Volume 9 ~ Issue 2 ~ Series-1 [ February - 2019]


Paper Type

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Research Paper

Title

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METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF TAMSULOSIN IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UPLC

Country

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India

Authors

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P. Sirisha || G. Ashwini || V. Mohan Goud || JVC Sharma || Ch. B. Praveena Devi ||
Linga Kumara Swamy

Page No.

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01-07

Paper Index
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XXXX

A simple, Précised, Accurate method was developed for the estimation of Tamsulosin by RP-UPLC technique. Chromatographic conditions used are stationary phase Hibra C18 100mm x 1.8 mm, 2.6.,Mobile phase0.01N KH2PO4 (3.2 pH): Acetonitrile in the ratio of 60:40 and flow rate was maintained at 0.3ml/min, detection wave length was 224nm, column temperature was set to 30oC. System suitability parameters were studied by injecting the standard six times and results were well under the acceptance criteria. Linearity study was carried out between25% to150 % levels, R2 value was found to be as 0.999. Precision was found to be 0.6 for repeatability and 0.4 for intermediate precision.LOD and LOQ are 0.039μg/ml and 0.120μg/ml respectively. By using above method assay of marketed formulation was carried out 100.23% was present. Degradation studies of Tamsulosin were done, in all conditions purity threshold was more than purity angle and within the acceptable range..

 

Keywords: UPLC, Tamsulosin, Method development, ICH Guidelines,

[1]. "Tamsulosin Hydrochloride Monograph for Professionals". Drugs.com. AHFS. Retrieved 24 December 2018.
[2]. R.C. Wang, Smith-Bindman, R, Whitaker, E, Neilson, J, Allen, IE,Stoller, ML,Fahimi, J . "Effect of Tamsulosin on Stone Passage for Ureteral Stones,A Systematic Review and Meta-analysis". Annals of Emergency Medicine. doi,10.1016/j.annemergmed.2016.06.044. PMID 27616037.7 September 2016
[3]. British national formulary ,BNF 76. Pharmaceutical Press. ISBN 9780857113382. 2018. p. 767
[4]. Hutchison, C.Lisa, Sleeper, B.Rebecca. Fundamentals of Geriatric Pharmacotherapy,An Evidence-Based Approach. ASHP. ISBN 9781585283057.2010, p. 209.
[5]. "NADAC as of 2018-12-19". Center for Medicare and Medicaid Services. Retrieved 22 December 2018..

 

Paper Type

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Research Paper

Title

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Study of importante thno medicinal plants in sacredgroves of bhoramdev wildlife sanctuary of kabirdham district

Country

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India

Authors

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Krishna Chandra Yadav || Ashish Saraf || Ashis Kumar Sarkar

Page No.

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08-16

Paper Index
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XXXX

Culturally protected forest patches or sacred groves have been the integral part of many traditional societies. Sacred groves of Kabirdham like in other places, are forests patches conserved by the local community intertwined with their socio-cultural and religious practices. These groves harbour biodiversity and play a significant role in the conservation of biodiversity. The Bhoramdev Wildlife Sanctuary is located at a distance of 16 kms from Kawardha town,it is named after the famous 11th century Bhoramdeo Temple. Its total area is 351.24 sq. kms.There are 14 sacred groves inside the WL sanctuary which are very rich repository for ethno medicinal plants require detailed investigation............

 

Keywords: Sacred groves, Wildlife sanctuary, Herbal resource, eheno-medicinal resource Biodiversity conservation,

[1]. D. Brandis, Indigenous Indian Forestry: sacred Groves in Indian Forestry, Working Oriental Institute, UK., 1987, 12-13. [2]. H.G. Champion and S.K. Seth, Revised survey of forest types of India. Government of India Press, Delhi, India, 1968, 117.
[3]. K. Subramanyam, Management:Sacred Groves as CPR of Bastar Region and its Socio-economic and Politico-legal Significance in the Tribal Life: An Indigenous Perspective doctoral diss., Pt.Sundarlal Sharma (Open) University, Chhattisgarh, Bilaspur, 2003.
[4]. K.C. Yadav, Management Plan of Bhoramdev Wildlife Sanctuary Kabirdham Dist., Government of Chhattisgarh Publication, 2003a.
[5]. K.C. Yadav, Working Plan of Kawardha Forest Division, Forest Department, C.G., 2003b.

 

Paper Type

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Research Paper

Title

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A Review on Herbal Plants Having Antiinflammatory Activity

Country

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India

Authors

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Chaturvedi Mohit || Patel Rakesh || Saraswat Rohit

Page No.

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17-22

Paper Index
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XXXX

Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. It is characterized by redness, swollen joints, joint pain, its stiffness and loss of joint function. Inflammation is currently treated by NSAIDs. Herbal plants play a vital role in drug discovery. Herbal plants are very useful for human to cure various ailments. In the present article, an attempt has been made to investigate the anti-inflammatory activity of some herbal plants.

[1]. Burke, A. et al. (2010). Analgesic antipyretic agents; pharmacotherapy of gout. Brunton, L. B., Lazo, J. S. & Parker, K. L. (Ed.) Goodman & Gilman's the Pharmacological Basis of Therapeutics, New York: McGraw-Hill. 671-715.
[2]. Medzhitov, R. (2010). Inflammation: New Adventures of an Old Flame. Cell. 140: 771–776.
[3]. Dinarello, C. (2010). Anti-inflammatory Agents: Present and Future. Cell. 140: 935–950.
[4]. Pilotto, A. et al. (2010). Nonsteroidal anti-inflammatory drug use in the elderly. Surgical Oncology. 19: 167-172.
[5]. Nadkarhi, A. K. (2000). Indian Material Medica. Popular Press BL dg.

 

Paper Type

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Research Paper

Title

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Decrypting the Outbreak of Nipah Virus in Kerala

Country

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India

Authors

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Raghuram.Janagam || Nagaraja.Jarugula || Dr.M.Prasadrao || Akrambaig.Moghal

Page No.

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23-27

Paper Index
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XXXX

Nipah virus, microscopically called as Paramyxovirus had been retrospectively investigated as the probable etiologic agent for an outbreak of causing Acute Encephalitis in Kerala , as it recently re-emerged , but there is no evidence of suggesting that it has been transmitted by fruit bats as suspected initially . It is a highly contagious disease which exacerbates on time as it was mis-diagnoised with typical encephalitis which is caused by Japanese encephalitis virus, Herpes simplex virus, leptospire bacteria primarily targets CNS. In Kerala, at Kozhikode's Baby Memorial hospital a patient was suspected with encephalitis and is samples were examined by the concerned doctors at Manipal center of Virus............

 

Keywords: Nipah virus, Encephalitis, misdiagnoised, Ribavirin, catastrophic.

[1]. Centers for Disease Control and Prevention: Outbreak of Hendra-likevirus–Malaysia and Singapore, 1998–1999. MMWR Morb Mortal WklyRep 1999, 48:265–269
[2]. K.B. Chua, K.J. Goh, K.T. Wong, A. Kamarulzaman, P.S.K. Tan, T.G. Ksiazek, S.R. Zaki, G. Paul, S.K. Lam, C.T. Tan, Fatal encephalitis due to Nipah virus among pig farmers in Malaysia, Lancet 354 (1999) 1257–1259.
[3]. CDC, Update: outbreak of Nipah virus – Malaysia and Singapore, MMWR-Morb. Mortal. Wkly. Rep. 48 (1999b) 335–337.
[4]. K.B. Chua, W.J. Bellini, P.A. Rota, B.H. Harcourt, A. Tamin, S.K. Lam, T.G. Ksiazek, P.E. Rollin, S.R. Zaki, W.J. Shieh, C.S. Goldsmith, D.J. Gubler, J.T. Roehrig, E. Eaton, A.R. Gould, J. Olson, H. Field, P. Daniels, A.E. Ling, C.J. Peters, L.J. Anderson, B.W.J. Mahy, Nipah virus: a recently emergent deadly paramyxovirus, Science 288 (2000) 1432–1435.

 

Paper Type

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Research Paper

Title

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Study of Renal Function Test in Patients of Acute Haemorrhagic Stroke

Country

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India

Authors

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Dr Parimal sarkar || Dr Bidhan Ghoswami

Page No.

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28-30

Paper Index
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XXXX

Stroke is a major cause of mortality and morbidity world wide . It is the 2nd commonest cause of death and one of the most important cause of disability (strong 2007). Acute haemorrhagic stroke is the largest killer apart from Ischaemic stroke.Cases of haemorrhagic stroke frequently presents as a sudden loss of consciousness, vomiting , convulsion and Hemiplegia. Hypertension has been observed as one of the commonest association of sroke. But in many cases BP may be low or normal Vascular malformation, aneurysms and various types of angiopathies may be associated with stroke mainly sub- arachnoid haemorrhage . Early stroke survivors has been followed and investigation showed raised serum creatinine concentration in them (Friedman et al).When followed for a period of 18 months it was observed that mortality was higher in patients who had higher serum creatinine concentration.

[1]. Aaron S.Intra-arterial thrombolysis in acute ischemic stroke .Neutol India 2010; 58:504-5
[2]. AHA/ASA Guidelines on prevention of Recurrent Stroke-MARA LAMBRET:STROKE; 2011: Apr15;83(8):993-1001.
[3]. Aly.zarmeneh.et al. Awareness of stroke , risk factor , signs and treatment in a Pakistani population . Journal of Pakistan medical association.2009; 59(7):495-499.
[4]. Beena T , Malathi , Navaneetha M.Risk status of stroke among adults and the effectives of an awareness program on primary preventation of stroke . International journal of nursing 2011 3(2):12-14.
[5]. Circulation . 2013;127:e6-e245 .) Heart Disease and stroke Statistics-2013 Update - A Report from the American heart Association.

 

Paper Type

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Research Paper

Title

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Comparative Study of The Physicochemical Properties And Dissolution Profiles of Some Brands of Acetylsalicylic Acid Tablets Marketed In Benin City, Edo State, Nigeria

Country

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Nigeria

Authors

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Obarisiagbon Aiwaguorejohnbull || Egbunuhauwa Kulu || Umoru Albert

Page No.

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31-36

Paper Index
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XXXX

In this study, effort was made to assess the quality of some commercially available brands of Acetylsalicylic acid 300 mg tablets dispense in Benin City. Acetylsalicylic acid (ASA) tablet is one of the safest and most affordable over the counter (OTC) drug globally. It is used in the treatment of general pain, fever, and also to relieve mild to moderate pain from conditions such as muscle aches, toothaches, common cold and headache. Different parameters of quality control of pharmaceutical product that can guarantee the quality, bioavailability and optimal therapeutic activities were studied............

[1]. James Beckerman (2018). Should you take Aspirin for Heart Disease? – A Review. Web MD Medical Reference. Web MD, LLC.
[2]. John A. Avbunudiogba, Omonyemen E. Cash-Torunarigha and IkechukwuOnah (2013). Effect of Humidity on the Physical Properties of Aspirin Tablets Produced by Melt Granulation and Slugging Methods. Journal of Pharmacy and Biological Sciences, 7(5): 20 – 25.
[3]. X. Garcia-Albeniz and AT Chan (2011). Aspirin for the prevention of Colorectal Cancer. Best Pract Res ClinGastroenterol, 25(0): 461 – 472.
[4]. Feghaly J, Al Hout AR, MerciecaBalbi M (2017). Aspirin safety in patients with acute coronary syndrome undergoing percutaneous coronary intervention. BMJ Case Rep. pii: bcr-2017-220483. Doi: 10. 1136/bcr-2017-220483.
[5]. Yuging Zhang, TuhinaNeogi, Clara Chen, Christine Chaisson, David J. Hunter and Hyon Choi (2014). Low –dose aspirin use and recurrent gout attacks. Ann Rheum Dis. 73(2): 385 – 390.

 

Paper Type

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Research Paper

Title

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Quantitative Estimation Of Total Phenolic Content And Total Flavonoid Content Of Yellow And Green Citrus Limon Peel Extracts

Country

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India

Authors

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Nidhi Chauhan || Dr. Jyoti Saxena

Page No.

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37-42

Paper Index
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XXXX

The lemon peel is known for its wider aspect in medico-pharmacology. The production of citrus juice leads to a large quantity of peel and seeds waste which possess high contents of bioactive components. These contents can be developed into useful and potential products after their value addition and may be useful as health enhancing drugs. The present study aims to estimate quantitatively the total phenolic and flavonoid content in different peel extracts of yellow and green Citrus limon. The extracts were investigated for the presence of phytochemicals and then analyzed for TPC and TFC using gallic acid and rutin as reference standard. The highest TFC was reported in ethyl acetate peel extracts............

 

Keywords: Citrus limon,peel extracts, antioxidant potential, total phenolic content, total flavonoid content.

[1]. Y.J. Zhang, R.Y. Gan, S. Li, Y. Zhou, A.N. Li, D.P. Xu, Antioxidant phytochemicals for the prevention and treatment of chronic diseases, Molecules, 20, 2015, 21138-56.
[2]. H.J. Doughari, Phytochemicals: Extraction methods, basic structures and mode of action as potential chemotherapeutic agents, Phytochemicals - A Global Perspective of Their Role in Nutrition and Health. Rijeka, Croatia: Intech, 2012, 1-33.
[3]. I. Morel, G. Lescoat, P. Cogrel, O. Sergent, N. Pasdecoup, P. Bcissot, P. Cillard, J. Cillard, Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat heptaocyte cultures, Biochemical Pharmacology, 1, 1993, 13-19.
[4]. P.G. Pietta, Flavonoids as antioxidants, J Nat Prod, 63(7), 2000, 1035-42.

 

Paper Type

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Research Paper

Title

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A Study on Prevalence and Management of Polycystic Ovarian Syndrome in a Tertiary Care Hospital

Country

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India

Authors

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Dr. Asok kumar. K || Dr.Lalitha || Larissa Carola Bamurange || Shakkithevelu.P || Sherif Musa Osman Idriss || Umadevi . H

Page No.

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43-49

Paper Index
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XXXX

Background: Polycystic ovarian syndrome (PCOS) is the most prevalent endocrine disorder affecting females. Various factors such as heterogeneous disorder characterized by ovulatory dysfunction, hyperandrogenism, genetic factors and polycystic ovarian morphology. The potential complications of PCOS include obesity exacerbates and co morbidities of PCOS such as hypertension, diabetes, hypercholesterolemia, and heart disease. Objective: To estimate the prevalence of PCOS with anthropometric measures and hormonal levels were analysed statistically. To study the prescribing pattern and appropriateness of medications utilised, then diet and co-morbid conditions were screened.............

 

Keywords: Polycystic ovarian disease, anthropometric measures, hormonal levels, oral contraceptives, dietary and lifestyle modifications.

[1]. VG Padubidiri, Shirish N Daftar. Howkins and bourne shaw's textbook of gynecology. Reed Elsevier India private limited, India , Sixteen edition,2015,433.
[2]. Elmenim SOA and Emam AMM., Effect of lifestyle changes on symptoms of polycystic ovarian syndrome in obese girls. IOSR Journal of Nursing and Health Science,5(3), 2016,1-10.
[3]. Barbara .H. O. Schoge , Karen D Bradshaw, Lisa M. Halvorson , Joseph I. Schaffer, Marlene M.Corton. Williams gynaecology. Mc-graw hill education, USA, Third edition, 2016 ,386-400.
[4]. Ricardo Azziz. The polycystic ovary syndrome: current concepts on pathogenesis and clinical care, Springer Science and Business Media, New York,2007,1-11.
[5]. DC Dutta . Dc dutta's Textbook of gynaecology, Jaypee Brothers Medical Publishers Private limited ,sixth edition, Nov 2013,459-472.

 

Paper Type

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Research Paper

Title

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Antibacterial potential of Tridex procumbensL.against Human pathogen

Country

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India

Authors

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Doli J. Jain || Suchita K. Rajurkar

Page No.

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50-53

Paper Index
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XXXX

Plants and its parts are rich source of bioactive molecule which offers a new source of antibacterial agent.In recent years Tridex procumbens plants have been reported Antibacterial activity of the methanol, chloroform, ethanol, & aqueou extract (Suryakantet.al.2017).Tridexprocumbensis medicinal herb and used by many ethano-medical practitioners, In India Tridex procumbens is employed as indigenous medicine. It has been found to possess significant medicinal properties against Dysentery ,Diarrhoea, Stomach ache and Liver disorder. It also shows Antidiabetic and anti-inflammatory actions. (Jain 2012).Tridex procumbens plant is found all over India .belonging to family-Asteraceae. It is commonly knowncoat button.It has been extensively used in Indian traditional medicinal system.

[1]. Shahnawaz Ahmad Mir, Zubair JanShafia MirAyazMahmood Darand GouriChitale ( 2017)A Concise Review on Biological Activity of Tridaxprocumbens Linn . Organic chemistry current research.
[2]. Ankita Jain , DV Rao , AmlaBatra and Amita Jain (2012),Study on antibacterial potential of Tridex procumbens (L.) against clinical isolates.
[3]. Sheeraz Ahmad Suryakant, Dr. SudhanshuDharDwivedi( 2008), Antibacterial Activity of Extract Obtained from TridexProcumbensagainst Different Pathogenic Bacteria ,Ethnobotanical Leaflets,Vol- 12, pp.1090-1095.
[4]. R. Dhanabalan, A. Doss, M. Jagadeeswari, S. Balachandar, E. Kezia, V. Parivuguna,C.M. Reena Josephine, R. Vaidheki and K. Kalamani ( 2008)Ethnobotanical Leaflets 12: 1090-95. 2008.In vitro Phytochemical Screening and Antibacterial Activity of Aqueous andMethanolic Leaf Extracts of Tridexprocumbensagainst Bovine Mastitis Isolated Staphylococcus aureus.

 

Paper Type

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Research Paper

Title

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A Review: Liquid Chromatography-Nuclear Magnetic Resonance Spectroscopy (LC-NMR) and Its Applications

Country

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India

Authors

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Dr. K. Bhavyasri || K.Sindhu || Dr. D.Rambabu

Page No.

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54-62

Paper Index
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XXXX

The hyphenated technique is developed from the coupling of a separation technique an on-line spectroscopic detection technology. Mainly chromatographic techniques are combined with spectroscopic techniques. Then the separated components of the mixture from chromatographic technique will enter into the spectroscopic technique through an interphase .The remarkable improvements in hyphenated analytical methods over the last two decades have significantly broadened their applications in the analysis of biomaterials, especially natural products.LC-NMR is the hyphenated technique in which HPLC is combined with the NMR. This technique is widely used for the analysis of complex mixtures which contain unknown impurities, natural products and synthetic polymers. In LC-NMR LC does the separation and NMR does the identification of separated components.

 

Keywords: Hyphenated technique, LC-NMR, LC-NMR Coupling ,Separation technique.

[1]. Ahuja S, Michael D, Handbook of pharmaceutical analysis by LC, separation Science and Technology, Sixth edition, 2005, 1-15.
[2]. Albert K, On-line LC-NMR and Related Techniques. John Wiley & Sons Ltd, First edition 2002, 1-20.
[3]. Pasch H, Heinz LC, Macko T, Hiller W, Pure and Applied Chemistry, 80, 2008, 1747.
[4]. Albert K, Dachtler M, Strohschein, Tseng S, On Line Coupling of separation Techniques to NMR, Journal of High Resolution Chromatography, 22, 1999, 135-143.
[5]. Phalke P, Kavade S, Review on Hyphenated Techniques, International Journal of Chemical Studies, 1, 2013, 160.

 

Paper Type

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Research Paper

Title

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Clinical Evaluation of Mizaj (Temperament) of the Patients of Zeequn Nafas (Bronchial Asthma)

Country

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India

Authors

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Nida Sultana || Dr. M.Y. Siddiqui || Dr. M.Mohsin

Page No.

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63-67

Paper Index
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XXXX

Aims and objectives : To know the incidence of Zeequn Nafas (Bronchial Asthma) in the patients of different temperaments at Ajmal khan Tibbiya College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh. Methodology : The study was conducted on the outdoor patients who attended the Moalajat and modern medicine OPD of Ajmal Khan Tibbiya College, Aligarh Muslim University, Aligarh, with the shortness of breath due to Bronchial Asthma during 2013-2015. Sixty (60) individuals of both the sexes were included in the study between the ages of 15 to 60 years. The eligible individuals were selected randomly on the basis of clinical symptoms, examinations and who were taking bronchodilator drugs. Then their temperaments were assessed by the pre-structured proforma based on Ajnas-e-Ashra. Lastly on the basis of total score of Ajnas-e-Ashra (10 determinants), a particular Mizaj was assigned to the patient............

 

Keywords: Zeequn Nafas, Bronchial Asthma, Mizaj, Ajnas-e-Ashra.

[1]. Freed R, Anderson S D and Wyndham J (2002).The use of bronchial provocation tests for identifying asthma, A review of the problems for occupational assessment and a proposal for a new direction, ADF Health; Vol.3, pp. 77-85.

[2]. Marketos SG, Ballas CN (1982).Bronchial asthma in the medical literature of Greek antiquity. J Asthma. , Vol.19 (4), pp.263-9.
[3]. David L Duffy (1997). Asthma and allergic diseases in Australian twins and their families, Department of Medicine, University of Queensland, pp. 32.
[4]. Longo et al (2012). Harrison's Principles of internal medicine, Eighteenth Edition, The McGraw-Hill Companies, pp.4274-4285,3607,3586,2102-2115.
[5]. Masoli et al (2004) .The global burden of asthma: executive summary of the GINA Dissemination Committee Report, Allergy, Vol.59, pp.469–478.