Volume 9 ~ Issue 1 ~ Series-1 [ January - 2019]


Paper Type

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Research Paper

Title

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Antimicrobial potential of Mimosa pudica Linn against multi-drug resistant bacteria species

Country

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India

Authors

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Bhargab Jyoti Sahariah || Dipankar Bardalai || Prakash KishoreHazam

Page No.

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01-05

Paper Index
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XXXX

Therapeutic applications of herbal drugs have been crucial in Indian system of medicine. A plethora of modern drugs have their roots originated from nature's basket. In our current work, we also tried to explore the antimicrobial potential of one such medicinal plant, Mimosa pudica Linn. against resistant bacterial species. The aqueous extract was tested against gentamycin resistant MRSA, which showed significant bactericidal activity. The effectiveness of the Mimosa pudica Linn. against microbial infection has been stated in the medical text of Indian system of medicine.

 

Keywords: Antimicrobial, Resistant, Mimosa, MDR, Ayurveda,

[1]. P.K. Mukherjee, A. Wahile, Integrated approaches towards drug development from Ayurveda and other Indian system of medicines, Journal of ethnopharmacology, 103 (2006) 25-35.
[2]. I. Raskin, D.M. Ribnicky, S. Komarnytsky, N. Ilic, A. Poulev, N. Borisjuk, A. Brinker, D.A. Moreno, C. Ripoll, N. Yakoby, Plants and human health in the twenty-first century, TRENDS in Biotechnology, 20 (2002) 522-531.
[3]. N.J. Gogtay, H.A. Bhatt, S.S. Dalvi, N.A. Kshirsagar, The use and safety of non-allopathic Indian medicines, Drug safety, 25 (2002) 1005-1019.
[4]. N.R. Farnsworth, Screening plants for new medicines, Biodiversity, 15 (1988) 81-99.
[5]. P.M. Barnes, E. Powell-Griner, K. McFann, R.L. Nahin, Complementary and alternative medicine use among adults: United States, 2002, Seminars in integrative medicine, Elsevier, 2004, pp. 54-71.

 

Paper Type

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Research Paper

Title

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The Effects of Vitamin D Supplementation on Serum Levels and Genes Expression of Some Inflammatory and Endothelial Biomarkers in Patients with Type-2 Diabetes Mellitus: A Study Protocol for a Randomized Double-Blind Controlled Trial

Country

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Iran

Authors

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Mahsa Omidian || Maryam Abshirini || Mona Djalali || Parisa Omidian || MahnazZarei || Hossein Hasani || Mahmoud Djalali

Page No.

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06-11

Paper Index
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XXXX

Background: Diabetes mellitus has adverse effectson small and large vessels and causes micro- and macro-angiopathy.Vascular complications of diabetes are among the leading cause of mortality and morbidity in diabetic patients. Several studies have suggested the possible health benefit of vitamin D on development of diabetic vascularcomplications, but little is known regarding theinvolvedmolecular mechanisms.Endothelial dysfunction is an importantearly event in the pathogenesis of vascular complications which is defined by aproinflammatory state, and prothromboticproperties. The objective of our study was to determine the effect of vitamin D supplementation on bloodglucose indices, lipids, inflammatory profiles, endothelial dysfunction biomarkers, gene expression of enzyme glyoxalas-1, chitinase-3-like-1 (YKL40), and receptor for advanced glycation end products (RAGE) in peripheral blood mononuclear cells (PBMC) in type-2diabetes mellitus(T2DM)participants.............

 

Keywords: Diabetes, Vitamin D,Vascular complications.

[1]. International DF. Five questions on the IDF Diabetes Atlas. Diabetes research and clinical practice. 2013;102(2):147.
[2]. Deckert T, Yokoyama H, Mathiesen E, et al. Cohort study of predictive value of urinary albumin excretion for atherosclerotic vascular disease in patients with insulin dependent diabetes .Br Med J. 1996;312:871–874.
[3]. Gall MA, Borch-Johnsen K, Hougaard P, Nielsen FS, Parving HH. Albuminuria and poor glycemic control predict mortality in non-insulin dependent diabetes mellitus . Diabetes 1995;44:1301–1309.
[4]. Choudhuri S, Dutta D, Sen A, Chowdhury IH, Mitra B, Mondal LK, et al. Role of N–epsilon-carboxy methyl lysine, advanced glycation end products and reactive oxygen species for the development of nonproliferative and proliferative retinopathy in type 2 diabetes mellitus. Molecular vision. 2013;19:100.
[5]. Zhou X, Wang B, Zhu L ,Hao S. A novel improved therapy strategy for diabetic nephropathy, Targeting AGEs. 2012;8(1): 18-21.

 

Paper Type

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Research Paper

Title

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Frequency of Visit to Doctor and Health Problem Redresses of Farm Women: The Interactions and Impact in Rural Health Management

Country

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India

Authors

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Riti Chatterjee || Sankar Kumar Acharya || Amitava Biswas

Page No.

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12-20

Paper Index
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XXXX

The farm women are one of the neglected individuals in the farm ecology in Indian scenario. They have to work for a longer time under the scorching sun and rain in the field as well as they serve their family along with. So, they suffer from various types of diseases and physical problems all the year round. But at the end of the day their health issues are severely neglected. Sometimes they pay visit to the doctor at later stages of problem or sometimes there is no visit to doctor . Lack of systematic screening and prevention for both acute and chronic illness is a greater constraint for poor farm women. The present study focuses its target on the farm womens' frequency of visit to the doctor.A study on this topic, was carried out at Boinchigram village under Pandua Block in Hooghly district of west bengal with objectives to generate classified information on occupational hazards of farm women,to estimate.............

 

Keywords: BMI, Doctor, Farm women, Health, Occupational hazards.

[1]. Adejare, Taiwo Grace. (2001). "Health Problems of Women Cassava Processors in Oluyole Local Government area." M.sc Thesis, Department of Agricultural Extension and Rural Department. University of Ibadan. Ibadan.
[2]. MAQARI Team (2011). Mapping Medical Providers in Rural India: Four Key Trends. Center for Policy Research. New Delhi: Centre for Policy Research. Retrieved on December 6, 2013, from http://cprindia.org/sites/default/files/policy%20brief_1.pdf
[3]. Rao, M., Mant, D. (2012). Strengthening Primary Healthcare in India: White Paper on Opportunities for Partnership. BMJ. 344- e3151. Doi: http://dx.doi.org/10.1136/bmj.e3151

Paper Type

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Research Paper

Title

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Formulation, Development and Evaluation of Mouth Dissolving Tablet Containing Cyclodextrin as Taste Masker

Country

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India

Authors

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Swati L. Khedekar || Subhash V. Deshmane

Page No.

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21-29

Paper Index
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XXXX

Mouth dissolving dosage form is very important for geriatric patients who have difficulty in swallowing tablets or in situation where access of water is not possible. The present study was carried out to prepare Telmisartan mouth dissolving tablet that can used as an antihypertensive drug. To mask the bitter taste of the drug, the drug-polymer complex (DPC) were prepared in various ratio(1:1, 1:2, 1:3, 1:4, 1:5 & 1:6) by solvent evaporation method and the characterization of DPCs were carried out by determining Drug content , in-vitro evaluation of drug complex & Threshold value determination. The threshold value was determined at 200μg/ml and the DPC was selected which masked the taste of drug was 1:3 ratio. Selection of superdisintegrants like crosspovidone, sodium starch glycolate, crosscarmellose sodium was carried out. Tablets were prepared along with other additives by direct compression method was used for preparation of mouth dissolving tablets. Tablets were evaluated for various tests like weight variation, hardness, friability, content uniformity, wetting time, water absorption ratio, in-vitro disintegration time, in-vitro dispersion time & dissolution..

 

Keywords: Antihypertensive, Bitter Taste, , Superdisintegrants, Telmisartan, Threshold Value.

[1]. Lachman L. & Liberman H.A, The theory and practice of industrial pharmacy; Varghese publishing house, third edition. 1990, 329-335.

[2]. Aulton M.E; Aulton's pharmaceutics, The design and manufacture of medicines; third edition; 2007,441-482.

[3]. Ansel H.C; Ansel's pharmaceutics dosage forms & drug delivery system; edition 9th; 2011, 225-256.

[4]. Prabhakar V., Agarwal S., Chauhan R., Sharma S: Fast dissolving tablet –an overview; International journal of pharmaceutical science review and research; 2012, 16(1), 17-24.

[5]. Gupta A., Mittal A. & Prof. K. K. Jha; Fast dissolving tablet- A Review; The Pharma Innovation, 2012, 1(1), 1-7.

 

Paper Type

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Research Paper

Title

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GC-MS Analysis of the Polyherbal Mixture

Country

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India

Authors

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Sumia Fatima || Dr. C Ramesh || A Saheel Qureshi

Page No.

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30-33

Paper Index
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XXXX

The aim of the study was to investigate the phytoconstituents of chloroform extract of polyherbal mixture containing Argemone mexicana leaves, Echinops echinatus roots and Tricholepis glaberrima aerial parts using GC-MS(gas chromatography mass spectrometry). GC-MS analysis of polyherbal mixture was performed by using Agilent 6890 GC with 59739N MSD and GC-MS equipped with Elite-I fused with silica capillary column (Cpsil 8cb: 30mm x 25mm x 0.25mm). The result of analysis confirms the presence of 11 compounds. The most prevailing compounds of medicinal value are Azotensin, Thymol, Erythrocentaurin, Neophytadiene, Hexadecanoic acid, Cis-9,cis-12-Octadecadienoic acid, Squalene etc.

 

Keywords: Polyherbal mixture, Argemone mexicana leaves, Echinops echinatus roots and Tricholepis glaberrima aerial parts, GC-MS Analysis.

[1]. Kanthal LK, Dey A, Satyavathi K and Bhojaraju P. GC-MS analysis of bioactive compounds in methanolic extract of Lactuca runcinata DC, Pharmacognosy Research, 6(1), 2014 Jan-Mar, 58-61.

[2]. Padashetty SA, Mishra SH. An HPTLC method for the evaluation of two medicinal plants commercially available in the Indian market under the trade name Brahmadandi, Chromatographia, 64, 2007, 447-449.
[3]. Fatima S et. al. Evaluation of Antiulcer activity of 70% Hydroethanolic leaf extract of Argemone mexicana Linn. in experimental rats, IOSR Journal of Pharmacy, 6(4), 2016, 41-50.
[4]. Qureshi AS, Dr. Pasha K, Fatima S. HPTLC fingerprint analysis of 70% Hydroethanolic roots extract of Echinops echinatus, World Journal of Pharmacy and Pharmaceutical Sciences, 6(4), 2017, 1100-1105.
[5]. Naphade SS, et. al. Neuropharmacological profile of Tricholepis glaberrima extract in mice, Pharmacology Online, 2, 2009, 140-150.

 

Paper Type

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Research Paper

Title

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Incidence of AKI with or without hemodialysis in tribal population of Chhattisgarh

Country

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India

Authors

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Ashish D || Dr. Punit G || Ghanaram S || Vijay B

Page No.

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34-37

Paper Index
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XXXX

The information regarding the incidence of acute kidney injury (AKI) with or without haemodialysis in tribal population of Chhattisgarh is limited. The aim of the study was to find the incidence, prognostic factors, and outcome of patients with AKI. We also assessed whether only urine output criteria of risk, injury, failure, loss, end (RIFLE) classification can be used to look at the outcome of AKI. Acute kidney injury (AKI) is a common clinical problem in the community and especially in critically ill patients and is associated with an increase in morbidity and mortality, reduction in glomerular filtration rate (GFR) over a short time period, is a common and severe complication in patients with cirrhosis and is often triggered by a precipitating event (i.e. overdose of diuretics, large-volume paracentesis...........

 

Keywords: Acute Kidney Injury(Aki) Haemodialysis(Hd) Incidence, Mortality

[1]. Eswarappa M, Gireesh MS, Ravi V, Kumar D, Dev G. Spectrum of acute kidney injury in critically ill patients: A single center study from South India. Indian J Nephrol. 2014;24(5):280-5
[2]. Prakash J, Singh TB, Ghosh B, Malhotra V, Rathore SS, Vohra R, et al. Changing epidemiology of community-acquired acute kidney injury in developing countries: Analysis of 2405 cases in 26 years from eastern India. Clin Kidney J. 2013;6:150–5

[3]. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, et al. Acute renal failure in critically ill patients. JAMA. 2005;294:813–8. doi: 10.1001/jama.294.7.813

[4]. Lombardi R, Yu L, Younes-Ibrahim M, Schor N, Burdmann EA. Epidemiology of acute kidney injury in Latin America. Semin Nephrol. 2008;28:320–9. doi: 10.1016/j.semnephrol.2008.04.001

[5]. Naicker S, Aboud O, Ghrbi MB. Epidemiology of acute kidney injury in Africa. Semin Nephrol. 2008;28:348–53. doi: 10.1016/j.semnephrol.2008.04.003

 

Paper Type

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Research Paper

Title

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Formulation and Evaluation of Floating Tablet of Pantoprazole Sodium

Country

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India

Authors

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Aiswarya Patnaik || Hara Prasad Patnaik

Page No.

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34-37

Paper Index
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XXXX

The Present research work focuses on the formulation and evaluation of Floating tablet of Pantoprazole sodium. Floating tablets were prepared by direct compression method. 40mg of Pantoprazole was taken in a single tablet of 250mg. Floating tablet of pantoprazole sodium increase the gastric residence time as well as bioavailability and thereby showed increased therapeutic efficacy. The addition of gel forming polymer (HPMC) and gas generating agent sodium bicarbonate and citric acid was essential to achieve In vitro buoyancy. Preformulation studies were conducted to select suitable excipient, Combination of different excipient was used to formulate pantoprazole floating tablets. The evaluation parameter such as Weight variation, Thickness, Hardness, Friability, disintegration time, In-vitro drug release studies was conducted. The results were within the limit and were compared with marketed formulation.

 

Keywords: Pantoprazole Sodium, Floating tablet, Gastric residence time, HPMC

[1]. S.P Vyas and R.K Khar, Controlled drug delivery, First edition, page no-(197-215).
[2]. Michel E.Aulton,Pharmaceutis, third edition, page-49.
[3]. Bhise SD and NH Aloorkar: Formulation and In vitro evaluation of floating capsules of Theophylline. Indian J Pharm Scien. 2008; 70(2): 88-93.
[4]. Dumpeti Janardhan, Meka Lingam, Chinnala Krishna Mohan and Vadlaboina Venkateshvarlu: Formulation and In vitro evaluation of gastro retentive drug delivery system for Ranitidine HCl. Int J. Pharm Scien and Nanotechnology. 2008; 1(3): 227-232.
[5]. Ferdous Khan, Mohammed Shaikhul Millat Ibn, Razzak, Mohammed Ziaur RahmanKhan, Kazi Rashidul Azam and Sams Mohammed Anowar Sadat: Preparation and in vitro evaluation of Theophylline loaded gastro retentive floating tablet of Methocel K4 M. Dhaka university J Pharm Scien. 20087(1): 184-189.

Paper Type

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Research Paper

Title

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Study of Combined Impact of Chlorella Vulgaris And Spirulina Platensis on Sub - Lethal & Lethal Concentrations of Copper & Zinc Toxicity on Labeo Rohita (Ham), Clarias Batrachus (Linn) And Channa Punctatus (Bloch).

Country

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India

Authors

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Avinash R.Nichat || S. A. Shaffi || V. K. Kakaria

Page No.

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44-49

Paper Index
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XXXX

The Chlorella vulgaris and Spirulina platensis influenced the sub-lethal & lethal effect of copper & zinc caused variations in brain compartmentation (cerebrum, diencephalons, cerebellum & medulla oblongata) of hexokinase in Labeo rohita, Clarias batrachus & Channa punctatus under acute or short term exposure. The sub-lethal and lethal levels of copper & zinc inhibited the hexokinase to a highest extent in diencephalon than in cerebrum, medulla oblongata & cerebellum in Labeo rohita in comparison to Clarias batrachus & Channa punctatus but lesser than the fall of the hexokinase enzymes in the above said fish species directly exposed to sub-lethal & lethal levels of copper & zinc directly without Chlorella vulgaris and Spirulina platensis compelled us to develop an insight to understand the positive impact on important bio-chemical parameters like enzymes.....

 

Keywords: Chlorella vulgaris , Spirulina platensis, Copper, Zinc hexokinase, Labeo rohita, Clarias batrachus , Channa punctatus

[1]. Aniko,K.P.,Ferenc,K.,Attila, F. & Timea, P. (2015). Biosorption characteristics of Spirulina & Chlorella cells for the accumulation of heavy metals. J. Serb. Chem.Soc. 80(3)407-419.
[2]. Ansari, M.N. & Bhandari, U. (2008). Protective effect of Emblica ribes (Burm.) on methionine induced hyperhomocysteinemia and oxidative stress in rat brain. Ind. J. Exp. Biol. 46(7) : 521-527.
[3]. Bano, M., Vyas, R., Bist ,R. & Bhatt ,D.K. (2007). Protective role of combination of certain antioxidants against lindane (y-HCH) induced olfactory dysfunction in mice. J. Cell & Tissue Res. 7 (3) : 26.
[4]. Bashiru, B.O. & Rosemary, I.E. (2007). Heavy metals (Lead, Cadmium, & Mercury) accumulation in the body tissue of Pachymelania aurita (Muller). Inter. J. Ecol. & Environ. Sci. 33(4) : 301-307.
[5]. Bert, V., Seuntjens, P., Dejonghe, W., Lacherez, S., Thi, H.T.T. & Vandecasteele, B. (2009). Phyto-remediation as a management option for contaminated sediments in tidal marshes, flood control areas and dredged sediment land fill sites. Environ. Sci. Poll. Res. 16(7) doi:10.1007/s11356-009-0205-6

Paper Type

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Research Paper

Title

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Simultaneous spectrophotometric determination of Levofloxacin and Azithromycin using π-acceptors as analytical reagents

Country

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India

Authors

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Sayanna || S. Vittal || T. Veeraiah || Ch. Venkata Ramana Reddy

Page No.

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50-61

Paper Index
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XXXX

Two sensitive and precise spectrophotometric methods have been developed for the simultaneous determination of levofloxacin and azithromycin in pure mixture and in pharmaceutical binary dosage forms. A new concept of area under curve (AUC) is proposed for simultaneous estimation of two drugs by these methods. Method A involves the use of DDQ (2,3-Dichloro-5,6-dicyano-1,4-benzoquinone) as analytical reagent and the AUC between 390nm and 690nm for DDQ was used for determination. Method B involves the use of p-CA (p-Chloranilic acid: 2,5-Dichloro-3,6-dihydroxy-1,4-benzoquinone) as an analytical reagent and the AUC between 400nm and 700nm for p-CA was used for determination. The methods developed and construction of calibration curves using two analytical reagents viz., DDQ and p-CA are described. Optical and analytical parameters for the individual and simultaneous determination of levofloxacin and azithromycin using AUC are tabulated. The methods have been validated and compared with HPLC methods in terms of standard deviation, t-test and F-test..

 

Keywords: Spectrophotometry, Simultaneous estimation, AUC, Levofloxacin, Azithrmycin, Azitech-Le tablet, DDQ, p-CA, CT Complex, Validation

[1]. Macor J E, Annual Report in Medicinal Chemistry, Vol 21. London: Academic Press, 2007; p331
[2]. Gomes G C, Salgado H R N, Validation of UV Spectrophotometric method for determination of lomefloxacin in pharmaceutical dosage form, Acta Farm. Bonaerense, 2005; 24 (3);24 (3):406-408.

[3]. El-Brashy A M, Metwally M E, El-Sepai FA, Spectrophotometric determination of some fluoroquinolone antibacterials through charge-transfer and ion-pair complexation reactions, Bulletinof the Korean Chemical Society, 2004;25(3):365-372.
[4]. Ross D L, Riley C M, Aqueous solubilities of some variously substituted quinolone antimicrobials, International Journal of Pharmaceutics, 1990;63:237–250.
[5]. Burhenne J, Ludwig M, Spiteller M, Chemosphere, Polar photodegradation products of quinolones determined by HPLC/MS/MS, Chemosphere,1999; 38:1279–1286.

Paper Type

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Research Paper

Title

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Evaluation of Cytotoxic and Mutagenic Activities of Tabebuia aurea (Silva Manso) Benth. & Hook. f. ex S. Moore

Country

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Brazil

Authors

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Claudia Perboni Lucas || Rafaela da Silva Oliveira || José Artur Nestor Neto || Rafael Binow Schmidt || Ely Eduardo Saranz Camargo || Jeferson de Oliveira Salvi || Francisco Carlos da Silva

Page No.

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62-69

Paper Index
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XXXX

With antimicrobial and antiseptic properties, Tabeuia aurea is used in folk medicine to treat pain, inflammation, and several conditions such as cancer, tuberculosis, malaria, stomach problems, influenza, nasal congestion, snake bites, and skin lesions. This study assessed the toxicological and mutagenic effects of methanolic and aqueous extracts of the bark of T. aurea. The microcrustacean Artemia salina was used as bioindicator in the cytotoxic analysis. Also, cytotoxicity and mutagenicity were investigated using the Allium cepa test. The methanolic extract had LD50 of 4608 μg/mL, while for the aqueous extract the LD50 value was 104656 μg/mL, indicating that they are atoxic. No extract induced significant changes in mitotic index in roots of Allium cepa. However, the methanolic.........

 

Keywords: Allium cepa, Artemia salina, Medicinal plants, Tabeuia aurea, Toxicity

[1]. L.M. Batista and A.M.G. Valença, A fitoterapia no âmbito da atenção básica no SUS: realidades e perspectivas, Pesquisa Brasileira em Odontopediatria Clínica Integrada, 129 (2), 2012, 293-296. [2]. F.C. Oliveira, U.P. Albuquerque, V.S. Fonseca-Kruel, and N. Hanazaki, Avanços nas pesquisas etnobotânicas no Brasil, Acta Botanica Brasilica, 23(1), 2009, 590-505.

[3]. P.V. Santos and R. Sebastiani, Plantas medicinais utilizadas por uma comunidade universitária no Município de São Paulo, SP. 2011.

[4]. M.M. Robinson and X. Zhang, The world medicines situation traditional medicines: Global situation, issues and challenges (Geneva: World Health Organization, 2011).

[5]. W. Schmitz, A.Y. Saito, D. Estevão, and H.O. Saridakis, Green tea as a chemoprotector, Semina: Ciências Biológicas e da Saúde, 26(2), 2005, 119-130.

Paper Type

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Research Paper

Title

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In Vitro: Inhibitory Effects of Three Traditional and Medicinal Plants On Some Human Pathogenic Bacteria

Country

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Egypt

Authors

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Hameda E. A. El Sayed || Nazeha S. A. Fallatah || Samyah D. Jastaniah || Magda M. Aly

Page No.

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70-76

Paper Index
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XXXX

The misuse of antibiotics leads to the spread of resistant bacteria, which cause serious health problems. The search for new antibiotics is urgent. Secondary products of different plants showed inhibitory effects to different bacterial pathogens. All the tested bacteria were from the reference strains. Abutilon pannosum, Salvadora persica and Matricaria chamomilla were collected and extracted with either water or methanol. Their antimicrobial activities were determined using agar well diffusion method and compared to control. The water extracts and the methanol extracts of the tested plant materials were the most active compared to the ethanol extracts. No Activity or very weak activities were recorded for petroleum ether, diethyl ether, acetone and benzene. Water..........

 

Keywords: Medicinal plants; Abutilon pannosum; Salvadora persica; Matricaria chamomilla; Bacterial pathogens, MIC.

[1]. Akiyama, H.; Kazuyas, F.; Yamasaki, O.; Oono, T.; Iwatsuki, K. (2001): Antibacterial action of several tannins against Staphylococcus aureus. Journal Antimicrob. Chemother., 48:487-491.
[2]. Aly, M. M. and Gumgumjee, N. M. (2011): Antimicrobial efficacy of Rheum palmatum, Curcuma longa and Alpinia officinarum extracts against some pathogenic microorganisms. African Journal Biotechnology, 10 (56); 12058-12063.
[3]. Arulsamy, E. P.; Boovizhikannan, T.; Arunkanth, C.; Satchidanandam, S. K.; Murugesan, K.; Ramadoss, K. (2009): Antibacterial activity of various extracts of Abutilon indicum (L.) sweet leaves. Journal Pharm. Res. 2(8):1324-1325.
[4]. Bagi, M. K.; Kalyani, G. A.; Denis, T. J.; Kumar, K. A.; Kakrani, H. K. (1985): A preliminary pharmacological screening of Abutilon indicum: II Analgesic activity. Fitoterapia 56:169-171.

[5]. Chand, S.; Lusunzi, I.; Veal, D.A.L.; Williams, R.; Karuso, P. (1994): Rapid Screening of the Antimicrobial Activity of Extracts and Natural Products. Journal of Antibiotics, 47, 1295-1304