September - 2019 (Volume-9 ~ Issue-9 ~ Series-2)

Paper Type

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Research Paper

Title

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A Prospective Study on Assessment of Risk Factors and Effect of Counselling In Parents of Children with Febrile Seizure

Country

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India

Authors

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Nithika Chacko || Anjaly S Kumar || Renjith Raj S.A || Manuja V.S || Neethu .J

Page No.

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01-09

A febrile seizure, also known as a febrile fit or febrile convulsion, is a seizure associated with a high body temperature but without any serious underlying health issue.This study aimed at identifying the possible risk factors of Febrile Seizure and assessing the knowledge, attitude and practice of parents having children with FS and the impact of parental counselling on KAP. The data were collected and recorded in specially designed pro forma. The impact of patient counselling on quality of life was assessed using a knowledge, attitude and practice questionnaire. Information was provided through patient information leaflet. A total of 134 Patients with febrile seizure are selected for the study. Based on this study ,the majority of age group belongs to less than 3years(87%) with a positive..............

 

Key Words: Febrile seizure [FS], KAP questionnaire, Patient information leaflet.

[1]. Sajun Chung MD. Febrile Seizures. Korean Journal of Pediatrics. 2014; 9 (57): 384–95.
[2]. Indar Kumar Sharawat, Jitendar Singh, Lesa Dawman and Amitabh Singh. Evaluation of Risk Factors Associated with First Episode Febrile Seizure. Journal of Clinical and Diagnostic Research. 2016; 10(5): 10–13.
[3]. Alireza Eskandarifar, Asadolah Fatolahpor, Gamileh Asadi, Ibrahim Gader. The Risk Factors in Children with Simple and Complex Febrile Seizures: An Epidemiological Study. InternationalJournal of Pediatrics. 2017; 5(6): 5137-44.
[4]. Mongens Vestergaard, Olga Basso, Tine Brink Henriksen, John R Ostergaard and Jorn Olsen. Risk factors for Febrile Convulsion. Journal of Epidemiology. 2002; 30(3): 282-87.
[5]. Parisa.R, Maryam.S and Reyhaneh.M. Assement of causative factors of febrile seizure related to a group of children in Iran.Journal of biomedical research. 2017; 28(4): 1548-52.

 

Paper Type

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Research Paper

Title

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Zidovudine Induced Anaemia in Perinatally Transmitted HIV Patient: A Case Report

Country

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India

Authors

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HimaBindu P || Dr H N Girish || Raksha M A || Inayathulla K || Dr VarunLal

Page No.

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10-12

The main of the study is to report the occurrence of drug related problem in order to prevent its recurrence. A 15years old male patient presented with complaints of loose stools, fever and decreased appetite since 15 days, fatigability and generalized body achesince 10days. Patient is known case of HIV that is transmitted perinatally from mother to child since 15years and taking Lamivudine 150mg, Nevirapine 200mg and Zidovudine 300mg o.d. since last 15years. He was having pallor and his haemoglobin level is 3.6g/dLi.e. the patient is severely anaemic. He was treated with 1 pint Packed red blood cells transfusion IV o.d., Tab. Ferrous fumarate + folic acid 325mg +1500mcg PO b.i.d., Tab. B ComplexPO o.d., Inj. Vit B1, B6, B12 1ampule IV o.d., Tab. Paracetamol 500mg PO t.i.d for 5days. During this treatment Antiretroviral treatment was on hold.

 

Key Words: Zidovudine(AZT), Human Immunodeficiency Virus (HIV), Anaemia.

[1]. Purushothama Reddy K, Rajesh Asija, Purushothamam M, ArshiyaBanu S. Detecting Adverse Drug Reaction in Hopitalized HIV/AIDS Patients Using Highly Active Antiretroviral Therapy (HAART). International Journal of Pharmacy & Therapeutics, 2018; vol 9(3): 88-97.
[2]. Ejeliogu E U, Oguche S, Ebonyi A O, Okpe S E, Yiltok E S, Lge O and et al. Zidovudine Induced Anaemia in Human Immunodeficiency Virus Infected Children on High Active Anti-Retroviral Therapy in Jos, Nigeria. Journal of advances in medical and pharmaceutical science, 2014; vol 1(1): 1-10.
[3]. Dash K R, Meher L K, Hui P k, Behera S K, Nayak S N. High Incidence of Zidovudine Induced Anaemia in HIV Infected Patients in Southern Odisha, India J HematolTransfus, 2015; vol 31(2): 247-250.
[4]. Wubetu M and Mebratu E. Assessment of the Prevalence of Zidovudine Induced Anaemia among Adult HIV/AIDS Patients on HAART in an Ethiopian Hospital, Occupational Medical & Health Affairs2018,vol 6 (1)1-5
[5]. Agarwal D, Jaya C, Chube L Rai M Agarwal N R, Sundar S.High Incidence of Zidovudine Induced anaemia in HIV Infected Patients In Eastern India.Indian J Med Res132 oct2010.

 

Paper Type

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Research Paper

Title

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Growth and Development Effects Following In Utero Exposure to Varied Doses of Enarapril in Albino Rats (Rattus Norvegicus)

Country

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Kenya

Authors

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Macharia Peris || Kweri Joseph || Thuo Reuben || Kafaya George

Page No.

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13-17

In utero exposure to Enarapril; a widely prescribed antihypertensive due to its success as a monotherapy, cost effectiveness, relative paucity of side effects, bone, cardio and nephron protective effects in comparison tostandard therapy for equal level of blood pressure control has been associated with foetal deleterious effects. These include renal failure, intrauterine growth retardation, hypocalvaria, persistent patent ductus arteriosus and cerebral complications. It blocks Foetal renin- angiotensin- system that comes to play during the second and third trimesters of pregnancy documenting it safe during first trimester. In contrast, other studies reports major deleterious effects during the first trimester including cardiovascular, nervous, and renal and limb defects effects yielding conflicting report on the most critical periods..............

[1]. Bullo M, Tschumi S, Bucher BS, Bianchetti MG, Simonetti GD. Pregnancy outcome following exposure to angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists: A systematic review. Hypertension. 2012;60(2):444-450. doi:10.1161/HYPERTENSIONAHA.112.196352.
[2]. Lewis EJ, Hunsicker LG, Bain RP R, RD. The effect of angiotensin–converting- enzyme inhibition on diabetic nephropa- thy. N Engl J Med 1993;329:1456-62. [Erra- tum NEJM 1993;330:152. . No Title.
[3]. 1., Lonn EM, Yusuf S, Jha P et al. E-, 1994;90:2056-69. ing role of angiotensin-converting enzyme inhibitors in cardiac and vascular protec-tion. C. No Title.
[4]. Turan İ, Bayar A, Turan A, Gülle K, Akpolat M, Turhan E. The Effects of the Angiotensin Converting Enzyme Inhibitor Enalapril and the Angiotensin II Type 1 Receptor Blocker Losartan on Fracture Healing in Rats. Clin Investig Med. 2017;38(4):164. doi:10.25011/cim.v38i4.24261.
[5]. Bullo M, Tschumi S, Bucher BS, Bianchetti MG, Simonetti GD. Pregnancy Outcome Following Exposure to Angiotensin-Converting Enzyme Inhibitors or Angiotensin. 2012. doi:10.1161/HYPERTENSIONAHA.112.196352.

 

Paper Type

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Research Paper

Title

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A Review on Steven Johnsons Syndrome: Hypersensitivity Reaction

Country

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India

Authors

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Gotte Priyanka || Jagiri Aishwarya Goud || Varagandhi Susmitha || Kadarla Rohith Kumar

Page No.

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18-38

Stevens-Johnson syndrome (SJS) is a rare immune-complex–mediated type-IV hypersensitivity reaction that primarily affects the skin and the mucous membranes leading to cell death or cell apoptosis. The etiology of this disorder is multiple, including drugs in almost 75% of cases, infectious agents, genetic predisposition and idiopathic causes account for 25% of cases. It is characterized by skin and mucous membrane reactions potentially fatal result from hypersensitivity to precipitating factors, such as infections by viruses, fungi, bacteria, diseases of the connective tissue, malignant neoplasms, multiple vaccines and medicines. Stevens-Johnson syndrome is a form of a life –threatening skin conditions, in which cell death causes the epidermis to separate from the dermis. This syndrome is thought to be a hypersensitivity complex that affects the skin and the mucous membranes..............

 

Key Words: Steven Johnson syndrome,type-IV hypersensitivity,malignant neoplasms.

[1]. FUCHS, et al. Clinical Pharmacology. Publisher. Rio de Janeiro. Guanabara Koogan. 2008.
[2]. NOGUEIRA, a. quality of life of patients with Stevens-Johnson Syndrome. ARQ Bras Ophthalmolo 2003;66:67-70.
[3]. Brazil. The national health surveillance agency. Federal Alerts. Federal Alerts. SNVS alert/Anvisa/Ufarm nº5, October 1, 2004 Vioxx ® removed from world market for heart risks, available at:http://www.anvisa.gov.br/farmacovigilancia/alerta/federal/2004/federal_5_04.htm >: Access 4/10/2011.
[4]. GARCIA, j. b. s. Serious skin reaction Induced by Carbamazepine on post herpetic Neuralgia treatment. Case report. Brazilian Journal of Anesthesiology. Vol. 60, no. 4, July/ago, 2010.
[5]. ANVISA, Drug Surveillance. Available at: www.anvisa.gov.br/farmacovigilancia/index.htm. Access in:4/10/2011.