Volume 7 ~ Issue 12,~Version 1,~December - 2017


Paper Type

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Research Paper

Title

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Screening of Phytochemicals and Isolation of Endophytic Fungi from Medicinal plant Helicteres isora L

Country

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India

Authors

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Gayathri Pai || Chandra M

Page No.

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01-05

Paper Index
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XXXX

The objective of this study was to screen the phytochemicals and isolate the endophytic fungi harbored in the leaf and stem of medicinal plant Helicteres isora L.. Medicinal plants play a key role in traditional medicine and medicinal property is found to be because of phytochemical constituents present in the plants. Phytochemicals such as alkaloids, carbohydrates, tannins, steroids, flavonoids, saponins, terpenoids, coumarins, carboxylic acid, resins, quinone and phenolic compounds were analyzed by using ethanol as solvent. There is a correlation between phytochemicals and secondary metabolites produced by the endophytic fungi. The medicinal plants and their fungal endophytic communities produce similar therapeutic products. The results of the present study showed the presence of secondary metabolites and endophytic fungi such as Penicillium citrinum, Aspergillus niger, Curvularia vermiformis, Rhizopus sp., Cladosporium sp., Alternaria alternata and Fusarium sp., were isolated and identified by morphological characters.

 

Keywords: Endophytic fungi, Helicteres isora L., Phytochemicals, Secondary metabolites.

[1]. Kirthikar,K.R.,Basu,B.D.Indian medicinal plants .National Publishers,Deharadun,1999.pp.371.
[2]. Zhang HW, Song YC, Tan RX. Biology and chemistry of endophytes. Nat Prod Rep 2006;23:753-71.
[3]. Kaul S, Ahmed M, Zargar K, Sharma P, Dhar MK. Prospecting endophytic fungal assemblage of digitalis lanata Ehrh, (foxglove) as a novel source of digoxin: a cardiac glycoside, Biotechnology 2013;3:335-40.
[4]. Sandhu SS, Suneel K, Aharwal RP,Shukla H and Rajak RC. EndophyticFungi: As A Source ofAntimicrobialsBioactive Compounds. World J PharPharmac Sci. 2014a;3(2):1179-1197.
[5]. Strobel G and Daisy B. Bioprospecting for microbial endophytes and their natural products. Microbiol Molecular Biol Rev. 2003;67:491-500.

 

Paper Type

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Research Paper

Title

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Haematological and Biochemical findings of Hair Dye Poisoning

Country

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India

Authors

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Awad Elkareem Abass || Noon mobasher || Fatima Ali || Randah Salah || Nada
Mohamed

Page No.

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06-10

Paper Index
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XXXX

Background/aim: Hair dye containing paraphenylenediamine (PPD) is commonly used in Sudan as
cosmetic agent. The direct toxic effect of PPD can lead to many pathological problems. Therefore, present study aimed to investigate some hematological and biochemical parameters in Sudanese who exposed to hair dye poisoning. Patients/methods: A cross sectional hospital -based study was conducted in Ear-Nose-Throat (ENT) Hospital- Khartoum, 30 PPD- poisoned patients who were admitted for clinical management were enrolled in the study. Clinical manifestations were examined by clinician in the Hospital. Full blood count, renal function tests, and liver function tests were performed for each patient.............

 

Keywords: Hair dye, investigation, Laboratory, Poisoning, PPD, Signs.

[1]. Sampathkumar K, Sooraj YS, Mahaldar AR, Ajeshhkumar RP, Muthiah R. Hair dye poisoning: An emerging threat. Indian J Crit Care Med, 11, 2007, 212-214.
[2]. Ayoub Filali, I. Semlali, V. Ottaviano, C. Furnari, Danilo Corradini, Rachida Soulaymani. A
retrospective study of acute systemic poisoning of paraphenylenediamine (occidental takawt) in
Morocco. Afr J Tradit Complement Altern Med, 39, 2006, 142–149.
[3]. Suliman SM, Fadlalla M, Nasr Mel M, et al. Poisoning with hair-dye containing paraphylene diamine: ten years experience. Saudi J Kidney Dis Transpl, 6, 1995, 286–289.
[4]. Kallel H, Chelly H, Dammak H, et al. Clinical manifestations of systemic paraphenylene diamine
intoxication. J Nephrol, 18, 2005, 308–311.
[5]. Ashar A. Acute angioedema in paraphenalinediamine poisoning. J Pak Med Assoc, 53, 2003, 120-122.

 

Paper Type

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Research Paper

Title

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Volumetric and Acoustical Study of Antimalarial Hydroxychloroquine Sulfate Drug in DMSO-Water mixtures at different temperatures

Country

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India

Authors

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Shweta Pendse || H G Jahagirdar || MKN Yenkie

Page No.

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11-19

Paper Index
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XXXX

The densities and speeds of sound have been measured for ternery mixtures of hydroxychloroquine sulfate in aqueous-dimethyl sulfoxide(DMSO) mixtures at 20 vol% interval of the cosolvent at 303.15, 308.15 and 313.15 K and frequency 2MHz. The experimental data has been used to determine various acoustic/thermodynamic parameters viz. isentropic compressibility ( ks), intermolecular free length (Lf), relative association (RA) and specific acoustic impedance (Z). The changes in these properties with composition and temperature are used to interpret the nature of solute-solvent, solute- solute interactions in the system.

 

Keywords: Acoustical properties, Antimalarial, DMSO, Molecular interactions, Ultrasonic velocity

[1]. Marcus Y., Solvent mixtures: properties and selective salvation (Marcel Dekker: New York (NY); 2002)
[2]. A. Awasthi, A. Awasthi, Acoustic, volumetric, and spectroscopic studies of formamide with 2-alkoxyethanols at different temperatures. J Chem Thermodyn.,53, 2012, 144–151
[3]. A. Awasthi, A. Awasthi, Intermolecular interactions in formamide + 2-alkoxyethanols: viscometric study, Thermochimica Acta.,537, 2012, 57–64.
[4]. A. Awasthi, A. Awasthi, Intermolecular interaction in binary mixtures of formamide with 2-alkoxyethanol at different temperatures: optical and internal pressure study, Phys Chem Liqs., 51, 2013, 112–123.
[5]. A. Awasthi, Tripathi BS, A. Awasthi, Applicability of corresponding-states group-contribution methods for the estimation of surface tension of multicomponent liquid mixtures at 298.15 K, Fluid Phase Equilibria, 287, 2010, 151–154.

 

Paper Type

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Research Paper

Title

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Prevalence of Gastrointestinal Tract Cancer Cases among Population of Tripura: A Histological Study

Country

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India

Authors

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Asis Debbarma || Arup Bhaumik || Biswajit Chowdhury || Payel Chakraborty || Souvik Ghatak || Sandeep Roy Sarkar

Page No.

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20-23

Paper Index
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XXXX

Histochemistry is currently the widely used methodology for recognition of gastrointestinal tract (GI tract) cancers like stomach, rectum, colon and oesophagus. Limited studies have addressed the prevalence of GI tract malignancies in Tripura. The objectives of this study were to find out the prevalence of gastrointestinal tract cancers among the population of Tripura, located in North-Eastern part of India. Accordingly, a hospital based study was carried out to evaluate the histopathological aspects of gastrointestinal tract cancer patients attending to Agartala Govt. Medical College during the period of 2010-2017. In this study 161 cases of GI cancers belonging to age between 5 to 85 years were found positive out of total 187 suspected samples. The present study demonstrates.............

 

Keywords: GI tract cancer, Histology, Haematoxylin and eosin stain, Tripura.

[1]. Report on Causes of Death in India 2001-03, Office of Registrar General, India, New Delhi. 2009. Available from: URL:http://censusindia.gov.in/Vital_Statistics/Summary_Report_Death_01_03.pdf. Accessed September 24, 2017.
[2]. J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, et. al, Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer, 136, 2015, 359–86.
[3]. S. Ghatak, P. Chakraborty, S.R. Sarkar, B. Chowdhury, A. Bhaumik, and N.S. Kumar, Novel APC gene mutations associated with protein alterations in diffuse type gastric cancer. BMC Medical Genetics, 18, 2017, 61.
[4]. N.S. Ghadyalpatil, S. Chopra, P. Patil, A. Dsouza, A. Saklani. Gastrointestinal cancers in India: Treatment perspective, South Asian Journal of Cancer, 5(3), 2016, 126–136.
[5]. A. Sharma, Gastrointestinal cancers in India: Treatment perspective, South Asian Journal of Cancer, 5(3), 2016, 125–126.

 

Paper Type

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Research Paper

Title

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Microwave-Assisted Fast and Efficient Green Synthesis of 9-Anthracenyl Chalcones and their Anti-Bacterial Activity

Country

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India

Authors

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Maddela Prabhakar || Thechano Merry || Ruokuosenuo Zatsu || Shurhovolie Tsurho || Ramchander Merugu

Page No.

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24-32

Paper Index
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XXXX

A simple, fast and efficient green synthetic protocol was developed for the synthesis of 9-anthracenyl chalcones (3a-p) in excellent yields under microwave irradiation conditions. These microwave irradiated reactions of 9-acetyl anthracene with various aryl/substitutedaryl/heteroaryl/ aldehydes in presence of potassium hydroxide avoids the routine longer reaction time and expansive catalysts and provides several advantages such as solvent-free and short reaction time as eco-friendly green synthesis. All the newly synthesized 9-anthracenyl chalcone compounds were evaluated for their biological activity studies towards the anti-bacterial activity. The compounds 3d, 3h, 3j, 3l, 3n demonstrated potent activity against Staphylococcus aureus (MTCC 96) and Bacillus subtilis (MTCC 121), and two Gram-negative organisms, Escherichia coli (MTCC 43) and Klebsiella pneumonia (MTCC 530).

 

Keywords: Green Synthesis, 9-Anthracenyl Chalcones, Microwave Irradiation, Solvent-free, Anti-Bacterial Activity.

[1]. Li, Y.; Fang, H.; Xu, W. Mini Rev Med Chem. 2007, 7,663-78.
[2]. Dhar, D. N. The chemistry of chalcones and related compounds; Wiley Interscience: New York, 1981.
[3]. Chahar, M. K.; Sharma, N.; Dobhal, M. P.; Joshi, Y. C. Pharmacogn Rev. 2011, 5, 1–12.
[4]. Sharma, N.; Joshi,Y.C. International Journal of Pharmacy and Pharmaceutical Sciences, 2012, Vol 4, 4.
[5]. Sathyanarayana, S.; Krishnamurthy, H. G. Catalyst.Curr.Sci. 1988, 57, 1114-1116.

 

Paper Type

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Research Paper

Title

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Formulation of Antiaging Gel from Roselle Calyces Extract

Country

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Indonesia

Authors

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Rosemary Hutagaol

Page No.

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33-37

Paper Index
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XXXX

Roselle (Hibiscus sabdariffa L.) is known to have many active compounds that function as
antioxidants such as flavonoids, polyphenols, and vitamin C. High antioxidant content has a high antiaging effect. This study aims to create a cream dosage form that has antiaging properties with active ingredients roselle calyx ethanolic extract that meets the requirements of physical evaluation, stability evaluation, and has an antiaging activity before and after use. The ethanol extract of roselle calyx is made by maceration. Creams were made with variations of vitamin C concentration of 1% (w/w), and 2.0% (w/w), also roselle calyx ethanolic extract concentration of 0.5% (w/w), 1% (w/w), 1.5% (w/w), and 2.0% (w/w). Antiaging activity test performed by measurement of moisture, evenness, pore, spot, and wrinkle by using skin analyzer tool..............

 

Keywords: Antiaging, Cream, Roselle Calyx, Hibiscus sabdariffa, Vitamin C.

[1]. Ansel, H.C. (1989). Pengantar Bentuk Sediaan Farmasi. Edisi Keempat. Jakarta: Penerbit Universitas Indonesia. Pg. 107.
[2]. Aramo. (2012). Skin and Hair Diagnostic System. Sugnam: Aram Huvis Korea Ltd. Pg. 1-10.
[3]. Bernatoniene, J., Masteikova, R., Davalgiene, J., Peciura, R., Gauryliene, R., Bernatoniene, R,.Majiena, D., Lazauskas, R.,Civinskiene, G., Velziene, S., Muselik, J., danChalupova, Z., 2011, Topikal Application of Calendula officinalis (L.) : Formulation and Evaluaton of Hydrophilic Cream With Antioxidant Activity, Journal of Medical Plants Research, Vol. 5 (6) pg. 868-877.
[4]. Garg, A., Aggarwal, D., Garg, S., danSigla, A.K., 2002, Spreading of Semisolid Formulation: An Update, Pharmaceutical Technology, 84-102.
[5]. Hayati, E.K., Budi, U.S., dan Hermawan, R. (2012). Konsentrasi Total Senyawa Antosianin Ekstrak Kelopak Bunga Rosella (Hibiscussabdariffa L.): Pengaruh Temperatur dan pH. Malang. Jurnal Kimia. 6(2): 139.

 

Paper Type

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Research Paper

Title

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Phytochemical screening and antibacterial properties ofhydroalcoholic and ethanolic extracts from Brassica olerea L

Country

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Zambia

Authors

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Désiré Ndayazi || Félicien Mushagalusa Kasali || Ngoupayo Joseph || YassaPiere Yoniene || Jean-Marie VianneyTshimbila Kabangu

Page No.

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38-43

Paper Index
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XXXX

Objective: It has long been recognized that some plant materials exhibit antimicrobial properties. The objective of the present study is to explore the properties of Brassica olerea, a medicinal plant used in Congolese Medicinal Traditional, in treatment of burns and infectious diseases. Material and methods:The leaves of Brassica olerea has submitted for chemical screening by conventional techniques focusing on color reactions and chemical precipitation. The susceptibility testing was realized and the extracts were tested against nineteen strains mainlyStaphylococcus pneumonae, Staphylococcus aureus(6 strains), Shigellaflexineri, Salmonelleenterica(3 strains), Pseudomonas aeruginosa, Klebsiellapneumoniae(3 strains), Eschericha coli (2 strains), Enterococcus fecalis, Hemophyllus influenza and Amoxicillinas reference drug. The macrodilution in liquid medium for 24 hours was used to determine the Minimal inhibition concentration...............

 

Keywords: Brassica olerea, hydroalcoholic and ethanolic extracts, phytochemical screening, antibacterial activities.

[1]. Amare A, Hadush A, Aregawi H, Kide N. Antibacterial activity of oil extracts of Black Mustard (Brassica nigra) seeds against bacteria isolated from fresh juice in selected areas of Axum town, International Journal of integrative Sciences, Innovation and Technology (IJIIT) 2015; 4(4): 15-18.
[2]. Ayshwarya M, Rameshwari KS. Antimicrobial activity of the plant extracts of Brassicaoleracea var. Capitatarubra. Journal of international academicresearch for multidisciplinary 2015; 3(10): 149-156.
[3]. Begum RA, Poonkothai M. In vitro antimicrobial activity and phytochemical analysis of Brassica oleracea. Int J PharmPharmSci. 2013; 5(2): 405-408.
[4]. Borate PP and Disale SD. Studies on Antibacterial Activity of Acmellaoleracea(L.) Murr. International Journal of Pharmaceutical Science and Health Care Issue 2013; 3(5): 36-42.
[5]. Chauhan ES, Tiwari A, Singh A. Phytochemical screening of Knol-Khol (Brassica caulorapa) Powder and Juice - A comparative study. International Journal of Home Science 2016; 2(3): 123-126.

 

Paper Type

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Research Paper

Title

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Chromogenic Spectrophotometric Estimation of Brivaracetam in
Bulk drug & its Formulation with Folin Ciocalteu reagent

Country

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India

Authors

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Imam Pasha.S || Murali BalaramVaranasi || Ibrahim Mohammed

Page No.

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44-48

Paper Index
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XXXX

Simple, precise, economic & less time consuming visible spectroscopic method for Brivaracetam was developed by using Folin Ciocalteu Reagent (FCR) in the presence of base. The absorption maximum of the chromogen was found to be 475 nm. The developed method was obeying Beer Lambert's law in the range of 2-20 μg/ml concentration. The method has also been statistically evaluated & the results were within the limits. Molar absorptivity, Sand ell's sensitivity a& Correlation –co-efficient were found to be 1.528 x 103, 0.109 and 0.998 respectively & the method is free from the interferences of other additives present in the formulation.

 

Keywords: Brivaracetam, Folin Ciocalteu Reagent (FCR), Quantification, Chromogenic.

[1]. Maria Laura, Sargentini-Maier, Pascal Espié, Alain Coquette and ArmelStockis, Pharmacokinetics and Metabolism of 14C-Brivaracetam, a Novel SV2A Ligand in Healthy Subjects, Aspet journals,36 (1), 2008,36- 45.
[2]. Arnaud Schülé, Alain Merschaert, Christophe Szczepaniak, Christophe Maréchal, Nicolas Carly, John O'Rourke, and CélalAtes, A Biocatalytic Route to the Novel Antiepileptic Drug Brivaracetam, Organic Process Research and Development, 20 (9), 2016 , 1566–1575.
[3]. Jean-Marie Nicolas,Jonas Hannestad,Daniel HoldenSophieKervyn,Nabeel Nabulsi,Dominique
Tytgat,Yiyun Huang,Hugues Chanteux, Ludovicus Staelens,Alain Matagne,François-Xavier Mathy,Joël Mercier,ArmelStockis,Richard E. Carson,Henrik Klitgaard. Brivaracetam, a selective high-affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action, Epilepsia, Official Journal of the International League against Epilepsy, 57( 2),2016, 201–209.

 

Paper Type

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Research Paper

Title

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Role Of Ultrasonography And Color DopplerInIntrauterine Growth Restriction For Prediction Of Adverse Perinatal Outcome- A Prospective Study

Country

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India

Authors

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Dr Paresh Bhowmik || Dr (Prof) J. K. Podder || Dr(Prof)Pardip Kumar Deb || Dr. Jaybrata Roy

Page No.

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49-53

Paper Index
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XXXX

To determine umbilical artery PI and PI of middle cerebral artery and the MCA PI/UA PI ratio to assess the fetal hypoxia by Color Doppler study and its adverse effect on perinatal outcome. Methodology: A total 50 cases of clinically suspected IUGR pregnant mothers were enrolled in our study and all of them were evaluated by Colour Doppler study,following detailed clinical examination. In colour Doppler study umbilical artery flow Pulsatility index(PI)in regards to normal, reverse and absent end diastolic flow were recorded. PI index of Middle Cerebral artery was measured in each case and ratio of MCA PI &UA PI were calculated. All those 50 cases were followed up till early neonatal period. Fetal outcome in respect of umbilical and middle cerebral artery flow and MCA PI & UA PI ratio were recorded................

 

Keywords: Intrauterine Growth Retardation, Pulsatility Index, revers diastolic flow, absent diastolic flow , cerebral redistribution, umbilical artery(UA), middle cerebral artery(MCA) ,MCA PI/ UA PI ratio and reduced diastolic flow.

[1]. Raghupathy R, Al-Azemi M, Azizieh F. Intrauterine Growth Restriction: Cytokine Profile of Trophoblast Antigen-stimulated Maternal Lymphocytes. Clinical and Developmental Immunology. 2012; article ID734865:1-10.
[2]. Doi: 10. 1155/2012/734865.
[3]. Meyberg R, Boos R, Babajan A, Ertan AK, Schmidt W.Intrauterine growth retardation--perinatal mortality and postnatal morbidity in a perinatal center.Z Geburtshilf Neonatal.2000 Nov-Dec; 204(6):218-23.
[4]. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Rouse DJ, Spong CY editors. Text book of Williams Obstetrics.USA: McGraw Hill books Ltd; 2010.
[5]. Peleg D, Kennedy C M, Stephen KH. Intrauterine Growth Restriction: Identification and management. Am Fam Physician1998 Aug1; 58(2):453-60.

 

Paper Type

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Research Paper

Title

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Optimization of Bioanalytical LC Method for Simultaneous Determination of Risperidone And Its Active Metabolite 9-OH Risperidone in Human Plasma And Urine

Country

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Macedonia (FYROM)

Authors

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Zorica Naumovska || Katerina Brezovska || Jasmina Tonic-Ribarska || Aleksandra Kapedanovska Nestorovska || Zoran Sterjev || Aleksandra Grozdanova || Ana Filipce || Aleksandar Dimovski || Ljubica Suturkova

Page No.

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54-64

Paper Index
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XXXX

Risperidone is the most widely used first line mono therapy in schizophrenia and combined therapy in bipolar disorders. Unpredictable dose/concentration ratio, narrow therapeutic index, clinically relevant interactions, along with serious adverse reactions (ADR), raises the need for individualization of risperiodone treatment and establishing of good therapeutic regime using TDM. Optimization and validation of simple and rapid HPLC method with UV detection for simultaneous determination of risperidone and its active metabolite 9-OH risperidone in human plasma and urine samples, using liquid - liquid extraction procedure for sample preparation. Satisfactory separation was achieved on a reversed-phase C8 column, using acetonitrile and phosphate buffer as a mobile phase with gradient elution, for a total analysis time of 10 minutes. Clozapine was used as an internal standard.................

 

Keywords: Risperidone, 9-OH risperidone, HPLC, liquid-liquid extraction, plasma, urine

[1]. de Leon, J., Sandson, N.B., Cozza, K.L. (2008) Psychosomatics. 49, 347-61.
[2]. Wang, J.S., DeVane, C.L., Gibson, B.B., Donovan, J.L., Markowitz, J.S., Zhu, H.J. (2006) Psychopharmacology (Berl). 183(4), 490-9.
[3]. Leysen, J.E., Gommeren, W., Eens, A., de Chaffoy de Courcelles, D., Stoof, J.C., Janssen, P.A. J Pharmacol Exp Ther. (1988), 247,661-70.
[4]. Seto, K., Dumontet, J., Ensom, M.H. (2011) Ther Drug Monit.,33,275-83.
[5]. Foroutan, S.M., Zarghi, A., Shafaati A. (2006) Iranian Journal of Pharmaceutical Research. 1, 37-40

 

Paper Type

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Research Paper

Title

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A Pharmacoeconomic Study of Consequences, Continuity & Adherence of Polypharmacy in Elderly Patients

Country

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India

Authors

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Dr.Anusha Joel.A || B .Srikanth || Ch.Usha Sai Sree || L.Vyshnavi || K.Mounika

Page No.

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65-74

Paper Index
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XXXX

Aim: A study of consequences, continuity & adherence of polypharmacy in elderly patients Objectives: To find out the prevalence of polypharmacy and unnecessary medication use, to investigate the extent and reasons for modification to the medication regimen in elderly patients and to study their adherence to treatment after modification. Methodology: A prospective observational study was conducted in multiple tertiary care centers of various departments. The data was categorized based on various parameters like age, gender, co morbidities, antibiotic usage in geriatrics and drugs per prescription were collected and analyzed..................

 

Keywords: .................

[1]. Maher RL, Hanlon JT, Hajjar ER. Clinical Consequences of Polypharmacy in Elderly. Expert opinion on drug safety. 2014;13(1

[2]. Beadles CA, Voils CI, Crowley MJ, Farley JF, Maciejewski ML. Continuity of medication management and continuity of care: Conceptual and operational considerations. SAGE Open Medicine. 2014;2.

[3]. Chu HY1, Chen CC, Cheng SH. Continuity of care, potentially inappropriate medication, and health care outcomes among the elderly: evidence from a longitudinal analysis in Taiwan.

[4]. Zelko E, Klemenc-Ketis Z, Tusek-Bunc K. MEDICATION ADHERENCE IN ELDERLY WITH POLYPHARMACY LIVING AT HOME: A SYSTEMATIC REVIEW OF EXISTING STUDIES. Materia Socio-Medica. 2016;28(2):129-132.

[5]. MURRAY MD, KROENKE K. Polypharmacy and Medication Adherence: Small Steps on a Long Road. Journal of General Internal Medicine. 2001;16(2):137-139

 

Paper Type

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Research Paper

Title

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Development And Optimization of Boswellia Serrata Self-Micro Emulsifying Formulation: An Ameliorative Effort Towards the Herbal Formulation

Country

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India

Authors

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Kunal Detholia || Dashrath Patel || Swayamprakash Patel

Page No.

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75-83

Paper Index
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XXXX

Development of self-micro emulsifying drug delivery system (SMEDDS) of herbal extracts is challenging task per se, as the herbal extracts contains many active and non-active constituents with various physicochemical properties. Present work focuses on development and evaluation of self-micro emulsifying formulation of Boswellia Serrata Extracts (BSE). An optimized formulation of BSE-SMEDDS composed of the equal fraction of Capmul-MCM®, Acrysol EL135® and Acconon MC8® was developed by employing the 33 Full Factorial experimental design.The optimized formulation having capability to self-micro emulsification within less than one minute and droplet size of 189.3 nm (0.432 PDI) was evaluated for In-vitro drug release and ex-vivo diffusion for its comparison with the marketed formulation of the Boswellia Serrata Extract.

 

Keywords: About five key words in alphabetical order, separated by comma

[1]. MacLennan AH, Wilson DH, Taylor AW, Prevalence and cost of alternative medicine in Australia, The Lancet, 347(9001), 1996, 569-73.
[2]. Egede LE, Ye X, Zheng D, Silverstein MD, The prevalence and pattern of complementary and alternative medicine use in individuals with diabetes, Diabetes Care, 25(2), 2002, 324-9.
[3]. Yates JS, Mustian KM, Morrow GR, Gillies LJ, Padmanaban D, Atkins JN, et al., Prevalence of complementary and alternative medicine use in cancer patients during treatment, Support Care Cancer, 13(10), 2005, 806-11.
[4]. Ernst E, The prevalence of complementary/alternative medicine in cancer, Cancer, 83(4), 1998, 777-82.
[5]. Pal SK, Shukla Y, Herbal medicine: current status and the future, Asian Pac J Cancer Prev, 4(4), 2003, 281-8.