November - 2024 (Volume-14 ~ Issue-11)

Paper Type

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Research Paper

Title

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Advancements in Paclitaxel Formulation: The Role of Amorphous Solid Dispersion and Modern Excipients in Enhancing Drug Delivery

Country

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India

Authors

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Devendra C. Sonawane, Rutik N. Liddad, Prof. Mrs Dipali Kothawade

Page No.

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01-12

Amorphous Solid Dispersion (ASD) technology has emerged as a promising strategy to enhance the solubility and bioavailability of poorly water-soluble drugs, such as Paclitaxel, a key agent in cancer therapy. Despite its significant antitumor activity against various malignancies, Paclitaxel's clinical application has been hampered by its low solubility and adverse effects associated with its conventional formulation, which utilizes Cremophor® EL. This review highlights recent advancements in ASD formulations aimed at improving Paclitaxel delivery through innovative polymer systems, nanotechnology, and advanced manufacturing techniques such as spray drying and hot melt extrusion..........

Keywords : Amorphous Solid Dispersion (ASD), Paclitaxel, Solubility, Bioavailability, Polymer, Drug delivery, Passive diffusion, Cancer therapy.

[1]. Paclitaxel ASD formulation in Nanotechnology (https://www.sciencedirect.com/science/article/abs/pii/S093964111930479X)
[2]. Amorphous Solid Dispersion of Paclitaxel (https://link.springer.com/article/10.1007/s11095-010-0174-2)
[3]. Recent Advances in ASD for Chemotherapy Drugs (https://www.mdpi.com/1999-4923/13/2/168)
[4]. Baghel, S.; Cathcart, H.; O'Reilly, N.J. Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs. J. Pharm. Sci. 2016, 105, 2527–2544. [Google Scholar] [CrossRef] [PubMed] [Green Version]

[5]. Vo, C.L.-N.; Park, C.; Lee, B.-J. Current Trends and Future Perspectives of Solid Dispersions Containing Poorly Water-Soluble Drugs. Eur. J. Pharm. Biopharm. 2013, 85, 799–813. [Google Scholar] [CrossRef] [PubMed]


Paper Type

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Research Paper

Title

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Can the rights and admission criteria for studying pharmacy be reconciled for students with severe motor disabilities?

Country

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Syria

Authors

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Omar Ahmed Toukaj

Page No.

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13-21

Many health profession colleges use technical standards for the admission and graduation of students, reflecting the physical and mental skills and abilities necessary to work efficiently as professionals in the health sector. Students with disabilities are often rejected on the grounds that they do not meet these standards; however, this is not always a justified reason for their exclusion, as they can be academically successful. International laws also stipulate their right to education, with or without accommodations...........

Keywords : Reconciliation. Entitlement. Admission standards. Pharmacy studies. Disability. Congenital absence of upper limbs.

[1]. (Bamshad et al. 1999) as cited in Sebastiano Bianca, G. B. (2009, August 26). Fetal upper limb amelia with increased nuchal translucency. Congenital Anomalies, pp. 121-122. Retrieved from https://doi.org/10.1111/j.1741-4520.2009.00238.x
[2]. Abdel Moneim, S. M. (2023, January). Educational Empowerment for Students with Special Needs in Pre-University Education (Field Study). pp. 223-255. doi:10.21608/ALTC.2023.295807
[3]. Accreditation Council for Pharmacy Education. (2011). Accreditation Standards and Guidelines for the Professional Program in Pharmacy Leading to the Doctor of Pharmacy Degree (Guidelines Version 2.0). Chicago: Accreditation Council for Pharmacy Education. Retrieved 8 31, 2023, from http://www.acpe-accredit.org/pdf/FinalS2007Guidelines2.0.pdf
[4]. ADA. (2002). Enforcement Guidance on Reasonable Accommodation and Undue Hardship under the ADA. U.S. Equal Employment Opportunity Commission. Retrieved from https://www.eeoc.gov/laws/guidance/enforcement-guidance-reasonable-accommodation-and-undue-hardship-under-ada
[5]. ADA. (2002, 10 17). Enforcement Guidance on Reasonable Accommodation and Undue Hardship under the ADA. (U.S. Equal Employment Opportunity Commission) Retrieved 7 13, 2023, from https://www.eeoc.gov/ar/almlwmat-ballght-alrbyt