoparticles, Micron Oxf. Engl. 1993. 54-55 (2013) 1–27.

Paper Type	::	Research Paper
Title	::	Undiagnosed Depression and Patients with Type 2 Diabetes Mellitus
Country	::	United States
Authors	::	Dr. Joseph Tiscani || Dr. Theresa Galakatos || Dr. Guangwei Fan || Dr. Jennifer Wei
Page No.	::	61-71

Background: Diabetes adversely affects 29.1 million people in the United States and 387 million worldwide ("American Diabetes," 2014; "International Diabetes," 2014). Yet patients with diabetes have a higher risk of depression and decreased glycemic control, adherence to diet, exercise, and taking medications (Huang, Wei, Wu, Chen, & Guo, 2013; Singh, Raju, Dubey, Kurrey, Bansal, & Malik, 2014; Zhao, Chen, Lin, & Sigal, 2006). There is compelling evidence that strategies are urgently needed to address undiagnosed depression in patients with diabetes to alter the course of complications and disease severity. Objective: The purpose of this project is to determine the relationship between depressive symptoms and glycemic control (hemoglobin A1C) in patients with Type 2 Diabetes Mellitus..............

 

Keywords:Beck Depression Inventory-2, depression, Diabetes Mellitus Type 2, undiagnosed depression
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[2] Andreoulakis, E., Hyphantis, T., Kandylis, D., & Iacovides, A. (2012). Depression in diabetes mellitus: A comprehensive review. Hippokratia, 16(3), 205-214.
[3] Avasthi, A., Grover, S., Bhansali, A., Kate, N., Kumar, V., Das, E. M., & Sharma, S. (2015). Presence of common mental disorders in patients with diabetes mellitus using a two stage evaluation method. Indian Journal of Medical Research, 141, 364-367.
[4] Ayman, A., Hayek, A., Asirvatham, R, Mohamed, A., Dawish, A., Marwan, M. Z., . . .Alzaid, A. (2013) Impact of an education program on patientanxiety,depression, glycemic control, and adherence to self‑care and medication in type 2 diabetes. Journal of Family and Community Medicine, 20(2), 77-82.
[5] Bajaj, S., Agarwal, S. K., Varma, A., & Singh, V. K. (2012). Association of depression and its relation with complications in newly diagnosed type 2 diabetes. Indian Journal of Endocrinology & Metabolism, 16(5), 759-763.