Background: Heart failure is a clinical syndrome where the heart is not pumping enough blood when compared to normal circumstances. We aimed to ascertain the health-related quality of life among heart failure patients. Secondly, we wished to assess the knowledge, assessment, and practice of heart failure patients. Aim: In this study, we assessed the Health-Related Quality of Life in Heart Failure patients. Materials and methods: In this prospective study conducted 49 Heart Failure were included. Data collected were coded in SPSS software for statistical analysis. The correlation between KAP and HRQOL was assessed with Pearson correlation. A P - Value of 0f < 0.05 was considered statistically significant.........

KEYWORDS: Heart failure, Health-related quality of life, Knowledge, attitude, practice.

[1]. Baman Jr, Ahamad Fs, Heart Failure. Jama. 2020;324(10): 1015.Doi:10.1001/Jama.2020.13310.
[2]. Ponikowski P, Et.Al, Esc Scientific Document Group. 2016 Esc Guidelines For The Diagnosis And Treatment Of Acute And Chronic Heart Failure: The Task Force For The Diagnosis And Treatment Of Acute And Chronic Heart Failure Of The European Society Of Cardiology (Esc)Developed With The Special Contribution Of The Heart Failure Association (Hfa) Of The Esc. Eur Heart J. 2016 Jul 14;37(27):2129-2200. [3]. Gianluigi Savarese Et Al, Global Burden Of Heart Failure: A Comprehensive And Updated Review Of Epidemiology, Cardiovascular Research, Volume 118, Issue 17, December 2022, Pages 3272–3287.
[4]. Andrew. P Et.Al The Global Health And Economic Burden Of Hospitalizations For Heart Failure: Lessons Learned From Hospitalized Heart Failure Registries, Journal Of The American College Of Cardiology, Volume 63, Issue 12, 2014, Pages 1123-1133, Issn 0735-1097, Available From: Https://Doi.Org/10.1016/J.Jacc.2013.11.053. [5]. Coelho R, Ramos S, Prata J, Bettencourt P, Ferreira A Et Al. Heart Failure And Health Related Quality Of Life. Clin Pract Epidemiol Ment Health. 2005 Oct 4;1:19. Doi: 10.1186/1745-0179-1-19. Pmid: 16202163; Pmcid: Pmc1274338.

Background: Traditional medicine constitutes for Africa in general and for Niger in particular a cultural and economic heritage of undeniable importance. However, the development of this heritage poses a certain number of problems, one of the most important of which remains the distrust of healers in sharing their often initiatory knowledge. Thus, it is important to conduct an ethnobotanical study to keep the medicinal secrets of plants in writing. Materials and Methods: An ethnobotanical survey was carried out, using a pre-established questionnaire addressed to traditional practitioners according to their availability through direct and individual interviews. For this, the technique of semi-structured open interviews is used to collect information.........

KEYWORDS: Medicinal plants, Niger, Traditional medicine, Antihelminthic, gastrointestinal

[1]. Ake Assi L., 1983. Santé et valorisation des plantes médicinales en Cóte d'Ivoire. Bothalia. 14. 3 & 4 : 603-605.
[2]. Barmo S., 2008. Analyse socio-économique de l'exploitation des ressources végétales de la Reserve Totale de Faune de Tamou (RTFT)-Niger. Mémoire de DEA. Biologie. Faculté des Sciences et Techniques. Université Abdou Moumouni de Niamey. 67p.
[3]. Benkhnigue. O., Zidane, L., Fadli M., Elyacoubi, H., Rochdi, A., Allal Douira A., 2011. Etude ethnobotanique des plantes médicinales dans la région de Mechraâ Bel Ksiri (Région du Gharb du Maroc). Acta Bot. Barc. 53: 191-216.
[4]. Bigendako-Polygenis. M. J et Lejoly. J., 1990. La pharmacopée traditionnelle au Burundi. Pesticides et médicaments en santé animale. Pres. Univ. Namur. Pp. 425-442.
[5]. Bitsindou M, 1986. Enquête sur la phytothérapie traditionnelle à Kindamba et Odzala (Congo) et analyse de convergence d'usage des plantes médicinale en Afrique centrale.Mem. Doc (inéd.). Univ. Libre de Bruxelles. 482 ppand Related Disorders. 2009;7(3):221–230.

In the present it is aim to develop a RP- HPLC method for the quantitation of Chlorpromazine HCl and Trihexiphenidyl HCl simultaneously. The aim was achieved by using chromatographic conditions ODS C18 (250×4.6mm, 5μ) Column, mixture of Ammonium acetate Buffer and Methanol in the ratio of 15:85 with the flow rate of 1ml/min and column temperature was 200C. The effluents were detected at the wavelength of 211nm. Retention time was 2.5 min and 4.4 min for Chlorpromazine HCl and Trihexiphenidyl respectively. The proposed new method was validated according to ICH guidelines and successfully applied to the determination of both drugs in their combined pharmaceutical formulation with mean recoveries of 99.58-100.45 ± 0.386-0.931. Linearity obeys in the range of 60-140μg/ml and 2.4-5.6μg/ml for both drugs correspondingly with correlation coefficient values as 0.998 and 0.996 respectively. The results obtained were found to be satisfactory, when statistically compared to those obtained from a reference method.

KEYWORDS: Chlorpromazine HCl, Trihexiphenidyl HCl, Ammonium acetate, RP-HPLC.

[1]. Douglas, Skoog.A , James.F, Stanley. HRC. Liquid Chromatography, In Instrumental Analysis, 9 th ed, Cengage Learning India Pvt. Ltd, New Delhi, 2007, p 893 - 934.
[2]. Skoog, Holler, Crouch, Liquid Chromatography, In Instrumental Analysis, Cengage Learning India, New Delhi, 2011, p 893.
[3]. Chatwal, RG, Anand, KS. High Performance Liquid Chromatography, In Instrumental Methods Of Chemical Analysis, , Himalaya Publishers, 5th ed, 2010, p 2.570 - 2.629.
[4]. Braithwaite, A, Smith, F. J. Liquid Phase Chromatography on Columns. In Chromatographic methods, Kluwer Academic Publishers, 5th ed ,1999, p 129.
[5]. Manoj, KS, Pramod, KS, Sambhu, CM, Preet, KK, Nitin K, Rupesh DA perspective review on method development and validation by HPLC. International Journal of Pharmaceutical Sciences, vol 4, 2011, p 1387-1413.

Glaucoma is a complicated eye disease that causes progressive optic nerve damage and is frequently associated with elevated intraocular pressure (IOP).Apigenin is a naturally occurring flavonoid found in fruits and vegetables has received interest for its possible medicinal characteristics including anti-inflammatory and antioxidant activities. In this study we use an in-silico approach to investigate apigenin's apigenin molecular docking studies against antiglaucoma targets. Apigenin may offer promise as a potential candidate for the treatment of glaucoma by targeting critical proteins involved in the disease's pathogenesis according to the findings

[1]. GoldmanH.Cortisoneglaucoma.ArchOphthalmol1962;68:621–626.
[2]. Smith RS, Zabaleta A, Savinova OV, John SW. The mouse anterior chamber angle and trabecular meshwork develop without cell death. BMC Dev Biol.2001; 1:3.
[3]. Chang RC, Koon-Ching Ip A, Chiu K, Yuen WH, Zee SY, et al. Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. ExpNeurol.2007;203: 269-73.
[4]. Morrison JC, Johnson EC, Cepurna WO. Hypertonic Saline Injection Model ofExperimentalGlaucomainRats.MethodsMolBiol.2018; 1695:11-21.
[5]. Lee DA, Higginbotham EJ. Glaucoma and its treatment: a review. Am J Health Syst Pharm. 2005;62: 691-9.

In the traditional treatment of pain and inflammatory illnesses, Hirudo medicinalis (Medicinal leeches) are used therapeutically. Leeches are connected to the afflicted areas and start sucking blood after a first, painless bite. Instead of the blood extracted during biting, the majority of these therapeutic benefits originate from the numerous bioactive substances found in saliva, such as hyaluronidase, hirudin, calin, destabilase, apyrase, eglin, and many others. Treatments focus on reducing regional pain syndromes, primarily for osteoarthritis of the knee or other joint conditions. The use of this technology extends to plastic surgery, where it is used to maintain blood flow in clogged skin flaps, reconstructive procedures, cardiovascular complications, varicose veins.........

Key words: Introduction,leech therapy process,leech therapy benefits,conclusion, reference.

[1]. Singh, A. P. 2010. "Medicinal Leech Therapy (Hirudotherapy): A Brief Overview." Complement Ther Clin Pract 16 (4): 213-5.
[2]. Bhatia, M. L.: Hirudinaria (the Indian cattle leech). In: The Indian zoology memoir, K. N. Bahl, ed., Vol. VIII. Lucknow: Lucknow Publishing House 1941.
[3]. Bernard Aschner. Theories and Philosophies of Medicine, Institute of History of Medicine and Medical Research, New Delhi, 1973, pp. 242-253.
[4]. Nutt, E. M., Jain, D., Lenny, A. B., et al. 1991. "Purification and Characterization of Recombinant Antistasin: A Leech-derived Inhibitor of Coagulation Factor xa." Arch Biochem Biophys 285 (1): 37-44.
[5]. Korkmaz, B., Moreau, T., and Gauthier, F. 2008. "Neutrophil Elastase, Proteinase 3 and Cathepsin G: Physicochemical Properties, Activity and Physiopathological Functions." Biochimie 90 (2): 227-42.

Pharmaceuticals review and assessment by regulatory bodies justifies necessity to maintain consistency, transparency, and efficiency during evaluation. Standardized approach followed during research ensures clear objective, thorough evaluation, evaluation of preformulation parameters, and hence ultimately safeguarding public health. Pharmaceutical regulatory bodies play a pivotal role in safeguarding public health by organizing the development, manufacturing, and distribution of pharmaceutical products in an effective way. Regulatory bodies are responsible for ensuring drugs standards, safety, efficacy, and quality. Regulatory bodies are responsible for guidelines enforcement and assessment of lifecycle of pharmaceuticals, which includes preclinical studies and clinical studies and then evaluation of clinical trials humans......

Keywords: Regulatory body, GMP, Pharmaceutical sector and government regulation

[1]. Aungst TD. (2017). The Evolution of US Generic Drug Regulation. Clinical Pharmacology & Therapeutics, 102(6), 909-911.
[2]. Ahlqvist-Rastad J, et al. (Eds.). (2018). The Development of the Chinese Legal System: Change and Challenges. Springer.
[3]. Barker M et al. (Eds.). (2020). Regulation of Pharmaceuticals in the European Union and United States. Springer.
[4]. Brauer R. (2016). Compliance Handbook for Pharmaceuticals, Medical Devices, and Biologics. CRC Press.
[5]. Bannenberg GL et al. (2018). The ICH M7 guideline: a critical analysis of the recent revision. Regulatory Toxicology and Pharmacology, 98, 144-152.