This research work was performed to evaluate the antipsychotic activity of jatamansi against dexamethasone induced psychosis in rats. Antipsychotic potentials of the jatamansi were compared with haloperidol. Dexamethasone induced severe behavioural changes in experimental animals. Behavioural abnormalities were studied in rats by using climbing behaviour apparatus and actophotometer. Rats of either sex were divided into 9 groups of 6 animals in each group. Group I- Distilled water (Vehicle), group II- Saline water, Group III- Dexamethasone (2 mg/kg), Group IV- Jatamansi (200 mg/kg), Group V- Haloperidol (1 mg/kg), Group VI- Dexamethasone + Haloperidol, Group VII- Jatamansi + Dexamethasone, Group VIII- Jatamansi + Haloperidol, Group IX- Jatamansi + Dexamethasone + Haloperidol. All test solutions were freshly prepared daily and administered to animals by intraperitoneal (i.p.) route.........

KEYWORDS: Dexamethasone, Haloperidol.

[1]. Ahmad, Ashfaq., Munavvar, Z. A., Sattar, Rathore., Hassan, A., Fatima, Tabinda., Akhtar, Safia., Afzal, Sheryar., Mohamed, Lazhari., Ahmed, Fiaz, U. din and Eseyin o. (2013).Pharmacological importance of Nardostachys jatamansi DC: A potential therapeutic agent in different pathological ailments, Journal of Chemical and Pharmaceutical Research. 5(10), 431-8.
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[4]. Damodara, K.M., Shetty, Lathika Krishna, A.P., Kumari, Suchetha N., Gowda, Sanjeev, Ganesh., P. Naveen & Sharada, V. (2013). Ethanolic extract of Nardostachys jatamansi Potentiates Hematopoietic System in Albino Wistar rats. Nitte University Journal of Health Science, NUJHS. 3(1), 2249-7110.

The integration of a nanoemulsion system into the hydrogel matrix has a positive impact on skin penetration. Nanoemulgels are formulations that combine nanoemulsion with hydrogel. Nanoemulgel enhances the stability of the nanoemulsion formulation by reducing surface and interfacial tension, resulting in increased viscosity of the aqueous phase. Due to its higher viscosity compared to the nanoemulsion system, nanoemulgel is also referred to as hydrogel-thickened nanoemulsions. Nanoemulgel is highly effective for delivering hydrophobic medications. It offers greater drug loading capacity, improved solubilizing efficiency, enhanced bioavailability through superior permeability, and controlled drug release. As a result, it serves as an efficient alternative delivery technique for treating various disorders........

KEYWORDS: Nanoemulgel, Nanoemulsion, Bioavailability.

[1]. Dandamudi M, McLoughlin P, Behl G, Rani S, Coffey L et al (2021) Chitosan-coated plea nanoparticles encapsulating triamcinolone acetonide as a potential candidate for sustained ocular drug delivery. Pharmaceutics.
[2]. Pandey VN, Tiwari N, Pandey VS, Rao A, Das I et al (2019) Targeted drug delivery and gene therapy through natural biodegradable nanostructures in pharmaceuticals. Nanoarchitectonics in Biomedicine.
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Background: A type of breast cancer referred to as human epidermal growth factor receptor 2 (HER-2) is characterized by a positive detection of the HER-2 protein, which encourages the growth of cancer cells. Approximately one in every five breast cancer cases is more aggressive due to the presence of extra copies of the genes responsible for producing the HER2 protein. Identifying plant compounds capable of reducing the expression of HER-2 proteins could offer potential treatment options for breast cancer patients, particularly in developing countries where herbal therapy is commonly used. The chemical composition of a Carica papaya leaf extract was analyzed using gas chromatography-flame ionization detector (GC-FID) to explore its potential for breast cancer treatments.........

KEYWORDS: Computational drug design, Breast cancer, Medicinal plants, Carica papaya, Epicatechin.

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