Volume 6 ~ Issue 12,~Version 1,~December - 2016


Paper Type

::

Research Paper

Title

::

Studies on Structural and Optical Properties of Pure and Lanthanum Oxides Doped: L-Alanine Alaninium Nitrrate (LAAN) Organic Nonlinear Optical Single Crystal

Country

::

India

Authors

::

M A Ahlam ||, and A P Gnana Prakash

Page No.

::

01-11

Paper Index
::
XXXX
Single crystals of pure and Lanthanum oxides (La2O3) doped L-Alanine Alaninium Nitrrate (LAAN) crystals were grown by slow evaporation method. The lattice parameters were analyzed by single crystal X-ray diffraction technique. The slight changes in the lattice parameters were observed for the doped crystals compared to pure LAAN crystal. The presence of functional groups of the pure and dopant LAAN molecules were studied using Fourier Transform Infrared (FTIR) spectra. The identification of Lanthanum ion in the doped crystals was done using the energy dispersive X-Ray (EDX) spectrum. The UV-Vis transmission spectra of La2O3 doped LAAN showed excellent transmittance from 255 nm to 800 nm. The optical band gap energy of the grown crystals were also calculated. Improvement in the second harmonic generation (SHG) efficiency was studied by the Kurtz and Perry method. The SHG efficiency was found to be more for La2O3 doped LAAN comber to pure LAAN . The various studies showed the incorporation of the impurity La2O3 into LAAN crystal and the investigations indicated that the impurity played an important role in the changes of the properties of LAAN crystals. Key word: Nonlinear optics, Organic materials, Doping effects, X-ray diffraction, Optical properties
[1] Karunanithi U., Arulmozhi S., Dinesh Raja M. and Madhavan J., Growth and characterization of pure and doped L- phenylalanine maleate single crystals , Int. j. Eng. Res. Dev. , 2012, 3(11), 51-55.
[2] Javidi S., Esmaeil Nia M., Aliakbari N and Taheri F., Effect of La3+ ions on the habit of KDP crystals, Semicond. Phys. Quantum Electron. Opto-Electron., 2008. 11( 4), 342-344.
[3] Zaitseva N., Carman L., Smolsky I., Torres R and Yan M., The effect of impurities and super saturation on the rapid growth of KDP crystals, J. Cryst. Growth, 1999, 204, 512-514.
[4] Varma K.B.R and Prasad K.V.R., The effect of Cr4-2 ions on the electro-optic properties of KDP single crystals , J. Phys. D: Appl. Phys., 1990, 23, 1723-1726.
[5] Kannan V., Ganesh R.B., Sathyalakshmi R., Rajesh N.P and Ramasamy P., Influence of La3+ ions on growth and NLO properties of KDP single crystals, J. Cryst. Res. Technol., 2006, 41 (7), 678-682.

 

Paper Type

::

Research Paper

Title

::

Effect of a new Quinoline-2-one Derivatives( Compound 3) onPurified DNA gyrase from clinical isolatePseudomonas aeruginosaPA31

Country

::

Iraq

Authors

::

EssamFadel Al-Jumaily, ||, Abdal- Kader SaeedLatif, ||, Redha Al-Bayati

Page No.

::

12-18

Paper Index
::
XXXX
The aim of this study to evaluate Study of new Quinoline -2-one derivatives (Q3) and application of the molecule on the DNA gyrase which purified from clinical Pseudomonas aeruginosa PA31.Methods: DNA gyrase enzyme was purified from clinical Pseudomonas aeruginosa PA31 with 70% saturation of ammonium sulphate then DEAE-cellulose column with final stage gel filtration. Results:Purified DNA gyrase showed activity on agarose gel against catenated DNA. Synthesized compound (Q3) was chosen for inhibition studies with purified enzyme, compound (Q3) showed full inhibition against purified DNA gyrase at concentration (1000 mg/ml) on agarose gel.Conclusion:Invitro showed that compound (Q3) has highest functional score against DNA gyrase. Key words: DNA gyrase, Quinoline-2-one derivatives (Q3), Clinical Pseudomonas aeruginosa PA31.
[1] Joseph, E.; Deweese, A.; Osherof, F and Osheroff, N., DNA Topology and Topoisomerases Teaching a "Knotty", Biochem. Mol. Biol. Educ. 37(1), 2008, 2–10.
[2] Gentry, A. C and Osheroff, N. DNA topoisomerases: Type II. In Encyclopedia of Biological Chemistry, Elsevier Inc., Amsterdam.163−168 (2013).
[3] Tretter, E. M and Berger, J. M., Mechanisms for defining supercoiling set point of DNA gyraseorthologs: II. The shape of the GyrA subunit C-terminal domain (CTD) is not a sole determinant for controlling supercoiling efficiency. J. Biol. Chem. 287,2012, 18645−18654.
[4] Leo, E., Pommier, Y., Zhang, H., and Marchand, C. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs.Chem. Biol. 17(5):,2010, 421−433.

 

Paper Type

::

Research Paper

Title

::

Concept Of Salutariness In Ayurveda With Specialreference To Aahar (Food)

Country

::

India

Authors

::

Dr. Hadole Shrikant ||, Dr. Namburi U.R. Sekhar ||, Dr. Jadhav Shubhangi ||,

Dr. Khode Nakul ||, Dr. Suryavanshi Milind

Page No.

::

19-22

Paper Index
::
XXXX
New data from World Health Organization (WHO) reveals the growing problem of food borne illness around the world. Around 351000 deaths occurred in the year 2010 due to food poisoning. With the kind of health risks that are posed to the human race today, it has become vital to stay as hygienic as possible. Hygiene is a habit that needs to be focused on and it need not be restricted to our bodies alone; it needs to be maintained in our intakes and surroundings also. Concept of food hygiene is not new to Ayurveda. The importance of hygienic food and hazardous effects of unhygienic food are deliberately described in the ancient texts. Since ancient times our Aacharyas were aware of these facts, they stressed upon the hygiene. One can find the roots of today's methods of procuring, storing, processing and cooking of foods in the ancient literatures. Presently various sanitation methods, preservatives and methods of food preparations are having the impact on the immunity and are leading to hazardous effects on health therefore the development of the food hygiene practice should be based on traditional methods which are being followed since thousands of years.

[1] Dr. Ambikadatta Shastri, Sushrut samhita sutrasthan Chpt. 46/(Chaukhambha Sanskrit Prakashan, Varanasi187 p)
[2] Dr. Ambikadatta Shastri, Sushrut samhita sutrasthan Chpt. 46/3 (Chaukhambha Sanskrit Prakashan, Varanasi 187 p)
[3] Bramhanand Tripathi, Charak Samhita sutrasthana Chpt. 27/350, (Chaukhambha, Sanskrit Prakashan, Varanasi)

[4] Dr. Ambika Dutta Shastri, Susruta Samhita Sutra Sthan Chpt. 46/451-453 (Chaukambha Sanskrit Sansthan Varanasi 191 p)

[5] Dr. Ambika Dutta Shastri, Susruta Samhita Sutra Sthan, Chpt. 46/346, (Chaukambha Sanskrit Sansthan Varanasi 191p)

 

Paper Type

::

Research Paper

Title

::

Mechanical Characterization of Jute and Rubber Particles Reinforced Epoxy Polymer Composites

Country

::

India

Authors

::

Madhusudhan T ||, SenthiL Kumar M

Page No.

::

23-27

Paper Index
::
XXXX
In an attempt to determine the characterization of Bio-degradable hybrid polymer composites, the jute fiber and natural rubber particle combination was tested to assess the critical weight percentage combination for tensile strength, flexural strength and ductility. Specially prepared specimens by hand layup technique were subjected to mechanical characterization process including SEM micrograph analysis to determine the optimum combination of the material system. The results so obtained reflected on typical characters of jute and rubber combination leading to estimate their usage criteria for different applications.
[1] Li X, Tabil L G, Panigrahi S and Crerar W J. The Influence of Fiber Content on Properties of Injection Molded Flax Fiber-HDPE Bio composites. Canadian Bio systems Engineering, 2013, 08-148, pp. 1-10. [2] Nabi Saheb D and Jog J P. Natural Fiber Polymer Composites: A Review, Advanced in Polymer Technology: 2009, Vol. 18, pp. 351-363. [3] Huq T., Khan A., Akter T., Noor N., Dey K., Sarker B., Saha M.,2011. Thermo-mechanical, Degradation, and Interfacial Properties of Jute Fiberreinforced PET-based Composite, DOI: 10.1177/0892705711401846. [4] Chin C.W., Yousif B.F., 2009.Potential of kenaf fibres as reinforcement for tribological applications, Wear, 267, p. 1550. [5] Flavio de Andrade Silva, Romildo Dias Toledo Filho, Joao de Almeida Melo Filho, Eduardo de Moraes Rego Fairbairn, Physical and mechanical properties of durable sisal fiber-cement composites, Construction and Building Materials;2010;24:777 785. [6] Jarukumjorn Kasama and Suppakarn Nitinat. Effect of glass fiber hybridization on properties of sisal fiber polypropylene composites. Composites: Part B 40, 2013, pp. 623–627.

 

Paper Type

::

Research Paper

Title

::

US Generic Drug Market – A Study on Evolving Trends

Country

::

India

Authors

::

Roger Kabetu

Page No.

::

28-30

Paper Index
::
XXXX
Generic drugs generate a lot of interest in the sector in recent times. There is a lot of competition between generic drugs and brand names in the market. Recently there are growing conditions which hinder the smooth adoption of these medicinal products in the market. This paper will discuss some of the issues which revolve around the generic drug industry. Keywords - About five key words in alphabetical order, separated by comma

[1] Samrat Sisodia, 2013, Opportunities and Challenges Brought by GDUFA in 2013, International Journal of Advanced Research in Pharmaceutical & Bio Science, Vol 3, pg 10-13. [2] Brennan, Z. (2016, July 25). FDA Continues Steady Reduction of Generic Drug Application Backlog | RAPS. Retrieved from http://raps.org/Regulatory-Focus/News/2016/07/25/25388/FDA-Continues-Steady-Reduction-of-Generic-Drug-Application-Backlog

[3] Samrat Sisodia, 2015, Generic Drug Submissions, Chapter 15, Fundamentals of US Regulatory Affairs, Regulatory Affairs Professional Society (RAPS) Publication, 9th edition, pg 183-196

[4] Elsevier. (2015). The Impact of Rising Generic Drug Prices on the U.S. Drug Supply Chain. Retrieved from http://www.ncpa.co/pdf/elsevier_wp_genericdrug.pdf

[5] Herrick, D. M. (2015, September). What Is Increasing the Cost of Generic Drugs? Retrieved from http://www.ncpa.org/pdfs/st371.pdf

 

Paper Type

::

Research Paper

Title

::

Drug Induced Lymphadenopathy

Country

::

India

Authors

::

Dr.Ankita Chouksey ||, Dr. H.G Varudkar ||, Dr. Arti Julka ||, Dr.Mustafa Singapurwala ||, Dr. Nipun Agrawal ||, Dr. Ravi Shankar Mishra

Page No.

::

31-32

Paper Index
::
XXXX
Many a times lymphadenopathy is misdiagnosed as tubercular but there is more into it. We report one such case where a wrongly diagnosed lymphadenopathy revealed itself in a different way. Case Description: An 18 year old female presented with bilateral swelling in cervical region(fig 1), dry cough, fever and reduced appetite since one and a half years . FNAC of cervical lymph nodes was done which showed necrotising lymphadenitis. Anti tubercular treatment was thus started but patient defaulted after one month due to intolerance. Though Sputum for mycobacterium was negative but somehow ATT was continued. She also had gingival hyperplasia and rashes on face (fig 2). Routine investigations like complete blood counts, liver and renal function test did not revealed any abnormality.Peripheral Smear showed anisopoikilocytes with microcytic hypochromic picture. Chest X-ray(fig 3) revealed mediastinal widening .SubsequentlyHRCT (fig 4)revealed
[1] Mcnamar J O. Pharmacotherapy of the epilepsies-Chapter 19. In Goodman & Gilman's the Pharmacological Basis of Therapeutics - 11th ed. Editor Brunton L L (2006) Mcgraw-Hill Medical Publishing Division, New York Chicago 2006:
[2] Coope R. Burrows RGR. Treatment of epilepsy with sodium diphenylhydantoinate.Lancet 1940; i490-2.
[3] Saltzstein SL, Ackerman LV. Lymphadenopathy induced by anticonvulsant drugs and
mimicking clinically and pathologically malignant lymphomas. Cancer 1959; 12;164-82
[4] Hyman GA, Sommers SC, the development of Hodgkin's disease and lymphoma
during anticonvulsant therapy. Blood 1966; 28; 416-27.
[5] SG Chong,A O'Brien, BP Casserly et al.An Unusual Cause Of Mediastinal

 

Paper Type

::

Research Paper

Title

::

Formulation and Evaluation of Mucoadhesive Microspheres of Metoprolol Tartarate

Country

::

India

Authors

::

Yadav V.D. ||, Bhise C.B. ||, Jadhav P.D. ||, Kanase K.R. ||, Salunkhe P.S.

Page No.

::

33-40

Paper Index
::
XXXX
The purpose of this research was to prepare and evaluate mucoadhesive microspheres of Metaprolol tartarate an antihypertensive drug for prolonged residence time and sustained drug release. Microspheres were prepared by Ionotropic gelation technique using sodium alginate, HPMC K4M as polymers in varying ratios. The microspheres were evaluated for its percentage yield, drug entrapment efficiency, particle size and shape, in vitro mucoadhesion study and in vitro drug release studies. The mucoadhesive microspheres showed particle size, drug entrapment efficiency and yield in the ranges of 280.14 – 596.16 μm, 55.47 – 88.36 % and 78.16 – 87.06 % respectively. In vitro drug release and mucoadhesion study confirms formulation F13 was the best formulation as it releases 97.96 % at the end of 12 hr. in controlled manner and percentage mucoadhesion of 76.13 % after 10 hr. This confirms the developed Metaprolol tartarate mucoadhesive microspheres are promising drug delivery system for oral sustained administration of Metaprolol tartarate. Keywords :- Drug entrapment efficiency, In vitro mucoadhesion study, Metaprolol tartarate, Mucoadhesive microspheres, Residence time.
[1] Patel S.B., Murthy RSR. Mahan HS., Wagh RD., Gattani SG. Mucoadhesive polymers: means of improving drug delivery. Pharma Times. 2006; 38: 25-28.
[2] Bahadur S., Chanda R., Roy A, Chowdhary A., Das S., Saba S. Preparation and evaluation of mucoadhesive microcapsules of Captopril for oral controlled release. Research journal pharma technology. 2008; 1: 100-105.
[3] Chowdary KP., Sree Deepthi K., Srinivasa Rao Y. Mucoadhesive microcapsules of Indomethacin: Evaluation for controlled release and ulcerogenic activity. International Journal of Pharmaceutical Sciences and drug Research. 2009; 1: 74-79.
[4] Kaurav H. Mucoadhesive Microspheres as Carriers in Drug Delivery: a Review. International Journal of Drug and Research, 2012; 4(2): 21-34.
[5] Garg A. Mucoadhesive Microspheres: A Short Review. Asian Journal of Pharmaceutical and clinical research. 2012; 5(3): 24-27.

 

Paper Type

::

Research Paper

Title

::

Intravenous immunoglobulin therapy for infants with Kawasaki diseaseyounger than 6 months

Country

::

India

Authors

::

Toshimasa Nakada

Page No.

::

41-46

Paper Index
::
XXXX
Infants with Kawasaki disease younger than 6 months have a high risk for developing coronary artery lesions (CAL). This retrospective study included 231 patients who received initial IVIG therapy at 2g/kg/dose from 1999–2016. Patients were divided into a younger group aged ≦ 6 months (n = 25), and an older group aged > 6 months (n = 206). The prevalence of incomplete type (defined as patients with fewer than five major symptoms) was higher in the younger group than the older group. However, this difference was not statistically significant (16.0% vs. 10.2%, P = 0.491). The start time of initial IVIG therapy was significantly earlier in the younger group than the older group, with median days of illness being 5 (range 4–6) vs. 5 (range 3–16), P = 0.017. The prevalence of CAL was similar in the two groups both before (4.0% vs. 4.4%, P = 1.000) and after 30 days of illness (4.0% vs. 1.5%, P = 0.370). Initial IVIG therapy at 2g/kg/dose before day 6 of the illness may suppress the prevalence of CAL development caused by Kawasaki disease in younger infants to a rate similar to that in older children.
[1] Burns JC, Glod é MP. Kawasaki syndrome, Lancet364 (9433), 2004, 533–544.
[2] Rosenfeld EA, Corydon KE, Shulman ST. Kawasaki disease in infants less than one year of age,J Pediatr 126(4), 1995, 524–9.
[3] Lee KY1, Hong JH, Han JW, Lee JS, Lee BC, Burgner D. Features of Kawasaki disease at the extremes of age, J Paediatr Child Health 42 (7–8), 2006, 423–7.
[4] Nakada T. Intravenous immunoglobulin therapy for older children with Kawasaki disease,IOSR Journal of Pharmacy, 6 (5), 2016, 35–41.
[5] Ayusawa M, Sonobe T, Uemura S, Ogawa S, Nakamura Y, Kiyosawa N, et al. Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition),PediatrInt, 47(2), 2005, 232–4.

 

Paper Type

::

Research Paper

Title

::

Clinical presentation of hypothyroidism which depends on initial dosage among hypothyroidism patient in hail city.

Country

::

India

Authors

::

Hanadi Hilail mohammad elenzi ||, Rasheed Abdulkaeeem ALtwiher ||,

Maher Ahmed Edrees

Page No.

::

47-54

Paper Index
::
XXXX
There are no enough studies that focus on the Clinical presentation of hypothyroidism which depends on initial dosage among hypothyroidism .Objective: To recognize Clinical presentation of hypothyroidism which depends on initial dosage among hypothyroidism patient in hail city .Methodology: A Cross- Sectional based study conducted at King Khalid Hospital in Hail city, Saudi Arabia. Data were collected through personal structured interviews after informal consents from the patients. Data was entered and analyzed by Statistical Package for Social Software Program (SPSS) version 14.Result: From 420 questionnaires 400were collected and analyzed. The predominant gender respondents were female 380 (92%)and the mean age was more than 42% they were more than 40 years (168 pt). The top three clinical presentation were (27 % )of patients suffering from Fatigue and tiredness ,( 16 %) of patients are suffering from increased their weight ,14%they suffering from hair loss. (40%) started with 50 micro/gram as initial dosage . Conclusion: Findings showed 40 % started with 50 micro/gram as initial dosage (30.2 % Fatigue and tiredness , overweight 18.1% , hair loss 15.5%) 53% good prognosis and 47% poor prognosis main of them need to increased the initial dosage So we think it is important to help them by a educated the correct way how use the hypothyroids medication and follow the doctors instruction .

[1] www.thyroid.org. 2005. American Thyroid Association. 13 Mar. 2008. 8 Dec.

[2] Groot, Leslie J., Nobuyuki Amino, and Akamizu Takashi. "Hashimoto's Thryoiditis." 30 Jan. 2007. Takashi Akamizu.

[3] "hypothyroidism - definition of hypothyroidism in English from the Oxford dictionary". OxfordDictionaries.com.

[4] "Hypothyroidism". Merck Veterinary Manual, 10th edition (online version). 2012.

[5] Khandelwal D, Tandon N; Tandon (January 2012). "Overt and subclinical hypothyroidism: who to treat and how".