Volume 8 ~ Issue 1,~Version 1,~January - 2018


Paper Type

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Research Paper

Title

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Development And Optimization of Boswellia Serrata Self-Micro Emulsifying Formulation: An Ameliorative Effort Towards The Herbal Formulation

Country

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India

Authors

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Krunal Detholia || Dashrath Patel || Swayamprakash Patel

Page No.

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01-08

Paper Index
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XXXX

Development of self-micro emulsifying drug delivery system (SMEDDS) of herbal extracts is challenging task per se, as the herbal extracts contains many active and non-active constituents with various physicochemical properties. Present work focuses on development and evaluation of self-micro emulsifying formulation of Boswellia Serrata Extracts (BSE). An optimized formulation of BSE-SMEDDS composed of the equal fraction of Capmul-MCM®, Acrysol EL135® and Acconon MC8® was developed by employing the 33 Full Factorial experimental design.The optimized formulation having capability to self-micro emulsification within less than one minute and droplet size of 189.3 nm (0.432 PDI) was evaluated for In-vitro drug release and ex-vivo diffusion for its comparison with the marketed formulation of the Boswellia Serrata Extract.

 

Keywords: Boswellia Serrata, Self-Micro Emulsifying Drug Delivery System, SMEDDS, Herbal Formulaiton.

[1]. MacLennan AH, Wilson DH, Taylor AW, Prevalence and cost of alternative medicine in Australia, The Lancet, 347(9001), 1996, 569-73.
[2]. Egede LE, Ye X, Zheng D, Silverstein MD, The prevalence and pattern of complementary and alternative medicine use in individuals with diabetes, Diabetes Care, 25(2), 2002, 324-9.
[3]. Yates JS, Mustian KM, Morrow GR, Gillies LJ, Padmanaban D, Atkins JN, et al., Prevalence of complementary and alternative medicine use in cancer patients during treatment, Support Care Cancer, 13(10), 2005, 806-11.
[4]. Ernst E, The prevalence of complementary/alternative medicine in cancer, Cancer, 83(4), 1998, 777-82.
[5]. Pal SK, Shukla Y, Herbal medicine: current status and the future, Asian Pac J Cancer Prev, 4(4), 2003, 281-8.

 

Paper Type

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Research Paper

Title

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Phytochemical Studies on the Leaves of Pergularia Daemia Collected from Villupuram District, Tamil Nadu, India

Country

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India

Authors

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R. Nithyatharani || U.S.Kavitha

Page No.

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09-12

Paper Index
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XXXX

Pergularia daemia is a fetid smelling, perennial twinning herb, widely distributed in the roadsides of tropical and sub tropical areas. It is used as an important medicinal plant since ancient times. The present study deals with the qualitative and quantitative analysis of the leaves of Pergularia daemia in different solvents and also this study deals with the separation of compounds present in crude methanolic extract of Pergularia daemia leaves by High Performance Liquid Chromatography. The qualitative analysis of the leaves showed the presence of alkaloids, steroids, terpenoids, flavanoids, saponins, phenols, tannins, aminoacids, cardiac glycosides, carbohydrates and proteins. The quantification of the compounds like alkaloids, flavanoids and phenols were done. HPLC shows the presence of two major peaks and exhibited the presence of two major components in the methanolic extract of the leaves. The results suggested that Pergularia daemia has significant phytocomponents and can be used as a source of many pharmacological studies and a curative for various ailments.

 

Keywords: Ancient times, HPLC, medicinal plant, Pergularia daemia, phytochemical screening.

[1]. Vyas BA, Vyas RB, Joshi SV, Santani DD. Journal of Young Pharmacist, 3(1), 2011, 36-40.
[2]. Khare CP (2007): Indian medicinal plants: An illustrated dictionary. New York, Springer, pp. 472.
[3]. Pankaj O (2003): Doomar or gular (ficus glomeruta) as medicinal herbs in chattisgarh, India. Research note. http://botanical.com/site/column_poudhia/127_doomar,html.

[4]. Sathish CJ, Sharma RA, Jain R, Mascolo N, Capasso F, Vijayvergia R, Mittal C (1998). Ethnopharmacological evaluation of Pergularia daemia (Forsk.) chiov. Phytother res 12: 378-380.
[5]. Sureshkumar SV, Mishra SH (2006). Hepatoprotective effect of extracts of Pergularia daemia Forsk. J. Ethanopharmacol., 107: 164-168.

 

Paper Type

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Research Paper

Title

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Chemical Composition, Free Radical Scavenging And Antifungal Activity of Zanthoxylum Leprieurii Essential Oils Against Epidermophyton Floccosum And Microsporum Gypseum, two Most Prevalent Cutaneous Mycosis

Country

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France

Authors

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Tchabong, S.R. || Sameza, M.L. || Tchameni, N.S. || Mounbain F. || Mouelle, S.A. || Jazet, D.P.M. || Menut, C T || choumbougnang, F

Page No.

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13-19

Paper Index
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XXXX

Background: These investigations were carried out to analyze the chemical composition, to evaluate the radical scavenging, and the anti-fungal activities of essential oils from leaves and fruits of Zanthoxylum leprieurii. Methods: Oils were obtained by hydro distillation using a Clevenger type apparatus. The compounds were identified by gas chromatography and gas chromatography coupled with Mass Spectrometry. Antifungal activity of the essential oils was tested in vitro against Epidermophyton floccosum and Microsporum gypseum while free radical scavenging activity evaluation was done using 2,2 diphenyl picrylhydrazyl method.
Results: Results showed that, the major components of the leaves oil were (E)-ß-ocimene (91.5 %) while the most abundant components from fruits oil were also (E)-ß-Ocimene (90.3 %) with pinocarveol (2.8%) and myrcene (2.3 %). The total growth inhibition of the pathogens................

 

Keywords: Essential oil, Antidermatophytitic activity, Antioxidant activity, Zanthoxylum leprieurii

[1]. Canizares, O. and Harman, R. Clinical tropical dermatology. 1992; 2nd ed. Boston: Blackwell Scientific Publications 859p
[2]. Summerbell, R.C., Weitzman I. and Padhye A. A. Trichophyton, Microsporum, Epidermophyton and agents of superficial mycoses. In PR Murray et al. (eds) 2007; Manual of Clinical Microbiology. Ch. 124. 9th ed. ASM Press. Washington, DC. p1874-1897.
[3]. Elewski, B.E. Onychomycosis: Pathogenesis, Diagnosis, and Management. 1998; Clin. Microbiol. Rev. 11(3): 415-429.
[4]. Mau, J.L., Chao, G.R., and Wu, K.T. (2001). Antioxidant properties of methanolic extracts from several mushrooms. 2001; J. Agric. Food Chem. 49(11):5461–5467.
[5]. Pinto, E., Silva, L.V., Cavaleiro, C., and Salgueiro, L. Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species. 2009; J. Med. Microbiol. 58:1454-1462.

 

Paper Type

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Research Paper

Title

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Effect of Aqueous Extracts From Hildegardiabarteri Leaves on Lipid Metabolism of Wistarrats: Possible Implication In Arterial Pressure Variation

Country

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Benin

Authors

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Hoteyi Ismael || Michodjehoun Loetitia || Houndeffo Tiburce || Agonvonon Faith || Ahokpe Melanie || sezan Alphonse

Page No.

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20-26

Paper Index
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XXXX

The aim of this work is to evaluate the impact of aqueous extracts of the leaves of Hildegardiabarteri on the lipid metabolism of wistar rats: possible involvement in blood pressure variations.To achieve our goal an aqueous powder extract of the dried leaves of Hidegardiabarteri was made with a yield of 13.18% and then the phytochemical screening (screening) was carried out by the method of Houghton and Raman in order to identify the phytochemicals Who are present there. This test reveals that our extract is rich in bioactive molecules extractable by water of which: an abundance of tannins, flavonoids, mucilages, reducing compounds, saponosides, triterpenoids, coumarins of quinone derivatives and catechic tannins or Condensed (not abundant). We had 09 lots of 02 rats (180-220g of pc)..............

 

Keywords: Hidegardiabarteri, wistar rats, lipid profile, diuretic activity, and furosemide.

[1]. Hurtel J. (2006). Huiles essentielles et médecine. Phytothérapie, plantes médicinales, aromathérapie, huiles essentielles. Phytomania.
[2]. Novais J. (2004). Studies on pharmaceuticalethnobotany in Arrabida Natural Park (Portugal), 93 : 183-
[3]. Kostermans A. (1954). A Note on SomeAfricanSterculiaceae Bulletin du Jardin botanique de l'État à Bruxelles, Vol. 24, Fasc. 4, pp. 335-338
[4]. Schott H, Endlicher S. (1832) Meletemata Botanica. (Vienna: Carolus Gerold)
[5]. Tokoudagba J. (2009). "Recherches de plantes à potentialités antihypertensives dans la biodiversité béninoise". Ethonopharmacologie 44, P : 35

 

Paper Type

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Research Paper

Title

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Heavy Metal Pollution Induced Histopathological Changes in Anabas testudineus collected from Periyar River at Ernakulam district and the Recovery Responses in Pollution free water

Country

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India

Authors

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Ml Joseph || Asha Raj Kr

Page No.

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27-37

Paper Index
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XXXX

Heavy metal (lead, nickel, zinc, arsenic and cadmium) pollution status in water, sediment and the corresponding bioaccumulation in biomass of Anabas testudineus from two different stations of Periyarriver at Ernakulam district (Station I- Eloor Industrial area, Station II- Irumbanam, Ernakulam) of two year period analysis showed that the bioaccumulation rate depends on pollution status in the environment. The histopathological changes in liver, gills and muscle varied based on the pollution load. The recovery responses were studied in fishes kept in aquaria maintained at controlled laboratory conditions for 30 days and from the results it was apparent that the pollution induces stress in fishes that has been reflected in the histological characteristics of vital organs. However by keeping them in pollution free waters positively influenced towards recovery from stress.

 

Keywords: Periyarriver, Ernakulam, Anabas testudineus.

[1]. D. Roganovic – Zafirova, M. Jordanova, S. Panov, and L.Velkova – Jordanoska. Hepatic capillariasis in the Mediterranean barbell (Barbusmeridionalispetenyi heck.) from lakeOhrid. Folia Veterinaria., 47(1), 2003. 35 – 37.
[2]. M. Pacheco and M. Santos. Biotransformation, genotoxic, and histopathological effect of environmental contaminants in European eel (Anguilla anguilla L.). Ecotoxicology and Environmental Safety, 53, 2002. 331–47.
[3]. C.K.C. Wong, H.Y. Yeung, R.Y.H. Cheung, K.K.L.Yung, and M.H. Wong.Ecotoxicological assessment of persistent organic and heavy metal contamination in Hong Kong coastal sediment. Arch Environ ContamToxicol., 38, 2000. 486-93.
[4]. C. Wong, et al. Specific expression of cytochrome P4501A1 gene in gill, intestine and liver of tilapia exposed to coastal sediments. Aquatic Toxicology, 54, 2001. 69–80.

 

Paper Type

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Research Paper

Title

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Citrus aurantifolia (Lime) Juice Negatively Influences Estrous
Cycle of Wistar Rats

Country

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Nigeria

Authors

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Aprioku JS || Briggs OEI

Page No.

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38-43

Paper Index
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XXXX

Citrus aurantifolia(Lime) fruit is commonly consumed and known to be rich in vitamins and other
important phytochemicals. The effect of Limejuice on estrous cycle was evaluated in female Wistar
rats.Different groups of rats (n=6 per group) with regular estrous cycleswere gavaged orally with 1ml Lime juice (25, 50 or 100%) consecutively for fourteen days. A fourth (control) group was given distilled water.Vaginal lavage was analyzed daily in treated animals for ten days from the fourth day of administration to determine estrous cycle phases, but prior to juice treatment, estrous cyclesof rats were established. Animal body weights in treatment and control groups were monitored.

 

Keywords: Estrous cycle, Citrus aurantifolia,diestrus, lime juice, vaginal smear

[1]. A. Abdelqader,Q. Bassam, A. Diya, andD. Gurbuz. Anthelmintic effects of citrus fruit peels ethanolic extract against Ascaridiagalli. Veterinary Parasitology, 2012, 10, 1-7.
[2]. O.S. Enejoh, I.O. Ogunyemi, M.S. Bala, I.S. Oruene, M.M. Suleiman, and S.F. Ambali. Ethnomedical importance of Citrus aurantifolia (Christm) Swingle. The Pharma Innovation Journal, 2015, 4(8), 01-06.
[3]. N. Narang, and W. Jiraungkoorskul. Anticancer activity of key lime, Citrus aurantifolia. Pharmacognosy Reviews, 2016, 10(20), 118-122.
[4]. D. Okwu, and I., Emenike. Evaluation of the phytonutrients and vitamin content of citrus fruits.
International Journal of Molecular Medicine&Advanced Science, 2006, 21: 1-6.
[5]. M. Ladaniya.Fruit Biology: Technology and Evaluation. Goa, India: Academic Press, 2008.

 

Paper Type

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Research Paper

Title

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Arteriovenous Malformation Of The Uterus

Country

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India

Authors

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M.M Begum || S. Sultana || M.A Hossain || M. Quddus

Page No.

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44-46

Paper Index
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XXXX

Uterine Arteriovenous malformations (UAVM) are uncommon entities and should be considered in patients who present with profuse genital tract bleeding. There are two types of uterine AVM: acquired and congenital. Acquired uterine AVMs are conformed by communications between the uterine arteries and the myometrial veins, and are caused by an iatrogenic event or a pathological condition. Congenital AVMs are the result of abnormal development of primitive vessels that result in connections between pelvic arteries and veins in the uterus without an interconnecting capillary bed. Initial evaluation of UAVMs is made with ultrasonograghy (US) and US-Doppler. MRI is used when a UAVM is suspected at US. Treatment can be surgical (hysterectomy or surgical removal of AVM), or with selective uterine arterial embolization. We report a case of abnormal uterine bleeding due to UAVM.

 

Keywords: Arterio-venous malformation, US-Doppler, MRI, Embolization, Genital bleeding, uterine artery

[1]. Cura M, Martinez N, Cura A, Dalsaso TJ, Elmerhi F, (2009) Arteriovenous malformations of the uterus. Acta Radiol 50(7): 823-829.
[2]. Huang MW, Muradali D, Thurston WA, Burns PN, Wilson SR. Uterine Arteriovenous malformations: gray-scale and Doppler US features with MR imaging correlation. Radiology 1998; 206: 115-123.
[3]. Polat P, Suma S, Kantarcy M, Apler F, Levent A (2002) Color Doppler US in the evaluation of uterine vascular abnormalities. Radiograghics 22(1): 47-53.
[4]. Dubreuil G, Loubat E (1926) Aneurysme cirsoide de l' uterus. Ann Anat Pathol 3: 697-718.
[5]. Nicholson AA, Turnbull LW, Coady AM, Guthrie K (1999). Diagnosis and management of uterine arterio-venous malformations. Clin Radiol 54: 265-269.

 

Paper Type

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Research Paper

Title

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Alternative Medicine In The Management of Oral Mucosal
Lesions- A Review

Country

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India

Authors

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Pankaj Gupta || Kanaparthi Alekhya

Page No.

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47-53

Paper Index
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XXXX

The term Alternative Medicine is used to denote a form of medicine that falls outside the main stream of western medicine. These kinds of medicines exist in all cultures to some degrees and terms such as traditional medicines, indigenous medicines, holistic medicines, folk medicines and oriental medicines are used. These medicines when used in dentistry, the term holistic dentistry is used. Alternative medicines or therapy encompasses a variety of disciplines including acupuncture, chiropractic treatment, guided imagery, yoga, biofeedback, hypnosis, romatherapy, herbal remedies, relaxation, massage etc. There is common patient belief that these therapies are safe to use..........

 

Keywords: Alternative medicine, Anti-oxidant, Herbal medicines, Holistic, Oral mucosal lesions

[1]. Little JW. Complementary and alternative medicine: Impact on dentistry. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;98:137-45
[2]. WHO, National Policy on Traditional Medicine and Regulation of Herbal Medicines - Report of a WHO Global Survey, (May 2005), at 121–122.
[3]. Chithra R Sajithlal GB, Chandrakasan G. Influence of aloe vera on collagen characteristics in healing dermal wounds in rats. Mol Cell Biochem. 1998; 181:71–6.
[4]. Kim HS, Kacew S, Lee BM (1999).. In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis Miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor). Carcinogenesis. 20: 1637–1640.
[5]. Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P. The efficacy of Aloe vera gel in the treatment of oral lichen planus: A randomized controlled trial. Br J Dermatol. 2008; 158:573–7.

 

Paper Type

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Research Paper

Title

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Prevalence of Obesity among Female School Children of Jaipur
City

Country

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India

Authors

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Poonam Singh || Pramjeet Singh Ghuman || Devendra Somwanshi

Page No.

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54-59

Paper Index
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XXXX

Country like India, is also suffering from problems of overweight and obesity among children,
adolescents, adults, and old age. Obesity with associated problems is affecting to all age groups.
Objectives: 1. To find out and compare the prevalence of obesity among female school children. 2. To find out the relationship between Obesity and Socioeconomic status. Material & Method: For the purpose of the study, total 800 female children were selected randomly from four private schools and four government schools. The age of the children was ranged from 6 to 10 years. In the
study two variables were examined namely obesity and socioeconomic status. The data regarding height was obtained by stadiometer and weight by weighing machine

 

Keywords: Prevalence, Obesity, Childhood Obesity, Overweight, Socio-economic status, BMI

[1]. Aronovitch, K.M., et al. (2014). "Blood Pressure in Obese and Overweight Children and Adolescents." IMAJ, 16: 157–161.
[2]. Bagudai, Satyajit., et al. (2014). "Prevalence of obesity & hypertension in adolescent school going children of Berhampur, Odisha, India." International Journal of Physiotherapy and Research, 2(6): 777-80.
[3]. Chudasama, Rajesh K., et al. (2016). "Obesity and Overweight Prevalence among School Children and Adolescents Aged 8-18 Years in Rajkot, Gujarat." Indian Pediatrics, 54: 1-4.
[4]. Dong, Bin., et al. (2013). "The Association of Overweight and Obesity with Blood Pressure among Chinese Children and Adolescents." Biomed Environment Science, 26 (6): 437-444.
[5]. Fernandes, Nicolle., et al. (2015). "Overweight Status in Indian Children: Prevalence and Psychosocial Correlates." Indian Pediatrics, 52: 131-134.