Volume 7 ~ Issue 9,~Version 1,~September - 2017


Paper Type

::

Research Paper

Title

::

Nephro Protective, Diuretic and Anti inflammatory Evaluation of
Monocot Grass Kyllinga triceps rottb

Country

::

India

Authors

::

Amit Upadhyay || Dr. Suman Jain

Page No.

::

01-04

Paper Index
::
XXXX

Kyllinga triceps rottb in commonly grown monocot grass of Gwalior Chambal region. In ayurvedic literatures it is known as musta. In various ethno botanical studies grass is reported to be diuretic, anti inflammatory hepatoprotective and antidiabetic. In present study we have been evaluated kullinga triceps rhizomes for its diuretic, nephroprotective and anti inflammatory potential.

 

Keywords: ..............

[1]. K.K. Saxena, Saini Manish, Bhatt Shaily, virani Shalini, Asian Journal of pharmaceutical and clinical research, 09, 1, 2016, 113-117.
[2]. Kota kumar pavan, P. Prasad Dharani, A. Rao Narayana P. Reddy Dayakar, Abhinay G., International journal of pharma and bio Sciences, vol-1, 4, 2010, 435-438. Ref
[3]. Amrita Bhaiji, Rakesh Sagar, Subhan Gankar Nandy, Ranjah Sudhanshu Swain, Bhusan Himanshu, Sahoo, International Research Journal of Pharmacy, 2012, 3, 5, 246-250.
[4]. Rajesh Kumar S., Manohar S., Ramesh K, International journal of pharm fech research, 2014, 6, 1, 403-408.
[5]. Patil S Praveen, Medabala tambi, chrstina, Suyana Bahu Suresh, Asian Journal of Pharmaceutical and clinical Research, 7, 4, 2014, 157-159.
[6]. Harish M.S., Samiula D.S., Indian journal of Pharmacology, 2000, 32, 112-113.
[7]. Chitra M., Jagachitra J., Int. J. Pharmacol. Biol, Sci., Vol-1 (2), 2007, 53-55.

 

Paper Type

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Research Paper

Title

::

Identification and Structure Elucidation of Principle Active Flavonoids from Aqueous-Methanolic Extract Of Olea Cuspidata

Country

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India

Authors

::

Preeti Majgaine || D. L. Verma

Page No.

::

05-09

Paper Index
::
XXXX

Olea cuspidata, a subspecies of Olea europaea and native to Indian Himalaya, is a oil producing evergreen traditional medicinal plant. Olea cuspidata is an excellent fodder producing plant and its leaves have been used as a good supplement to lactating animals of Kumaun hills. The leaves of the plant have medicine to cure cardiovascular and various forms of inflammatory diseases by the local inhabitants of kumaun hills. Therefore, various extracts derived from the leaves of the plant were screened for the isolation and characterization of prominent active catechol grouping flavonoids.

 

Keywords: Olea cuspidata, flavonoids, antioxidant activity.

[1]. Altona, C. and Hasnoot, C.A.G. (1980). Org. Mag_. Resonance. 13. p. 417.
[2]. Bors, W., Hellers, W., Michel, C., Saran, M. Radical chemistry of flavonoid antioxidants. In, Antioxidants in therapy and preventive medicine. Vol.1,165–170. New York: Plenum Press.1990.
[3]. Chandler B.V. and Harper, K.A. (1961). Aust. J. Chem., 14, 586.
[4]. Feigl, E. (1960). In spot test in organic chemistry. Elsevier publishing company, London, p. 337.
[5]. Geiger, H and Homberg.. H. (1983). Z. T~la1urt`orsch. 3316). p. 253-257.

 

Paper Type

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Research Paper

Title

::

Anti ulcer Activity of Ethanolic Extract of Kyllinga Triceps Rottb. Rhizomes

Country

::

India

Authors

::

Amit Upadhyay || Dr. Suman Jain

Page No.

::

10-12

Paper Index
::
XXXX

Kyllinga Triceps family cyperaceae more over known as musta is a herbacious, perennial monocot grass scattered throughout India. In the present study plant extract is evaluated for anti ulacer activity with the help of ulcer index. Ranitidine is used as standard drug. Preliminary phytochemical studies and acute oral toxicity studies were also carried out. The extract showed significant reduction in Ph, gastric volume, total acidity and ulcer index in dose dependant manner as compared to control. The extract did not produced any toxic effect even at high doses. Anti ulcer effects are probably due to the presence of terpenes and terpenoids.

 

Keywords: Kyllinga triceps, ranitidine, ulcer index, terpenes and terpeniods, cyperaceae

[1]. G Kumar Bharath, Kumari Divya, G Sravanthi, G Rajeshwar, V Umadevi, Kotla Goud Niranjan, Int. J. Pharm. Sci. Drug Res. 2014, 6, 1, 38-40.
[2]. Rao Mahadeva U.S., Ahmad Ado Bashir, Mohd suryati Khamsah, Zin Thant Malaysian J. of Analytical sciences 20, 5, 2016, 1203-1216.
[3]. Deore Bhalchandra, Sapakal Dnyandev Vinayak, Dashpure laxman Neelam Naikwade S. Nilofer, J. of Applied pharmaceutical science, 01, 05, 2011, 151-154.
[4]. Amin Jalilzadeh Ghader, Najarnezhad vahid, Anassori Ehsan, Mosta Favi Mosta Fa, Keshipour hadi, Iranian Journal of Pharmaceutical Research 2015, 14, 4, 1163-1170.
[5]. Okonta Mathew Jegbefume, Adibe Maxwell, Ubaka Chukwuemeka, Asian Pacific journal of tropical medicine, 2010, 412-420.

 

Paper Type

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Research Paper

Title

::

Corrosion Inhibitive Effects of Tylophora Indica (A Medicinanl Plant) on Tin in Acidic Media

Country

::

India

Authors

::

Archna Kumari || Dr. Alok Chaturvedi || Dr.Seema Kothari

Page No.

::

13-19

Paper Index
::
XXXX

Corrosion can be considered either chemical or electro chemical in nature . Corrosion decays the metallic properties.Corrosion of metals may be prevented by either barrier protection , sacrificial protection , by alloying or by antirust solutions of ligands containing N , S, O, Se and P as hetero atoms. The naturally occurring plant product are eco-friendly, non-polluting , less toxic, easily available , biodegradable and economic to be used as corrosion inhibitor . Tylophora Indica is known as anantmul. This plant is distributed throughout southern and eastern part of India in plain and forest places. The plant has been reported to contain 0.2 - 0.46 % alkaloid viz, tylophorine flavonoids............

 

Keywords: Tylophora Indica, Corrosion inhibition efficiency, Corrosion rate, Weight loss method, thermometric method, Tin metal etc.

[1]. A.A El. Warraky and El.Meleigt ,"Electrochemical and Spectroscopic Investigation of Synergestic Effects in Corrosion Inhibitor of Al Bronze Part 1- in pure HCl," Journal of British Corrosion, vol.37 No. 4 ,2000.305-310.
[2]. H.Ashassi-.Sorkhabi ,B.Shabani ,B.Alighalipour and D.Seifzadeh, "The Effect of Some Schiff Bases on the Corrosion of Aluminiumn in HCl Solution", Applied Surface Science, vol.252 No.12, 2006,.4039-4047.
[3]. G.Berkt,A.Pinharbasi and C.Orgretir, "Benzimi- dazole-2-tione and Benzgoxazale-2 tione Dervative as Corrosion Iinhibitors for Al in HCl Acid," Anticorrosion, Method and Material vol. 51,No.4,2004,282-293.
[4]. A.H.Ali Ahmed ,A.H. Ahmed ,T.A. Mohammad and B.H. Mohammad ",Chelates and Corrosion Inhibition of Newly Synthesized Schiff Bases Derived from o- tolidine," Transition Metal Chemistry , vol.32, No.4,2004,461-467.
[5]. R.K. Upadhayay,S.Anthony and S.P .Mathur , Polish J. of Chem.43,(2007),238.

 

Paper Type

::

Research Paper

Title

::

Auto-activated Thrombin Expression from Pichia pastorisSMD1168 Optimized by Plackett-Burman Design and Response Surface Methodology

Country

::

Indonesia

Authors

::

Muhammad Fadhlillah || Wulan Pertiwi || Ersanda Hafiz || Sheila Chairunnisa || Eria S. Widyaningsih || Inten Ihsannunisa || Toto Subroto

Page No.

::

20-27

Paper Index
::
XXXX

Recombinant thrombin (rThrombin) has been used topically as one component of fibrin sealant as the tissue adhesive. Recombinant prethrombin-2 is used as the precursor to generate rThrombin which is then activated by ecarin. Autoactivated thrombin (autoTrm) can be produced by altering four amino acids (EDGE) in prethrombin-2 thus obviate the use of ecarin and simplify the purification process. In this study, Pichia pastorisSMD1168 was used to producing autoTrm in flask culture. Influencing factors on P. pastorisSMD1168 culture in producing autoTRM were screened by Plackett-Burman (PB) design and the optimization of was carried out by Response Surface Methodology............

 

Keywords: Autoactivated thrombin, P. pastoris SMD1168, PTM1 supplemented medium, Placket-Burman design, Response SurfaceMethodology

[1]. Bas D, Boyaci IH, Bas D, Boyaci IH. 2007. Modeling and optimization I: Usability of response surface methodology. J Food Eng. 78:836–45.
[2]. Cereghino GP, Cereghino JL, Ilgen C, Cregg JM. 2002. Production of recombinant proteins in fermenter cultures of the yeast Pichia pastoris. CurrOpinBiotechnol. 13(4):329-32.
[3]. Cregg JM, Cereghino JL, Shi JY, Higgins DR. 2000. Recombinant protein expression in Pichia pastoris. Mol Biotechnol. 16:23–52. [4]. Enus S., Natadisastra G., Shahib MN, Sulaeman R. 2011. Peran lem fibrin otologus pada penempelan tandur konjungtiva bulbi mata kelinci terhadap ekspresi gen fibronektin dan integrin. MKB. 43:183-188
[5]. Plackett RL, Burman JP. 1946. The design of optimum multifactorial experiments. Biometrika. 33:305–25.

 

Paper Type

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Research Paper

Title

::

A New Species of Rare Monogenoidean Genus Thaparogyrus
Gusev, 1976 From gills Of Labeo bata (Hamilton, 1822)

Country

::

India

Authors

::

Dr. Karuna Vaishya || Dr. Nirupama Agrawal

Page No.

::

28-29

Paper Index
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XXXX

A new species of rare monogenoidean genus Thaparogyrus Gusev, 1976 has been described. The worms were collected on the gills of L. bata at Manjhura, District Kheri. It is characterized by the dissimilar size of hooks and copulatory tube broad at base pointed at ends; accessory piece with two short flaps support to hold the tube medially and solid tip of tube by terminal flap and broad base of copulatory tube also attached to accessory piece of copulatory complex.

 

Keywords: ...............

[1] Gusev, A. V. 1976a. Freshwater Indian Monogenoidea. Principles of systematics, analysis of world faunas and their evolution. Indian J. Helminth, 25 & 26, 1-241.
[2] Gusev, A. V. 1976b. The systematic composition of the Indian fauna, Zoogeography and Evolution of freshwater monogeneans. Novaya Seriva., 35, 5-32.
[3] Jain, S. L. 1957b. Monogenea of Indian freshwater fishes. VI. Three new Trematodes belonging to the genus Neodactylogyrus Price, 1938 (Family: Dactylogyridae) from some freshwater fishes of Lucknow, India. Proc. Nat. Acad. Sci., 27, 53-63.
[4] Jain, S. L. 1960. Monogenea of Indian freshwater fishes. XII. New Dactylogyrid trematodes from the gill filaments of Cyprinidae and Gobidae hosts. Sobr. Libro Hom. E. Caballeroy C., 161-171.
[5] Lim, L.H.S. 1996. Thaparocleidus Jain, 1952, the senior synonym of Siluridiscoides Gussev, 1976 (Monogenea: Odiscoidinae), Syst. Parasitol., 35, 207-215.

 

Paper Type

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Research Paper

Title

::

Synthesis, Optimization and Characterization of Folate-Chitosan polymer conjugate for Possible Oral delivery of Macromolecular drugs

Country

::

Egypt

Authors

::

Eman Sadder El-Leithy || Hend Mohamed Abdel-Bar || Raghda Abd el-Moneum

Page No.

::

30-38

Paper Index
::
XXXX

Folate-chitosan (FA-CS) conjugate was assorted as a pharmaceutical approach to increase the cellular uptake of macromolecular drugs. It was synthesized by coupling the carboxylic group of the folic acid (FA) with the amino group of chitosan (CS) using carbodiimide. The designed conjugate was suggested to combine the mutual features of both FA and CS. Factors affecting the conjugation process was optimized using Box-Behnken design to maximize the amount of FA that could be coupled with CS. The influence of FA: CS ratio, reaction temperature and time on coupling ratio were studied. The prepared FA-CS conjugate was subjected to in-depth study including FT-IR, 1H NMR, mass spectroscopy, DSC, and XRD studies............

 

Keywords: Box-Behnken, Chitosan, Conjugate, Folic acid, Optimization.

[1] Griffin BT, Guo J, Presas E, Donovan MD, Alonso MJ, O'Driscoll CM, 2016. Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs. Adv Drug Deliv Rev, 15, 2016, 367-380.
[2] Rekha MR, Sharma CP, Oral delivery of therapeutic protein/peptide for diabetes--future perspectives, Int J Pharm,440(1), 2013, 48-62.
[3] Wang XQ, Zhang Q, pH-sensitive polymeric nanoparticles to improve oral bioavailability of peptide/protein drugs and poorly water-soluble drugs, Eur J Pharm Biopharm,82(2), 2012, 219-248.
[4] Chaturvedi K, Ganguly K, Kulkarni AR, Rudzinski WE, Krauss L, Nadagouda MN, Aminabhavi TM, Oral insulin delivery using deoxycholic acid conjugated PEGylated polyhydroxybutyrate co-polymeric nanoparticles, Nanomedicine (Lond),10(10), 2015,1569-1652.
[5] Yin N, Brimble MA, Harris PW, Wen J, Enhancing the Oral Bioavailability of Peptide Drugs by using Chemical Modification and Other Approaches, Med chem 4, 2014,763-769

 

Paper Type

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Research Paper

Title

::

Pattern of Acute Poisoning Presenting at a Tertiary Care Hospital

Country

::

India

Authors

::

Surya Diana Sande || Padmaja Uday kumar

Page No.

::

39-42

Paper Index
::
XXXX

Acute poisoningis a medical emergency. It is important to know the nature, severity and outcome of acute poisoning cases in order to take up appropriate planning, prevention and management techniques. This studyaimed to assess the pattern and outcome of acute poisoning cases in a tertiary care hospital in Karnataka. This is a retrospectivehospital record-basedwhichstudyincluded 120 cases. Data on Sociodemographicdetails, type of poisoning, outcome, circumstances of poisoning (suicidal/accidental) and treatmentgivenwerecollected in the prestructuredproforma. Poisoningwas more commonamong males (61.67%) compared to females (38.33). Most cases of acute poisoningpresentedamong............

 

Keywords: Acute poisoning, pattern and outcome, tertiary care hospital

[1] KSN. Reddy, The essentials of forensic medicine and Toxicology (Hyderabad:Sugunadevi, 2013)
[2] WHO: Environmental Health Criteria 2010.
[3] L Vijaykumar, Indian research on suicide, Indian Journal of Psychiatry,52, 2010, 25-8.
[4] A Basu, Study of Organophosphorus poisoning over 3 years, Journal of association of Physicians of India, 36, 1988, 21.

 

Paper Type

::

Research Paper

Title

::

Virtual Docking Analysis of Zeorin With Fungal Glucan Transglycosylase

Country

::

India

Authors

::

Ashutosh Pathak

Page No.

::

43-45

Paper Index
::
XXXX

Lichen thallus, a consortium of mycobiont and photobiont, produces numerous secondary metabolites and zeorin is one of them. The antifungal activity of zeorin producing lichen extracts have provided the evidence for the current study. The present study was focused on the binding affinity and virtual docking of glucan transglycosylase (Gas2p). The structure of protein was downloaded from RSCB whereas the ligand file was downloaded from PubChem compound database. The docking was performed using AutoDock Vina and visualized by Chimera 1.11.2 whereas the active binding sites were evaluated by MetaPocket 2.0. The successful docked results of Gas2p with zeorin exhibited the potential of zeorin in the inhibition of glucan chain elongation of fungal cell wall via disturbing the hydrolysis and transglycosylation activity of glucan transglycosylase and proves its potential as candidate for future antifungal drug.

 

Keywords: Docking, fungal cell wall, Glucan transglycosylase, Lichen, zeorin

[1] A. Pathak, R.K. Mishra, S.K. Shukla, R. Kumar, A. Pandey, M. Pandey, and A. Dikshit, Flavoaparmelia caperata, a host for Beauveria sp. in subalpine forest of Chakrata district, Uttarakhand, India, and Natural selection in B. bassiana, Asian Journal of Microbiology, Biotechnology and Environmental Sciences, 18(4), 2016, 983-990.
[2] K. Molnar, and E. Farkas, Current results on biological activities of lichen secondary metabolites: A Review, Zeitschrift fur Naturforschung C, 65, 2010, 157-173.
[3] A. Pathak, R.K. Mishra, S.K. Shukla, R. Kumar, M. Pandey, M. Pandey, A. Qidwai, and A. Dikshit, In vitro evaluation of antidermatophytic activity of five lichens, Cogent Biology, 2, 2016, 1197472.
[4] K. Marijana, R. Branislav, and S. Slobodadn, Antimicrobial activity of the lichen Lecanora frustulosa and Parmeliopsis hyperopta and their divaricatic acid and zeorin constituents, African Journal of Microbiology Research, 4(9), 2010, 885-890.

 

Paper Type

::

Research Paper

Title

::

Characterization of Amylase Inhibitor from the Seeds of
Mucuna utilis

Country

::

India

Authors

::

Rajiv Bharadwaj P || K S Chandrashekharaiah

Page No.

::

46-51

Paper Index
::
XXXX

Proteinaceous amylase inhibitors are present in plants which regulate the activity of amylases. An α- Amylase inhibitor was isolated and purified by conventional protein purification techniques (ammonium sulphate fractionation, Sephadex G-10, sephadex G-50 chromatography and HPLC) from Mucuna utilis seeds. Its molecular weight as determined by gel-permeation chromatography on Sephadex G-100 was found to be 15 kDa. The purified inhibitor was temperature stable and retained more than 75% activity at 65 °C. Inhibitor was found to have pH optima of 6.9. 100% Zone of inhibition was observed when the inhibitor was added on the plated organisms. The Mucuna utilis amylase inhibitor was found to inhibit the activity of human salivary α- amylase. Inhibitory activity of α-amylase inhibitor against mammalian amylases could suggest its potential in
treatment of diabetes and cure of nutritional problems, which result in obesity.

 

Keywords: Amylase inhibitors, isolation, characterization, Mucuna utilis seeds

[1]. M D O' Donnell, O. FitzGerald and K. F. McGeeney, Differential serum amylase determination by use of an inhibitor and design of a routine procedure. Clinical Chemistry, 23, 1977, 560-566.
[2]. E Gilles Turcotte, Linda Nadeau, Jean-Claude Forest, Pierre Douville, Pierre Leclerc, Jean Bergeron, Bernard Fruteau de Laclos, A new rapid immunoinhibition pancreatic amylase assay: Diagnostic value for pancreatitis. Clinical Biochemistry, 27(2), 1994, 133 – 139.
[3]. H Bischoff, H.J. Ahr, D. Schmidt and J. Stoltefuss, Acarbose—ein neues Wirkprinzip in der
Diabetestherapie Nachrichten aus Chemie, Technik und Laboratorium, 42, 1994, 1109–112.
[4]. M J Chrispeels, M.F. Grossi-de-Sa, T.J.V. Higgins, Genetic engineering with α-amylase inhibitors seeds resistant to bruchids. Seed Science Research, 8, 1998, 257-263.
[5]. A M R Gatehouse, Gatehouse, J.A. Identifying proteins with insecticidal activity: Use of encoding genes to produce insect-resistant transgenic crops. Pesticide Science, 52, 1998, 165-175.

 

Paper Type

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Research Paper

Title

::

Anticandidal and synergistic anticandidal activity and chemical composition of Citrus reticulata and Azadirachta indica essential oils

Country

::

India

Authors

::

Tejas Rathod || Hemali Padalia || Sumitra Chanda

Page No.

::

52-71

Paper Index
::
XXXX

The aim of the present work was to evaluate anticandidal activity of Azadirachta indica A. Juss. and Citrus reticulate Blanco (neem and orange) essential oils alone and their synergistic activity i.e. essential oils in combination with some two polyene antibiotics viz. Amphotericin B, Nystatin and four azole antibiotics viz. Fluconazole, Ketoconazole, Clotrimazole and Itraconazole against multidrug resistant clinical isolates of Candida. The synergistic antifungal activity of both essential oils with six commercial antibiotics was evaluated against clinical isolates by disc diffusion assay. C. reticulata fruit peel essential oil showed better synergistic antifungal activity than A. indica seed essential oil..........

 

Keywords: Azadirachta indica, Citrus reticulate, Candida albicans, Fluconazole, essential oils, Synergistic activity

[1]. Zhang Z, Elsohly HN, Jacob MR, Pasco DS, Walker LA, Clark AM (2002). Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii. Planta Medica 68:49-54.
[2]. Choukri F, Benderdouche M, Sednaoui P (2014). In vitro susceptibility profile of 200 recent clinical isolates of Candida spp. to topical antifungal treatments of vulvovaginal candidiasis, the imidazoles and nystatin agents. Journal de Mycologie Médicale 24: 303—307.
[3]. Lai CC, Tan CK, Huang YT, Shao PL, Hsueh PR (2008). Current challenges in the management of invasive fungal infections. Journal of Infection and Chemotheraphy 14:77-85.
[4]. Mukherjee P K, Saritha G, Suresh B (2002). Antimicrobial potential of two different Hypericum species available in India. Phytotherapy Research 16:692-695.
[5]. Magro A, Carolino M, Bastos M, Mexia A (2006). Efficacy of plant extracts against stored products fungi. Revista Iberoamericana de Micologia 23:176-178.

 

Volume 7 ~ Issue 9,~Version 2,~September - 2017

 

Paper Type

::

Research Paper

Title

::

Drug Utilization Evalauation of Antibiotics in Dh Uttarakashi

Country

::

India

Authors

::

Kanishk Kala || Rupinder Kaur Sodhi || Upendra Kumar Jain

Page No.

::

01-05

Paper Index
::
XXXX

Drug Use Evaluation (DUE) is recognized as an effective tool for detecting and improving drug use and to strengthen clinical pharmacy and patient care It is vital for almost all drugs most importantly for antibiotics for being the highly used drug in hospitals and community The objective of this study was to do drug utilization evaluation of antibiotics in dh uttarakashi. It was a hospital based retrospective study was conducted for a period of one month December 2016 A total of 15 patient records were collected randomly evaluated for prescribing pattern using WHO drug indicators. Results showed male dominance (33 %) were in the age group 61-80 years...........

 

Keywords: ................

[1] B Shrikala, K Kranthi, et al. A prospective study on evaluation of antibiotic prescription practices in an intensive care unit of a tertiary care hospital. Journal of Clinical and Diagnostic Research. (4): 2010, 3387-3391.
[2] B.K Lalan, R.S Hiray, et al. Drug prescription pattern of outpatients in a tertiary care teaching hospital in Maharashtra. International Journal of Pharma and Bio Science. 3(3) 2012; 225 – 229.
[3] B.R. Meher, D. Mukharjee, A study on antibiotic utilization pattern in a general medicine ward of a tertiary care teaching hospital. Journal of Chemical and Pharmaceutical Research, 6(7): 2014, 1847-1849.
[4] Demeke, B, F. Molla, et al. Evaluation of drugs utilization pattern using who prescribing indicators in ayder referral hospital, northern Ethiopia. International Journal of Pharma Sciences and Research 6(2) 2015, 343 347.
[5] G. Venu, K Rama, et al.Prescribing pattern of antibiotics in the general medicine and paediatrics departments of a tertiary care teaching hospital. International Journal of Pharmacy and Pharmaceutical Sciences, 6(2),2014, 221-224.

 

Paper Type

::

Research Paper

Title

::

Association of Antidiabetic Medication Targetting ppar-Gamma Agonists: Design, Synthesis & Evaluation

Country

::

India

Authors

::

Ritu Sharma || Mehul Zaveri || Gourav Jain || Neha Kawathekar

Page No.

::

06-17

Paper Index
::
XXXX

Thiazolidinedione is an important target for Antidiabetic drugs. There is still significant potential for designing new chemical entity with affordable, safe and efficacious Antidiabetic drug. In present study 2-thioxo-4-thiazolidinedione derivatives were designed and interaction of these was investigated by docking studies in the binding site of PPARγ using (PDB ID 1FM9) enzyme using Glide v 5.6 (Schrodinger LLC., New York, USA; http://www.schrodinger.com). Among the series of designed compounds seven compounds with good potential were synthesized. Structural confirmation of these compounds was done by FT-IR, 1H-NMR and Mass spectroscopy. The compounds were evaluated for in vitro Antidiabetic activity against PPARγ agonists. The activity of compound RS4 and RS20 was found to be comparable with Pioglitazone. The above study could be very useful for further design and development of new Antidiabetic drug.

 

Keywords: Antidiabetic, Docking, PPARγ agonist, 2-Thioxo-4-thiazolidinedione

[1]. C. Pickup and G. Williams, Epidemiology of Diabetes Mellitus, Blackwell, Oxford, UK, 1997
[2]. American Diabetes Association, "Standards of medical care for patients with diabetes mellitus (position statement)," Diabetes Care, vol. 20, no. 1, pp. 518–520, 1997.
[3]. L. Dey, A. S. Attele, and C. Yuan, "Alternative therapies for type 2 diabetes," Alternative Medicine Review, vol. 7, no. 1, pp. 45–58, 2002.
[4]. http://gohom.win/ManualHom/Schrodinger/Schrodinger_20152_docs/maestro/maestro_user_manual
[5]. Erickson JA, Jalaie M, Robertson DH, Lewis RA, Vieth M. Lessons in molecular recognition: the effects of ligand and protein flexibility on molecular docking accuracy. J. Med. Chem. 2004;47:45–55.

 

Paper Type

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Research Paper

Title

::

Evaluation of CV Technology for reducing levels of heavy metals in polluted Hussainsagar lake water, Hyderabad, Telangana state, India

Country

::

India

Authors

::

Sreenu Noothi || C. Venkateswar || B. Reddya Naik || J. Avinash Kumar

Page No.

::

18-23

Paper Index
::
XXXX

Heavy metals are stable and are determined as environmental contaminants since they cannot be degraded or destroyed, therefore they accumulate in the soils, water and sediments. Three water i.e., control water (Bore water), polluted and treated Hussainsagar lake water were collected from Hyderabad area which were analyzed to investigate the concentrationof heavy metals like Cr, Mn, Fe and Co. In the present study polluted Hussainsagar lake water was treated by using C.V. Technologyfrom 2012 to 2015. The results indicated that concentrations of heavy metals were very high in polluted Hussainsagar lake water compared to control and treated Hussainsagar lake water which were within the permissible levels. The treated Hussainsagar lake water showed concentration of all metals below detectable range except manganese.

 

Keywords: CV technology, Heavy metals, Hussainsagar Polluted water, Osmania University bore water

[1]. Abbasi S.A., Nipaney, P.C and Soni, R (1991a). Occurence, essentiality and toxicity of chromium, J. Inst. Public Health Engineers, India.90(2). 25 pp.
[2]. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Manganese. (2012). Available online: http://www.atsdr.cdc.gov/toxprofiles/tp151.pdf (accessed on 15 April 2015).
[3]. American Ground Water Trust. The American Well Owner, (2002). Available online: http://www.agwt.org/ content/iron-problems (accessed on 24 November 2015).
[4]. Armitage PD, Bowes MJ, Vincent HM, (2007). Long-term changes in macroinvertebrate communities of a heavy metal polluted stream: The river nent (Cumbria, UK) after 28 years. River Res. 23:997–1015.
[5]. Bayazit S.S and KerkezO¨ (2014). Hexavalent chromium adsorption on super paramagnetic multi-wallcarbon nanotubes and activated carbon composites. Chemical Engineering Research and Design 92: 2725–2733.

 

Paper Type

::

Research Paper

Title

::

Acute Toxicity and Behavioural Response in Fresh water Fish Danio aequipinnatus (Ham Buch) Exposed to Floraguard (Biopesticide)

Country

::

India

Authors

::

S. S. Ishi || R. D. Patil

Page No.

::

24-27

Paper Index
::
XXXX

The Flora guard is agro-biopesticide that is widely used in agriculture. Floraguard is organic research product, is an agro-biopesticide. It acts as systemic as well as contact poison to the pest of the crop. It is immediately control all sucking pests, like thrips, aphids and jassids. It is commonly applied on grapes, mango, strawberry, brinjal, chili and onion etc. Aim of present the study was to assess acute toxicity and behavioural changes of this chemical on fresh water fish Danio aequipinnatus. The fish were exposed to Floraguard to determine the LC50 values. The static bioassay experiments were carried out by Finney's method (1971).The fish was exposed to different concentrations of floraguard and the result showed the LC50 values at 24, 48, 72 and96 hours were 2.6230 ppm, 2.3474 ppm, 2.1478 ppm and 1.9870 respectively.
The results of the present study indicates that floraguard has highly toxic effects on the fish Danio aequipinnatus.

 

Keywords: Acute toxicity, Behavioural changes, Danio aequipinnatus.

[1]. Alinezad R. "Determining LC50 In 96h Regent Insecticide, Hinosan ungicide, Persicus.(M.Sc Thesis)." Lahijan Azad University. 2004.
[2]. Ansari BA, Sharma DK,. "Toxic Effect of Synthetic Pyrethroids Deltamethrin and Neem Based Formulation Achook on zebra Fish Danio rerio." Trends in Biosciences , 2009; 2(2):: 18-20.
[3]. APHA, AWWA. standard methods for the examination of water and waste water APHA (17TH ed) INC, New York, 1985. n.d.
[4]. Bagheri A, Nezami A. "Effect of Weed Control and Plant Densities on Yield and Morphological Characteristics of Chickenpea in Dry Farmin of North Khorasan. ." Journal of Agricultural Science and Indusries Iran. 2000: 14.
[5]. Caguam AG, Aree RG,. "Overview of Pesticides Use In Rice Fish Farming South East Asia.In: C.R.Dela Cruz, C. Lightfood, B. Coasta Pierce, V.R. Carangal and M.P.Bimbao(Eds).Rice-fish research and development in Asia." International centre for Living Aquatic Resources Managment (ICLARM) Conf.Proc. Philippines , 1992: 24:217-233.

 

Paper Type

::

Research Paper

Title

::

Assessment of Potential Carcinogenic Metals in Palm Wines of Northern Cross River State, Nigeria

Country

::

Nigeria

Authors

::

B. U. Ngang

Page No.

::

28-34

Paper Index
::
XXXX

Palm wine samples collected from five major areas in Northern Cross River State, South-south Nigeria were assessed in triplicates for their contents of five carcinogenic metals including arsenic (As), cadmium (Cd), mercury (Hg), Ni (Ni) and lead (Pb) using Flame Atomic Absorption Spectrophotometer (FAAS) following a 2:5 HNO3/H2O2 mixture digestion according to standard procedure. The study was repeated in three consecutive years and in each case, the results were compared with WHO acceptable limits of the metals in drinks. The results revealed that As, Cd, Ni and Pb mean contents were significantly above WHO recommended limits at α (0.0 5) and υ (14) in the samples within the three years period of the study.............

 

Keywords: Assessments, carcinogens, metals, Nigeria, palm-wine.

[1]. United State Environmental Protection Agency, Glyphosate Issue Paper: Evaluation of Carcinogenic Potential, EPA's Office of Pesticide Programs September 12, 2016, 63.
[2]. M. A. Lushenko, A risk assessment for ingestion of toxic chemicals in fish from Imperial beach, California: San Diego State University, 2012.
[3]. F. Fenglian and W. Qi, Removal of Heavy Metal ions from Waste Waters: A review. J. Environ. Manage. 92(3), 2011, 407-418.
[4]. Y. Ouyang , J. Higman, J. Thompson , O. T. Toole and D. Campbell, Characterization and spatial distribution of heavy metals in sediment from Cedar and Ortega Rivers sub-basin. J. Contam. Hydrol. 54, 2002, 19-35.
[5]. USEPA, Waste and cleanup risk assessment, USEPA, 2012, available online at http://www2.epa.gov/risk/waste-and-cleanup-risk-assessment.

 

Paper Type

::

Research Paper

Title

::

Prophylactic effect of sodium valproate in traumatic brain injury
patients with early post-traumatic seizures

Country

::

India

Authors

::

Ch. Jyothi || Dr. P. Kishore || Dr. T. Sanjay || Dr. D. Sudheer kumar || R. Deepthi

Page No.

::

35-40

Paper Index
::
XXXX

Background: Post traumatic seizures has been described as a particularly heterogeneous condition, specifically because of the heterogenesity associated with TBI Epidemiological studies have found that PTE accounts for 10–20% of symptomatic epilepsy in the general population and 5% of all epilepsies Seizure activity in the early post-traumatic period after head injury may cause secondary brain damage. Prophylaxis for PTS refers to the practice of administering anti convulsants to the patients following head injury to prevent the occurrence of seizures. Aims: The present study was undertaken to evaluate the prevalence of early posttraumatic seizures in TBI and effectiveness of sodium valproate in treating seizures..............

 

Keywords: PTS, TBI, GCS, GOS, Sodium valproate.

[1]. Loretta Piccenna, Graeme Shears, and Terence J. O'Brien, Management of post-traumatic epilepsy: An evidence review over the last 5 years and future directions. Epilepsia Open, 2(2):123–144, 2017 doi: 10.1002/epi4.12049.
[2]. MA Chi-yuan, et al. Sodium valproate for prevention of early posttraumatic Seizures. Chinese Journal of Traumatology 2010; 13(5):293-296.
[3]. Management and prognosis of severe traumatic brain injury. A joint project of the Brain Trauma Foundation. American Association of Neurological Surgeons, Joint Section on Neurotrauma and Critical care.2000, Brain Trauma Foundation.ISBN O-9703144-0X.
[4]. Ilmari Asikainen, Markku Kaste and f-Seppo Sarna. Early and Late Posttraumatic Seizures in Traumatic Brain Injury Rehabilitation Patients: Brain Injury Factors Causing Late Seizures and Influence of Seizures on Long-Term Outcome. Epilepsia, 1999. 40 (5); 584-589.
[5]. Frey LC. The epidemiology of posttraumatic epilepsy: a critical review. Epilepsia 2003;44:11–7.

 

Paper Type

::

Research Paper

Title

::

Loss and Dilution Optimization of Valuable Minerals in Mining
Complex Structured Limestone Deposits

Country

::

Russia

Authors

::

FOMIN S.I. || TRAN Dinh Bao

Page No.

::

42-46

Paper Index
::
XXXX

The paper analyzes kinds of losses of basic valuable minerals in mining complex structured limestone deposits. Diagrams of loss of valuable deposits and the blend of waste rock are also made in mining bedding deposits. Technical and economic data explaining for the proper decrease of the loss show that raising the dilution or loss needs to base on the comparison of mining alternatives fulfilled in the contact area of waste rock and material. Norm of loss of valuable mineral is created to determine the technical and economic of each mining block using geological exploration documents. The criterion of maximum NPV of mined deposit should be used to determine the norm of loss of valuable mineral. In addition, the paper proposes a technology to ensure a proper use of mineral resource and to decrease the loss of valuable loss in mining complex structured
limestone deposits.

 

Keywords: Loss, dilution, limestone deposits, NPV.

[1]. Arsentiev, A.I., 2002. Opencast mine output. SPb: St. Petersburg Mining Institute.
[2]. Aristov, I.I., S.K. Rubtsov, 2006. Enhancement of standardization and accounting of losses and dilution of ore methodologies at
complex structure deposits development. Nedropolzovanie – XXI century, 1, 28-37.
[3]. Elborn, J., 1986. Ore losses, rock dilution and recovery estimation, design and operation. Proceedings CIM Ore reserve Symposium,
pp. 130-134.
[4]. Knissel, W, J.Hilger, M.Fahlbusch, 1995. Significance of selective mineral exploitation for economical and environmentally
beneficial underground ore mining. Mineral resources engineering, Imperial College Press, 4 (2), 165-174.
[5]. Mening, S., 2004. Evaluation of accuracy loss ratios of iron ore mining. Mining information-analytical bulletin, 5, 186-187.

 

Paper Type

::

Research Paper

Title

::

Study on Availability of Various traditionally used Medicinal plants in Basara, Nirmal district, Telangana, India

Country

::

India

Authors

::

S. Vinod kumar || Gadapa Susmitharaj || Koochamgari Naresh || Nirmala Baburao

Page No.

::

47-49

Paper Index
::
XXXX

Since ancient times, plants are being used as medicines, foods, agrochemicals and pharmaceuticals by large number of tribal, rural and urban people. The present study revealed that a total of 27 medicinal plants, belongs to 23 families are recorded for the treatment of different diseases viz. asthma, arthritis, cough, fever, diabetes, dysentery, gastric and indigestion, jaundice, toothache, skin diseases, etc. Some important medicinal plants widely used are Achyranthes aspera, Balanites aegyptiaca, Cymbopogon citrates, Mimosa pudica, Withania somnifera, Catharanthus roseus and etc. Some of the species reported in the present paper are in critical conditions due to deforestation, various activities of human population for their survival and other developmental activities such as agriculture, urbanization etc. as a result of which the rich habitats are gradually depleting day by day.

 

Keywords: Medicinal plants, Traditional medicine, Basra, Ethno medicine, Telangana.

[1]. Anonymous, Gazetteer of Adilabad District, Government of Andhra Pradesh, (Government Press, Hyderabad) (1975)
[2]. Ravishankar T, Ethnobotanical studies in Adilabad and Karimnagar districts of Andhra Pradesh, India, (Ph.D. thesis, Bharathiar University, Coimbatore), 1990
[3]. Ravishankar T & AN Henry, Ethnobotany of Adilabad district, Andhra Pradesh, India, Ethnobotany, 4 (1992) 45-52.
[4]. Pullaiah T, Prasanna, PV & Obulesu G, Flora of Adilabad district, (C.B.S Publishers, New Delhi) 1992.
[5]. Pullaiah T and Ravi Prasad Rao B. Flora of Nizamabad, Andhra Pradesh India, BhisensinghMahendrapalsingh, Dehradun, 1995.

 

Paper Type

::

Research Paper

Title

::

Caffeine Induced Restless Legs Syndrome

Country

::

India

Authors

::

Sagar Pamu || Lakshmi Thakkalapally || Vidyavanthi Badugu || Deepak Pawar

Page No.

::

50-52

Paper Index
::
XXXX

Restless legs syndrome (RLS) an unusual condition was reported due to excess consumption of coffee drink and eating coffee chocolates. A female software employee aged 45 years admitted in hospital with the chief complaints of back pain, sleeplessness nights due to rhythmic and pulling sensations at her lower limbs. She was an Indian origin but settled in America and came to India. Her history was found to be frequent consumption of coffee 10-12 times per day and eating coffee chocolate atleast 3 per day. Her family history was known with parkinson's disease in her grandfather. She has past medication history. She was treated with tramadol 100mg, pantoprazole 40mg and diazepam 2mg for one week but no recovery was observed in rhythmic and pulling sensations but well responded to back pain..............

 

Keywords: Caffeine, sensations, coffee, coffee chocolates, sleeplessness, Parkinson 's disease.

[1]. BR Krueger, Restless legs syndrome and periodic movements of sleep, Mayo Clin Proc, 65(7), 1990, 999-1006.

[2]. CE Gamaldo, CJ Earley, Restless legs syndrome: a clinical update, Chest, 130(5), 2006, 1596-1604.

[3]. MH Silber, Restless legs syndrome, Mayo Clin Proc, 72(3), 1997, 261-264.

[4]. AS Walters, C LeBrocq, A Dhar, Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome, Sleep Med, 4(2), 2003, 121-132.
[5]. KetakiBhalsing, K Suresh, BM Uday, KP Pramod, Prevalence and profile of Restless Legs Syndrome in Parkinson's disease and other neurodegenerative disorders: A case-control study, Parkinsonism & Related Disorders, 19(4), 2013, 426-430.

 

Paper Type

::

Research Paper

Title

::

An Ethnobotanical survey of Medicinal plants used by ethnic people in Bodhan, Nizamabad district, Telangana state, India

Country

::

India

Authors

::

S. Vinod kumar || Gadapa Susmitharaj || Koochamgari Naresh || Nirmala Baburao

Page No.

::

53-57

Paper Index
::
XXXX

This study was carried out in Bodhan area of Nizamabad district, Telangana state, to document the traditional knowledge of local people on medicinal plants, and to investigate the distribution, abundance, taxonomic diversity and biological activity of medicinal plants. The Use of herbal medicines in Asia represents a long history of human interactions with the environment. Plants used for traditional medicine contain a wide range of substances that can be used to treat chronic as well as infectious diseases. Field trips were conducted and ethnomedicinal data were collected through conversation with traditional healers', and elder people in the field trips. During the interviews local names, useful plant parts, method of preparation and dosage were recorded...............

 

Keywords: Bodhan, traditional, ethnomedicines, folk and herbal medicine.

[1] Pullaiah T and Ravi Prasad Rao B. Flora of Nizamabad, Andhra Pradesh India, BhisensinghMahendrapalsingh, Dehradun, 1995.
[2] Ravishankar T, Ethnobotanical studies in Adilabad and Karimnagar districts of Andhra Pradesh, India, (Ph.D. thesis, Bharathiar University, Coimbatore), 1990.
[3] JAIN S.K., 1991. Dictionary of Indian Folk Medicines andethno botany. Deep Publications, New Delhi.
[4] Reddy S.D., 2015. Ethno botanical study of bodycoolants used by tribal's of Nallamallais in Telangana, India, inter. National Journal of Advance Research,Vol 3, issue 4,411-415.
[5] Rajashekaran B., Michael warren D., Suresh ChandraBabu., 1994. Farmer participatory approaches to achieve fodder security in south Indian villages. Agriculture and human values, 11 (2-3), 159-167.