Background: A simple, specific, linear, precise and accurate reverse phase liquid chromatographic (RP-HPLC) method was developed to analysis speed by minimizing run time and retention timeof Cetirizine Hydrochloride in tablet dosage forms. The chromatographic separation was performed using Phenomenex Luna 5μ C18 100A (250 x 4.6 mm). Mobile phase composed of Acetonitrile and water (60:40 v/v) was selected and a flow rate of 1.000 ml/minute is monitored..........

Keywords : Cetirizine Hydrochloride, method development, Validation

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N-octyl cinnamic is a compound that has potential as a drug as an antioxidant, anti-inflammatory, but is constrained by the nature of n-octyl cinnamate which is difficult to dissolve in water, causing low bioavailability in the systemic circulation. To overcome this problem, curcumin is formulated in the form of nanoparticles using chitosan polymer, a derivative of chitin which can be obtained from crab and shrimp shell waste. This study aims to synthesize n-octyl cinnamic nanoparticles using a simple.......

Keywords:Nanoparticle, Anti-inflammatory, n-octyl cyanamate/Alginate/chitosan, Synthesis

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Diabetes mellitus (DM), also termed as "sugar," is a chronic, noncommunicable disease (NCD) which has emerged as one of the leading global health problem associated with the pancreas in the production of insulin leading to hyperglycemia . Type 2 diabetes mellitus is associated with a combination of resistance to insulin action and inadequate.....

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This work aimed to investigate the anti-gastric ulcer activity of the hydro alcoholic extract of Perichlaenarichardii leaves in rat. Its effect on gastric mucosa was studied on gastric lesions induced by orally administering indomethacin at dose 30 mg/kg for 5 days. Misoprostol, at the dose of 1.4 μg/kg, was used as reference, while the effect of extract P. richardii on acid secretion was investigated after pylorus ligation. The extract P. richardii reduces indomethacin induced gastric surface ulcerous lesions. The administration of the extract at doses 150 and.......

Keywords: anti-secretory,antiulcer, muco-protector, rat

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Background: Ketoprofen (KETO) is an example of drugs with limited solubility and high permeability that are classified as biopharmaceutics classification system (BCS) class II. Its poor water solubility can give rise to formulation problems and reduce its therapeutic efficiency and bioavailability. Materials and Methods: A simple solution mixing method was used to formulate KETO into solid dispersion with cationic hydrophilic polymers; Eudragit® E (EE) and chitosan (CH). These solid dispersions were prepared at various drug.....

Key-words: Ketoprofen; Chitosan; Eudragit E; Solid dispersion; Solvent evaporation

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Background: Atorvastatin, an inhibitor of 3-hydroxy-3-methylglutarylcoenzyme-A (HMG-CoA) reductase, is widely prescribed in adult and pediatric patients for its potent cholesterol lowering effect. However, atorvastatin is only commercially available in tablet form. Therefore, pharmacists have compounded atorvastatin suspension making the medication available to more pediatric patients and select adults unable to take tablets. Limited reports on the preparation.....

Key-words: Stability; Chemical stability; HPLC; Suspension; Physicochemical properties; US Pharmacopeia (USP)

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